{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:13:36Z","timestamp":1777878816165,"version":"3.51.4"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900631"],"award-info":[{"award-number":["81900631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270281"],"award-info":[{"award-number":["82270281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2020jcyj-msxmX0210"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0210"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M653354"],"award-info":[{"award-number":["2019M653354"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["cstc2019jcyj-bsh0012"],"award-info":[{"award-number":["cstc2019jcyj-bsh0012"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["W0133"],"award-info":[{"award-number":["W0133"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.ejps.2023.106531","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:20:37Z","timestamp":1689812437000},"page":"106531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["RNA-Seq transcriptome analysis of renal tissue from spontaneously hypertensive rats revealed renal protective effects of dapagliflozin, an inhibitor of sodium-glucose cotransporter 2"],"prefix":"10.1016","volume":"189","author":[{"given":"Jiangjun","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangyan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianglin","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiaCheng","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2023.106531_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112628","article-title":"The dynamic interplay between AMPK\/NF\u03baB signaling and NLRP3 is a new therapeutic target in inflammation: emerging role of dapagliflozin in overcoming lipopolysaccharide-mediated lung injury","volume":"147","author":"Abd El-Fattah","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejps.2023.106531_bib0002","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.3389\/fimmu.2019.03049","article-title":"Complement receptor-mediated phagocytosis induces proinflammatory cytokine production in murine macrophages","volume":"10","author":"Acharya","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejps.2023.106531_bib0003","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0140-6736(05)17789-7","article-title":"Chronic kidney disease: the global challenge","volume":"365","author":"Ame","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ejps.2023.106531_bib0004","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ejps.2023.106531_bib0005","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/dom.12352","article-title":"Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): implications for GLP-1 measurements in clinical studies","volume":"16","author":"Bak","year":"2014","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.ejps.2023.106531_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11100690","article-title":"Apolipoprotein B and cardiovascular disease: biomarker and potential therapeutic target","volume":"11","author":"Behbodikhah","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.ejps.2023.106531_bib0007","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejps.2023.106531_bib0008","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s00125-015-3547-2","article-title":"Effects of canagliflozin on body weight and relationship to HbA1c and blood pressure changes in patients with type 2 diabetes","volume":"58","author":"Cefalu","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejps.2023.106531_bib0009","article-title":"Dapagliflozin, SGLT2 inhibitor, attenuates renal ischemia-reperfusion injury","volume":"11","author":"Chang","year":"2016","journal-title":"PLoS One"},{"issue":"Suppl 4","key":"10.1016\/j.ejps.2023.106531_bib0010","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.ejps.2023.106531_bib0011","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cca.2005.12.002","article-title":"Analytical validation of an HPLC assay for urinary albumin","volume":"367","author":"Contois","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ejps.2023.106531_bib0012","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrneph.2016.170","article-title":"Renal, metabolic and cardiovascular considerations of SGLT2 inhibition","volume":"13","author":"DeFronzo","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejps.2023.106531_bib0013","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-018-1104-y","article-title":"Zbtb20 regulates developmental neurogenesis in the olfactory bulb and gliogenesis after adult brain injury","author":"Doeppner","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejps.2023.106531_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106591","article-title":"Atrial fibrillation: epigenetic aspects and role of sodium-glucose cotransporter 2 inhibitors","volume":"188","author":"Donniacuo","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejps.2023.106531_bib0015","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1042\/CS20201017","article-title":"Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)","volume":"135","author":"Elmarakby","year":"2021","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.ejps.2023.106531_bib0016","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41581-018-0072-9","article-title":"Lipid management in patients with chronic kidney disease","volume":"14","author":"Ferro","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejps.2023.106531_bib0017","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/HYPERTENSIONAHA.117.08314","article-title":"Hypertensive kidney injury and the progression of chronic kidney disease","author":"Griffin","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.ejps.2023.106531_bib0018","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.022637","article-title":"Different responses of muscle sympathetic nerve activity to dapagliflozin between patients with type 2 diabetes with and without heart failure","volume":"10","author":"Hamaoka","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ejps.2023.106531_bib0019","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.ejps.2023.106531_bib0020","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1111\/bph.12503","article-title":"Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?","volume":"171","author":"Higgins","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejps.2023.106531_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112246","article-title":"Antihypertensive and metabolic effects of empagliflozin in Ren-2 transgenic rats, an experimental non-diabetic model of hypertension","volume":"144","author":"Hojna","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejps.2023.106531_bib0022","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1038\/s41467-020-17525-6","article-title":"Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors","volume":"11","author":"Hosaka","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejps.2023.106531_bib0023","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.advms.2017.06.004","article-title":"A systematic review on the role of eicosanoid pathways in rheumatoid arthritis","volume":"63","author":"Hoxha","year":"2018","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.ejps.2023.106531_bib0024","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3389\/fendo.2019.00441","article-title":"Dapagliflozin attenuates renal tubulointerstitial fibrosis associated with type 1 diabetes by regulating STAT1\/TGF\u03b21 signaling","volume":"10","author":"Huang","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.ejps.2023.106531_bib0025","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/physrev.00021.2011","article-title":"Epoxides and soluble epoxide hydrolase in cardiovascular physiology","volume":"92","author":"Imig","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejps.2023.106531_bib0026","first-page":"1456","article-title":"Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system","volume":"10","author":"K","year":"1996","journal-title":"Faseb J. Off. Publ. Feder. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.ejps.2023.106531_bib0027","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejps.2023.106531_bib0028","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(05)17741-1","article-title":"Global burden of hypertension: analysis of worldwide data","volume":"365","author":"Kearney","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ejps.2023.106531_bib0029","doi-asserted-by":"crossref","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ejps.2023.106531_bib0030","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1161\/HYPERTENSIONAHA.122.19177","article-title":"Dapagliflozin attenuates sympathetic and pressor responses to stress in young prehypertensive spontaneously hypertensive rats","volume":"79","author":"Kim","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.ejps.2023.106531_bib0031","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3389\/fimmu.2020.00553","article-title":"Phagocytosis of apoptotic cells in resolution of inflammation","volume":"11","author":"Kourtzelis","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejps.2023.106531_bib0032","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1042\/CS20170177","article-title":"Oxidative imbalance and kidney damage in spontaneously hypertensive rats: activation of extrinsic apoptotic pathways","volume":"131","author":"La Russa","year":"2017","journal-title":"Clin. Sci. (London, England: 1979)"},{"key":"10.1016\/j.ejps.2023.106531_bib0033","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/dom.12127","article-title":"Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes","volume":"15","author":"Lambers Heerspink","year":"2013","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.ejps.2023.106531_bib0034","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ejps.2023.106531_bib0035","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/CCM.0b013e3181c98d21","article-title":"Inflammation and coagulation","volume":"38","author":"Levi","year":"2010","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ejps.2023.106531_bib0036","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/bioinformatics\/btn025","article-title":"SOAP: short oligonucleotide alignment program","volume":"24","author":"Li","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ejps.2023.106531_bib0037","doi-asserted-by":"crossref","first-page":"14824","DOI":"10.1038\/ncomms14824","article-title":"Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejps.2023.106531_bib0038","doi-asserted-by":"crossref","first-page":"11097","DOI":"10.1073\/pnas.1301257110","article-title":"Zinc finger protein ZBTB20 promotes toll-like receptor-triggered innate immune responses by repressing I\u03baB\u03b1 gene transcription","volume":"110","author":"Liu","year":"2013","journal-title":"Pnas"},{"key":"10.1016\/j.ejps.2023.106531_bib0039","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2023.106531_bib0040","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1001\/jamainternmed.2017.4377","article-title":"Association between more intensive vs less intensive blood pressure lowering and risk of mortality in chronic kidney disease stages 3 to 5: a systematic review and meta-analysis","volume":"177","author":"Malhotra","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.ejps.2023.106531_bib0041","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrneph.2010.38","article-title":"Renal glucose transporters: novel targets for hyperglycemia management","volume":"6","author":"Mather","year":"2010","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejps.2023.106531_bib0042","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/CIRCRESAHA.116.303697","article-title":"Inflammation, immunity, and hypertensive end-organ damage","volume":"116","author":"McMaster","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejps.2023.106531_bib0043","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejps.2023.106531_bib0044","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1124\/jpet.121.001251","article-title":"Empagliflozin improves the microRNA signature of endothelial dysfunction in patients with heart failure with preserved ejection fraction and diabetes","volume":"384","author":"Mone","year":"2023","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ejps.2023.106531_bib0045","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ejps.2023.106531_bib0046","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.ejps.2023.106531_bib0047","doi-asserted-by":"crossref","first-page":"594","DOI":"10.2353\/ajpath.2010.090268","article-title":"Human nephrosclerosis triggers a hypoxia-related glomerulopathy","volume":"176","author":"Neusser","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejps.2023.106531_bib0048","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12933-020-01071-y","article-title":"SGLT2i: beyond the glucose-lowering effect","volume":"19","author":"Ni","year":"2020","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.ejps.2023.106531_bib0049","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112394","article-title":"The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity","volume":"9","author":"Oelze","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejps.2023.106531_bib0050","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/bcpt.13371","article-title":"Doxazosin down-regulates sodium-glucose cotransporter-2 and exerts a renoprotective effect in rat models of acute renal injury","volume":"126","author":"Rezq","year":"2020","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejps.2023.106531_bib0051","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.4049\/jimmunol.1203487","article-title":"Complement in immune and inflammatory disorders: pathophysiological mechanisms","volume":"190","author":"Ricklin","year":"2013","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.ejps.2023.106531_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109686","article-title":"Gastroprotective effect of dapagliflozin in ethanol-induced gastric lesions in rats: crosstalk between HMGB1\/RAGE\/PTX3 and TLR4\/MyD88\/VEGF\/PDGF signaling pathways","volume":"115","author":"Salama","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejps.2023.106531_bib0053","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1056\/NEJMc1600827","article-title":"Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes","volume":"374","author":"Sarafidis","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejps.2023.106531_bib0054","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12933-017-0621-8","article-title":"Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study","volume":"16","author":"Solini","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.ejps.2023.106531_bib0055","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1210\/jc.2019-00706","article-title":"The effects of dapagliflozin on systemic and renal vascular function display an epigenetic signature","volume":"104","author":"Solini","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejps.2023.106531_bib0056","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1084\/jem.191.1.61","article-title":"The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules","volume":"191","author":"Stein","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejps.2023.106531_bib0057","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejps.2023.106531_bib0058","first-page":"205","article-title":"Zbtb20 restrains CD8 T cell immunometabolism and restricts memory differentiation and antitumor immunity","author":"Sun","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejps.2023.106531_bib0059","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5590855","article-title":"ZBTB20 positively regulates oxidative stress, mitochondrial fission, and inflammatory responses of ox-LDL-induced macrophages in atherosclerosis","volume":"2021","author":"Tao","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ejps.2023.106531_bib0060","first-page":"255","volume":"22","author":"Tjelle","year":"2000"},{"key":"10.1016\/j.ejps.2023.106531_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106659","article-title":"Dapagliflozin protects the kidney in a non-diabetic model of cardiorenal syndrome","volume":"188","author":"Urbanek","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejps.2023.106531_bib0062","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.pec.2010.06.031","article-title":"Effect of a group-based rehabilitation programme on glycaemic control and cardiovascular risk factors in type 2 diabetes patients: the Copenhagen type 2 diabetes rehabilitation project","volume":"84","author":"Vadstrup","year":"2011","journal-title":"Patient Educ. Couns."},{"key":"10.1016\/j.ejps.2023.106531_bib0063","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.3892\/mmr.2014.3006","article-title":"Analysis of the protein-protein interaction networks of differentially expressed genes in pulmonary embolism","volume":"11","author":"Wang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejps.2023.106531_bib0064","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s12272-023-01430-9","article-title":"Dapagliflozin attenuates myocardial remodeling in hypertension by activating the circadian rhythm signaling pathway","volume":"46","author":"Wang","year":"2023","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.ejps.2023.106531_bib0065","article-title":"Arachidonic acid metabolism and kidney inflammation","volume":"20","author":"Wang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejps.2023.106531_bib0066","first-page":"e13","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.ejps.2023.106531_bib0067","article-title":"Arachidonic acid metabolism controls macrophage alternative activation through regulating oxidative phosphorylation in PPAR\u03b3 dependent manner","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejps.2023.106531_bib0068","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nm.2575","article-title":"PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells","volume":"18","author":"Xue","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejps.2023.106531_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109272","article-title":"Therapeutic efficacy of dapagliflozin on diabetic kidney disease in rats","volume":"113","author":"Yang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejps.2023.106531_bib0070","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jcp.26851","article-title":"Sodium-glucose cotransporter 2 inhibitors and inflammation in chronic kidney disease: possible molecular pathways","volume":"234","author":"Yaribeygi","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejps.2023.106531_bib0071","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1038\/s41598-021-82733-z","article-title":"Complement and coagulation cascades activation is the main pathophysiological pathway in early-onset severe preeclampsia revealed by maternal proteomics","volume":"11","author":"Youssef","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejps.2023.106531_bib0072","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1186\/s12864-017-4002-1","article-title":"Evaluation and comparison of computational tools for RNA-seq isoform quantification","volume":"18","author":"Zhang","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ejps.2023.106531_bib0073","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41418-021-00874-0","article-title":"The E3 ubiquitin ligase TRIM31 plays a critical role in hypertensive nephropathy by promoting proteasomal degradation of MAP3K7 in the TGF-\u03b21 signaling pathway","volume":"29","author":"Zhang","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejps.2023.106531_bib0074","first-page":"3862","article-title":"ZBTB20 promotes cell migration and invasion of gastric cancer by inhibiting I\u03baB\u03b1 to induce NF-\u03baB activation","volume":"47","author":"Zhang","year":"2019","journal-title":"Artif. Cells"},{"key":"10.1016\/j.ejps.2023.106531_bib0075","doi-asserted-by":"crossref","DOI":"10.2174\/1389200033336892","article-title":"Kidney CYP450 enzymes: biological actions beyond drug metabolism","author":"Zhao","year":"2003","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.ejps.2023.106531_bib0076","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41569-021-00559-8","article-title":"Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension","volume":"18","author":"Zhou","year":"2021","journal-title":"Nat. Rev. Cardiol."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098723001616?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098723001616?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:28:38Z","timestamp":1777591718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098723001616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":76,"alternative-id":["S0928098723001616"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2023.106531","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RNA-Seq transcriptome analysis of renal tissue from spontaneously hypertensive rats revealed renal protective effects of dapagliflozin, an inhibitor of sodium-glucose cotransporter 2","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2023.106531","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106531"}}