{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:17:45Z","timestamp":1781716665251,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ejps.2023.106602","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T02:14:43Z","timestamp":1696558483000},"page":"106602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["8-octyl berberine combats Staphylococcus aureus by preventing peptidoglycan synthesis"],"prefix":"10.1016","volume":"191","author":[{"given":"Xiaoduo","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengcai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuegang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ejps.2023.106602_bib0001","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.micres.2012.02.005","article-title":"In vitro antibacterial potential of Eugenia jambolana seed extracts against multidrug-resistant human bacterial pathogens","volume":"167","author":"Bag","year":"2012","journal-title":"Microbiol. Res."},{"issue":"2","key":"10.1016\/j.ejps.2023.106602_bib0002","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1574-6976.2007.00089.x","article-title":"The biosynthesis of peptidoglycan lipid-linked intermediates","volume":"32","author":"Bouhss","year":"2008","journal-title":"FEMS Microbiol. Rev."},{"issue":"6","key":"10.1016\/j.ejps.2023.106602_bib0003","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1139\/cjpp-2014-0465","article-title":"Emodin is identified as the active component of ether extracts from Rhizoma Polygoni Cuspidati, for anti-MRSA activity","volume":"93","author":"Cao","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejps.2023.106602_bib0004","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.fitote.2011.09.014","article-title":"Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells","volume":"83","author":"Chen","year":"2012","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejps.2023.106602_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112652","article-title":"Metabolomics analysis to evaluate the antibacterial activity of the essential oil from the leaves of Cinnamomum camphora (Linn.) Presl","volume":"253","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.ejps.2023.106602_bib0006","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1021\/jacs.6b13317","article-title":"Rapid and efficient genome editing in Staphylococcus aureus by using an engineered CRISPR\/Cas9 system","volume":"139","author":"Chen","year":"2017","journal-title":"J. Am. Chem. Soc."},{"issue":"7604","key":"10.1016\/j.ejps.2023.106602_bib0007","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature17636","article-title":"Structural insights into inhibition of lipid I production in bacterial cell wall synthesis","volume":"533","author":"Chung","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ejps.2023.106602_bib0008","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.2174\/156802605774463042","article-title":"MraY inhibitors as novel antibacterial agents","volume":"5","author":"Dini","year":"2005","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejps.2023.106602_bib0009","first-page":"1","article-title":"A new coumarin compound DCH combats methicillin-resistant biofilm by targeting arginine repressor","volume":"6","author":"Di Qu","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejps.2023.106602_bib0010","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1039\/c39820000222","article-title":"Corynetoxins causative agents of annual ryegrass toxicity; their identification as tunicamycin group antibiotics","volume":"4","author":"Edgar","year":"1982","journal-title":"J. Chem. Soc. Chem. Commun."},{"issue":"8","key":"10.1016\/j.ejps.2023.106602_bib0011","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41579-020-0366-3","article-title":"Regulation of peptidoglycan synthesis and remodelling","volume":"18","author":"Egan","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"10.1016\/j.ejps.2023.106602_bib0012","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1021\/acs.chemrev.0c01010","article-title":"beta-lactams against the fortress of the gram-positive Staphylococcus aureus bacterium","volume":"121","author":"Fisher","year":"2021","journal-title":"Chem. Rev."},{"issue":"2","key":"10.1016\/j.ejps.2023.106602_bib0013","first-page":"880","article-title":"Study of the enumeration of twelve clinical important bacterial populations at 0.5 McFarland standard","volume":"6","author":"Gayathiri","year":"2018","journal-title":"Int. J. Creat. Res. Thoughts (IJCRT)"},{"issue":"1","key":"10.1016\/j.ejps.2023.106602_bib0014","first-page":"1","article-title":"Recent advances in targeted antibacterial therapy basing on nanomaterials","volume":"3","author":"Geng","year":"2023","journal-title":"Exploration"},{"key":"10.1016\/j.ejps.2023.106602_bib0015","doi-asserted-by":"crossref","first-page":"25R","DOI":"10.1093\/glycob\/11.3.25R","article-title":"Formation of the glycan chains in the synthesis of bacterial peptidoglycan","volume":"11","author":"Heijenoort","year":"2001","journal-title":"Glycobiology"},{"issue":"5","key":"10.1016\/j.ejps.2023.106602_bib0016","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1039\/a804532a","article-title":"Recent advances in the formation of the bacterial peptidoglycan monomer unit (1985 to 2000)","volume":"18","author":"Heijenoort","year":"2001","journal-title":"Nat. Prod. Rep."},{"issue":"5","key":"10.1016\/j.ejps.2023.106602_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/EXP.20210145","article-title":"A dynamic covalent polymeric antimicrobial for conquering drug-resistant bacterial infection","volume":"2","author":"Huang","year":"2022","journal-title":"Exploration"},{"issue":"12","key":"10.1016\/j.ejps.2023.106602_bib0018","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1093\/cid\/ciz123","article-title":"Methicillin-susceptible and methicillin-resistant Staphylococcus aureus bacteremia: nationwide estimates of 30-day readmission, in-hospital mortality, length of stay, and cost in the United States","volume":"69","author":"Inagaki","year":"2019","journal-title":"Clin. Infect. Dis."},{"issue":"11","key":"10.1016\/j.ejps.2023.106602_bib0019","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.7164\/antibiotics.38.1617","article-title":"Liposidomycins: novel nucleoside antibiotics which inhibit bacterial peptidoglycan synthesis","volume":"38","author":"Isono","year":"1985","journal-title":"J. Antibiot."},{"issue":"39","key":"10.1016\/j.ejps.2023.106602_bib0020","doi-asserted-by":"crossref","first-page":"11722","DOI":"10.1002\/anie.201606396","article-title":"Natural products at work: structural insights into inhibition of the bacterial membrane protein MraY","volume":"55","author":"Koppermann","year":"2016","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"12","key":"10.1016\/j.ejps.2023.106602_bib0021","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1016\/j.bmc.2010.04.023","article-title":"Bacterial transferase MraY inhibitors: synthesis and biological evaluation","volume":"18","author":"Lecercle","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejps.2023.106602_bib0022","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.phymed.2018.09.228","article-title":"Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo","volume":"52","author":"Li","year":"2019","journal-title":"Phytomedicine"},{"issue":"6","key":"10.1016\/j.ejps.2023.106602_bib0023","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1021\/acsnano.9b01346","article-title":"Natural berberine-based chinese herb medicine assembled nanostructures with modified antibacterial application","volume":"13","author":"Li","year":"2019","journal-title":"ACS Nano"},{"issue":"39","key":"10.1016\/j.ejps.2023.106602_bib0024","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1093\/eurheartj\/ehz175","article-title":"Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves","volume":"40","author":"Liesenborghs","year":"2019","journal-title":"Eur. Heart J."},{"issue":"18","key":"10.1016\/j.ejps.2023.106602_bib0025","doi-asserted-by":"crossref","first-page":"7699","DOI":"10.1007\/s00253-015-6657-3","article-title":"The direct anti-MRSA effect of emodin via damaging cell membrane","volume":"99","author":"Liu","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"7","key":"10.1016\/j.ejps.2023.106602_bib0026","first-page":"1","article-title":"Antibacterial activity and mechanism of limonene against Pseudomonas aeruginosa","volume":"39","author":"Liu Xue","year":"2018","journal-title":"Sci. Technol. Food Ind."},{"key":"10.1016\/j.ejps.2023.106602_bib0027","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev-biochem-061809-112742","article-title":"Structural perspective of peptidoglycan biosynthesis and assembly","volume":"81","author":"Lovering","year":"2012","journal-title":"Annu. Rev. Biochem."},{"issue":"6141","key":"10.1016\/j.ejps.2023.106602_bib0028","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1233606","article-title":"Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay","volume":"341","author":"Martinez Molina","year":"2013","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ejps.2023.106602_bib0029","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1038\/s41467-019-10957-9","article-title":"Chemical logic of MraY inhibition by antibacterial nucleoside natural products","volume":"10","author":"Mashalidis","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejps.2023.106602_bib0030","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.biomaterials.2015.05.014","article-title":"Epinecidin-1 antimicrobial activity: in vitro membrane lysis and in vivo efficacy against Helicobacter pylori infection in a mouse model","volume":"61","author":"Narayana","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejps.2023.106602_bib0031","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/1471-2180-14-197","article-title":"Antimicrobial and antibiofilm potential of biosurfactants isolated from lactobacilli against multi-drug-resistant pathogens","volume":"14","author":"Sambanthamoorthy","year":"2014","journal-title":"BMC Microbiol."},{"issue":"5","key":"10.1016\/j.ejps.2023.106602_bib0032","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1177\/1087057112436885","article-title":"A high-throughput, homogeneous, fluorescence resonance energy transfer-based assay for phospho-N-acetylmuramoyl-pentapeptide translocase (MraY)","volume":"17","author":"Shapiro","year":"2012","journal-title":"J. Biomol. Screen."},{"issue":"11","key":"10.1016\/j.ejps.2023.106602_bib0033","doi-asserted-by":"crossref","first-page":"10047","DOI":"10.1021\/acsami.7b02380","article-title":"Transcriptome analysis reveals silver nanoparticle-decorated quercetin antibacterial molecular mechanism","volume":"9","author":"Sun","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ejps.2023.106602_bib0034","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2174\/187152606784112128","article-title":"Phospho-MurNAc-Pentapeptide Translocase (MraY) as a target for antibacterial agents and antibacterial proteins","volume":"6","author":"Timothy","year":"2006","journal-title":"Infect. Disord. Drug Targets"},{"issue":"2","key":"10.1016\/j.ejps.2023.106602_bib0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrmicro2677","article-title":"From the regulation of peptidoglycan synthesis to bacterial growth and morphology","volume":"10","author":"Typas","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"issue":"11","key":"10.1016\/j.ejps.2023.106602_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/advs.202206154","article-title":"Flourishing antibacterial strategies for osteomyelitis therapy","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ejps.2023.106602_bib0037","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejmech.2017.12.090","article-title":"Discovery of novel piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections","volume":"145","author":"Wei","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejps.2023.106602_bib0038","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00044-010-9311-8","article-title":"Comparative research of chemical constituents and bioactivities between petroleum ether extracts of the aerial part and the rhizome of Atractylodes macrocephala","volume":"20","author":"Wei Peng","year":"2011","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.ejps.2023.106602_bib0039","first-page":"1","article-title":"The neutrally charged diarylurea compound PQ401 kills antibiotic-resistant and antibiotic-tolerant Staphylococcus aureus","volume":"11","author":"Wooseong Kim","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.ejps.2023.106602_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113806","article-title":"An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy","volume":"270","author":"Xiao","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.ejps.2023.106602_bib0041","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1055\/s-2007-967180","article-title":"Synthesis and antimicrobial activity of 8-alkylberberine derivatives with a long aliphatic chain","volume":"73","author":"Yang","year":"2007","journal-title":"Planta Med."},{"key":"10.1016\/j.ejps.2023.106602_bib0042","first-page":"319","article-title":"Effect of 8-alkylberberine homologues on erythrocyte membrane","volume":"49","author":"Yang Yong","year":"2011","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.ejps.2023.106602_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113691","article-title":"Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms","volume":"224","author":"Yu","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejps.2023.106602_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153216","article-title":"Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice","volume":"76","author":"Yu","year":"2020","journal-title":"Phytomedicine"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098723002324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098723002324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:09:23Z","timestamp":1760530163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098723002324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":44,"alternative-id":["S0928098723002324"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2023.106602","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"8-octyl berberine combats Staphylococcus aureus by preventing peptidoglycan synthesis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2023.106602","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106602"}}