{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:55:32Z","timestamp":1793073332005,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.ejps.2023.106608","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T18:59:46Z","timestamp":1697050786000},"page":"106608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Preconditioning of exosomes derived from human olfactory ensheathing cells improved motor coordination and balance in an SCA3\/MJD mouse model: A new therapeutic approach"],"prefix":"10.1016","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2791-0819","authenticated-orcid":false,"given":"Yu-Shuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horng-Jyh","family":"Harn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Xiang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Tung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Xuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsueh-Hui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peir-Rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsieh-Chih","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinn-Zong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Jung","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzyy-Wen","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2023.106608_bib0004","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1750-1172-6-35","article-title":"Machado-Joseph Disease: from first descriptions to new perspectives","volume":"6","author":"Bettencourt","year":"2011","journal-title":"Orphanet. J. Rare Dis."},{"key":"10.1016\/j.ejps.2023.106608_bib0007","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/acn3.51370","article-title":"Spinocerebellar ataxia clinical trials: opportunities and challenges","volume":"8","author":"Brooker","year":"2021","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.ejps.2023.106608_bib0047","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41419-021-03490-5","article-title":"Exosomes in ovarian cancer ascites promote epithelial\u2013mesenchymal transition of ovarian cancer cells by delivery of miR-6780b-5p","volume":"12","author":"Cai","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejps.2023.106608_bib0044","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.ymthe.2017.01.021","article-title":"Unravelling endogenous microrna system dysfunction as a new pathophysiological mechanism in Machado-Joseph disease","volume":"25","author":"Carmona","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejps.2023.106608_bib0048","doi-asserted-by":"crossref","first-page":"101042","DOI":"10.18632\/oncotarget.13205","article-title":"RUNX3 regulates renal cell carcinoma metastasis via targeting miR-6780a-5p\/E-cadherin\/EMT signaling axis","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejps.2023.106608_bib0006","article-title":"Identifying therapeutic targets for spinocerebellar ataxia type 3\/Machado-Joseph disease through integration of pathological biomarkers and therapeutic strategies","volume":"21","author":"Chen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejps.2023.106608_bib0023","first-page":"113","article-title":"Exosomes in clinical trial and their production in compliance with good manufacturing practice","volume":"32","author":"Chen","year":"2020","journal-title":"Ci Ji Yi Xue Za Zhi"},{"key":"10.1016\/j.ejps.2023.106608_bib0046","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.3390\/ijms21093063","article-title":"Identifying therapeutic targets for spinocerebellar ataxia type 3\/Machado-Joseph disease through integration of pathological biomarkers and therapeutic strategies","volume":"21","author":"Chen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejps.2023.106608_bib0045","doi-asserted-by":"crossref","first-page":"11445","DOI":"10.1038\/ncomms11445","article-title":"Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway","volume":"7","author":"Cunha-Santos","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejps.2023.106608_bib0057","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41563-022-01251-z","article-title":"STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity","volume":"21","author":"Dane","year":"2022","journal-title":"Nat. Mater."},{"key":"10.1016\/j.ejps.2023.106608_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6458237","article-title":"MSC-derived exosomes-based therapy for peripheral nerve injury: a novel therapeutic strategy","volume":"2019","author":"Dong","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ejps.2023.106608_bib0003","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10048-016-0473-5","article-title":"Spinocerebellar ataxia type 3\/Machado-Joseph disease starting before adolescence","volume":"17","author":"Donis","year":"2016","journal-title":"Neurogenetics"},{"key":"10.1016\/j.ejps.2023.106608_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070727","article-title":"Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis","volume":"8","author":"Doyle","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ejps.2023.106608_bib0030","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1248\/bpb.b17-00919","article-title":"A novel strategy to increase the yield of exosomes (extracellular vesicles) for an expansion of basic research","volume":"41","author":"Emam","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejps.2023.106608_bib0032","article-title":"Low level electricity increases the secretion of extracellular vesicles from cultured cells","volume":"21","author":"Fukuta","year":"2020","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.ejps.2023.106608_bib0017","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay1318","article-title":"Exosomes secreted by hiPSC-derived cardiac cells improve recovery from myocardial infarction in swine","volume":"12","author":"Gao","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejps.2023.106608_bib0018","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9923566","article-title":"Progress in mesenchymal stem cell therapy for ischemic stroke","volume":"2021","author":"Guo","year":"2021","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.ejps.2023.106608_bib0016","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1177\/0963689717732578","article-title":"Human olfactory ensheathing cell transplantation improves motor function in a mouse model of type 3 spinocerebellar ataxia","volume":"26","author":"Hsieh","year":"2017","journal-title":"Cell Transpl."},{"key":"10.1016\/j.ejps.2023.106608_bib0043","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1016\/j.febslet.2014.11.013","article-title":"miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3","volume":"588","author":"Huang","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejps.2023.106608_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2017.00024","article-title":"Glial cells and their function in the adult brain: a journey through the history of their ablation","volume":"11","author":"J\u00e4kel","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.ejps.2023.106608_bib0028","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12929-021-00736-4","article-title":"New therapeutic approaches of mesenchymal stem cells-derived exosomes","volume":"28","author":"Janockova","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejps.2023.106608_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2018.01.005","article-title":"Exosomes and regenerative medicine: state of the art and perspectives","volume":"196","author":"Jing","year":"2018","journal-title":"Transl. Res."},{"key":"10.1016\/j.ejps.2023.106608_bib0011","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40478-016-0326-3","article-title":"Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia","volume":"4","author":"Kemp","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.ejps.2023.106608_bib0050","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.repbio.2020.07.002","article-title":"A review on the stem cell therapy and an introduction to exosomes as a new tool in reproductive medicine","volume":"20","author":"Kharazi","year":"2020","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.ejps.2023.106608_bib0005","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1399-0004.2007.00910.x","article-title":"Survival estimates for patients with Machado-Joseph disease (SCA3)","volume":"72","author":"Kieling","year":"2007","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ejps.2023.106608_bib0041","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejps.2023.106608_bib0026","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.bbrc.2016.09.069","article-title":"Adipose-derived stem cell exosomes alleviate pathology of amyotrophic lateral sclerosis in vitro","volume":"479","author":"Lee","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejps.2023.106608_bib0029","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3390\/jcm10040711","article-title":"Therapeutic features and updated clinical trials of mesenchymal stem cell (MSC)-derived exosomes","volume":"10","author":"Lee","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ejps.2023.106608_bib0036","article-title":"n-Butylidenephthalide modulates autophagy to ameliorate neuropathological progress of spinocerebellar ataxia type 3 through mTOR pathway","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejps.2023.106608_bib0052","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s10571-017-0513-1","article-title":"Human umbilical cord mesenchymal stem cells protect against SCA3 by modulating the level of 70kD heat shock protein","volume":"38","author":"Li","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejps.2023.106608_bib0001","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2018.00740","article-title":"Is the high frequency of Machado-Joseph disease in china due to new mutational origins?","volume":"9","author":"Li","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.ejps.2023.106608_bib0049","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41419-020-2270-1","article-title":"miR-210-5p promotes epithelial-mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejps.2023.106608_bib0025","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/glia.22558","article-title":"Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system","volume":"61","author":"Lopez-Verrilli","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.ejps.2023.106608_bib0031","doi-asserted-by":"crossref","first-page":"6948","DOI":"10.1038\/s41598-020-63658-5","article-title":"Simultaneous inhibition of glycolysis and oxidative phosphorylation triggers a multi-fold increase in secretion of exosomes: possible role of 2\u2032,3\u2032-cAMP","volume":"10","author":"Ludwig","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejps.2023.106608_bib0038","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1083\/jcb.201506025","article-title":"Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models","volume":"212","author":"Matos","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejps.2023.106608_bib0054","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/brain\/awu352","article-title":"Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice","volume":"138","author":"Mendon\u00e7a","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.ejps.2023.106608_bib0024","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1038\/s41401-022-00902-w","article-title":"Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy","volume":"43","author":"Mukherjee","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejps.2023.106608_bib0033","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1016\/j.ymthe.2020.06.026","article-title":"Adiponectin stimulates exosome release to enhance mesenchymal stem-cell-driven therapy of heart failure in mice","volume":"28","author":"Nakamura","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejps.2023.106608_bib0035","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1093\/brain\/awr047","article-title":"Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado\u2013Joseph disease","volume":"134","author":"Nascimento-Ferreira","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.ejps.2023.106608_bib0039","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1021\/acschemneuro.5b00021","article-title":"Functional interplay between dopaminergic and serotonergic neuronal systems during development and adulthood","volume":"6","author":"Niederkofler","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ejps.2023.106608_bib0053","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.ymthe.2018.07.007","article-title":"Repeated mesenchymal stromal cell treatment sustainably alleviates Machado-Joseph disease","volume":"26","author":"Oliveira Miranda","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejps.2023.106608_bib0034","doi-asserted-by":"crossref","first-page":"28220","DOI":"10.1038\/srep28220","article-title":"Fibroblasts of Machado Joseph disease patients reveal autophagy impairment","volume":"6","author":"Onofre","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejps.2023.106608_bib0042","doi-asserted-by":"crossref","first-page":"W169","DOI":"10.1093\/nar\/gkt393","article-title":"DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows","volume":"41","author":"Paraskevopoulou","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejps.2023.106608_bib0040","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.neuropharm.2017.02.014","article-title":"n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3","volume":"117","author":"Rajamani","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejps.2023.106608_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymthe.2023.05.012","article-title":"Extracellular communication between brain cells through functional transfer of Cre mRNA mediated by extracellular vesicles","author":"Rufino-Ramos","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejps.2023.106608_bib0010","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s12311-011-0340-8","article-title":"Pathoanatomy of cerebellar degeneration in spinocerebellar ataxia type 2 (SCA2) and type 3 (SCA3)","volume":"11","author":"Scherzed","year":"2012","journal-title":"Cerebellum"},{"key":"10.1016\/j.ejps.2023.106608_bib0014","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1172\/JCI34363","article-title":"Implantation of olfactory ensheathing cells promotes neuroplasticity in murine models of stroke","volume":"118","author":"Shyu","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejps.2023.106608_bib0002","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1001\/archneur.58.7.1105","article-title":"Frequency analysis of autosomal dominant cerebellar ataxias in taiwanese patients and clinical and molecular characterization of spinocerebellar ataxia type 6","volume":"58","author":"Soong","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ejps.2023.106608_bib0013","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.3727\/096368912X663532","article-title":"Transplantation of autologous olfactory ensheathing cells in complete human spinal cord injury","volume":"22","author":"Tabakow","year":"2013","journal-title":"Cell Transpl."},{"key":"10.1016\/j.ejps.2023.106608_bib0027","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.celrep.2017.06.009","article-title":"Exosomes mediate mobilization of autocrine Wnt10b to promote axonal regeneration in the injured CNS","volume":"20","author":"Tassew","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejps.2023.106608_bib0008","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/ene.12341","article-title":"EFNS\/ENS Consensus on the diagnosis and management of chronic ataxias in adulthood","volume":"21","author":"van de Warrenburg","year":"2014","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.ejps.2023.106608_bib0015","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11068-005-5048-6","article-title":"Morphological and functional plasticity of olfactory ensheathing cells","volume":"34","author":"Vincent","year":"2005","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.ejps.2023.106608_bib0009","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3389\/fnins.2020.00749","article-title":"MR Imaging of SCA3\/MJD","volume":"14","author":"Wan","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejps.2023.106608_bib0019","article-title":"Mesenchymal stem cell-derived exosomes: a promising biological tool in nanomedicine","volume":"11","author":"Wei","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejps.2023.106608_bib0051","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s13287-020-01727-2","article-title":"Mesenchymal stem cell-derived exosomes improve motor function and attenuate neuropathology in a mouse model of Machado-Joseph disease","volume":"11","author":"You","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejps.2023.106608_bib0037","first-page":"179","article-title":"Plasma-derived exosomal miR-183 associates with protein kinase activity and may serve as a novel predictive biomarker of myocardial ischemic injury","volume":"18","author":"Zhao","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejps.2023.106608_bib0055","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/mt.2011.164","article-title":"Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain","volume":"19","author":"Zhuang","year":"2011","journal-title":"Mol. Ther."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098723002385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098723002385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:10:44Z","timestamp":1760530244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098723002385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":57,"alternative-id":["S0928098723002385"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2023.106608","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preconditioning of exosomes derived from human olfactory ensheathing cells improved motor coordination and balance in an SCA3\/MJD mouse model: A new therapeutic approach","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2023.106608","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106608"}}