{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:42:29Z","timestamp":1790480549143,"version":"4.1.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308565\/2021-5"],"award-info":[{"award-number":["308565\/2021-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ejps.2024.106766","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T22:03:01Z","timestamp":1712959381000},"page":"106766","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: A promising therapeutic and prophylactic treatment for viral respiratory infections"],"prefix":"10.1016","volume":"197","author":[{"given":"Daniela Pastorim","family":"Vaiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamile Lima","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia Campello","family":"Yurgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"JR","given":"Frank","family":"do Carmo Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauanda Larissa Mendon\u00e7a","family":"da Matta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Alice Bezerra","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Richter","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00edssa Nunes","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibiana Franzen","family":"Matte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larine","family":"Kupski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline","family":"Garda-Buffon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Bidone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza","family":"Muccillo-Baisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-1456","authenticated-orcid":false,"given":"Fabio","family":"Sonvico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana Lima","family":"Dora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2024.106766_bib0001","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tips.2008.11.002","article-title":"Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets","volume":"30","author":"Aggarwal","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejps.2024.106766_bib0002","article-title":"Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations","volume":"15","author":"Agrawal","year":"2020","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.ejps.2024.106766_bib0003","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s40121-020-00316-3","article-title":"Povidone-Iodine Demonstrates Rapid In Vitro Virucidal Activity Against SARS-CoV-2, The Virus Causing COVID-19 Disease","volume":"9","author":"Anderson","year":"2020","journal-title":"Infect. Dis. Ther."},{"key":"10.1016\/j.ejps.2024.106766_bib0004","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700447","article-title":"Safety Aspects of the Use of Quercetin as a Dietary Supplement","volume":"62","author":"Andres","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejps.2024.106766_bib0005","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/gutjnl-2012-304299","article-title":"Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells","volume":"63","author":"Anggakusuma","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.ejps.2024.106766_bib0006","unstructured":"Anvisa, Agencia National de Vigilancia Sanitaria, Minist\u00e9rio da Sa\u00fade 2019. Disp\u00f5e sobre os ensaios de desempenho in vitro de medicamentos nasais e inalat\u00f3rios orais, nos termos da Resolu\u00e7\u00e3o da Diretoria Colegiada - RDC no 278, de 16 de abril de 2019, relativa aos ensaios para comprova\u00e7\u00e3o de equival\u00eancia terap\u00eautica destes medicamentos."},{"key":"10.1016\/j.ejps.2024.106766_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.732891","article-title":"A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV","volume":"12","author":"Bachar","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejps.2024.106766_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131594","article-title":"Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols","volume":"373","author":"Bahun","year":"2022","journal-title":"Food Chem"},{"key":"10.1016\/j.ejps.2024.106766_bib0009","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijpharm.2012.09.049","article-title":"Antidiuretic effect of desmopressin chimera agglomerates by nasal administration in rats","volume":"440","author":"Balducci","year":"2013","journal-title":"Int J Pharm"},{"key":"10.1016\/j.ejps.2024.106766_bib0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fchem.2014.00113","article-title":"Farmer to pharmacist: curcumin as an anti-invasive and antimetastatic agent for the treatment of cancer1","volume":"2","author":"Bandyopadhyay","year":"2014","journal-title":"Front. Chem."},{"key":"10.1016\/j.ejps.2024.106766_bib0011","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.3390\/molecules16064567","article-title":"Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment","volume":"16","author":"Basnet","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2024.106766_bib0012","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejpb.2011.09.003","article-title":"Development of a novel model for comparative evaluation of intranasal pharmacokinetics and effects of anti-allergic nasal sprays","volume":"80","author":"Baumann","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2024.106766_bib0013","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1165\/rcmb.2018-0247TR","article-title":"How the Respiratory Epithelium Senses and Reacts to Influenza Virus","volume":"60","author":"Benam","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejps.2024.106766_bib0014","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s13346-019-00691-6","article-title":"Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies","volume":"10","author":"Ben-Shabat","year":"2020","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ejps.2024.106766_bib0015","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3389\/fimmu.2020.01451","article-title":"Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)","volume":"11","author":"Biancatelli","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejps.2024.106766_bib0016","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.3390\/v13101914","article-title":"Turmeric Root and Its Bioactive Ingredient Curcumin Effectively Neutralize SARS-CoV-2 In Vitro","volume":"13","author":"Bormann","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.ejps.2024.106766_bib0017","doi-asserted-by":"crossref","first-page":"211","DOI":"10.15171\/jhp.2018.33","article-title":"Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin","volume":"7","author":"Boroumand","year":"2018","journal-title":"J. Herbmed Pharmacol."},{"key":"10.1016\/j.ejps.2024.106766_bib0018","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejps.2008.12.015","article-title":"In vitro permeation of desmopressin across rabbit nasal mucosa from liquid nasal sprays: The enhancing effect of potassium sorbate","volume":"37","author":"Bortolotti","year":"2009","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.ejps.2024.106766_bib0019","article-title":"Recent Patents on Nasal Vaccines Containing Nanoadjuvants","volume":"16","author":"Candela","year":"2022","journal-title":"Recent Adv Drug Deliv Formulation"},{"key":"10.1016\/j.ejps.2024.106766_bib0020","unstructured":"CDER, C. for D.E. and R., 2002. Nasal Spray and Inhalation Solution, Suspension, and Spray Drug Products \u2014 Chemistry, Manufacturing, and Controls Documentation. Guidance for Industry."},{"key":"10.1016\/j.ejps.2024.106766_bib0021","article-title":"Distinct codon usage bias evolutionary patterns between weakly and strongly virulent respiratory viruses","volume":"25","author":"Chen","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.ejps.2024.106766_bib0022","first-page":"2895","article-title":"Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions","volume":"21","author":"Cheng","year":"2001","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ejps.2024.106766_bib0023","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.3390\/ijms20122957","article-title":"Quercetin Inhibits the Production of IL-1\u03b2-Induced Inflammatory Cytokines and Chemokines in ARPE-19 Cells via the MAPK and NF-\u03baB Signaling Pathways","volume":"20","author":"Cheng","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejps.2024.106766_bib0024","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40824-019-0166-x","article-title":"Therapeutic efficacy of nanoparticles and routes of administration","volume":"23","author":"Chenthamara","year":"2019","journal-title":"Biomater. Res."},{"key":"10.1016\/j.ejps.2024.106766_bib0025","first-page":"1","article-title":"Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection. Asian Pac","volume":"9","author":"Chiow","year":"2016","journal-title":"J. Trop. Med."},{"key":"10.1016\/j.ejps.2024.106766_bib0026","unstructured":"CHMP, C.F.M.P.F.H.U., 2006. Guideline on the pharmaceutical quality of inhalation and nasal products."},{"key":"10.1016\/j.ejps.2024.106766_bib0027","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2174\/1568026615666150108144655","article-title":"Opportunities and Challenges for the Nasal Administration of Nanoemulsions","volume":"15","author":"Comfort","year":"2015","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.ejps.2024.106766_bib0028","first-page":"424","article-title":"Antioxidant Activity and Hemocompatibility Study of Quercetin Loaded Plga Nanoparticles","volume":"19","author":"Derman","year":"2020","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.ejps.2024.106766_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112560","article-title":"Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy","volume":"146","author":"Dhanya","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejps.2024.106766_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/17425247.2020.1714589","article-title":"A consensus research agenda for optimising nasal drug delivery","volume":"17","author":"Forbes","year":"2020","journal-title":"Expert Opin Drug Del"},{"key":"10.1016\/j.ejps.2024.106766_bib0031","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ejps.2019.01.035","article-title":"Preparation, characterization and in vivo evaluation of novel hyaluronan containing niosomes tailored by Box-Behnken design to co-encapsulate curcumin and quercetin","volume":"130","author":"Ghadi","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2024.106766_bib0032","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.3390\/nu11102376","article-title":"Curcumin and Cancer","volume":"11","author":"Giordano","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.ejps.2024.106766_bib0033","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1080\/10717544.2018.1428242","article-title":"In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates","volume":"25","author":"Giuliani","year":"2018","journal-title":"Drug Deliv"},{"key":"10.1016\/j.ejps.2024.106766_bib0034","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1556\/1886.2022.00009","article-title":"Composition of naturally occurring compounds decreases activity of Omicron and SARS-CoV-2 RdRp complex","volume":"12","author":"Goc","year":"2022","journal-title":"Eur. J. Microbiol. Immunol."},{"key":"10.1016\/j.ejps.2024.106766_bib0035","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/medicina58010121","article-title":"Deciphering Respiratory-Virus-Associated Interferon Signaling in COPD Airway Epithelium","volume":"58","author":"Guo-Parke","year":"2022","journal-title":"Medicina"},{"key":"10.1016\/j.ejps.2024.106766_bib0036","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J"},{"key":"10.1016\/j.ejps.2024.106766_bib0037","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00210-022-02245-z","article-title":"Nanotechnology in drug and gene delivery","volume":"395","author":"Hamimed","year":"2022","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.ejps.2024.106766_bib0038","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn1413","article-title":"Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity","volume":"14","author":"Hartwell","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejps.2024.106766_bib0039","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/j.fct.2007.05.015","article-title":"A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic\/carcinogenic properties","volume":"45","author":"Harwood","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejps.2024.106766_bib0040","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/foods6100092","article-title":"Curcumin: A Review of Its\u2019 Effects on Human Health","volume":"6","author":"Hewlings","year":"2017","journal-title":"Foods"},{"key":"10.1016\/j.ejps.2024.106766_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105676","article-title":"Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis","volume":"74","author":"Hou","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejps.2024.106766_bib0042","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115475","article-title":"Houttuynia cordata Targets the Beginning Stage of Herpes Simplex Virus Infection","volume":"10","author":"Hung","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejps.2024.106766_bib0043","series-title":"International Conference on Harmonization of Technical Requirements for Registration of Pharmaceutics for Human Use. In: Q2B(R1): Guideline on validation of analytical procedure-methodology","year":"2005"},{"key":"10.1016\/j.ejps.2024.106766_bib0044","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/imm.13195","article-title":"Respiratory microbiome and epithelial interactions shape immunity in the lungs","volume":"160","author":"Invernizzi","year":"2020","journal-title":"Immunology"},{"key":"10.1016\/j.ejps.2024.106766_bib0045","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3390\/v12111242","article-title":"Curcumin as an Antiviral Agent","volume":"12","author":"Jennings","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.ejps.2024.106766_bib0046","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.2147\/IJN.S369978","article-title":"Investigation of the \u201cNose-to-Brain\u201d Pathways in Intranasal HupA Nanoemulsions and Evaluation of Their in vivo Pharmacokinetics and Brain-Targeting Ability","volume":"17","author":"Jiang","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejps.2024.106766_bib0047","doi-asserted-by":"crossref","first-page":"e09925","DOI":"10.1016\/j.heliyon.2022.e09925","article-title":"Nose to brain delivery of nanosuspensions with first line antiviral agents is alternative treatment option to Neuro-AIDS treatment","volume":"8","author":"Kakad","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.ejps.2024.106766_bib0048","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1002\/ptr.6467","article-title":"Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies","volume":"33","author":"Karimi","year":"2019","journal-title":"Phytotherapy Res"},{"key":"10.1016\/j.ejps.2024.106766_bib0049","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s13346-020-00891-5","article-title":"Intranasal drug delivery: opportunities and toxicologic challenges during drug development","volume":"12","author":"Keller","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ejps.2024.106766_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122570","article-title":"Nanocarriers based novel and effective drug delivery system","volume":"632","author":"Khizar","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2024.106766_bib0051","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000503030","article-title":"Innate Immune Evasion by Human Respiratory RNA Viruses","volume":"12","author":"Kikkert","year":"2020","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.ejps.2024.106766_bib0052","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.3390\/molecules25102379","article-title":"Antiviral Activities of Quercetin and Isoquercitrin Against Human Herpesviruses","volume":"25","author":"Kim","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2024.106766_bib0053","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.3390\/v13102068","article-title":"Metabolic Modifications by Common Respiratory Viruses and Their Potential as New Antiviral Targets","volume":"13","author":"Kleinehr","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.ejps.2024.106766_bib0054","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0169-409X(97)00067-7","article-title":"Nasal delivery systems and their effect on deposition and absorption","volume":"29","author":"Kublik","year":"1998","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejps.2024.106766_bib0055","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/bph.13621","article-title":"Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases","volume":"174","author":"Kunnumakkara","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejps.2024.106766_bib0056","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1099\/jgv.0.001466","article-title":"Antiviral and virucidal effects of curcumin on transmissible gastroenteritis virus in vitro","volume":"101","author":"Li","year":"2020","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.ejps.2024.106766_bib0057","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.3390\/molecules26226900","article-title":"Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms","volume":"26","author":"Mar\u00edn-Palma","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2024.106766_bib0058","series-title":"Drug Discovery and Development - From Molecules to Medicine. InTechOpen","first-page":"299","article-title":"Intranasal Drug Administration \u2014 An Attractive Delivery Route for Some Drugs","author":"Marx","year":"2015"},{"key":"10.1016\/j.ejps.2024.106766_bib0059","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/0006-2952(95)98514-A","article-title":"Inhibition of human immunodeficiency virus type-1 integrase by curcumin","volume":"49","author":"Mazumder","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejps.2024.106766_bib0060","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.nano.2018.05.021","article-title":"Lipid based nanocarriers: a translational perspective","volume":"14","author":"Mishra","year":"2018","journal-title":"Nanomed.: Nanotechnol., Biol. Med."},{"key":"10.1016\/j.ejps.2024.106766_bib0061","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejps.2024.106766_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-virology-012420-022445","article-title":"Seasonality of Respiratory Viral Infections","volume":"7","author":"Moriyama","year":"2020","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.ejps.2024.106766_bib0063","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.antiviral.2017.03.014","article-title":"Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding","volume":"142","author":"Mounce","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.ejps.2024.106766_bib0064","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.2174\/1568026615666150619142519","article-title":"Curcumin: A Natural Product for Diabetes and its Complications","volume":"15","author":"Nabavi","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ejps.2024.106766_bib0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0167-4889(02)00328-2","article-title":"The flavonoid, quercetin, differentially regulates Th-1 (IFN\u03b3) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells","volume":"1593","author":"Nair","year":"2002","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Cell Res."},{"key":"10.1016\/j.ejps.2024.106766_bib0066","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.1984","article-title":"Sulforhodamine B (SRB) Assay in Cell Culture to Investigate Cell Proliferation","volume":"6","author":"Orellana","year":"2016","journal-title":"BIO-Protoc."},{"key":"10.1016\/j.ejps.2024.106766_bib0067","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tips.2015.09.007","article-title":"Curcumin as an Adjunct Drug for Infectious Diseases","volume":"37","author":"Padmanaban","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejps.2024.106766_bib0068","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1080\/10408398.2018.1552244","article-title":"Cellular and molecular mechanisms of curcumin in prevention and treatment of disease","volume":"60","author":"Patel","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.ejps.2024.106766_bib0069","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.3892\/etm.2015.2749","article-title":"Biological and therapeutic activities, and anticancer properties of curcumin","volume":"10","author":"Perrone","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejps.2024.106766_bib0070","doi-asserted-by":"crossref","first-page":"288","DOI":"10.18433\/J3NC79","article-title":"Intranasal Drug Delivery: How, Why and What for?","volume":"12","author":"Pires","year":"2009","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.ejps.2024.106766_bib0071","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3389\/fmicb.2019.00912","article-title":"Anti-infective Properties of the Golden Spice Curcumin","volume":"10","author":"Praditya","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejps.2024.106766_bib0072","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Epidemiology"},{"key":"10.1016\/j.ejps.2024.106766_bib0073","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.cellbi.2007.04.009","article-title":"Antioxidative and prooxidative effects of quercetin on A549 cells","volume":"31","author":"Robaszkiewicz","year":"2007","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ejps.2024.106766_bib0074","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241739","article-title":"EGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2","volume":"15","author":"Roshdy","year":"2020","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejps.2024.106766_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2022.08.004","article-title":"The current status of COVID-19 vaccines. A scoping review","volume":"27","author":"Rueda-Fern\u00e1ndez","year":"2022","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.ejps.2024.106766_bib0076","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijpharm.2019.02.026","article-title":"How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods","volume":"561","author":"Salade","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2024.106766_bib0077","doi-asserted-by":"crossref","first-page":"11849","DOI":"10.1021\/acsomega.0c01818","article-title":"Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health","volume":"5","author":"Salehi","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejps.2024.106766_bib0078","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4155\/tde-2019-0086","article-title":"Nasal formulations for drug administration and characterization of nasal preparations in drug delivery","volume":"11","author":"Scherlie\u00df","year":"2020","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ejps.2024.106766_bib0079","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/17425247.2023.2263363","article-title":"Nasal delivery as a strategy for the prevention and treatment of COVID-19","volume":"20","author":"Sonvico","year":"2023","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ejps.2024.106766_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.colcom.2021.100533","article-title":"Nanoemulsions: Formulation, characterization, biological fate, and potential role against COVID-19 and other viral outbreaks","volume":"45","author":"Tayeb","year":"2021","journal-title":"Colloid Interface Sci. Commun."},{"key":"10.1016\/j.ejps.2024.106766_bib0081","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.3390\/molecules16032032","article-title":"Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications","volume":"16","author":"Uchide","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2024.106766_bib0082","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1023997","article-title":"The possible therapeutic role of curcumin and quercetin in the early-stage of COVID-19\u2014Results from a pragmatic randomized clinical trial","volume":"9","author":"Ujjan","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ejps.2024.106766_bib0083","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ijregi.2021.10.001","article-title":"Morbidity burden, seasonality and factors associated with the human respiratory syncytial virus, human parainfluenza virus, and human adenovirus infections in Kenya","volume":"1","author":"Umuhoza","year":"2021","journal-title":"IJID Reg"},{"key":"10.1016\/j.ejps.2024.106766_bib0084","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/pharmaceutics14010194","article-title":"In Vitro Evaluation of Curcumin- and Quercetin-Loaded Nanoemulsions for Intranasal Administration: Effect of Surface Charge and Viscosity","volume":"14","author":"Vaz","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2024.106766_bib0085","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3390\/nano12071073","article-title":"Curcumin and Quercetin-Loaded Lipid Nanocarriers: Development of Omega-3 Mucoadhesive Nanoemulsions for Intranasal Administration","volume":"12","author":"Vaz","year":"2022","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ejps.2024.106766_bib0086","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.3390\/nano10091650","article-title":"Curcumin and Quercetin-Loaded Nanoemulsions: Physicochemical Compatibility Study and Validation of a Simultaneous Quantification Method","volume":"10","author":"Vaz","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ejps.2024.106766_bib0087","first-page":"1","article-title":"Development of Nasal Lipid Nanocarriers Containing Curcumin for Brain Targeting","author":"Vaz","year":"2017","journal-title":"J. Alzheimer's Dis. Preprint"},{"key":"10.1016\/j.ejps.2024.106766_bib0088","article-title":"Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies","volume":"137","author":"Verma","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejps.2024.106766_bib0089","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nprot.2006.179","article-title":"Sulforhodamine B colorimetric assay for cytotoxicity screening","volume":"1","author":"Vichai","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejps.2024.106766_bib0090","doi-asserted-by":"crossref","first-page":"eabd9149","DOI":"10.1126\/science.abd9149","article-title":"Airborne transmission of respiratory viruses","volume":"373","author":"Wang","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ejps.2024.106766_bib0091","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1021\/jm070295s","article-title":"Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus","volume":"50","author":"Wen","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2024.106766_bib0092","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121180","article-title":"Intranasal vaccine: Factors to consider in research and development","volume":"609","author":"Xu","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2024.106766_bib0093","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8825387","article-title":"Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine","author":"Yang","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.ejps.2024.106766_bib0094","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1007\/s13346-021-00965-y","article-title":"Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control","volume":"11","author":"Yang","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ejps.2024.106766_bib0095","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1039\/C5NR07918G","article-title":"Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infection","volume":"8","author":"Yang","year":"2016","journal-title":"Nanoscale"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724000770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724000770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:57:09Z","timestamp":1778558229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098724000770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":95,"alternative-id":["S0928098724000770"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106766","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin and quercetin co-encapsulated in nanoemulsions for nasal administration: A promising therapeutic and prophylactic treatment for viral respiratory infections","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106766","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106766"}}