{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T18:27:04Z","timestamp":1755800824074,"version":"3.37.3"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008366","name":"Guangdong Pharmaceutical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ejps.2024.106768","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T05:39:51Z","timestamp":1713591591000},"page":"106768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The allostery and modification of hGHRH molecules and specific dimer produced significant fertility effect by proliferating and activating in-situ ovarian mesenchymal stem cells"],"prefix":"10.1016","volume":"197","author":[{"given":"Xu-Dong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Cheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-Xuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Mei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song-Shan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Xian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ejps.2024.106768_bib0005","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1177\/1933719110371683","article-title":"Diminished endometrial expression of ghrelin and ghrelin receptor contributes to infertility","volume":"17","author":"Aghajanova","year":"2010","journal-title":"Reprod. Sci."},{"issue":"121","key":"10.1016\/j.ejps.2024.106768_bib0017","first-page":"e33","article-title":"Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches","volume":"20","author":"Augello","year":"2010","journal-title":"Eur. Cell Mater."},{"key":"10.1016\/j.ejps.2024.106768_bib0012","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.1210\/en.2004-0732","article-title":"Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis","volume":"145","author":"Barreiro","year":"2004","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.ejps.2024.106768_bib0002","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3181\/00379727-206-43771","article-title":"Neuroendocrine and reproductive consequences of overexpression of growth hormone in transgenic mice","volume":"206","author":"Bartke","year":"1994","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.ejps.2024.106768_bib0007","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ygcen.2016.01.006","article-title":"Estradiol and testosterone modulate the tissue-specific expression of ghrelin, ghs-r, goat and nucb2 in goldfish","volume":"228","author":"Bertucci","year":"2016","journal-title":"Gen. Comp. Endocrinol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106768_bib0028","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1046\/j.1365-2265.2003.01680.x","article-title":"Acetylcholine does not play a major role in mediating the endocrine responses to ghrelin, a natural ligand of the GH secretagogue receptor, in humans","volume":"58","author":"Broglio","year":"2003","journal-title":"Clin. Endocrinol. (Oxf)"},{"issue":"6","key":"10.1016\/j.ejps.2024.106768_bib0032","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.tem.2007.06.004","article-title":"Brain-gut communication: cortistatin, somatostatin .and ghrelin","volume":"18","author":"Broglio","year":"2007","journal-title":"Trends. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.ejps.2024.106768_bib0001","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.2021.4788","article-title":"Diagnosis and Management of Infertility","volume":"326","author":"Carson","year":"2021","journal-title":"JAMa"},{"issue":"2","key":"10.1016\/j.ejps.2024.106768_bib0035","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1515\/hmbci-2015-0050","article-title":"Ghrelin action on GnRH neurons and pituitary gonadotropes might be mediated by GnIH-GPR147 system","volume":"25","author":"Celik","year":"2016","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"issue":"6","key":"10.1016\/j.ejps.2024.106768_bib0038","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/1043-2760(94)P3080-Q","article-title":"Ion channels and the signal transduction pathways in the regulation of growth hormone secretion","volume":"5","author":"Chen","year":"1994","journal-title":"Trends. Endocrinol. Metab."},{"key":"10.1016\/j.ejps.2024.106768_bib0018","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1210\/er.2018-00084","article-title":"Melatonin as a hormone: new physiological and clinical insights","volume":"39","author":"Cipolla-Neto","year":"2018","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejps.2024.106768_bib0009","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1210\/jc.2002-021196","article-title":"Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary","volume":"88","author":"Gaytan","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.ejps.2024.106768_bib0030","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1385\/ENDO:14:1:087","article-title":"Biologic activities of growth hormone secretagogues in humans","volume":"14","author":"Ghigo","year":"2001","journal-title":"Endocrine"},{"key":"10.1016\/j.ejps.2024.106768_bib0008","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1210\/jcem.87.6.8739","article-title":"The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans","volume":"87","author":"Gnanapavan","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejps.2024.106768_bib0014","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13287-018-1008-9","article-title":"The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure","volume":"9","author":"He","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"10","key":"10.1016\/j.ejps.2024.106768_bib0036","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1210\/en.2012-1194","article-title":"Acylation type determines ghrelin's effects on energy homeostasis in rodents","volume":"153","author":"Heppner","year":"2012","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.ejps.2024.106768_bib0013","first-page":"1190","article-title":"Effect of ghrelin on the cardiovascular system","volume":"11","author":"Hosoda","year":"2022","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.ejps.2024.106768_bib0004","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yhbeh.2017.10.012","article-title":"Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner","volume":"97","author":"Hylanda","year":"2018","journal-title":"Horm. Behav."},{"issue":"9","key":"10.1016\/j.ejps.2024.106768_bib0003","first-page":"1771","article-title":"Effect of growth hormone releasing hormone (GHRH) and vasoactive intestinal peptide (VIP) on in vitro bovine oocyte maturation","volume":"3","author":"Izadyar","year":"2005","journal-title":"Theriogenology"},{"issue":"18","key":"10.1016\/j.ejps.2024.106768_bib0024","doi-asserted-by":"crossref","first-page":"14703","DOI":"10.1074\/jbc.M111.323220","article-title":"Disruption of proproteinconvertase 1\/3 (PC1\/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion","volume":"287","author":"Jefaie","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.ejps.2024.106768_bib0029","first-page":"505","article-title":"Assessment of ghrelin, GHS-R, GH, and neurohormones in human fetal pituitary glands and central nervous system: an immunohistochemical study","volume":"47","author":"Kedzia1","year":"2009","journal-title":"Folia Histochem. Cytobiol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106768_bib0011","article-title":"Effect of ghrelin on the apoptosis of various cells. A critical review","volume":"70","author":"Kurowska","year":"2019","journal-title":"J. Physiol. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejps.2024.106768_bib0006","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000516147","article-title":"Effect of growth hormone secretagogue receptor deletion on growth, pulsatile growth hormone secretion, and meal pattern in male and female mice","volume":"112","author":"Labarthe","year":"2022","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.ejps.2024.106768_bib0010","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.psyneuen.2015.09.009","article-title":"Ghrelin and GHS-R1A signaling within the ventral and laterodorsal tegmental area regulate sexual behavior in sexually na\u00efve male mice","volume":"62","author":"Luna","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ejps.2024.106768_bib0037","first-page":"237","article-title":"Regulation of the pituitary somatotroph cell by GHRH and its receptor","volume":"55","author":"Mayo","year":"2000","journal-title":"Recent. Prog. Horm. Res."},{"key":"10.1016\/j.ejps.2024.106768_bib0039","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1210\/endo.140.9.6977","article-title":"The rat growth hormone-releasing hormone receptor gene: structure, regulation and generation of receptor isoforms with different signaling properties","volume":"140","author":"Miller","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejps.2024.106768_bib0031","doi-asserted-by":"crossref","first-page":"RC7","DOI":"10.1007\/BF03343831","article-title":"Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland","volume":"24","author":"Muccioli","year":"2001","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.ejps.2024.106768_bib0020","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12896-015-0176-2","article-title":"Ghrelin accelerates the growth and osteogenic differentiation of rabbit mesenchymal stem cells through the ERK1\/2 pathway","volume":"15","author":"Nan","year":"2015","journal-title":"BMC Biotechnol."},{"issue":"11","key":"10.1016\/j.ejps.2024.106768_bib0015","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1634\/stemcells.2007-0637","article-title":"Mesenchymal stem\/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair\u2014Current views","volume":"25","author":"Phinney","year":"2007","journal-title":"Stem Cells (1981)"},{"key":"10.1016\/j.ejps.2024.106768_bib0041","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1210\/endo.141.6.7513","article-title":"Growth hormonereleasing hormone stimulates mitogen-activated protein kinase","volume":"141","author":"Pombo","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejps.2024.106768_bib0040","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1210\/endo.140.4.6613","article-title":"Growth hormone (GH)-releasing factor differentially activates cyclic adenosine 3\u2019,5\u2019-monophosphate- and inositol phosphate-dependent pathways to stimulate GH release in two porcine somatotrope subpopulations","volume":"140","author":"Ramirez","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejps.2024.106768_bib0034","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/0470870796.ch12","article-title":"Control of growth hormone (GH) release by GH secretagogues","volume":"227","author":"Robinson","year":"2000","journal-title":"Novartis Found. Symp."},{"issue":"5","key":"10.1016\/j.ejps.2024.106768_bib0026","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1210\/endo.143.5.8893","article-title":"Is GHRH receptor essential to GHRP-2-induced GH secretion in primary cultured rat pituitary cells?","volume":"143","author":"Roh","year":"2002","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.ejps.2024.106768_bib0027","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1385\/ENDO:30:1:55","article-title":"Differential regulation of GHRH-Receptor and GHS-receptor expression by long-term in vitro treatment of ovine pituitary cells with GHRP-2 and GHRH","volume":"30","author":"Roh","year":"2006","journal-title":"Endocrine, v"},{"key":"10.1016\/j.ejps.2024.106768_bib0019","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/s43450-023-00370-1","article-title":"Molecular and therapeutic insights of alphalipoic acid as a potential molecule for disease prevention","volume":"33","author":"Tripathi","year":"2023","journal-title":"Revista Brasileira de Farmacognosia"},{"key":"10.1016\/j.ejps.2024.106768_bib0016","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/690491","article-title":"The therapeutic potential of umbilical cord mesenchymal stem cells in mice premature ovarian failure","author":"Wang","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ejps.2024.106768_bib0033","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1530\/eje.0.1500235","article-title":"Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH, pituitary transcription factor-1, GHRH-receptor, GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells","volume":"150","author":"Yan","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ejps.2024.106768_bib0025","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/jcbfm.2008.161","article-title":"Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains","author":"Zhan","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ejps.2024.106768_bib0022","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejps.2018.03.012","article-title":"Novel hGHRH homodimer promotes fertility of female infertile hamster by up-regulating ovarian GHRH receptor without trigering GH secretion","volume":"117","author":"Zhang","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.ejps.2024.106768_bib0023","doi-asserted-by":"crossref","first-page":"637","DOI":"10.4196\/kjpp.2018.22.6.637","article-title":"The treatment effect of novel hGHRH homodimer to male infertility hamster","volume":"22","author":"Zhang","year":"2018","journal-title":"Korean J. Physiol. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejps.2024.106768_bib0021","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3109\/08977194.2015.1010644","article-title":"Synthesis and biological evaluation of novel structure-related hGHRH agonistic analogs","volume":"33","author":"Zhou","year":"2015","journal-title":"Growth Factors"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724000794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724000794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T08:08:02Z","timestamp":1715069282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098724000794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":41,"alternative-id":["S0928098724000794"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106768","relation":{},"ISSN":["0928-0987"],"issn-type":[{"type":"print","value":"0928-0987"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The allostery and modification of hGHRH molecules and specific dimer produced significant fertility effect by proliferating and activating in-situ ovarian mesenchymal stem cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106768"}}