{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:51:03Z","timestamp":1793083863397,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ejps.2024.106775","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T05:39:51Z","timestamp":1713591591000},"page":"106775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Development of a dry powder insufflation device with application in in vitro cell-based assays in the context of respiratory delivery"],"prefix":"10.1016","volume":"197","author":[{"given":"Jorge F.","family":"Pontes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herm\u00ednio P.","family":"Diogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eus\u00e9bio","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui M.","family":"Borges dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2136-1396","authenticated-orcid":false,"given":"Ana","family":"Grenha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2024.106775_bib0001","first-page":"1","article-title":"Dry powder inhalation, part 1: ancient history and precursors to modern dry powder inhalers","author":"de Boer","year":"2022","journal-title":"Expert. Opin. Drug. Deliv"},{"key":"10.1016\/j.ejps.2024.106775_bib0002","first-page":"1","article-title":"Dry powder inhalation, part 2: the present and future","author":"de Boer","year":"2022","journal-title":"Expert. Opin. Drug. Deliv"},{"key":"10.1016\/j.ejps.2024.106775_bib0007","unstructured":"Directive 2010\/63\/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes, 2010."},{"issue":"5","key":"10.1016\/j.ejps.2024.106775_bib0004","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s40005-023-00626-x","article-title":"Polysaccharide-based platforms for nasal delivery: design, features, and perspectives","volume":"53","author":"Elmowafy","year":"2023","journal-title":"J. Pharm. Invest."},{"issue":"21","key":"10.1016\/j.ejps.2024.106775_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26216408","article-title":"Microencapsulated isoniazid-loaded metal-organic frameworks for pulmonary administration of antituberculosis drugs","volume":"26","author":"Fern\u00e1ndez-Paz","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2024.106775_bib0010","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fphar.2016.00181","article-title":"Measurements of deposition, lung surface area and lung fluid for simulation of inhaled compounds","volume":"7","author":"Fr\u00f6hlich","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejps.2024.106775_bib0022","unstructured":"Grenha, A.M., Pontes, J.F., Borges dos Santos, R.M., Concei\u00e7\u00e3o, E., Diogo, H., \u201cPatent WO 2023\/073658 A1: portable device to study the exposure of cells to dry powders,\u201d Patent Appl. PCT\/IB2022\/060464, 2023."},{"key":"10.1016\/j.ejps.2024.106775_bib0020","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.powtec.2018.09.068","article-title":"Spray-drying of konjac glucomannan to produce microparticles for an application as antitubercular drug carriers","volume":"342","author":"Guerreiro","year":"2019","journal-title":"Powder Technol."},{"key":"10.1016\/j.ejps.2024.106775_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120731","article-title":"Engineering of konjac glucomannan into respirable microparticles for delivery of antitubercular drugs","author":"Guerreiro","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2024.106775_bib0013","series-title":"Spray-dried Polysaccharide Microparticles Aimed At Pulmonary Delivery of Antitubercular Drugs","author":"Guerreiro","year":"2015"},{"issue":"4","key":"10.1016\/j.ejps.2024.106775_bib0016","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1021\/mp4006563","article-title":"Inhalable particles containing rapamycin for induction of autophagy in macrophages infected with Mycobacterium tuberculosis","volume":"11","author":"Gupta","year":"2014","journal-title":"Mol. Pharm."},{"issue":"9","key":"10.1016\/j.ejps.2024.106775_bib0017","doi-asserted-by":"crossref","DOI":"10.3390\/pr8091138","article-title":"A review of stereolithography: processes and systems","volume":"8","author":"Huang","year":"2020","journal-title":"Processes"},{"key":"10.1016\/j.ejps.2024.106775_bib0024","article-title":"Biological evaluation of medical devices - Part 5: tests for in vitro cytotoxicity","year":"2009","journal-title":"International Organization for Standardization"},{"key":"10.1016\/j.ejps.2024.106775_bib0011","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1743-8977-6-32","article-title":"A dose-controlled system for air-liquid interface cell exposure and application to zinc oxide nanoparticles","volume":"6","author":"Lenz","year":"2009","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.ejps.2024.106775_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114530","article-title":"A review of upper airway physiology relevant to the delivery and deposition of inhalation aerosols","volume":"191","author":"Mekonnen","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.ejps.2024.106775_bib0012","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10020056","article-title":"Combining MucilAirTM and Vitrocell\u24c7 Powder Chamber for the in vitro evaluation of nasal ointments in the context of aerosolized pollen","volume":"10","author":"Metz","year":"2018","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.ejps.2024.106775_bib0014","first-page":"A20","article-title":"Dextran sulfate microparticles encapsulating isoniazid and\/or rifabutin as carriers for pulmonary tuberculosis therapy","volume":"30","author":"Musacchio","year":"2017","journal-title":"J. Aerosol Med. Pulm. Drug. Deliv"},{"issue":"5","key":"10.1016\/j.ejps.2024.106775_bib0006","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.ejps.2013.06.004","article-title":"In vitro, in vivo and ex vivo models for studying particle deposition and drug absorption of inhaled pharmaceuticals","volume":"49","author":"Nahar","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1\u20132","key":"10.1016\/j.ejps.2024.106775_bib0018","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ijpharm.2017.06.088","article-title":"Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles","volume":"529","author":"Rodrigues","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.ejps.2024.106775_bib0019","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1007\/s13346-020-00799-0","article-title":"Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages","volume":"10","author":"Rodrigues","year":"2020","journal-title":"Drug. Deliv. Transl. Res."},{"issue":"2","key":"10.1016\/j.ejps.2024.106775_bib0021","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF01337937","article-title":"Verwendung von schwingquarzen zur w\u00e4gung d\u00fcnner schichten und zur mikrow\u00e4gung","volume":"155","author":"Sauerbrey","year":"1959","journal-title":"Zeitschrift f\u00fcr Physik"},{"issue":"4","key":"10.1016\/j.ejps.2024.106775_bib0009","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1007\/s13346-021-01011-7","article-title":"Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals","volume":"11","author":"Thiyagarajan","year":"2021","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.ejps.2024.106775_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120568","article-title":"A quantitative approach to predicting lung deposition profiles of pharmaceutical powder aerosols","volume":"602","author":"Yaqoubi","year":"2021","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.ejps.2024.106775_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10040263","article-title":"A comprehensive map of FDA-approved pharmaceutical products","volume":"10","author":"Zhong","year":"2018","journal-title":"Pharmaceutics"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724000861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724000861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T08:08:07Z","timestamp":1715069287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098724000861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":24,"alternative-id":["S0928098724000861"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106775","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a dry powder insufflation device with application in in vitro cell-based assays in the context of respiratory delivery","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106775","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106775"}}