{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:43:01Z","timestamp":1787060581708,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012249","name":"Jiangxi University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012249","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.ejps.2024.106778","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:18:03Z","timestamp":1713694683000},"page":"106778","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["A potential therapeutic agent for the treatment of hyperuricemia and gout: 3,4-Dihydroxy-5-nitrobenzaldehyde phenylthiosemicarbazide"],"prefix":"10.1016","volume":"198","author":[{"given":"Xiongying","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiwei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcui","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ejps.2024.106778_bib0001","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11926-016-0587-7","article-title":"Urate handling in the human body","volume":"18","author":"David","year":"2016","journal-title":"Curr. Rheumatol. Rep."},{"issue":"17","key":"10.1016\/j.ejps.2024.106778_bib0002","article-title":"Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome, cardiovascular diseases and chronic kidney disease","volume":"22","author":"Hidekatsu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejps.2024.106778_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102271","article-title":"U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia","volume":"51","author":"Crawley","year":"2022","journal-title":"Redox. Biol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106778_bib0004","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.numecd.2022.09.011","article-title":"The interaction between hyperuricemia and low-density lipoprotein cholesterol increases the risk of 1-year post-discharge all-cause mortality in ST-segment elevation myocardial infarction patients","volume":"33","author":"Liang","year":"2023","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.ejps.2024.106778_bib0005","article-title":"Hyperuricemia complicated with acute kidney injury is associated with adverse outcomes in patients with severely decompensated acute heart failure","author":"Shirakabe","year":"2019","journal-title":"Int. J. Cardiol."},{"issue":"9","key":"10.1016\/j.ejps.2024.106778_bib0006","article-title":"Efficacy of xanthine oxidase inhibitors in lowering serum uric acid in chronic kidney disease: a systematic review and meta-analysis","volume":"11","author":"Yoojin","year":"2022","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.ejps.2024.106778_bib0007","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0891-5849(02)00956-5","article-title":"Structure and function of xanthine oxidoreductase: where are we now?","volume":"33","author":"Harrison","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.ejps.2024.106778_bib0008","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1001\/jamainternmed.2018.4463","article-title":"Association of chronic kidney disease with allopurinol use in gout treatment","volume":"178","author":"Vargas-Santos","year":"2018","journal-title":"JAMA Intern. Med."},{"issue":"5","key":"10.1016\/j.ejps.2024.106778_bib0009","doi-asserted-by":"crossref","DOI":"10.1007\/s40744-022-00480-7","article-title":"Febuxostat therapy for patients with gout and stage 2-4 CKD: a retrospective study","volume":"9","author":"Zhang","year":"2022","journal-title":"Rheumatol. Ther."},{"issue":"2","key":"10.1016\/j.ejps.2024.106778_bib0010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10157-017-1452-3","article-title":"Effects of topiroxostat in hyperuricemic patients with chronic kidney disease","volume":"22","author":"Taro","year":"2018","journal-title":"Clin. Exp. Nephrol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106778_bib0011","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s13075-019-2011-y","article-title":"Acute kidney injury associated with febuxostat and allopurinol: a post-marketing study","volume":"21","author":"Amayelle","year":"2019","journal-title":"Arthritis Res. Ther."},{"issue":"10","key":"10.1016\/j.ejps.2024.106778_bib0012","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s40264-013-0084-0","article-title":"Allopurinol hypersensitivity: a systematic review of all published cases, 1950-2012","volume":"36","author":"Ramasamy","year":"2013","journal-title":"Drug Saf."},{"issue":"13","key":"10.1016\/j.ejps.2024.106778_bib0013","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1056\/NEJMoa1710895","article-title":"Cardiovascular safety of febuxostat or allopurinol in patients with gout","volume":"378","author":"White","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.ejps.2024.106778_bib0014","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.bcp.2013.08.011","article-title":"3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout","volume":"86","author":"L\u00fc","year":"2013","journal-title":"Biochem. Pharmacol."},{"issue":"20","key":"10.1016\/j.ejps.2024.106778_bib0015","article-title":"Benzimidazole bearing thiosemicarbazone derivatives act as potent \u03b1-amylase and \u03b1-glucosidase inhibitors; synthesis, bioactivity screening and molecular docking study","volume":"27","author":"Hayat","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2024.106778_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105928","article-title":"Dihydroxyphenyl-substituted thiosemicarbazone: a potent scaffold for the development of metallo-\u03b2-lactamases inhibitors and antimicrobial","volume":"127","author":"Liu","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"5","key":"10.1016\/j.ejps.2024.106778_bib0017","article-title":"New Pharmacological strategies against pancreatic adenocarcinoma: the multifunctional thiosemicarbazone FA4","volume":"27","author":"Dario","year":"2022","journal-title":"Molecules"},{"issue":"P1","key":"10.1016\/j.ejps.2024.106778_bib0018","article-title":"Synthesis and characterization of thiosemicarbazone metal complexes: crystal structure, and antiproliferation activity against breast (MCF7) and lung (A549) cancers","volume":"1274","author":"Mayada","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ejps.2024.106778_bib0019","article-title":"Advances in thiosemicarbazone metal complexes as anti-lung cancer agents","author":"Guang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejps.2024.106778_bib0020","article-title":"Biological properties of a new class of [Mo2O2S2]-based thiosemicarbazone coordination complexes","volume":"548","author":"Arcadie","year":"2023","journal-title":"Inorganica Chim. Acta"},{"issue":"6","key":"10.1016\/j.ejps.2024.106778_bib0021","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/cmdc.201100054","article-title":"Inhibition of xanthine oxidase by thiosemicarbazones, hydrazones and dithiocarbazates derived from hydroxy-substituted benzaldehydes","volume":"6","author":"Maria","year":"2011","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejps.2024.106778_bib0022","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molstruc.2018.01.020","article-title":"Investigation of the interaction between benzaldehyde thiosemicarbazone compounds and xanthine oxidase","volume":"1159","author":"Li","year":"2018","journal-title":"J. Mol. Struct."},{"issue":"11","key":"10.1016\/j.ejps.2024.106778_bib0023","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.inoche.2010.07.012","article-title":"Synthesis, crystal structures, and biological activities of 2-thiophene N(4)-methylthiosemicarbazone and its unusual hexanuclear silver(I) cluster","volume":"13","author":"Li","year":"2010","journal-title":"Inorg. Chem. Commun."},{"issue":"4","key":"10.1016\/j.ejps.2024.106778_bib0024","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/cbdd.12686","article-title":"Development of 2-(substituted benzylamino)-4-methyl-1, 3-thiazole-5-carboxylic acid derivatives as xanthine oxidase inhibitors and free radical scavengers","volume":"87","author":"Rahmat","year":"2016","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejps.2024.106778_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.126807","article-title":"Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations","volume":"323","author":"Zhao","year":"2020","journal-title":"Food Chem."},{"key":"10.1016\/j.ejps.2024.106778_bib0026","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0021-5198(19)43428-8","article-title":"Decreasing effect of allantoxanamide, a hyperuricemic agent on renal functions in rats","volume":"45","author":"Yonetani","year":"1987","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejps.2024.106778_bib0027","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0024-3205(78)90210-2","article-title":"Allantoxanamide: a potent new uricase inhibitor in vivo","volume":"23","author":"Johnson","year":"1978","journal-title":"Life Sci."},{"issue":"13","key":"10.1016\/j.ejps.2024.106778_bib0028","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1074\/jbc.M804517200","article-title":"Substrate orientation and catalysis at the molybdenum site in xanthine oxidase: crystal structures in complex with xanthine and lumazine","volume":"284","author":"Pauff","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.ejps.2024.106778_bib0029","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"James","year":"2015","journal-title":"J. Chem. Theory Comput."},{"issue":"11","key":"10.1016\/j.ejps.2024.106778_bib0030","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1021\/jz500737m","article-title":"Building force fields: an automatic, systematic, and reproducible approach","volume":"5","author":"Wang","year":"2014","journal-title":"J. Phys. Chem. Lett."},{"issue":"4","key":"10.1016\/j.ejps.2024.106778_bib0031","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1021\/acs.jafc.1c06110","article-title":"Integration of molecular docking analysis and molecular dynamics simulations for studying food proteins and bioactive peptides","volume":"70","author":"Abraham","year":"2022","journal-title":"J. Agric. Food Chem."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724000897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724000897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T18:44:10Z","timestamp":1717008250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098724000897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":31,"alternative-id":["S0928098724000897"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106778","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A potential therapeutic agent for the treatment of hyperuricemia and gout: 3,4-Dihydroxy-5-nitrobenzaldehyde phenylthiosemicarbazide","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106778","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106778"}}