{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:53:44Z","timestamp":1793303624156,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["955756"],"award-info":[{"award-number":["955756"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.ejps.2024.106798","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T02:48:14Z","timestamp":1715395694000},"page":"106798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["On the processes limiting oral drug absorption when amorphous solid dispersions are administered after a high-calorie, high-fat meal: Sporanox\u00ae pellets"],"prefix":"10.1016","volume":"199","author":[{"given":"Shirin","family":"Dietrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrto","family":"Dimoula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Argyropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Ceulemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Goumas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Vertzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6958-2147","authenticated-orcid":false,"given":"Christos","family":"Reppas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2024.106798_bib0001","first-page":"1198","article-title":"Temporal pattern of pancreatic insulin and C-peptide secretion and of plasma glucose levels after nutritional stimulation","volume":"75","author":"Balks","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejps.2024.106798_bib0002","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/AAC.37.4.778","article-title":"Food interaction and steady-state pharmacokinetics of itraconazole capsules in healthy male volunteers","volume":"37","author":"Barone","year":"1993","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.ejps.2024.106798_bib0003","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijpharm.2017.04.029","article-title":"Gastrointestinal behavior of itraconazole in humans - Part 1: supersaturation from a solid dispersion and a cyclodextrin-based solution","volume":"525","author":"Brouwers","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0004","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejps.2013.04.002","article-title":"Biopharmaceutical classification of poorly soluble drugs with respect to \"enabling formulations\"","volume":"50","author":"Buckley","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2024.106798_bib0005","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1023\/B:PHAM.0000026430.73789.e6","article-title":"In vitro and in vivo pharmacoscintigraphic evaluation of ibuprofen hypromellose and gelatin capsules","volume":"21","author":"Cole","year":"2004","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2024.106798_bib0006","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0378-5173(87)90137-2","article-title":"Gastrointestinal transit of a controlled-release pellet formulation of tiaprofenic acid and the effect of food","volume":"35","author":"Davis","year":"1987","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.xphs.2024.01.001","article-title":"Understanding the conditions under which drugs are transferred from the stomach through the upper small intestine after a high-calorie, high-fat meal","author":"Dietrich","year":"2024","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2024.106798_bib0008","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1023\/A:1007568900147","article-title":"Bioequivalence study of stressed and nonstressed hard gelatin capsules using amoxicillin as a drug marker and gamma scintigraphy to confirm time and GI location of in vivo capsule rupture","volume":"17","author":"Digenis","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2024.106798_bib0009","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jpba.2019.03.026","article-title":"Co-existing colloidal phases of human duodenal aspirates: intraindividual fluctuations and interindividual variability in relation to molecular composition","volume":"170","author":"Elvang","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ejps.2024.106798_bib0010","series-title":"European Medicines Agency Updates Guideline On Drug Interactions","year":"2012"},{"key":"10.1016\/j.ejps.2024.106798_bib0011","series-title":"Assessing the Effects of Food on Drugs in INDs and NDAs \u2014 Clinical Pharmacology Considerations Guidance For Industry","year":"2022"},{"key":"10.1016\/j.ejps.2024.106798_bib0012","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1021\/acs.molpharmaceut.7b00623","article-title":"Gastric water emptying under fed state clinical trial conditions is as fast as under fasted conditions","volume":"14","author":"Grimm","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2024.114277","article-title":"Is there a fast track (\"Darmstrasse\") for fluids in the small intestine? Evidence from magnetic resonance imaging","volume":"198","author":"Gro\u00dfmann","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0014","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1128\/AAC.32.9.1310","article-title":"Pharmacokinetics of itraconazole following oral administration to normal volunteers","volume":"32","author":"Hardin","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2024.106798_bib0015","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1021\/bi00460a012","article-title":"Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings","volume":"29","author":"Hernell","year":"1990","journal-title":"BiochemistryBiochemistry"},{"key":"10.1016\/j.ejps.2024.106798_bib0016","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1365-2036.2011.04609.x","article-title":"Review article: the role of gastric motility in the control of food intake","volume":"33","author":"Janssen","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2024.106798_bib0017","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1023\/A:1026155822121","article-title":"Comparison of the rates of disintegration, gastric emptying, and drug absorption following administration of a new and a conventional paracetamol formulation, using gamma scintigraphy","volume":"20","author":"Kelly","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2024.106798_bib0018","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1208\/s12248-023-00822-5","article-title":"Streamlining food effect assessment - are repeated food effect studies needed? An IQ Analysis","volume":"25","author":"Kesisoglou","year":"2023","journal-title":"AAPS. J."},{"key":"10.1016\/j.ejps.2024.106798_bib0019","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ijpharm.2016.10.018","article-title":"In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT","volume":"515","author":"Kourentas","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0020","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1021\/mp500022u","article-title":"Intragastric volume changes after intake of a high-caloric, high-fat standard breakfast in healthy human subjects investigated by MRI","volume":"11","author":"Koziolek","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0021","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s11095-016-1882-8","article-title":"Characteristics of the human upper gastrointestinal contents in the fasted state under hypo- and a-chlorhydric gastric conditions under conditions of typical drug - drug interaction studies","volume":"33","author":"Litou","year":"2016","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2024.106798_bib0022","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF01324736","article-title":"Different gastric, pancreatic, and biliary responses to solid-liquid or homogenized meals","volume":"24","author":"Malagelada","year":"1979","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ejps.2024.106798_bib0023","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1067\/mcp.2001.113185","article-title":"Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins","volume":"69","author":"Malhotra","year":"2001","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2024.106798_bib0024","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejpb.2015.03.009","article-title":"In-vitro simulation of luminal conditions for evaluation of performance of oral drug products: choosing the appropriate test media","volume":"93","author":"Markopoulos","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0025","unstructured":"Mudge, S.J., Hayes, D., Lukas, S.; Mayne Pharma International Pty Ltd, Melbourne (AU), Itraconazole compositions and dosage forms, and methods of using the same. United States Patent US 8,921,374 B2, 2014."},{"key":"10.1016\/j.ejps.2024.106798_bib0026","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1021\/mp200286x","article-title":"Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo","volume":"9","author":"M\u00fcllertz","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0027","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/jrr\/rrz054","article-title":"Assessment of abdominal organ motion using cine magnetic resonance imaging in different gastric motilities: a comparison between fasting and postprandial states","volume":"60","author":"Nonaka","year":"2019","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.ejps.2024.106798_bib0028","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0378-5173(87)90182-7","article-title":"The influence of food on the gastric emptying of multiparticulate dosage forms","volume":"34","author":"O'Reilly","year":"1987","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0029","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.ejpb.2013.05.007","article-title":"Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities","volume":"85","author":"Pedersen","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105535","article-title":"Characteristics of contents in the upper gastrointestinal lumen after a standard high-calorie high-fat meal and implications for the in vitro drug product performance testing conditions","volume":"155","author":"Pentafragka","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2024.106798_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105351","article-title":"Disposition of two highly permeable drugs in the upper gastrointestinal lumen of healthy adults after a standard high-calorie, high-fat meal","volume":"149","author":"Pentafragka","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2024.106798_bib0032","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrd2197","article-title":"Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs","volume":"6","author":"Porter","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejps.2024.106798_bib0033","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1208\/s12248-023-00865-8","article-title":"Drug dissolution in oral drug absorption: workshop report","volume":"25","author":"Raines","year":"2023","journal-title":"AAPS. J."},{"key":"10.1016\/j.ejps.2024.106798_bib0034","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1021\/acs.molpharmaceut.8b00865","article-title":"Gastric and Duodenal Diclofenac Concentrations in Healthy Volunteers after Intake of the FDA Standard Meal: in vivo Observations and in Vitro Explorations","volume":"16","author":"Rubbens","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0035","doi-asserted-by":"crossref","first-page":"370","DOI":"10.5056\/jnm20115","article-title":"Evaluations of Gastric Acid Pocket Using Novel Vertical 8-Channel pH Monitoring System and Effects of Acid Secretion Inhibitors","volume":"27","author":"Sumi","year":"2021","journal-title":"J. Neurogastroenterol. Motil."},{"key":"10.1016\/j.ejps.2024.106798_bib0036","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1021\/mp200479f","article-title":"Luminal Lipid Phases after Administration of a Triglyceride Solution of Danazol in the Fed State and Their Contribution to the Flux of Danazol Across Caco-2 Cell Monolayers","volume":"9","author":"Vertzoni","year":"2012","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2024.106798_bib0037","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1208\/s12248-021-00601-0","article-title":"Use of Physiologically Based Pharmacokinetic Modeling for Predicting Drug-Food Interactions: recommendations for Improving Predictive Performance of Low Confidence Food Effect Models","volume":"23","author":"Wagner","year":"2021","journal-title":"AAPS. J."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724001106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724001106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T22:53:28Z","timestamp":1718232808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098724001106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":37,"alternative-id":["S0928098724001106"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106798","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On the processes limiting oral drug absorption when amorphous solid dispersions are administered after a high-calorie, high-fat meal: Sporanox\u00ae pellets","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106798","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106798"}}