{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T15:12:12Z","timestamp":1793891532114,"version":"4.8.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007606","name":"Aarhus Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ejps.2024.106859","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T23:19:30Z","timestamp":1721517570000},"page":"106859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Penicillin concentrations in oropharyngeal and frontal sinus tissue following enteral and intravenous administration measured by microdialysis in a porcine model"],"prefix":"10.1016","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6845-1874","authenticated-orcid":false,"given":"Pelle","family":"Hanberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Christian","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Bue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiken","family":"Stilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Ren\u00e9","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth Krogsgaard","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne Gade","family":"Lille\u00f8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus A.","family":"Hvistendahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Bille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejs Ehlers","family":"Klug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejps.2024.106859_bib0009","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1302\/2046-3758.101.BJR-2020-0250.R1","article-title":"Flucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral administration","volume":"10","author":"Bendtsen","year":"2021","journal-title":"Bone Joint Res"},{"issue":"4","key":"10.1016\/j.ejps.2024.106859_bib0021","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/jor.23776","article-title":"Single-dose bone pharmacokinetics of vancomycin in a porcine implant-associated osteomyelitis model","volume":"36","author":"Bue","year":"2018","journal-title":"J. Orthop. Res."},{"issue":"2","key":"10.1016\/j.ejps.2024.106859_bib0008","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4103\/0976-500X.130042","article-title":"Switch over from intravenous to oral therapy: a concise overview","volume":"5","author":"Cyriac","year":"2014","journal-title":"J Pharmacol Pharmacother"},{"issue":"1","key":"10.1016\/j.ejps.2024.106859_bib0018","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1086\/344653","article-title":"Prevention of resistance: a goal for dose selection for antimicrobial agents","volume":"36","author":"Drusano","year":"2003","journal-title":"Clin. Infect. Dis."},{"issue":"4","key":"10.1016\/j.ejps.2024.106859_bib0004","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nrmicro862","article-title":"Antimicrobial pharmacodynamics: critical interactions of 'bug and drug","volume":"2","author":"Drusano","year":"2004","journal-title":"Nat. Rev. Micro."},{"key":"10.1016\/j.ejps.2024.106859_bib0006","unstructured":"EUCAST. https:\/\/mic.eucast.org\/search\/. 2023."},{"issue":"5","key":"10.1016\/j.ejps.2024.106859_bib0015","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02390-17","article-title":"Population pharmacokinetics of meropenem in plasma and subcutis from patients on extracorporeal membrane oxygenation treatment","volume":"62","author":"Hanberg","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2024.106859_bib0022","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.964005","article-title":"Dose optimization of \u03b2-lactams antibiotics in pediatrics and adults: a systematic review","volume":"13","author":"Haseeb","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106859_bib0023","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/hed.26908","article-title":"Antibiotic prophylaxis in head and neck cancer surgery: systematic review and Bayesian network meta-analysis","volume":"44","author":"Iocca","year":"2022","journal-title":"Head Neck"},{"issue":"9","key":"10.1016\/j.ejps.2024.106859_bib0012","doi-asserted-by":"crossref","first-page":"895","DOI":"10.2165\/00003088-200544090-00002","article-title":"Microdialysis: current applications in clinical pharmacokinetic studies and its potential role in the future","volume":"44","author":"Joukhadar","year":"2005","journal-title":"Clin. Pharmacokinet."},{"issue":"5","key":"10.1016\/j.ejps.2024.106859_bib0013","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1007\/s12035-016-9929-8","article-title":"A review on microdialysis calibration methods: the theory and current related efforts","volume":"54","author":"Kho","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.ejps.2024.106859_bib0005","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3343\/alm.2022.42.2.188","article-title":"Clinical differences in patients infected with fusobacterium and antimicrobial susceptibility of fusobacterium isolates recovered at a tertiary-care hospital in Korea","volume":"42","author":"Kim","year":"2022","journal-title":"Ann Lab Med"},{"issue":"7","key":"10.1016\/j.ejps.2024.106859_bib0001","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s10096-021-04180-y","article-title":"Microbiology of parapharyngeal abscesses in adults: in search of the significant pathogens","volume":"40","author":"Klug","year":"2021","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"issue":"2","key":"10.1016\/j.ejps.2024.106859_bib0024","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0196-6553(99)70088-X","article-title":"Guideline for prevention of surgical site infection, 1999. Centers for disease control and prevention (CDC) hospital infection control practices advisory committee","volume":"27","author":"Mangram","year":"1999","journal-title":"Am. J. Infect. Control"},{"issue":"3","key":"10.1016\/j.ejps.2024.106859_bib0014","doi-asserted-by":"crossref","first-page":"E37","DOI":"10.1111\/j.1469-0691.2011.03752.x","article-title":"The role of pharmacokinetics\/pharmacodynamics in setting clinical MIC breakpoints: the EUCAST approach","volume":"18","author":"Mouton","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"issue":"3","key":"10.1016\/j.ejps.2024.106859_bib0017","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/jac\/dkx427","article-title":"MIC-based dose adjustment: facts and fables","volume":"73","author":"Mouton","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"issue":"4","key":"10.1016\/j.ejps.2024.106859_bib0019","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s40265-018-0880-z","article-title":"Therapeutic drug monitoring of beta-lactams and other antibiotics in the intensive care unit: which agents, which patients and which infections?","volume":"78","author":"Muller","year":"2018","journal-title":"Drugs"},{"issue":"7","key":"10.1016\/j.ejps.2024.106859_bib0010","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s11095-022-03197-y","article-title":"Population pharmacokinetics of flucloxacillin in bone and soft tissue- standard dosing is not sufficient to achieve therapeutic concentrations","volume":"39","author":"\u00d6brink-Hansen","year":"2022","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.ejps.2024.106859_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-0691.2012.03766.x","article-title":"Guideline for the management of acute sore throat","volume":"18","author":"Pelucchi","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"issue":"7","key":"10.1016\/j.ejps.2024.106859_bib0011","article-title":"Intermittent short-term infusion vs. continuous infusion of piperacillin: steady state concentrations in porcine cervical spine tissue evaluated by microdialysis","volume":"11","author":"Petersen","year":"2022","journal-title":"Antibiotics (Basel)"},{"issue":"3","key":"10.1016\/j.ejps.2024.106859_bib0002","article-title":"Phenoxymethylpenicillin versus amoxicillin for infections in ambulatory care: a systematic review","volume":"7","author":"Skarpeid","year":"2018","journal-title":"Antibiotics (Basel)"},{"issue":"2","key":"10.1016\/j.ejps.2024.106859_bib0026","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/0300985811402846","article-title":"Swine as models in biomedical research and toxicology testing","volume":"49","author":"Swindle","year":"2012","journal-title":"Vet. Pathol."},{"issue":"12","key":"10.1016\/j.ejps.2024.106859_bib0016","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/apm.12996","article-title":"Bone, subcutaneous tissue and plasma pharmacokinetics of cefuroxime in total knee replacement patients - a randomized controlled trial comparing continuous and short-term infusion","volume":"127","author":"T\u00f8ttrup","year":"2019","journal-title":"APMIS"},{"issue":"2","key":"10.1016\/j.ejps.2024.106859_bib0027","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/bja\/53.2.153","article-title":"Endocrine and metabolic changes during surgery: anaesthetic implications","volume":"53","author":"Traynor","year":"1981","journal-title":"Br. J. Anaesth."},{"issue":"6","key":"10.1016\/j.ejps.2024.106859_bib0025","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1586\/eri.10.41","article-title":"Preventing surgical site infections","volume":"8","author":"U\u00e7kay","year":"2010","journal-title":"Expert Rev. Anti Infect. Ther."},{"issue":"1","key":"10.1016\/j.ejps.2024.106859_bib0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s13054-018-2155-1","article-title":"Pharmacokinetics-pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients","volume":"22","author":"Veiga","year":"2018","journal-title":"Crit. Care"},{"issue":"8","key":"10.1016\/j.ejps.2024.106859_bib0003","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3109\/00016489.2014.905702","article-title":"Variations in treatment of peritonsillar abscess in four Nordic countries","volume":"134","author":"Wikst\u00e9n","year":"2014","journal-title":"Acta Otolaryngol."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724001714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724001714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T22:55:19Z","timestamp":1728514519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098724001714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":27,"alternative-id":["S0928098724001714"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106859","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Penicillin concentrations in oropharyngeal and frontal sinus tissue following enteral and intravenous administration measured by microdialysis in a porcine model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106859","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106859"}}