{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:32:35Z","timestamp":1791433955693,"version":"4.3.3"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ejps.2024.106971","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T22:43:28Z","timestamp":1732661008000},"page":"106971","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Interaction of preservatives with contact materials during filling and storage of parenteral liquid formulations"],"prefix":"10.1016","volume":"204","author":[{"given":"Paul","family":"Gottschalk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2907-2118","authenticated-orcid":false,"given":"Patrick","family":"Schlossbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Schleicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Presser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Wittmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejps.2024.106971_bib0001","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1081\/PDT-100002251","article-title":"Sorption of parabens by flexible tubings","volume":"6","author":"Bahal","year":"2001","journal-title":"Pharm. Dev. Technol."},{"issue":"6","key":"10.1016\/j.ejps.2024.106971_bib0002","first-page":"417","article-title":"Sorption of parabens by fluoropolymer or fluoropolymer laminated flexible tubing","volume":"55","author":"Bahal","year":"2001","journal-title":"PDa J. Pharm. Sci. Technol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106971_bib0003","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1081\/PDT-120002230","article-title":"Sorption of benzoic acid, sorbic acid, benzyl alcohol, and benzalkonium chloride by flexible tubing","volume":"7","author":"Bahal","year":"2002","journal-title":"Pharm. Dev. Technol."},{"issue":"3","key":"10.1016\/j.ejps.2024.106971_bib0004","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1081\/PDT-120005728","article-title":"Spalling and sorption of tubing for peristaltic pumps","volume":"7","author":"Bahal","year":"2002","journal-title":"Pharm. Dev. Technol."},{"issue":"7","key":"10.1016\/j.ejps.2024.106971_bib0005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/jps.3030460717","article-title":"The preservation of aqueous preparations containing nonionic surfactants. II. Preservative studies in solutions and products containing nonionic surfactants","volume":"46","author":"BARR","year":"1957","journal-title":"J. Am. Pharm. Assoc. Am. Pharm. Assoc."},{"issue":"1-2","key":"10.1016\/j.ejps.2024.106971_bib0006","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ijpharm.2014.06.044","article-title":"Antimicrobial preservatives induce aggregation of interferon alpha-2a: the order in which preservatives induce protein aggregation is independent of the protein","volume":"472","author":"Bis","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2024.106971_bib0007","series-title":"European pharmacopoeia 10.0 - Chapter 5.1.3","year":"2011"},{"issue":"2","key":"10.1016\/j.ejps.2024.106971_bib0008","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.xphs.2020.09.027","article-title":"Antimicrobial excipient-induced reversible association of therapeutic peptides in parenteral formulations","volume":"110","author":"D'Addio","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2024.106971_bib0009","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejpb.2018.07.011","article-title":"Parenteral protein formulations: an overview of approved products within the European Union","volume":"131","author":"Gervasi","year":"2018","journal-title":"Euro. J Pharmaceut. Biopharmaceut."},{"issue":"6","key":"10.1016\/j.ejps.2024.106971_bib0010","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.xphs.2020.12.030","article-title":"Preservative induced polysorbate 80 micelle aggregation","volume":"110","author":"Gilbert","year":"2021","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ejps.2024.106971_bib0011","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1208\/ps050208","article-title":"Development of a multidose formulation for a humanized monoclonal antibody using experimental design techniques","volume":"5","author":"Gupta","year":"2003","journal-title":"AAPS. PharmSci."},{"issue":"10","key":"10.1016\/j.ejps.2024.106971_bib0012","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1007\/s11095-015-1697-z","article-title":"Interactions between peptide and preservatives: effects on peptide self-interactions and antimicrobial efficiency in aqueous multi-dose formulations","volume":"32","author":"Heljo","year":"2015","journal-title":"Pharm. Res."},{"issue":"4","key":"10.1016\/j.ejps.2024.106971_bib0013","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.xphs.2020.01.009","article-title":"Effects of tubing type, operating parameters, and surfactants on particle formation during peristaltic filling pump processing of a mAb formulation","volume":"109","author":"Her","year":"2020","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ejps.2024.106971_bib0014","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/jps.23362","article-title":"Effect of antimicrobial preservatives on partial protein unfolding and aggregation","volume":"102","author":"Hutchings","year":"2013","journal-title":"J. Pharm. Sci."},{"issue":"Suppl 3","key":"10.1016\/j.ejps.2024.106971_bib0015","first-page":"98","article-title":"Liquid growth hormone: preservatives and buffers","volume":"62","author":"Kappelgaard","year":"2004","journal-title":"Horm. Res."},{"issue":"32","key":"10.1016\/j.ejps.2024.106971_bib0016","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1016\/j.vaccine.2010.05.048","article-title":"Single versus multi-dose vaccine vials: an economic computational model","volume":"28","author":"Lee","year":"2010","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.ejps.2024.106971_bib0017","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1021\/acs.molpharmaceut.2c00449","article-title":"Molecular mechanism of antimicrobial excipient-induced aggregation in parenteral formulations of peptide therapeutics","volume":"19","author":"Li","year":"2022","journal-title":"Mol. Pharm."},{"issue":"12","key":"10.1016\/j.ejps.2024.106971_bib0018","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1002\/jps.20976","article-title":"Antimicrobial preservative use in parenteral products: past and present","volume":"96","author":"Meyer","year":"2007","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.ejps.2024.106971_bib0019","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1208\/s12249-010-9575-9","article-title":"Comparison of compendial antimicrobial effectiveness tests: a review","volume":"12","author":"Moser","year":"2011","journal-title":"AAPS. PharmSciTech."},{"issue":"5","key":"10.1016\/j.ejps.2024.106971_bib0020","doi-asserted-by":"crossref","DOI":"10.1002\/marc.202000360","article-title":"Silicone Surface Fundamentals","volume":"42","author":"Owen","year":"2021","journal-title":"Macromol. Rapid. Commun."},{"issue":"5","key":"10.1016\/j.ejps.2024.106971_bib0021","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0014-3057(84)90036-3","article-title":"Dipole moments of some poly(dimethylsiloxane) linear chains and cyclics","volume":"20","author":"Riande","year":"1984","journal-title":"Eur. Polym. J."},{"issue":"4","key":"10.1016\/j.ejps.2024.106971_bib0022","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1002\/jps.24357","article-title":"Particle shedding from peristaltic pump tubing in biopharmaceutical drug product manufacturing","volume":"104","author":"Saller","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2024.106971_bib0023","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejpb.2016.11.021","article-title":"Preservative loss from silicone tubing during filling processes","volume":"112","author":"Saller","year":"2017","journal-title":"Euro. J Pharmaceut. Biopharmaceut."},{"issue":"2","key":"10.1016\/j.ejps.2024.106971_bib0024","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.xphs.2022.11.021","article-title":"Multi-dose formulation development for a quadrivalent human papillomavirus virus-like particle-based vaccine: part II- real-time and accelerated stability studies","volume":"112","author":"Sharma","year":"2023","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.ejps.2024.106971_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15020563","article-title":"Antimicrobial preservatives for protein and peptide formulations: an overview","volume":"15","author":"Stroppel","year":"2023","journal-title":"Pharmaceutics."},{"issue":"2","key":"10.1016\/j.ejps.2024.106971_bib0026","first-page":"123","article-title":"The essentials of United States pharmacopeia Chapter <51 antimicrobial effectiveness testing and its application in pharmaceutical compounding","volume":"18","author":"Vu","year":"2014","journal-title":"Int. J. Pharm. Compd."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724002847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724002847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T19:37:58Z","timestamp":1738438678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098724002847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":26,"alternative-id":["S0928098724002847"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106971","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interaction of preservatives with contact materials during filling and storage of parenteral liquid formulations","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106971","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106971"}}