{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:37:04Z","timestamp":1789760224199,"version":"4.0.1"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ejps.2024.106982","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:51:10Z","timestamp":1733446270000},"page":"106982","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Pyrrolidine SS13 induces oxidative stress and autophagy-mediated cell death in colorectal cancer cells"],"prefix":"10.1016","volume":"205","author":[{"given":"Natalia","family":"Nosalova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Majirska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Keselakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Martinkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Fabianova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Mirossay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina Bago","family":"Pilatova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2454-5799","authenticated-orcid":false,"given":"Martin","family":"Kello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejps.2024.106982_bib0001","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13041-018-0364-9","article-title":"Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer's disease mouse models","volume":"11","author":"Abd-Elrahman","year":"2018","journal-title":"Mol. Brain"},{"issue":"2","key":"10.1016\/j.ejps.2024.106982_bib0002","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1080\/15548627.2018.1537769","article-title":"MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca(2+) communication: a dead end in cancer cells","volume":"15","author":"Ahumada-Castro","year":"2019","journal-title":"Autophagy"},{"issue":"01\/02","key":"10.1016\/j.ejps.2024.106982_bib0003","first-page":"89","article-title":"Essential oil from Myrica rubra leaves potentiated antiproliferative and prooxidative effect of doxorubicin and its accumulation in intestinal cancer cells","volume":"82","author":"Ambro\u017e","year":"2016","journal-title":"Planta Med."},{"key":"10.1016\/j.ejps.2024.106982_bib0004","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.fct.2018.05.054","article-title":"Activation of the p53 pathway with digiferrol isolated from Rubia philippinensis induces cell cycle arrest, apoptosis, and autophagy in colon cancer cells","volume":"118","author":"An","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.ejps.2024.106982_bib0005","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/bs.ctdb.2015.07.012","article-title":"Autophagy in cell life and cell death","volume":"114","author":"Anding","year":"2015","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.ejps.2024.106982_bib0006","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejmech.2013.12.027","article-title":"Novel spirooxindole-pyrrolidine compounds: synthesis, anticancer and molecular docking studies","volume":"74","author":"Arun","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejps.2024.106982_bib0007","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ejmech.2016.01.012","article-title":"PI3K\/Akt\/mTOR and Ras\/Raf\/MEK\/ERK signaling pathways inhibitors as anticancer agents: structural and pharmacological perspectives","volume":"109","author":"Asati","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejps.2024.106982_bib0008","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4161\/auto.1.1.1495","article-title":"The dynamics of autophagy visualized in live cells: from autophagosome formation to fusion with endo\/lysosomes","volume":"1","author":"Bampton","year":"2005","journal-title":"Autophagy."},{"issue":"8\u20139","key":"10.1016\/j.ejps.2024.106982_bib0009","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.dnarep.2004.03.002","article-title":"DNA damage responses to oxidative stress","volume":"3","author":"Barzilai","year":"2004","journal-title":"DNa Repair. (Amst)"},{"issue":"11","key":"10.1016\/j.ejps.2024.106982_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12113336","article-title":"The role of oxidative stress and its counteractive utility in colorectal cancer (CRC)","volume":"12","author":"Basak","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.ejps.2024.106982_bib0011","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ejmech.2018.02.086","article-title":"Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells","volume":"150","author":"Bello","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejps.2024.106982_bib0012","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0076-6879(08)03612-4","article-title":"Monitoring autophagic degradation of p62\/SQSTM1","volume":"452","author":"Bj\u00f8rk\u00f8y","year":"2009","journal-title":"Meth. Enzymol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106982_bib0013","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/abbi.1998.0618","article-title":"Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species","volume":"353","author":"Burkitt","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"issue":"21","key":"10.1016\/j.ejps.2024.106982_bib0014","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218135","article-title":"ROS-dependent ER stress and autophagy mediate the anti-tumor effects of tributyltin (IV) ferulate in colon cancer cells","volume":"21","author":"Celesia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1\u20133","key":"10.1016\/j.ejps.2024.106982_bib0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2008.07.024","article-title":"Involvement of activating transcription factors JNK, NF-kappaB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate\/Cu complex","volume":"594","author":"Chen","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejps.2024.106982_bib0016","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jss.2013.03.035","article-title":"Restoration of PTEN activity decreases metastases in an orthotopic model of colon cancer","volume":"184","author":"Chowdhury","year":"2013","journal-title":"J. Surg. Res."},{"issue":"7","key":"10.1016\/j.ejps.2024.106982_bib0017","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1084\/jem.20011508","article-title":"c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation","volume":"195","author":"Conze","year":"2002","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.ejps.2024.106982_bib0018","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3892\/ijo.2017.4049","article-title":"Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation","volume":"51","author":"Cusimano","year":"2017","journal-title":"Int. J. Oncol."},{"issue":"12","key":"10.1016\/j.ejps.2024.106982_bib0019","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1038\/onc.2009.519","article-title":"Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1","volume":"29","author":"Djavaheri-Mergny","year":"2010","journal-title":"Oncogene"},{"issue":"10","key":"10.1016\/j.ejps.2024.106982_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11101422","article-title":"The Emerging Roles of mTORC1 in macromanaging autophagy","volume":"11","author":"Dossou","year":"2019","journal-title":"Cancers"},{"issue":"5\u20136","key":"10.1016\/j.ejps.2024.106982_bib0021","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.mam.2006.08.005","article-title":"Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy","volume":"27","author":"Eskelinen","year":"2006","journal-title":"Mol. Aspects. Med."},{"key":"10.1016\/j.ejps.2024.106982_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.tet.2021.132380","article-title":"A straightforward approach toward cytotoxic pyrrolidine alkaloids: novel analogues of natural broussonetines","volume":"96","author":"F\u00e1bianov\u00e1","year":"2021","journal-title":"Tetrahedron"},{"issue":"5","key":"10.1016\/j.ejps.2024.106982_bib0023","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon","year":"1990","journal-title":"Cell"},{"issue":"2\u20133","key":"10.1016\/j.ejps.2024.106982_bib0024","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molimm.2009.09.016","article-title":"Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death","volume":"47","author":"Gancz","year":"2009","journal-title":"Mol. Immunol."},{"issue":"12","key":"10.1016\/j.ejps.2024.106982_bib0025","doi-asserted-by":"crossref","first-page":"6004","DOI":"10.1128\/JVI.76.12.6004-6015.2002","article-title":"Antiviral effects of pyrrolidine dithiocarbamate on human rhinoviruses","volume":"76","author":"Gaudernak","year":"2002","journal-title":"J. Virol."},{"issue":"3\u20134","key":"10.1016\/j.ejps.2024.106982_bib0026","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/1947601912454734","article-title":"The regulation of multiple p53 stress responses is mediated through MDM2","volume":"3","author":"Hu","year":"2012","journal-title":"Genes Cancer"},{"issue":"5\u20136","key":"10.1016\/j.ejps.2024.106982_bib0027","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1615\/CritRevOncog.2018027913","article-title":"Autophagy and hallmarks of cancer","volume":"23","author":"Huang","year":"2018","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/j.ejps.2024.106982_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113317","article-title":"Aflatoxin B1 promotes autophagy associated with oxidative stress-related PI3K\/AKT\/mTOR signaling pathway in mice testis","volume":"255","author":"Huang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.ejps.2024.106982_bib0029","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.bioorg.2018.10.036","article-title":"Synthesis of new thiazolo-pyrrolidine\u2013(spirooxindole) tethered to 3-acylindole as anticancer agents","volume":"82","author":"Islam","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"10","key":"10.1016\/j.ejps.2024.106982_bib0030","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12032-016-0820-2","article-title":"Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing","volume":"33","author":"Jauhri","year":"2016","journal-title":"Med. Oncol."},{"issue":"10","key":"10.1016\/j.ejps.2024.106982_bib0031","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1111\/j.1572-0241.2001.04677.x","article-title":"A systematic review and meta-analysis of familial colorectal cancer risk","volume":"96","author":"Johns","year":"2001","journal-title":"Am. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106982_bib0032","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4062\/biomolther.2022.044","article-title":"MHY2251, a New SIRT1 inhibitor, induces apoptosis via JNK\/p53 pathway in HCT116 human colorectal cancer cells","volume":"31","author":"Kang","year":"2023","journal-title":"Biomol. Ther."},{"issue":"5","key":"10.1016\/j.ejps.2024.106982_bib0033","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1021\/np060577f","article-title":"Habbemines A and B, pyrrolidine alkaloids with human delta-opioid receptor binding affinity from the leaves of Elaeocarpus habbemensis","volume":"70","author":"Katavic","year":"2007","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejps.2024.106982_bib0034","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.lfs.2016.06.017","article-title":"Sesamol induces mitochondrial apoptosis pathway in HCT116 human colon cancer cells via pro-oxidant effect","volume":"158","author":"Khamphio","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.ejps.2024.106982_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108688","article-title":"Coptisine induces autophagic cell death through down-regulation of PI3K\/Akt\/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells","volume":"697","author":"Kim","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.ejps.2024.106982_bib0036","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.bbrc.2018.10.045","article-title":"Arctigenin shows preferential cytotoxicity to acidity-tolerant prostate carcinoma PC-3 cells through ROS-mediated mitochondrial damage and the inhibition of PI3K\/Akt\/mTOR pathway","volume":"505","author":"Lee","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.ejps.2024.106982_bib0037","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2008.02.002","article-title":"Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology","volume":"134","author":"Levin","year":"2008","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.ejps.2024.106982_bib0038","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/gcc.20486","article-title":"Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase 1 DNA damage response axis in colon cancers","volume":"46","author":"Lewis","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"issue":"9","key":"10.1016\/j.ejps.2024.106982_bib0039","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.4161\/cc.8.9.8255","article-title":"PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches","volume":"8","author":"Ligresti","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ejps.2024.106982_bib0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.yjmcc.2015.10.032","article-title":"Regulation of autophagy by Beclin 1 in the heart","volume":"95","author":"Maejima","year":"2016","journal-title":"J. Mol. Cell Cardiol."},{"issue":"3\u20134","key":"10.1016\/j.ejps.2024.106982_bib0041","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s10495-018-1449-8","article-title":"Licarin A induces cell death by activation of autophagy and apoptosis in non-small cell lung cancer cells","volume":"23","author":"Maheswari","year":"2018","journal-title":"Apoptosis"},{"issue":"7","key":"10.1016\/j.ejps.2024.106982_bib0042","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131433","article-title":"Bioactivity studies of beta-lactam derived polycyclic fused pyrroli-dine\/pyrrolizidine derivatives in dentistry: in vitro, in vivo and in silico studies","volume":"10","author":"Meiyazhagan","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ejps.2024.106982_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2020.102043","article-title":"The role of autophagy in resistance to targeted therapies","volume":"88","author":"Mele","year":"2020","journal-title":"Cancer Treat. Rev."},{"issue":"8","key":"10.1016\/j.ejps.2024.106982_bib0044","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/01.cad.0000173476.67239.3b","article-title":"PI3K\/Akt\/mTOR pathway as a target for cancer therapy","volume":"16","author":"Morgensztern","year":"2005","journal-title":"Anticancer Drugs"},{"issue":"2","key":"10.1016\/j.ejps.2024.106982_bib0045","doi-asserted-by":"crossref","DOI":"10.3390\/biom8020014","article-title":"p53-mediated molecular control of autophagy in tumor cells","volume":"8","author":"Mrakovcic","year":"2018","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.ejps.2024.106982_bib0046","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174591","article-title":"Tetraarsenic hexoxide induces G2\/M arrest, apoptosis, and autophagy via PI3K\/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells","volume":"12","author":"Nagappan","year":"2017","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.ejps.2024.106982_bib0047","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/cas.12396","article-title":"An inhibition of p62\/SQSTM1 caused autophagic cell death of several human carcinoma cells","volume":"105","author":"Nihira","year":"2014","journal-title":"Cancer Sci."},{"issue":"5","key":"10.1016\/j.ejps.2024.106982_bib0048","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/ijc.21466","article-title":"Subcellular localization, modification and protein complex formation of the cdk-inhibitor p16 in Rb-functional and Rb-inactivated tumor cells","volume":"118","author":"Nilsson","year":"2006","journal-title":"Int. J. Cancer"},{"issue":"14","key":"10.1016\/j.ejps.2024.106982_bib0049","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411696","article-title":"Involvement of both extrinsic and intrinsic apoptotic pathways in tridecylpyrrolidine-diol derivative-induced apoptosis in vitro","volume":"24","author":"Nosalova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejps.2024.106982_bib0050","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ejmech.2017.08.054","article-title":"Design, synthesis and biological evaluation of new pyrrolidine carboxamide analogues as potential chemotherapeutic agents for hepatocellular carcinoma","volume":"139","author":"Omar","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejps.2024.106982_bib0051","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jinorgbio.2012.09.009","article-title":"A novel organobismuth compound, 1-[(2-di-p-tolylbismuthanophenyl)diazenyl]pyrrolidine, induces apoptosis in the human acute promyelocytic leukemia cell line NB4 via reactive oxygen species","volume":"117","author":"Onishi","year":"2012","journal-title":"J. Inorg. Biochem."},{"issue":"6","key":"10.1016\/j.ejps.2024.106982_bib0052","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2184.2012.00845.x","article-title":"Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis","volume":"45","author":"Ouyang","year":"2012","journal-title":"Cell Prolif."},{"issue":"19","key":"10.1016\/j.ejps.2024.106982_bib0053","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14194735","article-title":"Nuclear beclin 1 destabilizes retinoblastoma protein to promote cell cycle progression and colorectal cancer growth","volume":"14","author":"Pan","year":"2022","journal-title":"Cancers"},{"issue":"10","key":"10.1016\/j.ejps.2024.106982_bib0054","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1007\/s00044-016-1692-x","article-title":"Synthesis and anticancer activities of novel (tetrahydrobenzo [4, 5] thieno [2, 3-d] pyrimidine-4-yl)-pyrolidine-2-carboxylic acid derivatives","volume":"25","author":"Pavase","year":"2016","journal-title":"Medicin. Chem. Res."},{"issue":"4","key":"10.1016\/j.ejps.2024.106982_bib0055","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/jamaoncol.2016.5194","article-title":"Prevalence and spectrum of germline cancer susceptibility gene mutations among patients with early-onset colorectal cancer","volume":"3","author":"Pearlman","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ejps.2024.106982_bib0056","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.lfs.2017.07.024","article-title":"M(4)IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K\/Akt\/mTOR pathway","volume":"185","author":"Peng","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.ejps.2024.106982_bib0057","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijbiomac.2022.02.005","article-title":"Beclin1-mediated interplay between autophagy and apoptosis: new understanding","volume":"204","author":"Prerna","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.ejps.2024.106982_bib0058","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127571","article-title":"A Central Role for JNK\/AP-1 pathway in the pro-oxidant effect of pyrrolidine dithiocarbamate through superoxide dismutase 1 gene repression and reactive oxygen species generation in hematopoietic human cancer cell line U937","volume":"10","author":"Riera","year":"2015","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.ejps.2024.106982_bib0059","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/sj.emboj.7601623","article-title":"Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4","volume":"26","author":"Scherz-Shouval","year":"2007","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.ejps.2024.106982_bib0060","doi-asserted-by":"crossref","first-page":"e36828","DOI":"10.1371\/journal.pone.0036828","article-title":"Neuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibition","volume":"7","author":"Schmukler","year":"2012","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.ejps.2024.106982_bib0061","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrc1011","article-title":"ATM and related protein kinases: safeguarding genome integrity","volume":"3","author":"Shiloh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.ejps.2024.106982_bib0062","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.3390\/ijms15023145","article-title":"Autophagic cell death and cancer","volume":"15","author":"Shimizu","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ejps.2024.106982_bib0063","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3748\/wjg.v11.i3.403","article-title":"Lipid peroxidation and antioxidant status in colorectal cancer","volume":"11","author":"Skrzydlewska","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejps.2024.106982_bib0064","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/102735","article-title":"Role of the crosstalk between autophagy and apoptosis in cancer","volume":"2013","author":"Su","year":"2013","journal-title":"J. Oncol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106982_bib0065","doi-asserted-by":"crossref","first-page":"17259","DOI":"10.1038\/s41598-019-53863-2","article-title":"Treatment with a new benzimidazole derivative bearing a pyrrolidine side chain overcomes sorafenib resistance in hepatocellular carcinoma","volume":"9","author":"Suk","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.ejps.2024.106982_bib0066","doi-asserted-by":"crossref","DOI":"10.3390\/biom10020345","article-title":"Antiproliferative effect of acridine chalcone is mediated by induction of oxidative stress","volume":"10","author":"Takac","year":"2020","journal-title":"Biomolecules"},{"issue":"9","key":"10.1016\/j.ejps.2024.106982_bib0067","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13092196","article-title":"JNK in tumor microenvironment: present findings and challenges in clinical translation","volume":"13","author":"Tam","year":"2021","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.ejps.2024.106982_bib0068","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3892\/or.2017.5779","article-title":"Sodium cantharidinate induces HepG2 cell apoptosis through LC3 autophagy pathway","volume":"38","author":"Tao","year":"2017","journal-title":"Oncol. Rep."},{"issue":"3","key":"10.1016\/j.ejps.2024.106982_bib0069","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20200265","article-title":"Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways","volume":"40","author":"Wan","year":"2020","journal-title":"Biosci. Rep."},{"issue":"10","key":"10.1016\/j.ejps.2024.106982_bib0070","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1038\/aps.2017.192","article-title":"Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM\/gammaH2AX pathway","volume":"39","author":"Wang","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.ejps.2024.106982_bib0071","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s10549-011-1466-6","article-title":"LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis","volume":"131","author":"Wang","year":"2012","journal-title":"Breast. Cancer Res. Treat."},{"issue":"6","key":"10.1016\/j.ejps.2024.106982_bib0072","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc3262","article-title":"Deconvoluting the context-dependent role for autophagy in cancer","volume":"12","author":"White","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"8","key":"10.1016\/j.ejps.2024.106982_bib0073","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/j.1745-7254.2005.00146.x","article-title":"Oxidative stress and stress signaling: menace of diabetic cardiomyopathy","volume":"26","author":"Wold","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.ejps.2024.106982_bib0074","doi-asserted-by":"crossref","first-page":"e9996","DOI":"10.1371\/journal.pone.0009996","article-title":"Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation","volume":"5","author":"Wong","year":"2010","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.ejps.2024.106982_bib0075","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4161\/cbt.3.2.614","article-title":"The functional interactions between the MAPK and p53 signaling pathways","volume":"3","author":"Wu","year":"2004","journal-title":"Cancer Biol. Ther."},{"issue":"6","key":"10.1016\/j.ejps.2024.106982_bib0076","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/med.21574","article-title":"JNK signaling in cancer cell survival","volume":"39","author":"Wu","year":"2019","journal-title":"Med. Res. Rev."},{"issue":"2","key":"10.1016\/j.ejps.2024.106982_bib0077","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00253-019-10257-8","article-title":"Targeting PI3K\/AKT\/mTOR-mediated autophagy for tumor therapy","volume":"104","author":"Xu","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106982_bib0078","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.clinre.2012.03.002","article-title":"Reduced expression of PTEN and increased PTEN phosphorylation at residue Ser380 in gastric cancer tissues: a novel mechanism of PTEN inactivation","volume":"37","author":"Yang","year":"2013","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.ejps.2024.106982_bib0079","first-page":"321","article-title":"c-Jun N-terminal Kinase (JNK) signaling as a therapeutic target for Alzheimer's disease","volume":"6","author":"Yarza","year":"2015","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.ejps.2024.106982_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2021.103389","article-title":"Antiproliferative effects of levan polysaccharide against colorectal cancer cells mediated through oxidative stress-stimulated HOTAIR\/Akt signaling pathway: in vitro","volume":"14","author":"Zhan","year":"2021","journal-title":"Arab. J. Chem."},{"issue":"2","key":"10.1016\/j.ejps.2024.106982_bib0081","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/CAD.0b013e3282f2bdff","article-title":"Potent anticancer activity of pyrrolidine dithiocarbamate-copper complex against cisplatin-resistant neuroblastoma cells","volume":"19","author":"Zhang","year":"2008","journal-title":"Anticancer Drugs"},{"issue":"1","key":"10.1016\/j.ejps.2024.106982_bib0082","doi-asserted-by":"crossref","first-page":"147","DOI":"10.7150\/ijbs.36955","article-title":"Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1\/JNK signaling axis","volume":"16","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.ejps.2024.106982_bib0083","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20140141","article-title":"MAPK\/JNK signalling: a potential autophagy regulation pathway","volume":"35","author":"Zhou","year":"2015","journal-title":"Biosci. Rep."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724002951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724002951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T15:20:32Z","timestamp":1736608832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098724002951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":83,"alternative-id":["S0928098724002951"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106982","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pyrrolidine SS13 induces oxidative stress and autophagy-mediated cell death in colorectal cancer cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106982","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106982"}}