{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:27:14Z","timestamp":1790346434553,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","award":["825825"],"award-info":[{"award-number":["825825"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["201269156"],"award-info":[{"award-number":["201269156"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1032"],"award-info":[{"award-number":["SFB1032"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"BMBF Bonn","doi-asserted-by":"publisher","award":["03ZU1201AA"],"award-info":[{"award-number":["03ZU1201AA"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ejps.2024.106983","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T19:45:42Z","timestamp":1733514342000},"page":"106983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Dual pH-responsive CRISPR\/Cas9 ribonucleoprotein xenopeptide complexes for genome editing"],"prefix":"10.1016","volume":"205","author":[{"given":"Xianjin","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janin","family":"Germer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Burghardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Grau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"H\u00f6hn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"L\u00e4chelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8413-0934","authenticated-orcid":false,"given":"Ernst","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2024.106983_bib0001","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jconrel.2021.02.026","article-title":"Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain","volume":"332","author":"Abbasi","year":"2021","journal-title":"J. Controll. Releas."},{"key":"10.1016\/j.ejps.2024.106983_bib0002","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1093\/nar\/gkq1299","article-title":"Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo","volume":"39","author":"Andaloussi","year":"2011","journal-title":"Nucl. Acid. Res."},{"key":"10.1016\/j.ejps.2024.106983_bib0003","doi-asserted-by":"crossref","DOI":"10.1063\/5.0073494","article-title":"Performance of nanoparticles for biomedical applications: the in vitro\/in vivo discrepancy","volume":"3","author":"Berger","year":"2022","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.ejps.2024.106983_bib0004","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/acs.biomac.0c01779","article-title":"Optimizing pDNA Lipo-polyplexes: a Balancing Act between Stability and Cargo Release","volume":"22","author":"Berger","year":"2021","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejps.2024.106983_bib0005","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2307799120","article-title":"Dynamic carriers for therapeutic RNA delivery","volume":"121","author":"Berger","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejps.2024.106983_bib0006","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.ymthe.2023.01.005","article-title":"RNA editing: expanding the potential of RNA therapeutics","volume":"31","author":"Booth","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ejps.2024.106983_bib0007","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41586-024-07087-8","article-title":"Durable and efficient gene silencing in vivo by hit-and-run epigenome editing","volume":"627","author":"Cappelluti","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ejps.2024.106983_bib0008","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/hum.2023.053","article-title":"CRISPR-editing therapy for Duchenne muscular dystrophy","volume":"34","author":"Chemello","year":"2023","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ejps.2024.106983_bib0009","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/s41467-024-45998-2","article-title":"Engineering self-deliverable ribonucleoproteins for genome editing in the brain","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejps.2024.106983_bib0010","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s41576-022-00541-1","article-title":"Prime editing for precise and highly versatile genome manipulation","volume":"24","author":"Chen","year":"2023","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ejps.2024.106983_bib0011","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1021\/acs.accounts.3c00279","article-title":"Development of CRISPR\/Cas delivery systems for in vivo precision genome editing","volume":"56","author":"Chen","year":"2023","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ejps.2024.106983_bib0012","doi-asserted-by":"crossref","DOI":"10.1038\/s41573-024-00977-6","article-title":"The 60-year evolution of lipid nanoparticles for nucleic acid delivery","author":"Cullis","year":"2024","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.ejps.2024.106983_bib0013","doi-asserted-by":"crossref","DOI":"10.1126\/science.1258096","article-title":"Genome editing. The new frontier of genome engineering with CRISPR-Cas9","volume":"346","author":"Doudna","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ejps.2024.106983_bib0014","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202006619","article-title":"All-in-one dendrimer-based lipid nanoparticles enable precise HDR-mediated gene editing in vivo","volume":"33","author":"Farbiak","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejps.2024.106983_bib0015","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1056\/NEJMoa2031054","article-title":"CRISPR-Cas9 gene editing for sickle cell disease and \u03b2-thalassemia","volume":"384","author":"Frangoul","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejps.2024.106983_bib0016","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.addr.2020.03.005","article-title":"Optimizing synthetic nucleic acid and protein nanocarriers: the chemical evolution approach","volume":"168","author":"Freitag","year":"2021","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.ejps.2024.106983_bib0017","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1038\/s41467-020-14957-y","article-title":"Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping","volume":"11","author":"Gee","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejps.2024.106983_bib0018","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jconrel.2024.04.037","article-title":"Lipo-xenopeptide polyplexes for CRISPR\/Cas9 based gene editing at ultra-low dose","volume":"370","author":"Germer","year":"2024","journal-title":"J. Controll. Releas."},{"key":"10.1016\/j.ejps.2024.106983_bib0019","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1056\/NEJMoa2107454","article-title":"CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis","volume":"385","author":"Gillmore","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejps.2024.106983_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.102506","article-title":"Strategies and mechanisms for endosomal escape of therapeutic nucleic acids","volume":"81","author":"Grau","year":"2024","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ejps.2024.106983_bib0021","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejpb.2023.11.025","article-title":"Lipoamino bundle LNPs for efficient mRNA transfection of dendritic cells and macrophages show high spleen selectivity","volume":"194","author":"Haase","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2024.106983_bib0022","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/macp.201000479","article-title":"Polymers for control freaks: sequence-defined poly(amidoamine)s and their biomedical applications","volume":"212","author":"Hartmann","year":"2011","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.ejps.2024.106983_bib0023","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/mabi.201400167","article-title":"Introducing peptoplexes: polylysine-block-polysarcosine based polyplexes for transfection of HEK 293T cells","volume":"14","author":"Heller","year":"2014","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.ejps.2024.106983_bib0024","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.1038\/s41467-021-26714-w","article-title":"Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice","volume":"12","author":"Kenjo","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejps.2024.106983_bib0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jconrel.2021.09.016","article-title":"Dynamic mRNA polyplexes benefit from bioreducible cleavage sites for in vitro and in vivo transfer","volume":"339","author":"Krha\u010d Leva\u010di\u0107","year":"2021","journal-title":"J. Control. Releas."},{"key":"10.1016\/j.ejps.2024.106983_bib0026","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1021\/acs.bioconjchem.9b00853","article-title":"Delivery of Cas9\/sgRNA ribonucleoprotein complexes via hydroxystearyl oligoamino amides","volume":"31","author":"Kuhn","year":"2020","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejps.2024.106983_bib0027","doi-asserted-by":"crossref","first-page":"11527","DOI":"10.1021\/acs.chemrev.0c00997","article-title":"Polymeric delivery of therapeutic nucleic acids","volume":"121","author":"Kumar","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejps.2024.106983_bib0028","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nano.2013.07.008","article-title":"Fine-tuning of proton sponges by precise diaminoethanes and histidines in pDNA polyplexes","volume":"10","author":"L\u00e4chelt","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ejps.2024.106983_bib0029","doi-asserted-by":"crossref","first-page":"11043","DOI":"10.1021\/cr5006793","article-title":"Nucleic Acid Therapeutics Using Polyplexes: a Journey of 50 Years (and Beyond)","volume":"115","author":"L\u00e4chelt","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejps.2024.106983_bib0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/jgm.2807","article-title":"Increased tumor distribution and expression of histidine-rich plasmid polyplexes","volume":"16","author":"Leng","year":"2014","journal-title":"J. Gene. Med."},{"key":"10.1016\/j.ejps.2024.106983_bib0031","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1021\/acs.bioconjchem.3c00408","article-title":"mCherry on Top: a Positive Read-Out Cellular Platform for Screening DMD Exon Skipping Xenopeptide-PMO Conjugates","volume":"34","author":"Lessl","year":"2023","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ejps.2024.106983_bib0032","doi-asserted-by":"crossref","first-page":"15171","DOI":"10.1021\/jacs.3c01902","article-title":"Chemical evolution of amphiphilic xenopeptides for potentiated Cas9 Ribonucleoprotein delivery","volume":"145","author":"Lin","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ejps.2024.106983_bib0033","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1039\/D1BM01658J","article-title":"Non-viral delivery of the CRISPR\/Cas system: DNA versus RNA versus RNP","volume":"10","author":"Lin","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.ejps.2024.106983_bib0034","article-title":"Folate receptor-mediated delivery of Cas9 RNP for enhanced immune checkpoint disruption in cancer cells","volume":"19","author":"Lin","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.ejps.2024.106983_bib0035","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.aad5725","article-title":"Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy","volume":"351","author":"Long","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ejps.2024.106983_bib0036","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1021\/acsbiomaterials.2c00476","article-title":"Receptor-targeted dual pH-triggered intracellular protein transfer","volume":"10","author":"Lyu","year":"2024","journal-title":"ACS Biomater. Sci. Eng"},{"key":"10.1016\/j.ejps.2024.106983_bib0037","doi-asserted-by":"crossref","first-page":"eaav4324","DOI":"10.1126\/sciadv.aav4324","article-title":"CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells","volume":"5","author":"Min","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejps.2024.106983_bib0038","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1016\/j.biomaterials.2012.12.025","article-title":"The effect of molar mass and degree of hydroxyethylation on the controlled shielding and deshielding of hydroxyethyl starch-coated polyplexes","volume":"34","author":"Noga","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejps.2024.106983_bib0039","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jconrel.2012.01.006","article-title":"Controlled shielding and deshielding of gene delivery polyplexes using hydroxyethyl starch (HES) and alpha-amylase","volume":"159","author":"Noga","year":"2012","journal-title":"J. Control. Releas."},{"key":"10.1016\/j.ejps.2024.106983_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15102500","article-title":"Amphipathic cell-penetrating peptide-aided delivery of Cas9 RNP for in vitro gene editing and correction","volume":"15","author":"\u00d6ktem","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2024.106983_bib0041","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.cell.2024.01.042","article-title":"Past, present, and future of CRISPR genome editing technologies","volume":"187","author":"Pacesa","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.ejps.2024.106983_bib0042","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/bph.16337","article-title":"Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: a year in review","volume":"181","author":"Papapetropoulos","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejps.2024.106983_bib0043","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1021\/acs.biomac.9b00999","article-title":"Polymeric carriers for nucleic acid delivery: current designs and future directions","volume":"20","author":"Peng","year":"2019","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ejps.2024.106983_bib0044","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41573-020-0084-6","article-title":"Base editing: advances and therapeutic opportunities","volume":"19","author":"Porto","year":"2020","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.ejps.2024.106983_bib0045","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nbt.3481","article-title":"Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA","volume":"34","author":"Richardson","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ejps.2024.106983_bib0046","doi-asserted-by":"crossref","first-page":"eabk2855","DOI":"10.1126\/sciadv.abk2855","article-title":"High-throughput and high-content bioassay enables tuning of polyester nanoparticles for cellular uptake, endosomal escape, and systemic in vivo delivery of mRNA","volume":"8","author":"Rui","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejps.2024.106983_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2012.06.023","article-title":"Sequence-defined four-arm oligo(ethanamino)amides for pDNA and siRNA delivery: impact of building blocks on efficacy","author":"Salcher","year":"2012","journal-title":"J. Control. Releas."},{"key":"10.1016\/j.ejps.2024.106983_bib0048","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jconrel.2019.01.001","article-title":"Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo","volume":"295","author":"Sato","year":"2019","journal-title":"J. Control. Releas."},{"key":"10.1016\/j.ejps.2024.106983_bib0049","doi-asserted-by":"crossref","first-page":"8986","DOI":"10.1002\/anie.201102165","article-title":"Solid-phase synthesis of sequence-defined T-, i-, and U-shape polymers for pDNA and siRNA delivery","volume":"50","author":"Schaffert","year":"2011","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ejps.2024.106983_bib0050","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202304525","article-title":"Exploring mechanisms of lipid nanoparticle-mucus interactions in healthy and cystic fibrosis conditions","volume":"13","author":"Tafech","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.ejps.2024.106983_bib0051","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202211105","article-title":"Molecular chameleon carriers for nucleic acid delivery: the sweet spot between lipoplexes and polyplexes","volume":"35","author":"Thalmayr","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejps.2024.106983_bib0052","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2307796121","article-title":"Targeted nonviral delivery of genome editors in vivo","volume":"121","author":"Tsuchida","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.ejps.2024.106983_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2024.114207","article-title":"Comparative analysis of lipid Nanoparticle-Mediated delivery of CRISPR-Cas9 RNP versus mRNA\/sgRNA for gene editing in vitro and in vivo","volume":"196","author":"Walther","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2024.106983_bib0054","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1038\/s41467-020-17029-3","article-title":"Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing","volume":"11","author":"Wei","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejps.2024.106983_bib0055","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jconrel.2022.12.008","article-title":"Engineering poly- and micelleplexes for nucleic acid delivery - a reflection on their endosomal escape","volume":"353","author":"Winkeljann","year":"2023","journal-title":"J. Control. Releas."},{"key":"10.1016\/j.ejps.2024.106983_bib0056","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/d41586-023-03590-6","article-title":"UK first to approve CRISPR treatment for diseases: what you need to know","volume":"623","author":"Wong","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ejps.2024.106983_bib0057","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202400643","article-title":"In vivo endothelial cell gene silencing by siRNA-LNPs tuned with lipoamino bundle chemical and ligand targeting","author":"Yazdi","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.ejps.2024.106983_bib0058","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s41061-017-0112-0","article-title":"History of polymeric gene delivery systems","volume":"375","author":"Zhang","year":"2017","journal-title":"Top. Curr. Chem. (Cham.)"},{"key":"10.1016\/j.ejps.2024.106983_bib0059","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nbt.3081","article-title":"Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo","volume":"33","author":"Zuris","year":"2015","journal-title":"Nat. Biotechnol."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724002963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724002963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:57:30Z","timestamp":1778558250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098724002963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":59,"alternative-id":["S0928098724002963"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106983","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual pH-responsive CRISPR\/Cas9 ribonucleoprotein xenopeptide complexes for genome editing","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106983","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106983"}}