{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:48:21Z","timestamp":1778705301195,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ejps.2024.106987","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T16:47:19Z","timestamp":1733935639000},"page":"106987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Research on genetic variant characteristics in ADME genes based on whole-exome sequencing in the Han Chinese population"],"prefix":"10.1016","volume":"205","author":[{"given":"Ling","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiangGuang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6332-6716","authenticated-orcid":false,"given":"Chengxian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2024.106987_bib0001","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.jconrel.2022.10.043","article-title":"The past, present, and future of chemotherapy with a focus on individualization of drug dosing","volume":"352","author":"DeRidder","year":"2022","journal-title":"J. Control Release"},{"issue":"5","key":"10.1016\/j.ejps.2024.106987_bib0002","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1471-4914(01)01986-4","article-title":"Clinical application of pharmacogenetics","volume":"7","author":"Spear","year":"2001","journal-title":"Trends. Mol. Med."},{"issue":"6","key":"10.1016\/j.ejps.2024.106987_bib0003","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41576-022-00572-8","article-title":"Pharmacogenomics: current status and future perspectives","volume":"24","author":"Pirmohamed","year":"2023","journal-title":"Nat. Rev. Genet."},{"issue":"7549","key":"10.1016\/j.ejps.2024.106987_bib0004","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/520609a","article-title":"Personalized medicine: time for one-person trials","volume":"520","author":"Schork","year":"2015","journal-title":"Nature"},{"issue":"10197","key":"10.1016\/j.ejps.2024.106987_bib0005","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0140-6736(19)31276-0","article-title":"Pharmacogenomics","volume":"394","author":"Roden","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.ejps.2024.106987_bib0006","doi-asserted-by":"crossref","DOI":"10.1111\/joim.13772","article-title":"Precision medicine in cardiovascular therapeutics: evaluating the role of pharmacogenetic analysis prior to drug treatment","author":"Ingelman-Sundberg","year":"2024","journal-title":"J. Intern. Med."},{"issue":"3","key":"10.1016\/j.ejps.2024.106987_bib0007","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/cpt.2333","article-title":"PharmVar GeneFocus: CYP2C9","volume":"110","author":"Sangkuhl","year":"2021","journal-title":"Clin. Pharmacol. Ther."},{"issue":"12","key":"10.1016\/j.ejps.2024.106987_bib0008","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.tips.2022.09.011","article-title":"Pharmacogenomics in treatment of depression and psychosis: an update","volume":"43","author":"Jukic","year":"2022","journal-title":"Trends. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.ejps.2024.106987_bib0009","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/17425255.2021.1855141","article-title":"Genetic factors influencing the development of vincristine-induced neurotoxicity","volume":"17","author":"Pozzi","year":"2021","journal-title":"Expert. Opin. Drug Metab. Toxicol."},{"issue":"17","key":"10.1016\/j.ejps.2024.106987_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21175975","article-title":"Pharmacogenomics of Antibiotics","volume":"21","author":"Stocco","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejps.2024.106987_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115479","article-title":"Association of ADME gene polymorphisms on toxicity to CDK4\/6 inhibitors in patients with HR+ HER2- metastatic breast cancer","volume":"167","author":"Peruzzi","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ejps.2024.106987_bib0012","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/cpt.2903","article-title":"Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A genotypes and serotonin reuptake inhibitor antidepressants","volume":"114","author":"Bousman","year":"2023","journal-title":"Clin. Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.ejps.2024.106987_bib0013","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/cpt.1049","article-title":"Pharmacogenetic information in clinical guidelines: the European perspective","volume":"103","author":"Swen","year":"2018","journal-title":"Clin. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.ejps.2024.106987_bib0014","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/cpt.2122","article-title":"Pharmacogenetics at Scale: an Analysis of the UK Biobank","volume":"109","author":"McInnes","year":"2021","journal-title":"Clin. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.ejps.2024.106987_bib0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41525-022-00283-3","article-title":"Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data","volume":"7","author":"Lanillos","year":"2022","journal-title":"NPJ. Genom. Med."},{"issue":"3","key":"10.1016\/j.ejps.2024.106987_bib0016","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/cpt.2260","article-title":"Biobank scale pharmacogenomics informs the genetic underpinnings of simvastatin use","volume":"110","author":"Wendt","year":"2021","journal-title":"Clin. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.ejps.2024.106987_bib0017","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/cpt.2279","article-title":"Comprehensive allele genotyping in critical pharmacogenes reduces residual clinical risk in diverse populations","volume":"110","author":"Luo","year":"2021","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2024.106987_bib0018","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1146\/annurev-pharmtox-010818-021154","article-title":"Cardiovascular pharmacogenomics: does it matter if you're black or white?","volume":"59","author":"De","year":"2019","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.ejps.2024.106987_bib0019","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1517\/17425255.2012.657626","article-title":"Cytochrome P450 variations in different ethnic populations","volume":"8","author":"McGraw","year":"2012","journal-title":"Expert. Opin. Drug Metab. Toxicol."},{"issue":"3","key":"10.1016\/j.ejps.2024.106987_bib0020","first-page":"193","article-title":"Individual and ethnic differences in CYP2C19 activity in Chinese populations","volume":"21","author":"Shu","year":"2000","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.ejps.2024.106987_bib0021","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.clpt.6100015","article-title":"Frequency of CYP2D6*10 and *14 alleles and their influence on the metabolic activity of CYP2D6 in a healthy Chinese population","volume":"81","author":"Cai","year":"2007","journal-title":"Clin. Pharmacol. Ther."},{"issue":"12","key":"10.1016\/j.ejps.2024.106987_bib0022","first-page":"1780","article-title":"Genetic polymorphisms of CYP2D6 in Chinese mainland","volume":"115","author":"Ji","year":"2002","journal-title":"Chin. Med. J. (Engl)"},{"issue":"1","key":"10.1016\/j.ejps.2024.106987_bib0023","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41397-019-0104-2","article-title":"Genetic and epigenetic polymorphisms of eNOS and CYP2D6 in mainland Chinese Tibetan, Mongolian, Uygur, and Han populations","volume":"20","author":"Qi","year":"2020","journal-title":"Pharmacogenomics. J."},{"issue":"4","key":"10.1016\/j.ejps.2024.106987_bib0024","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2217\/pgs-2016-0179","article-title":"Systematic screening for CYP3A4 genetic polymorphisms in a Han Chinese population","volume":"18","author":"Hu","year":"2017","journal-title":"Pharmacogenomics"},{"issue":"4","key":"10.1016\/j.ejps.2024.106987_bib0025","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/bcpt.13356","article-title":"Genetic insight into cytochrome P450 in Chinese from the Chinese Millionome Database","volume":"126","author":"Qi","year":"2020","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejps.2024.106987_bib0026","article-title":"Genetic epidemiology of medication safety and efficacy related variants in the central Han Chinese population with whole genome sequencing","volume":"12","author":"Tian","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106987_bib0027","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.mayocp.2020.03.011","article-title":"Considerations when applying pharmacogenomics to your practice","volume":"96","author":"Nicholson","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ejps.2024.106987_bib0028","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1146\/annurev-genom-111621-102737","article-title":"Advancing pharmacogenomics from single-gene to preemptive testing","volume":"23","author":"Haidar","year":"2022","journal-title":"Annu Rev. Genomics. Hum. Genet."},{"issue":"2","key":"10.1016\/j.ejps.2024.106987_bib0029","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jtho.2022.11.006","article-title":"Clinician's guide to bioinformatics for next-generation sequencing","volume":"18","author":"Larson","year":"2023","journal-title":"J. Thorac. Oncol."},{"issue":"2","key":"10.1016\/j.ejps.2024.106987_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170843","article-title":"Exome sequencing covers >98% of mutations identified on targeted next generation sequencing panels","volume":"12","author":"LaDuca","year":"2017","journal-title":"PLoS ONE"},{"issue":"9","key":"10.1016\/j.ejps.2024.106987_bib0031","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/s41591-020-0966-5","article-title":"The role of exome sequencing in newborn screening for inborn errors of metabolism","volume":"26","author":"Adhikari","year":"2020","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.ejps.2024.106987_bib0032","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41397-018-0044-2","article-title":"An optimized prediction framework to assess the functional impact of pharmacogenetic variants","volume":"19","author":"Zhou","year":"2019","journal-title":"Pharmacogenomics. J."},{"issue":"11","key":"10.1016\/j.ejps.2024.106987_bib0033","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.jgg.2021.07.013","article-title":"The HuaBiao project: whole-exome sequencing of 5000 Han Chinese individuals","volume":"48","author":"Hao","year":"2021","journal-title":"J. Genet. Genomics."},{"issue":"1","key":"10.1016\/j.ejps.2024.106987_bib0034","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1001\/jama.2016.8662","article-title":"Association between CYP2C19 loss-of-function allele status and efficacy of clopidogrel for risk reduction among patients with minor stroke or transient ischemic attack","volume":"316","author":"Wang","year":"2016","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.ejps.2024.106987_bib0035","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCINTERVENTIONS.119.007811","article-title":"Clopidogrel pharmacogenetics","volume":"12","author":"Pereira","year":"2019","journal-title":"Circ. Cardiovasc. Interv."},{"issue":"5","key":"10.1016\/j.ejps.2024.106987_bib0036","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/cpt.2527","article-title":"SLCO1B1*5 allele is associated with atorvastatin discontinuation and adverse muscle symptoms in the context of routine care","volume":"111","author":"Voora","year":"2022","journal-title":"Clin. Pharmacol. Ther."},{"issue":"17","key":"10.1016\/j.ejps.2024.106987_bib0037","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.jacc.2009.04.053","article-title":"The SLCO1B1*5 genetic variant is associated with statin-induced side effects","volume":"54","author":"Voora","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.ejps.2024.106987_bib0038","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/aps.2016.96","article-title":"Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis","volume":"37","author":"Pei","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.ejps.2024.106987_bib0039","doi-asserted-by":"crossref","DOI":"10.1086\/505984","article-title":"The implications of a high allelic frequency of CYP2B6 G516T in ethnic Chinese persons","volume":"43","author":"Tong","year":"2006","journal-title":"Clin. Infect. Dis."},{"issue":"7","key":"10.1016\/j.ejps.2024.106987_bib0040","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1161\/STROKEAHA.122.040507","article-title":"Association between CYP2B6 polymorphisms and efficacy of clopidogrel in minor stroke or transient ischemic attack","volume":"54","author":"Qiu","year":"2023","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.ejps.2024.106987_bib0041","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.thromres.2014.05.028","article-title":"VKORC1 and CYP2C9 genotype distribution in Asian countries","volume":"134","author":"Gaikwad","year":"2014","journal-title":"Thromb. Res."},{"issue":"14","key":"10.1016\/j.ejps.2024.106987_bib0042","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0024-3205(00)00446-X","article-title":"Genetic variations of S-mephenytoin 4\u2032-hydroxylase (CYP2C19) in the Chinese population","volume":"66","author":"Xie","year":"2000","journal-title":"Life Sci."},{"issue":"1\u20132","key":"10.1016\/j.ejps.2024.106987_bib0043","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cccn.2004.11.005","article-title":"CYP3A5*3 and CYP3A4*18 single nucleotide polymorphisms in a Chinese population","volume":"353","author":"Hu","year":"2005","journal-title":"Clin. Chim. Acta"},{"issue":"1\u20132","key":"10.1016\/j.ejps.2024.106987_bib0044","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cca.2007.10.010","article-title":"Duplex pyrosequencing assay of the 388A>G and 521T>C SLCO1B1 polymorphisms in three Asian populations","volume":"388","author":"Kim","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ejps.2024.106987_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106087","article-title":"Identification and functional validation of novel pharmacogenomic variants using a next-generation sequencing-based approach for clinical pharmacogenomics","volume":"176","author":"Siamoglou","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejps.2024.106987_bib0046","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.3389\/fphar.2018.01437","article-title":"Computational methods for the pharmacogenetic interpretation of next generation sequencing data","volume":"9","author":"Zhou","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejps.2024.106987_bib0047","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/tpj.2016.77","article-title":"The global spectrum of protein-coding pharmacogenomic diversity","volume":"18","author":"Wright","year":"2018","journal-title":"Pharmacogenomics. J."},{"issue":"1","key":"10.1016\/j.ejps.2024.106987_bib0048","doi-asserted-by":"crossref","first-page":"8416","DOI":"10.1038\/s41598-017-08468-y","article-title":"Analysis of population-specific pharmacogenomic variants using next-generation sequencing data","volume":"7","author":"Ahn","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.ejps.2024.106987_bib0049","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1038\/s41416-020-01084-0","article-title":"Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier","volume":"123","author":"Zhou","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejps.2024.106987_bib0050","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.phrs.2018.10.017","article-title":"Genetic variability and population diversity of the human SLCO (OATP) transporter family","volume":"139","author":"Zhang","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"11\u201312","key":"10.1016\/j.ejps.2024.106987_bib0051","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s00439-019-02081-x","article-title":"The genetic landscape of the human solute carrier (SLC) transporter superfamily","volume":"138","author":"Schaller","year":"2019","journal-title":"Hum. Genet."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724003002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098724003002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T15:20:36Z","timestamp":1736608836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098724003002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":51,"alternative-id":["S0928098724003002"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106987","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research on genetic variant characteristics in ADME genes based on whole-exome sequencing in the Han Chinese population","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2024.106987","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106987"}}