{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:59:01Z","timestamp":1790474341114,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J01600"],"award-info":[{"award-number":["2023J01600"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2022QNA037"],"award-info":[{"award-number":["2022QNA037"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2023CXA017"],"award-info":[{"award-number":["2023CXA017"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ejps.2025.107003","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T03:18:14Z","timestamp":1736219894000},"page":"107003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Physiologically-based pharmacokinetic modeling to predict the exposure and provide dosage regimens of tacrolimus in pregnant women with infection disease"],"prefix":"10.1016","volume":"206","author":[{"given":"Jianwen","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuifang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinfang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuihong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2025.107003_bib0002","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10928-020-09711-2","article-title":"Prediction of maternal pharmacokinetics using physiologically based pharmacokinetic models: assessing the impact of the longitudinal changes in the activity of CYP1A2, CYP2D6 and CYP3A4 enzymes during pregnancy","volume":"47","author":"Abduljalil","year":"2020","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.ejps.2025.107003_bib0003","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.transproceed.2015.04.041","article-title":"Pregnancy after kidney transplantation: outcomes, tacrolimus doses, and trough levels","volume":"47","author":"Akturk","year":"2015","journal-title":"TransPlant Proc."},{"key":"10.1016\/j.ejps.2025.107003_bib0004","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/S0149-2918(00)87237-9","article-title":"Dose linearity after oral administration of tacrolimus 1-mg capsules at doses of 3, 7, and 10 mg","volume":"21","author":"Bekersky","year":"1999","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/cpt.113","article-title":"Clinical pharmacogenetics implementation consortium (CPIC) guidelines for CYP3A5 genotype and tacrolimus dosing","volume":"98","author":"Birdwell","year":"2015","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0006","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/FTD.0000000000000640","article-title":"Therapeutic drug monitoring of tacrolimus-personalized therapy: second consensus report","volume":"41","author":"Brunet","year":"2019","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.ejps.2025.107003_bib0007","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1007\/s00204-023-03576-3","article-title":"Physiologically based pharmacokinetic model combined with reverse dose method to study the nephrotoxic tolerance dose of tacrolimus","volume":"97","author":"Cai","year":"2023","journal-title":"Arch. Toxicol."},{"issue":"Suppl 1","key":"10.1016\/j.ejps.2025.107003_bib0008","first-page":"S63","article-title":"Model-informed dose optimization in pregnancy","volume":"60","author":"Chaphekar","year":"2020","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2025.107003_bib0009","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/cpt.3031","article-title":"Physiologically-based pharmacokinetic modeling of anti-tumor necrosis factor agents for inflammatory bowel disease patients to predict the withdrawal time in pregnancy and vaccine time in infants","volume":"114","author":"Chen","year":"2023","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0010","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1124\/dmd.122.000926","article-title":"Physiologically based pharmacokinetic modeling to predict drug-biologic interactions with cytokine modulators: are these relevant and is interleukin-6 enough?","volume":"50","author":"Chen","year":"2022","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2025.107003_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2024.106707","article-title":"Physiologically based pharmacokinetic modeling to predict maternal pharmacokinetics and fetal carbamazepine exposure during pregnancy","volume":"194","author":"Chen","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107003_bib0012","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/clpt.1994.82","article-title":"Acute-phase response, interleukin-6, and alteration of cyclosporine pharmacokinetics","volume":"55","author":"Chen","year":"1994","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0013","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/tpj.2015.99","article-title":"A pharmacogenomic study on the pharmacokinetics of tacrolimus in healthy subjects using the DMET(TM) Plus platform","volume":"17","author":"Choi","year":"2017","journal-title":"Pharmacogenomics. J."},{"key":"10.1016\/j.ejps.2025.107003_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/rmv.2141","article-title":"Interleukin-6 in Covid-19: a systematic review and meta-analysis","volume":"30","author":"Coomes","year":"2020","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.ejps.2025.107003_bib0015","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1124\/dmd.105.008680","article-title":"Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro","volume":"34","author":"Dai","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2025.107003_bib0016","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s40262-017-0538-0","article-title":"Physiologically based pharmacokinetic modeling of renally cleared drugs in pregnant women","volume":"56","author":"Dallmann","year":"2017","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2025.107003_bib0017","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/psp4.12300","article-title":"Applied concepts in PBPK modeling: how to extend an open systems pharmacology model to the special population of pregnant women","volume":"7","author":"Dallmann","year":"2018","journal-title":"CPT. Pharmacometrics. Syst. Pharmacol."},{"key":"10.1016\/j.ejps.2025.107003_bib0018","doi-asserted-by":"crossref","first-page":"485","DOI":"10.2165\/00003088-199937060-00004","article-title":"Cytochrome P450 3A: ontogeny and drug disposition","volume":"37","author":"de Wildt","year":"1999","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2025.107003_bib0019","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1124\/dmd.111.038679","article-title":"Effects of interleukin-6 (IL-6) and an anti-IL-6 monoclonal antibody on drug-metabolizing enzymes in human hepatocyte culture","volume":"39","author":"Dickmann","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2025.107003_bib0020","doi-asserted-by":"crossref","first-page":"930","DOI":"10.2174\/138920012802138642","article-title":"Effects of interleukin 1beta (IL-1beta) and IL-1beta\/interleukin 6 (IL-6) combinations on drug metabolizing enzymes in human hepatocyte culture","volume":"13","author":"Dickmann","year":"2012","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.ejps.2025.107003_bib0021","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1097\/TP.0b013e3181a23cb2","article-title":"The challenge of achieving target drug concentrations in clinical trials: experience from the Symphony study","volume":"87","author":"Ekberg","year":"2009","journal-title":"Transplantation."},{"key":"10.1016\/j.ejps.2025.107003_bib0022","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/psp4.12392","article-title":"A theoretical physiologically-based pharmacokinetic approach to ascertain covariates explaining the large interpatient variability in tacrolimus disposition","volume":"8","author":"Emoto","year":"2019","journal-title":"CPT. Pharmacometrics. Syst. Pharmacol."},{"key":"10.1016\/j.ejps.2025.107003_bib0023","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ejps.2018.04.017","article-title":"Placental disposition of the immunosuppressive drug tacrolimus in renal transplant recipients and in ex vivo perfused placental tissue","volume":"119","author":"Freriksen","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107003_bib0024","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1124\/dmd.111.039248","article-title":"Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction","volume":"39","author":"Gertz","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2025.107003_bib0025","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/clpt.2008.1","article-title":"Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study","volume":"84","author":"Hebert","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0026","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s40262-013-0120-3","article-title":"The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation","volume":"53","author":"Hesselink","year":"2014","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2025.107003_bib0027","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1128\/AAC.01596-05","article-title":"Pregnancy-related effects on nelfinavir-M8 pharmacokinetics: a population study with 133 women","volume":"50","author":"Hirt","year":"2006","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.ejps.2025.107003_bib0028","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/jcph.605","article-title":"Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole","volume":"56","author":"Imamura","year":"2016","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2025.107003_bib0029","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1208\/s12248-016-9890-5","article-title":"Development of a physiologically based pharmacokinetic model to predict disease-mediated therapeutic protein-drug interactions: modulation of multiple cytochrome P450 enzymes by interleukin-6","volume":"18","author":"Jiang","year":"2016","journal-title":"AAPS. J."},{"key":"10.1016\/j.ejps.2025.107003_bib0030","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.2215\/CJN.04410512","article-title":"Common infections in kidney transplant recipients","volume":"7","author":"Karuthu","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejps.2025.107003_bib0031","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10928-020-09677-1","article-title":"Anatomical and physiological alterations of pregnancy","volume":"47","author":"Kazma","year":"2020","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.ejps.2025.107003_bib0032","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/ctr.12494","article-title":"The optimal therapy of calcineurin inhibitors for pregnancy in kidney transplantation","volume":"29","author":"Kim","year":"2015","journal-title":"Clin. TransPlant"},{"key":"10.1016\/j.ejps.2025.107003_bib0033","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.2147\/DDDT.S142201","article-title":"New tablet formulation of tacrolimus with smaller interindividual variability may become a better treatment option than the conventional capsule formulation in organ transplant patients","volume":"11","author":"Kim","year":"2017","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0034","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.3389\/ti.2022.10269","article-title":"Increased tacrolimus exposure in kidney transplant recipients with COVID-19: inflammation-driven downregulation of metabolism as a potential mechanism","volume":"35","author":"Klomp","year":"2022","journal-title":"Transpl. Int."},{"key":"10.1016\/j.ejps.2025.107003_bib0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12272-014-0343-3","article-title":"Bioequivalence of tacrolimus formulations with different dynamic solubility and in-vitro dissolution profiles","volume":"38","author":"Kwon","year":"2015","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.ejps.2025.107003_bib0036","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/cpt.2146","article-title":"Impact of acute inflammation on cytochromes P450 activity assessed by the geneva cocktail","volume":"109","author":"Lenoir","year":"2021","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102763","article-title":"Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients","volume":"55","author":"Liu","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ejps.2025.107003_bib0038","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.cyto.2016.08.033","article-title":"Role of i nterleukin-6 to differentiate sepsis from non-infectious systemic inflammatory response syndrome","volume":"88","author":"Ma","year":"2016","journal-title":"Cytokine"},{"key":"10.1016\/j.ejps.2025.107003_bib0039","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/clpt.2013.79","article-title":"A physiologically based pharmacokinetic modeling approach to predict disease-drug interactions: suppression of CYP3A by IL-6","volume":"94","author":"Machavaram","year":"2013","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0040","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/17425255.2018.1482278","article-title":"Pediatric physiology in relation to the pharmacokinetics of monoclonal antibodies","volume":"14","author":"Malik","year":"2018","journal-title":"Expert. Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.ejps.2025.107003_bib0041","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1067\/mcp.2001.113183","article-title":"The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups","volume":"69","author":"Mancinelli","year":"2001","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0042","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01177-20","article-title":"Effect of systemic inflammatory response to SARS-CoV-2 on lopinavir and hydroxychloroquine plasma concentrations","volume":"64","author":"Marzolini","year":"2020","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.ejps.2025.107003_bib0043","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.clinthera.2011.07.010","article-title":"Bioequivalence of two tacrolimus formulations under fasting conditions in healthy male subjects","volume":"33","author":"Mathew","year":"2011","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0044","doi-asserted-by":"crossref","DOI":"10.1177\/10600280221078983","article-title":"Elevated tacrolimus levels at time of diagnosis of COVID-19 compared to baseline among hospitalized organ transplant recipients","author":"Mecadon","year":"2022","journal-title":"Ann. Pharmacother"},{"key":"10.1016\/j.ejps.2025.107003_bib0045","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s40262-020-00861-7","article-title":"Integration of placental transfer in a fetal-maternal physiologically based pharmacokinetic model to characterize acetaminophen exposure and metabolic clearance in the fetus","volume":"59","author":"Mian","year":"2020","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2025.107003_bib0046","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.dmpk.2014.09.004","article-title":"Effects of cytokines on CYP3A4 expression and reversal of the effects by anti-cytokine agents in the three-dimensionally cultured human hepatoma cell line FLC-4","volume":"30","author":"Mimura","year":"2015","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.ejps.2025.107003_bib0047","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5414\/CP203534","article-title":"Bioequivalence of two tacrolimus 1-mg formulations under fasting conditions in healthy subjects: a randomized, two-period crossover trial","volume":"58","author":"Mohanty","year":"2020","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0048","doi-asserted-by":"crossref","first-page":"e13142","DOI":"10.1111\/aji.13142","article-title":"Obstetric and perinatal outcome of the women with repeated implantation failures or recurrent pregnancy losses who received pre- and post-conception tacrolimus treatment","volume":"82","author":"Nakagawa","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.ejps.2025.107003_bib0049","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/bdd.1938","article-title":"In vitro-in vivo extrapolations to evaluate the effect of concomitant drugs on tacrolimus (FK506) exposure","volume":"36","author":"Oda","year":"2015","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.ejps.2025.107003_bib0050","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.clinthera.2007.01.016","article-title":"A randomized, open-label, two-period, crossover bioavailability study of two oral formulations of tacrolimus in healthy Korean adults","volume":"29","author":"Park","year":"2007","journal-title":"Clin. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0051","doi-asserted-by":"crossref","DOI":"10.3390\/v14112406","article-title":"Kidney transplant-associated viral infection rates and outcomes in a single-centre cohort","volume":"14","author":"Pullerits","year":"2022","journal-title":"Viruses."},{"key":"10.1016\/j.ejps.2025.107003_bib0052","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.healun.2020.02.005","article-title":"Pregnancy outcomes in heart transplant recipients","volume":"39","author":"Punnoose","year":"2020","journal-title":"J. Heart Lung TransPlant"},{"key":"10.1016\/j.ejps.2025.107003_bib0053","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.clpt.2004.11.003","article-title":"Identification and phenotype characterization of two CYP3A haplotypes causing different enzymatic capacity in fetal livers","volume":"77","author":"Rodriguez-Antona","year":"2005","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0054","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2131\/jts.36.181","article-title":"Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats","volume":"36","author":"Sanada","year":"2011","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.ejps.2025.107003_bib0055","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1186\/s12876-021-02043-6","article-title":"Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus","volume":"21","author":"Shimizu","year":"2021","journal-title":"BMC. Gastroenterol."},{"key":"10.1016\/j.ejps.2025.107003_bib0056","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1208\/s12248-019-0395-x","article-title":"Impact of interleukin-6 on drug-metabolizing enzymes and transporters in intestinal cells","volume":"22","author":"Simon","year":"2019","journal-title":"AAPS. J."},{"key":"10.1016\/j.ejps.2025.107003_bib0057","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/cpt.2402","article-title":"Physiologically based pharmacokinetic modelling to investigate the impact of the cytokine storm on CYP3A drug pharmacokinetics in COVID-19 patients","volume":"111","author":"Stader","year":"2022","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2025.107003_bib0058","doi-asserted-by":"crossref","first-page":"10051","DOI":"10.1038\/s41598-022-14317-4","article-title":"Tacrolimus dose adjustment is not necessary in dose to dose conversion from a twice daily to a prolonged release once daily dose form","volume":"12","author":"Tiankanon","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejps.2025.107003_bib0059","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00134-019-05597-y","article-title":"Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients","volume":"45","author":"Timsit","year":"2019","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.ejps.2025.107003_bib0060","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s12291-022-01108-x","article-title":"Dynamic changes in circulatory cytokines and chemokines levels in mild to severe COVID-19 patients","volume":"38","author":"Tiwari","year":"2023","journal-title":"Indian J. Clin. Biochem."},{"key":"10.1016\/j.ejps.2025.107003_bib0061","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ajog.2004.08.030","article-title":"Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy","volume":"192","author":"Tracy","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ejps.2025.107003_bib0062","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0041-1345(02)03002-6","article-title":"Usefulness of monitoring of AUC(0-4h) during the induction period of immunosuppressive therapy with tacrolimus after renal transplantation","volume":"34","author":"Uchida","year":"2002","journal-title":"TransPlant Proc."},{"key":"10.1016\/j.ejps.2025.107003_bib0063","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2133\/dmpk.22.313","article-title":"Decreased intestinal CYP3A and P-glycoprotein activities in rats with adjuvant arthritis","volume":"22","author":"Uno","year":"2007","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.ejps.2025.107003_bib0064","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2165\/00003088-199529060-00003","article-title":"Clinical pharmacokinetics of tacrolimus","volume":"29","author":"Venkataramanan","year":"1995","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2025.107003_bib0065","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/FTD.0b013e318198d092","article-title":"Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference","volume":"31","author":"Wallemacq","year":"2009","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.ejps.2025.107003_bib0066","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/cts.13164","article-title":"Utilization of physiologically-based pharmacokinetic model to assess disease-mediated therapeutic protein-disease-drug interaction in immune-mediated inflammatory diseases","volume":"15","author":"Wang","year":"2022","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.ejps.2025.107003_bib0067","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2125.2007.02922.x","article-title":"Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers","volume":"64","author":"Xin","year":"2007","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2025.107003_bib0068","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/psp4.12003","article-title":"Physiologically based pharmacokinetic model to assess the influence of blinatumomab-mediated cytokine elevations on cytochrome P450 enzyme activity","volume":"4","author":"Xu","year":"2015","journal-title":"CPT. Pharmacometrics. Syst. Pharmacol."},{"key":"10.1016\/j.ejps.2025.107003_bib0069","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1016\/j.transproceed.2019.01.150","article-title":"Use of tacrolimus during pregnancy after kidney transplantaion","volume":"51","author":"Yuksel","year":"2019","journal-title":"TransPlant Proc."},{"key":"10.1016\/j.ejps.2025.107003_bib0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1056-8719(02)00158-2","article-title":"Validation of methods to study the distribution and protein binding of tacrolimus in human blood","volume":"46","author":"Zahir","year":"2001","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.ejps.2025.107003_bib0071","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1124\/dmd.116.073957","article-title":"Development of a novel maternal-fetal physiologically based pharmacokinetic model II: verification of the model for passive placental permeability drugs","volume":"45","author":"Zhang","year":"2017","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2025.107003_bib0072","article-title":"Physiologically based pharmacokinetic modeling in pregnant women suggests minor decrease in maternal exposure to olanzapine","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejps.2025.107003_bib0073","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/bcp.12122","article-title":"Tacrolimus placental transfer at delivery and neonatal exposure through breast milk","volume":"76","author":"Zheng","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2025.107003_bib0074","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/FTD.0b013e3182708edf","article-title":"Pharmacokinetics of tacrolimus during pregnancy","volume":"34","author":"Zheng","year":"2012","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.ejps.2025.107003_bib0075","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/clpt.2012.175","article-title":"Measurement and compartmental modeling of the effect of CYP3A5 gene variation on systemic and intrarenal tacrolimus disposition","volume":"92","author":"Zheng","year":"2012","journal-title":"Clin. Pharmacol. Ther."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098725000028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098725000028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:24:10Z","timestamp":1762331050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098725000028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":74,"alternative-id":["S0928098725000028"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2025.107003","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiologically-based pharmacokinetic modeling to predict the exposure and provide dosage regimens of tacrolimus in pregnant women with infection disease","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2025.107003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107003"}}