{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:00:54Z","timestamp":1784232054654,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY029823"],"award-info":[{"award-number":["R01EY029823"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ejps.2025.107016","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T03:55:30Z","timestamp":1737086130000},"page":"107016","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Optimized PLGA encapsulated SA-2 nanosuspension exhibits sustained intraocular pressure reduction in the mouse microbead occlusion model of ocular hypertension"],"prefix":"10.1016","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-7053","authenticated-orcid":false,"given":"Charles E.","family":"Amankwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biddut","family":"DebNath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer H.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7330-269X","authenticated-orcid":false,"given":"Gretchen A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalendu","family":"Ranjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota L.","family":"Stankowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchismita","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ejps.2025.107016_bib0001","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1007\/s10792-021-01893-z","article-title":"Various modalities of cyclodestruction in non-refractory glaucoma: a comparative study","volume":"41","author":"Abdullatif","year":"2021","journal-title":"Int. Ophthalmol."},{"issue":"5","key":"10.1016\/j.ejps.2025.107016_bib0002","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.bmcl.2015.12.030","article-title":"Design and synthesis of novel hybrid sydnonimine and prodrug useful for glaucomatous optic neuropathy","volume":"26","author":"Acharya","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejps.2025.107016_bib0003","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.2147\/OPTH.S156038","article-title":"Latanoprostene bunod ophthalmic solution 0.024% in the treatment of open-angle glaucoma: design, development, and place in therapy","volume":"12","author":"Addis","year":"2018","journal-title":"Clinical ophthalmology (Auckland, NZ)"},{"key":"10.1016\/j.ejps.2025.107016_bib0004","series-title":"Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology","first-page":"233","article-title":"Recent advances in nanosensors for therapeutic drug monitoring (TDM)","author":"Agogo-Mawuli Percy","year":"2022"},{"issue":"2","key":"10.1016\/j.ejps.2025.107016_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/gels8020082","article-title":"Drug Delivery challenges and current progress in nanocarrier-based ocular therapeutic system","volume":"8","author":"Akhter","year":"2022","journal-title":"Gels."},{"issue":"11","key":"10.1016\/j.ejps.2025.107016_bib0006","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.addr.2006.07.022","article-title":"Industrial perspective in ocular drug delivery","volume":"58","author":"Ali","year":"2006","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.ejps.2025.107016_bib0007","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1080\/21645515.2015.1102804","article-title":"Peptide\/protein vaccine delivery system based on PLGA particles","volume":"12","author":"Allahyari","year":"2016","journal-title":"Hum. Vaccin. ImmunOther"},{"issue":"4","key":"10.1016\/j.ejps.2025.107016_bib0008","article-title":"Novel thiol containing hybrid antioxidant-nitric oxide donor small molecules for treatment of glaucoma","volume":"10","author":"Amankwa","year":"2021","journal-title":"Antioxidants. (Basel)"},{"issue":"11","key":"10.1016\/j.ejps.2025.107016_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11112959","article-title":"Therapeutic potential of antioxidants and hybrid tempol derivatives in ocular neurodegenerative diseases: a glimpse into the future","volume":"11","author":"Amankwa","year":"2023","journal-title":"Biomedicines."},{"issue":"14","key":"10.1016\/j.ejps.2025.107016_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411557","article-title":"Modulation of mitochondrial metabolic parameters and antioxidant enzymes in healthy and glaucomatous trabecular meshwork cells with hybrid small molecule SA-2","volume":"24","author":"Amankwa","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejps.2025.107016_bib0011","doi-asserted-by":"crossref","DOI":"10.4103\/IJO.IJO_2317_23","article-title":"Outcome of combined trabeculectomy with cataract surgery in patients on prostaglandin analogs and aqueous suppressants","author":"Aswin","year":"2024","journal-title":"Indian J. Ophthalmol."},{"issue":"8","key":"10.1016\/j.ejps.2025.107016_bib0012","first-page":"1711","article-title":"Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye","volume":"37","author":"Behar-Cohen","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.ejps.2025.107016_bib0013","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0161-6420(99)00523-0","article-title":"Impact of intraocular pressure regulation on visual fields in open-angle glaucoma","volume":"106","author":"Bergea","year":"1999","journal-title":"Ophthalmology."},{"key":"10.1016\/j.ejps.2025.107016_bib0014","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fphar.2012.00188","article-title":"Ocular drug delivery: a clue from nanotechnology","volume":"3","author":"Bucolo","year":"2012","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.ejps.2025.107016_bib0015","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ejps.2004.04.003","article-title":"Cystatin incorporated in poly(lactide-co-glycolide) nanoparticles: development and fundamental studies on preservation of its activity","volume":"22","author":"Cegnar","year":"2004","journal-title":"Eur. J. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.ejps.2025.107016_bib0016","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a017236","article-title":"Clinical characteristics and current treatment of glaucoma","volume":"4","author":"Cohen","year":"2014","journal-title":"Cold. Spring. Harb. Perspect. Med."},{"issue":"1-2","key":"10.1016\/j.ejps.2025.107016_bib0017","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ijpharm.2018.05.050","article-title":"Development of fluorometholone-loaded PLGA nanoparticles for treatment of inflammatory disorders of anterior and posterior segments of the eye","volume":"547","author":"Gonzalez-Pizarro","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ejps.2025.107016_bib0018","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/acs.chemrestox.6b00226","article-title":"Intersection of the roles of cytochrome p450 enzymes with xenobiotic and endogenous substrates: relevance to toxicity and drug interactions","volume":"30","author":"Guengerich","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ejps.2025.107016_bib0019","article-title":"Nano encapsulated novel compound SA-10 with therapeutic activity in both acute and chronic murine hindlimb ischemia models","volume":"35","author":"Hinkle","year":"2021","journal-title":"Nanomedicine"},{"issue":"109","key":"10.1016\/j.ejps.2025.107016_bib0020","first-page":"e53731","article-title":"A Magnetic microbead occlusion model to induce ocular hypertension-dependent glaucoma in mice","author":"Ito","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ejps.2025.107016_bib0021","doi-asserted-by":"crossref","first-page":"9373","DOI":"10.2147\/IJN.S272750","article-title":"PLGA nanoparticle platform for trans-ocular barrier to enhance drug delivery: a comparative study based on the application of oligosaccharides in the outer membrane of carriers","volume":"15","author":"Jiang","year":"2020","journal-title":"Int. J. Nanomedicine"},{"issue":"3","key":"10.1016\/j.ejps.2025.107016_bib0022","first-page":"592","article-title":"Improved ocular bioavailability of moxifloxacin hcl using plga nanoparticles: fabrication, characterization, in-vitro and in-vivo evaluation","volume":"20","author":"Khan","year":"2021","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.ejps.2025.107016_bib0023","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6590361","article-title":"Design and evaluation of voriconazole loaded solid lipid nanoparticles for ophthalmic application","volume":"2016","author":"Khare","year":"2016","journal-title":"J. Drug Deliv."},{"issue":"Pt 5","key":"10.1016\/j.ejps.2025.107016_bib0024","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/eye.2000.197","article-title":"Compliance and viewpoint of glaucoma patients in Greece","volume":"14","author":"Konstas","year":"2000","journal-title":"Eye (Lond)"},{"issue":"2","key":"10.1016\/j.ejps.2025.107016_bib0025","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.nano.2009.07.008","article-title":"Development of multiple-layer polymeric particles for targeted and controlled drug delivery","volume":"6","author":"Koppolu","year":"2010","journal-title":"Nanomedicine"},{"issue":"1","key":"10.1016\/j.ejps.2025.107016_bib0026","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1023\/B:JOFL.0000014655.89256.bd","article-title":"Fluorescence measurements of steady state peroxynitrite production upon SIN-1 Decomposition: NADH versus dihydrodichlorofluorescein and dihydrorhodamine 123","volume":"14","author":"Martin-Romero","year":"2004","journal-title":"J. Fluoresc."},{"issue":"6","key":"10.1016\/j.ejps.2025.107016_bib0027","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.actbio.2014.01.033","article-title":"Polymeric nanoparticles for pulmonary protein and DNA delivery","volume":"10","author":"Menon","year":"2014","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.ejps.2025.107016_bib0028","doi-asserted-by":"crossref","first-page":"e43199","DOI":"10.1371\/journal.pone.0043199","article-title":"Endothelin B receptors contribute to retinal ganglion cell loss in a rat model of glaucoma","volume":"7","author":"Minton","year":"2012","journal-title":"PLoS. One"},{"issue":"12","key":"10.1016\/j.ejps.2025.107016_bib0029","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1097\/j.jcrs.0000000000001000","article-title":"Long-term effect of canaloplasty on intraocular pressure and use of intraocular pressure-lowering medications in patients with open-angle glaucoma","volume":"48","author":"Ondrejka","year":"2022","journal-title":"J. Cataract. Refract. Surg."},{"key":"10.1016\/j.ejps.2025.107016_bib0030","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jconrel.2023.01.018","article-title":"Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases","volume":"354","author":"Onugwu","year":"2023","journal-title":"J. Control Release"},{"issue":"2","key":"10.1016\/j.ejps.2025.107016_bib0031","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/2231-4040.82950","article-title":"Nanosuspension: An approach to enhance solubility of drugs","volume":"2","author":"Patel","year":"2011","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.ejps.2025.107016_bib0032","article-title":"IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors","volume":"99","author":"Pitha","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.ejps.2025.107016_bib0033","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.exer.2015.05.008","article-title":"Electrophysiological assessment of retinal ganglion cell function","volume":"141","author":"Porciatti","year":"2015","journal-title":"Exp. Eye Res."},{"issue":"3","key":"10.1016\/j.ejps.2025.107016_bib0034","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2165\/00063030-200721030-00004","article-title":"Rho GTPase\/Rho kinase inhibition as a novel target for the treatment of glaucoma","volume":"21","author":"Rao","year":"2007","journal-title":"BioDrugs"},{"issue":"4","key":"10.1016\/j.ejps.2025.107016_bib0035","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1166\/jnn.2011.3802","article-title":"Effects of poly-(lactide-co-glycolide) nanoparticles on electrophysiological properties of enteroendocrine cells","volume":"11","author":"Shah","year":"2011","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.ejps.2025.107016_bib0036","doi-asserted-by":"crossref","first-page":"5577","DOI":"10.2147\/IJN.S171490","article-title":"PPARgamma agonist-loaded PLGA-PEG nanocarriers as a potential treatment for Alzheimer's disease: in vitro and in vivo studies","volume":"13","author":"Silva-Abreu","year":"2018","journal-title":"Int. J. Nanomedicine"},{"issue":"1","key":"10.1016\/j.ejps.2025.107016_bib0037","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11095-017-2319-8","article-title":"Optimization, biopharmaceutical profile and therapeutic efficacy of pioglitazone-loaded plga-peg nanospheres as a novel strategy for ocular inflammatory disorders","volume":"35","author":"Silva-Abreu","year":"2018","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.ejps.2025.107016_bib0038","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5005\/jp-journals-10078-1396","article-title":"Rho-kinase inhibitors in ocular diseases: a translational research journey","volume":"17","author":"Singh","year":"2023","journal-title":"J. Curr. Glaucoma Pract."},{"issue":"8","key":"10.1016\/j.ejps.2025.107016_bib0039","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1167\/iovs.18-25999","article-title":"Hybrid Compound SA-2 is Neuroprotective in Animal Models of Retinal Ganglion Cell Death","volume":"60","author":"Stankowska","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejps.2025.107016_bib0040","first-page":"37","article-title":"Nanoencapsulated hybrid compound SA-2 with long-lasting intraocular pressure-lowering activity in rodent eyes","volume":"27","author":"Stankowska","year":"2021","journal-title":"Mol. Vis."},{"issue":"2","key":"10.1016\/j.ejps.2025.107016_bib0041","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1167\/iovs.14-15008","article-title":"Neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma","volume":"56","author":"Stankowska","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.ejps.2025.107016_bib0042","doi-asserted-by":"crossref","first-page":"12270","DOI":"10.1038\/s41598-021-90792-5","article-title":"Sabliov CM. Stability and ocular biodistribution of topically administered PLGA nanoparticles","volume":"11","author":"Swetledge","year":"2021","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.ejps.2025.107016_bib0043","first-page":"1361","article-title":"The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice","volume":"10","author":"Tse","year":"2017","journal-title":"Int. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.ejps.2025.107016_bib0044","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14040799","article-title":"Mucoadhesive PLGA nanospheres and nanocapsules for lactoferrin controlled ocular delivery","volume":"14","author":"Varela-Fernandez","year":"2022","journal-title":"Pharmaceutics."},{"issue":"18","key":"10.1016\/j.ejps.2025.107016_bib0045","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMa"},{"key":"10.1016\/j.ejps.2025.107016_bib0046","first-page":"17","article-title":"Assessing the adherence behavior of glaucoma patients to topical eye drops","volume":"9","author":"Welge-Lussen","year":"2015","journal-title":"Patient. Prefer. Adherence"},{"issue":"1","key":"10.1016\/j.ejps.2025.107016_bib0047","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4103\/0974-9233.106384","article-title":"Nanotechnology approaches for ocular drug delivery","volume":"20","author":"Xu","year":"2013","journal-title":"Middle East. Afr. J. Ophthalmol."},{"key":"10.1016\/j.ejps.2025.107016_bib0048","first-page":"2483","article-title":"Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide","volume":"7","author":"Youshia","year":"2012","journal-title":"Int. J. Nanomedicine"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098725000156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098725000156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T03:56:54Z","timestamp":1777262214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098725000156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":48,"alternative-id":["S0928098725000156"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2025.107016","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimized PLGA encapsulated SA-2 nanosuspension exhibits sustained intraocular pressure reduction in the mouse microbead occlusion model of ocular hypertension","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2025.107016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107016"}}