{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:59:33Z","timestamp":1792519173968,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ejps.2025.107167","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T15:51:37Z","timestamp":1749657097000},"page":"107167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Preparation and biological activity of isoperrottetin A and its phosphonium salts derivatives"],"prefix":"10.1016","volume":"212","author":[{"given":"M\u00e1rio","family":"Markuliak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Kos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Voj\u00e1\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branislav","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"\u0160vajdlenka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janka","family":"Leskovsk\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Pis\u00e1r\u010dik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladim\u00edr","family":"Kry\u0161tof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois","family":"\u010c\u00ed\u017eek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Jamp\u00edlek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo\u0161","family":"Luk\u00e1\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2025.107167_bib0001","first-page":"1011","article-title":"Evaluation of a colorimetric assay based on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) for rapid detection of rifampicin resistance in Mycobacterium tuberculosis","volume":"2","author":"Abate","year":"1998","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"10.1016\/j.ejps.2025.107167_bib0002","doi-asserted-by":"crossref","first-page":"5738","DOI":"10.1002\/ejoc.201601179","article-title":"A Corey-Seebach macrocyclisation strategy for the synthesis of Riccardin C and an unnatural macrocyclic bis(bibenzyl) analogue: a Corey-Seebach macrocyclisation strategy for the synthesis of Riccardin C and an unnatural macrocyclic bis(bibenzyl) analogue","volume":"2016","author":"Almalki","year":"2016","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0003","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11224-023-02259-0","article-title":"Synthesis, crystal structure, and biological activity of menthol-based chiral quaternary phosphonium salts (CQPSs)","volume":"35","author":"Arkhipova","year":"2024","journal-title":"Struct. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0004","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.2174\/138161208786404272","article-title":"Liverworts-potential source of medicinal compounds","volume":"14","author":"Asakawa","year":"2008","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejps.2025.107167_bib0005","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.phytochem.2004.01.003","article-title":"Chemosystematics of the hepaticae","volume":"65","author":"Asakawa","year":"2004","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejps.2025.107167_bib0006","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/978-1-4615-4689-4_12","article-title":"Phytochemistry of bryophytes","author":"Asakawa","year":"1999","journal-title":"Phytochemicals in Human Health Protection, Nutrition, and Plant Defense"},{"key":"10.1016\/j.ejps.2025.107167_bib0007","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0031-9422(91)84130-K","article-title":"Prenyl bibenzyls from the liverworts Radula perrottetii and Radula complanata","volume":"30","author":"Asakawa","year":"1991","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejps.2025.107167_bib0008","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1021\/acs.jnatprod.1c00302","article-title":"Bis-bibenzyls, bibenzyls, and terpenoids in 33 genera of the Marchantiophyta (Liverworts): structures, synthesis, and bioactivity","volume":"85","author":"Asakawa","year":"2022","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ejps.2025.107167_bib0009","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/0031-9422(82)85245-X","article-title":"Novel bibenzyl derivatives and ent-cuparene-type sesquiterpenoids from Radula species","volume":"21","author":"Asakawa","year":"1982","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejps.2025.107167_bib0010","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1155\/2000\/570265","article-title":"Chemical structures of macrocyclic bis(bibenzyls) isolated from liverworts (Hepaticae)","volume":"14","author":"Asakawa","year":"2000","journal-title":"Spectroscopy"},{"key":"10.1016\/j.ejps.2025.107167_bib0011","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.3390\/ijms25052761","article-title":"Anti gram-positive bacteria activity of synthetic quaternary ammonium lipid and its precursor phosphonium salt","volume":"25","author":"Bacchetti","year":"2024","journal-title":"IJMS"},{"key":"10.1016\/j.ejps.2025.107167_bib0012","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3390\/molecules24061078","article-title":"Derivatization of Rosmarinic acid enhances its in vitro antitumor, antimicrobial and antiprotozoal properties","volume":"24","author":"Bittner Fialov\u00e1","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2025.107167_bib0013","series-title":"Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance","first-page":"147","article-title":"Antitubercular in vitro drug discovery: tools for begin the search","author":"Bueno","year":"2012"},{"key":"10.1016\/j.ejps.2025.107167_bib0014","doi-asserted-by":"crossref","first-page":"6607","DOI":"10.1021\/jm060639z","article-title":"Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition","volume":"49","author":"Colabufo","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0015","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/(SICI)1099-0690(200004)2000:8<1527::AID-EJOC1527>3.0.CO;2-G","article-title":"Isolation of macrocyclic metacyclophanes from the attempted synthesis of [7.0]metacyclophanes of the myricanone series by Thorpe-Ziegler - intramolecular cyclization of diaryls substituted by \u03c9-cyanoalkyl chains","volume":"2000","author":"Dansou","year":"2000","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0016","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jep.2010.04.025","article-title":"Eugenol (an essential oil of clove) acts as an antibacterial agent against Salmonella typhi by disrupting the cellular membrane","volume":"130","author":"Devi","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejps.2025.107167_bib0017","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1016\/j.bmc.2008.02.078","article-title":"Co-existence of \u03b1-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development","volume":"16","author":"Dodo","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0018","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ijantimicag.2012.07.016","article-title":"Dissemination of IncFIIK-type plasmids in multiresistant CTX-M-15-producing Enterobacteriaceae isolates from children in hospital paediatric oncology wards","volume":"40","author":"Dolejska","year":"2012","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejps.2025.107167_bib0019","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1055\/s-0033-1340307","article-title":"2,6-Difunctionalization of N-substituted dithienothiazines via dilithiation","volume":"25","author":"Dostert","year":"2013","journal-title":"Synlett"},{"key":"10.1016\/j.ejps.2025.107167_bib0020","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/(SICI)1099-0690(199805)1998:5<877::AID-EJOC877>3.0.CO;2-S","article-title":"Syntheses of cyclic bisbibenzyl systems","volume":"1998","author":"Eicher","year":"1998","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0021","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1016\/j.tetlet.2004.07.068","article-title":"Efficient synthesis of isoplagiochin D, a macrocyclic bis(bibenzyls), by utilizing an intramolecular Suzuki\u2013Miyaura reaction","volume":"45","author":"Esumi","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejps.2025.107167_bib0022","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1039\/j39710000205","article-title":"Lythraceous alkaloids. Part III. Synthesis of the product of dehydrogenation of dideoxy-NO-dimethyl-lythranidine; the structure of lythranidine","author":"Fujita","year":"1971","journal-title":"J. Chem. Soc., C"},{"key":"10.1016\/j.ejps.2025.107167_bib0023","series-title":"Vogel\u2019s Textbook of Practical Organic Chemistry","author":"Furniss","year":"1989"},{"key":"10.1016\/j.ejps.2025.107167_bib0024","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/10426507.2012.740694","article-title":"Synthesis and antimicrobial activities of phosphonium salts on basis of triphenylphosphine and 3,5-di-tert-butyl-4-hydroxybenzyl bromide","volume":"188","author":"Galkina","year":"2013","journal-title":"Phosphorus Sulfur Silicon Relat. Elem."},{"key":"10.1016\/j.ejps.2025.107167_bib0025","unstructured":"Ganase, Z., 2015. An Experimental Study on the Effects of Solvents on the Rate and Selectivity of Organic Reactions (Dissertation thesis). Imperial College, London."},{"key":"10.1016\/j.ejps.2025.107167_bib0026","unstructured":"Global Laboratory Standards for a Healthier World. https:\/\/clsi.org\/ (accessed 24 May 2025)."},{"key":"10.1016\/j.ejps.2025.107167_bib0027","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.acthis.2018.03.007","article-title":"Current methodology of MTT assay in bacteria \u2013 a review","volume":"120","author":"Grela","year":"2018","journal-title":"Acta Histochem."},{"key":"10.1016\/j.ejps.2025.107167_bib0028","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.3390\/molecules24132471","article-title":"Antibacterial activity of terpenes and terpenoids present in essential oils","volume":"24","author":"Guimar\u00e3es","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.ejps.2025.107167_bib0029","doi-asserted-by":"crossref","unstructured":"Hashimoto, T., Kanayama, S., Kan, Y., Tori, M., Asakawa, Y., 1996. Isoplagiochins C and D, New Type of Macrocyclic Bis(bibenzyls), Having two biphenyl linkages from the liverwort Plagiochila fruticosa. Chem. Lett. 25, 741\u2013742. https:\/\/doi.org\/10.1246\/cl.1996.741.","DOI":"10.1246\/cl.1996.741"},{"key":"10.1016\/j.ejps.2025.107167_bib0030","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1021\/mp500324n","article-title":"One-pot multi-tracer synthesis of novel 18 F-labeled PET imaging agents","volume":"11","author":"Haslop","year":"2014","journal-title":"Mol. Pharmaceut."},{"key":"10.1016\/j.ejps.2025.107167_bib0031","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1080\/00397910701569080","article-title":"Comparison of iodination of methoxylated benzaldehydes and related compounds using iodine\/silver nitrate and iodine\/periodic acid","volume":"37","author":"Hathaway","year":"2007","journal-title":"Synth. Commun."},{"key":"10.1016\/j.ejps.2025.107167_bib0032","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.bmcl.2008.12.022","article-title":"Synthesis of riccardin C and its seven analogues. Part 1: the role of their phenolic hydroxy groups as LXR\u03b1 agonists","volume":"19","author":"Hioki","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejps.2025.107167_bib0033","doi-asserted-by":"crossref","first-page":"6073","DOI":"10.1016\/j.tet.2011.06.018","article-title":"Efficient and diversity-oriented total synthesis of Riccardin C and application to develop novel macrolactam derivatives","volume":"67","author":"Iwashita","year":"2011","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ejps.2025.107167_bib0034","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1021\/op050137f","article-title":"Efficient total synthesis of Lycophyll (\u03c8,\u03c8-Carotene-16,16\u2018-diol)","volume":"9","author":"Jackson","year":"2005","journal-title":"Org. Process Res. Dev."},{"key":"10.1016\/j.ejps.2025.107167_bib0035","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1016\/j.bmc.2012.02.004","article-title":"Synthesis of macrocyclic bisbibenzyl derivatives and their anticancer effects as anti-tubulin agents","volume":"20","author":"Jiang","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0036","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1055\/s-2006-958116","article-title":"Isolation and Antibacterial activity of Marchantin A, a cyclic bis(bibenzyl) constituent of Hungarian Marchantia polymorpha","volume":"61","author":"K\u00e1mory","year":"1995","journal-title":"Planta Med."},{"key":"10.1016\/j.ejps.2025.107167_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/7411957","article-title":"Synthesized phosphonium compounds demonstrate resistant modulatory and antibiofilm formation activities against some pathogenic bacteria","volume":"2022","author":"Kodjo Amengor","year":"2022","journal-title":"Heteroat. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0038","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202300718","article-title":"Chimeric amphiphilic disinfectants: quaternary ammonium\/quaternary phosphonium hybrid structures","volume":"19","author":"Leatherbury","year":"2024","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejps.2025.107167_bib0039","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1055\/s-2000-7106","article-title":"Total synthesis of marchantinquinone","volume":"2000","author":"L\u00f3pez","year":"2000","journal-title":"Synthesis"},{"key":"10.1016\/j.ejps.2025.107167_bib0040","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jconrel.2015.10.023","article-title":"Delivery of drugs and macromolecules to the mitochondria for cancer therapy","volume":"240","author":"Lu","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ejps.2025.107167_bib0041","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11743-016-1908-6","article-title":"Novel phospholium-type cationic surfactants: synthesis, aggregation properties and antimicrobial activity","volume":"20","author":"Luk\u00e1\u010d","year":"2017","journal-title":"J. Surfact. Deterg."},{"key":"10.1016\/j.ejps.2025.107167_bib0042","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/jsde.12439","article-title":"Synthesis, surface activity, and biological activities of phosphonium and metronidazole salts","volume":"23","author":"Luk\u00e1\u010d","year":"2020","journal-title":"J. Surfact. Deterg."},{"key":"10.1016\/j.ejps.2025.107167_bib0043","first-page":"1200","article-title":"Caffeic acid phosphanium derivatives: potential selective antitumor","volume":"25","author":"Luk\u00e1\u010d","year":"2024","journal-title":"Antimicrob. Antiprotozoal Agents, IJMS"},{"key":"10.1016\/j.ejps.2025.107167_bib0044","article-title":"Modeling tuberculosis in Mycobacterium marinum infected adult zebrafish","volume":"58299","author":"Luukinen","year":"2018","journal-title":"JoVE"},{"key":"10.1016\/j.ejps.2025.107167_bib0045","doi-asserted-by":"crossref","first-page":"S868","DOI":"10.1134\/S1070363223170036","article-title":"Design and application of novel sterically hindered phosphonium salts in the development of functional materials","volume":"93","author":"Lyubina","year":"2023","journal-title":"Russ. J. Gen. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0046","unstructured":"Measuring Cell Viability \/Cytotoxicity Dojindo EU GmbH. https:\/\/www.dojindo.eu.com\/Protocol\/Dojindo-Cell-Proliferation-Protocol.pdf\/ (accessed 16 December 2023)."},{"key":"10.1016\/j.ejps.2025.107167_bib0047","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1246\/bcsj.20180223","article-title":"Effect of substituents on TiO 2 photocatalytic oxidation of trans -Stilbenes","volume":"92","author":"Miyake","year":"2019","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"10.1016\/j.ejps.2025.107167_bib0048","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0169-409X(01)00134-X","article-title":"Targeting large molecules to mitochondria","volume":"49","author":"Muratovska","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejps.2025.107167_bib0049","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s40199-020-00341-0","article-title":"Bibenzyls and bisbybenzyls of bryophytic origin as promising source of novel therapeutics: pharmacology, synthesis and structure-activity","volume":"28","author":"Nandy","year":"2020","journal-title":"DARU J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107167_bib0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000855","article-title":"A timescale for evolution, population expansion, and spatial spread of an emerging clone of methicillin-resistant Staphylococcus aureus","volume":"6","author":"N\u00fcbel","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejps.2025.107167_bib0051","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3390\/ijms25010504","article-title":"Efficacy of novel quaternary ammonium and phosphonium salts differing in cation type and alkyl chain length against antibiotic-resistant Staphylococcus aureus","volume":"25","author":"Nunes","year":"2023","journal-title":"IJMS"},{"key":"10.1016\/j.ejps.2025.107167_bib0052","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/1462-2920.12213","article-title":"American crows as carriers of vancomycin-resistant enterococci with vanA gene","volume":"16","author":"Oravcova","year":"2014","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.ejps.2025.107167_bib0053","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1086\/381972","article-title":"Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of gram-positive bacterial infections","volume":"38","author":"Pankey","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ejps.2025.107167_bib0054","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1021\/acs.jpcb.1c08135","article-title":"Membrane permeability of modified butyltriphenylphosphonium cations","volume":"126","author":"Rokitskaya","year":"2022","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ejps.2025.107167_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2023.184183","article-title":"Efficiency of mitochondrial uncoupling by modified butyltriphenylphosphonium cations and fatty acids correlates with lipophilicity of cations: protonophoric vs leakage mechanisms","volume":"1865","author":"Rokitskaya","year":"2023","journal-title":"Biochim. Biophys. Acta (BBA) - Biomembr."},{"key":"10.1016\/j.ejps.2025.107167_bib0056","doi-asserted-by":"crossref","first-page":"23355","DOI":"10.1039\/C9CP03460A","article-title":"Effect of methyl and halogen substituents on the transmembrane movement of lipophilic ions","volume":"21","author":"Rokitskaya","year":"2019","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.ejps.2025.107167_bib0057","first-page":"2776","article-title":"Total synthesis of 3\u2032,3\u2032\u2032\u2032-binaringenin and related biflavonoids","author":"Sagrera","year":"2010","journal-title":"Synthesis"},{"key":"10.1016\/j.ejps.2025.107167_bib0058","doi-asserted-by":"crossref","first-page":"6563","DOI":"10.1016\/j.bmcl.2013.10.069","article-title":"Structure\u2013anti-MRSA activity relationship of macrocyclic bis(bibenzyl) derivatives","volume":"23","author":"Sawada","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ejps.2025.107167_bib0059","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.00760","article-title":"Synergistic and additive effect of oregano essential oil and biological silver nanoparticles against multidrug-resistant bacterial strains","volume":"7","author":"Scandorieiro","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejps.2025.107167_bib0060","series-title":"Antimicrobial Susceptibility Testing Protocols","author":"Schwalbe","year":"2007"},{"key":"10.1016\/j.ejps.2025.107167_bib0061","doi-asserted-by":"crossref","first-page":"6760","DOI":"10.1002\/ejoc.201001023","article-title":"Syntheses of macrocyclic bis(bibenzyl) compounds derived from Perrottetin E","author":"Speicher","year":"2010","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0062","article-title":"Syntheses of marchantins C, O and P as promising highly bioactive compounds","volume":"6","author":"Speicher","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.ejps.2025.107167_bib0063","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3987\/COM-09-S(S)113","article-title":"Synthesis of some new biheterocycles by a one-pot Suzuki-Miyaura coupling reaction","volume":"80","author":"St","year":"2010","journal-title":"Heterocycles"},{"key":"10.1016\/j.ejps.2025.107167_bib0064","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1016\/j.bmc.2009.05.077","article-title":"Synthesis and multidrug resistance reversal activity of dihydroptychantol A and its novel derivatives","volume":"17","author":"Sun","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0065","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.polymer.2014.10.041","article-title":"Well-defined cyclopropenone-masked dibenzocyclooctyne functionalized polymers from atom transfer radical polymerization","volume":"64","author":"Sun","year":"2015","journal-title":"Polymer"},{"key":"10.1016\/j.ejps.2025.107167_bib0066","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.jiph.2020.06.023","article-title":"Features of the biochemistry of Mycobacterium smegmatis, as a possible model for Mycobacterium tuberculosis","volume":"13","author":"T","year":"2020","journal-title":"J. Infect. Public Health"},{"key":"10.1016\/j.ejps.2025.107167_bib0067","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0031-9422(00)90371-6","article-title":"Bibenzyl cannabinoid and bisbibenzyl derivative from the liverwort Radula perrottetii","volume":"37","author":"Toyota","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ejps.2025.107167_bib0068","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1248\/cpb.50.1390","article-title":"New bibenzyl cannabinoid from the New Zealand Liverwort Radula marginata","volume":"50","author":"Toyota","year":"2002","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.ejps.2025.107167_bib0069","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1016\/S0040-4039(00)95135-9","article-title":"Perrottetins E, F, and G from (liverwort)\u2013isolation, structure determination, and synthesis of perrottetin e","volume":"26","author":"Toyota","year":"1985","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ejps.2025.107167_bib0070","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1128\/AAC.19.4.578","article-title":"Outer membrane permeability barrier disruption by polymyxin in polymyxin-susceptible and -resistant Salmonella typhimurium","volume":"19","author":"Vaara","year":"1981","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2025.107167_bib0071","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ijantimicag.2019.02.015","article-title":"Antibacterial and antifungal properties of resveratrol","volume":"53","author":"Vestergaard","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.ejps.2025.107167_bib0072","author":"Weinstein","year":"2018","journal-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically: M07-A11"},{"key":"10.1016\/j.ejps.2025.107167_bib0073","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.1016\/j.bmc.2010.07.055","article-title":"Bisbibenzyl derivatives sensitize vincristine-resistant KB\/VCR cells to chemotherapeutic agents by retarding P-gp activity","volume":"18","author":"Xi","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.ejps.2025.107167_bib0074","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1021\/acs.orglett.8b01366","article-title":"Total syntheses of pusilatins A\u2013C, liverwort-derived macrocyclic bisbibenzyl dimers","volume":"20","author":"Yamada","year":"2018","journal-title":"Org. Lett."},{"key":"10.1016\/j.ejps.2025.107167_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/349534","article-title":"In vitro bactericidal activity of 4- and 5-chloro-2-hydroxy- N -[1-oxo-1-(phenylamino)alkan-2-yl]benzamides against MRSA","volume":"2015","author":"Zadrazilova","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejps.2025.107167_bib0076","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1021\/acs.chemrev.7b00042","article-title":"Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications","volume":"117","author":"Zielonka","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ejps.2025.107167_bib0077","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/anie.199101301","article-title":"Bryophytes, a source of biologically active, naturally occurring material?","volume":"30","author":"Zinsmeister","year":"1991","journal-title":"Angew. Chem. Int. Ed. Engl."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098725001666?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098725001666?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T10:14:13Z","timestamp":1757844853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098725001666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":77,"alternative-id":["S0928098725001666"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2025.107167","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preparation and biological activity of isoperrottetin A and its phosphonium salts derivatives","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2025.107167","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107167"}}