{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:37:28Z","timestamp":1778852248872,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ejps.2025.107355","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:11:50Z","timestamp":1761783110000},"page":"107355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The impact of solid and liquid lipids and their lipolysis on griseofulvin bioavailability. In vitro dissolution, in vivo and ex vivo porcine model study"],"prefix":"10.1016","volume":"215","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-3827","authenticated-orcid":false,"given":"Sigal","family":"Saphier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oljora","family":"Rezhdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Yaccov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada","family":"Wenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Goldvaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziv","family":"Klausner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavya","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahman Md","family":"Moshikur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahaf","family":"Katalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Carrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2025.107355_bib0001","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ejpb.2016.11.034","article-title":"Food, gastrointestinal pH, and models of oral drug absorption","volume":"112","author":"Abuhelwa","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2025.107355_bib0002","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.3390\/biomedicines10092055","article-title":"Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics","volume":"10","author":"Bhalani","year":"2022","journal-title":"Biomedicines."},{"key":"10.1016\/j.ejps.2025.107355_bib0003","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1021\/jf800159e","article-title":"Influence of lipid physical State on the in vitro digestibility of emulsified lipids","volume":"56","author":"Bonnaire","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejps.2025.107355_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2019.104967","article-title":"Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems","volume":"137","author":"Boyd","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0005","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1007\/s11095-013-1238-6","article-title":"Effect of ingested lipids on drug dissolution and release with concurrent digestion: a modeling approach","volume":"30","author":"Buyukozturk","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2025.107355_bib0006","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/0016-5085(93)90908-U","article-title":"Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans","volume":"105","author":"Carriere","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejps.2025.107355_bib0007","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/js960085v","article-title":"Physicochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH","volume":"86","author":"Charman","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0008","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/jps.24270","article-title":"Evaluation of the use of G\u00f6ttingen minipigs to predict food effects on the oral absorption of drugs in humans","volume":"104","author":"Christiansen","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0009","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/jid.1961.154","article-title":"Human pharmacology of Griseofulvin: the effect of fat intake on gastrointestinal Absorption11From the Department of Dermatology, University of Miami Medical School, Miami, Florida","volume":"37","author":"Crounse","year":"1961","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejps.2025.107355_bib0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1211\/0022357011775163","article-title":"Gastrointestinal transit of dosage forms in the pig","volume":"53","author":"Davis","year":"2001","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2025.107355_bib0011","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1194\/jlr.R054114","article-title":"Intestinal transport and metabolism of bile acids","volume":"56","author":"Dawson","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ejps.2025.107355_bib0012","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1080\/10543406.2011.578313","article-title":"A note on power and sample size calculations for the Kruskal\u2013Wallis test for ordered categorical data","volume":"22","author":"Fan","year":"2012","journal-title":"J. Biopharm. Stat."},{"key":"10.1016\/j.ejps.2025.107355_bib0013","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.addr.2016.04.007","article-title":"50 years of oral lipid-based formulations: provenance, progress and future perspectives","volume":"101","author":"Feeney","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejps.2025.107355_bib0014","first-page":"418","article-title":"Diet, age and intestinal bile acids in pigs","volume":"8","author":"Flores","year":"1992","journal-title":"Nutrition"},{"key":"10.1016\/j.ejps.2025.107355_bib0015","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/03610919808813500","article-title":"Size performance of some tests in one-way anova","volume":"27","author":"Gamage","year":"1998","journal-title":"Commun. Stat. - Simul. Comput."},{"key":"10.1016\/j.ejps.2025.107355_bib0016","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13546","article-title":"Advances in the physiology of gastric emptying","volume":"31","author":"Goyal","year":"2019","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.ejps.2025.107355_bib0017","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejps.2007.01.007","article-title":"Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state","volume":"31","author":"Grove","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0018","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ejps.2018.03.017","article-title":"Exploring gastric emptying rate in minipigs: effect of food type and pre-dosing of metoclopramide","volume":"118","author":"Henze","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0019","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejpb.2020.06.009","article-title":"Development and evaluation of a biorelevant medium simulating porcine gastrointestinal fluids","volume":"154","author":"Henze","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2025.107355_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2021.105840","article-title":"Combining species specific in vitro & in silico models to predict in vivo food effect in a preclinical stage \u2013 case study of Venetoclax","volume":"162","author":"Henze","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0021","article-title":"Toward the establishment of a standardized pre-clinical porcine model to predict food effects \u2013 Case studies on fenofibrate and paracetamol","volume":"1","author":"Henze","year":"2019","journal-title":"Int. J. Pharm. X."},{"key":"10.1016\/j.ejps.2025.107355_bib0022","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/jphp.12912","article-title":"The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review","volume":"71","author":"Henze","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2025.107355_bib0023","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1023\/A:1015936426906","article-title":"Gastrointestinal transit of nondisintegrating, nonerodible oral dosage forms in pigs","volume":"7","author":"Hossain","year":"1990","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2025.107355_bib0024","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1093\/jn\/113.9.1691","article-title":"Response of bile flow, biliary lipids and bile acid pool in the pig to quantitative variations in dietary fat","volume":"113","author":"Juste","year":"1983","journal-title":"J. Nutr."},{"key":"10.1016\/j.ejps.2025.107355_bib0025","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/biomet\/57.2.421","article-title":"Sample size requirements: one-way analysis of variance","volume":"57","author":"Kastenbaum","year":"1970","journal-title":"Biometrika"},{"key":"10.1016\/j.ejps.2025.107355_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2021.105733","article-title":"Mechanisms of drug solubilization by polar lipids in biorelevant media","volume":"159","author":"Katev","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0027","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1021\/acs.molpharmaceut.1c00778","article-title":"Importance of gastric secretion and the rapid gastric emptying of ingested water along the lesser curvature (\u201cMagenstra\u00dfe\u201d) in predicting the In vivo performance of liquid oral dosage forms in the Fed State using a modeling and simulation","volume":"19","author":"Kiyota","year":"2022","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2025.107355_bib0028","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.xphs.2021.09.008","article-title":"Lipophilic salts and lipid-based formulations for bridging the food effect gap of venetoclax","volume":"111","author":"Koehl","year":"2022","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0029","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ijpharm.2011.03.002","article-title":"In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems","volume":"417","author":"Larsen","year":"2011","journal-title":"Int. J. Pharm."},{"issue":"11","key":"10.1016\/j.ejps.2025.107355_bib0030","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1080\/17425247.2021.1982891","article-title":"Oral delivery of solid lipid nanoparticles: underlining the physicochemical characteristics and physiological condition affecting the lipolysis rate","volume":"18","author":"Mahmoudian","year":"2021","journal-title":"Expert. Opin. Drug Deliv."},{"key":"10.1016\/j.ejps.2025.107355_bib0031","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/bimj.4710380510","article-title":"Estimation of the power of the Kruskal-Wallis test","volume":"38","author":"Mahoney","year":"1996","journal-title":"Biometrical J."},{"key":"10.1016\/j.ejps.2025.107355_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121695","article-title":"Bio-enabling strategies to mitigate the pharmaceutical food effect: a mini review","volume":"619","author":"Meola","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2025.107355_bib0033","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1039\/C3FO60702J","article-title":"A standardised static in vitro digestion method suitable for food \u2013 an international consensus","volume":"5","author":"Minekus","year":"2014","journal-title":"Food Funct."},{"key":"10.1016\/j.ejps.2025.107355_bib0034","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s11051-012-1113-0","article-title":"In vitro digestion of curcuminoid-loaded lipid nanoparticles","volume":"14","author":"Noack","year":"2012","journal-title":"J. Nanoparticle Res."},{"key":"10.1016\/j.ejps.2025.107355_bib0035","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1080\/00949650903580047","article-title":"Monte Carlo comparison of seven normality tests","volume":"81","author":"Noughabi","year":"2011","journal-title":"J. Stat. Comput. Simul."},{"key":"10.1016\/j.ejps.2025.107355_bib0036","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1023\/A:1018939204809","article-title":"Variability in gastric pH and delayed gastric emptying in Yucatan miniature pigs","volume":"11","author":"Oberle","year":"1994","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2025.107355_bib0037","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.chroma.2014.10.010","article-title":"A single step reversed-phase high performance liquid chromatography separation of polar and non-polar lipids","volume":"1369","author":"Olsson","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.ejps.2025.107355_bib0038","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1016\/j.xphs.2024.04.007","article-title":"In vitro lipolysis model to predict food effect of poorly water-soluble drugs itraconazole, Rivaroxaban, and Ritonavir","volume":"113","author":"Patel","year":"2024","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0039","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejpb.2020.11.010","article-title":"Characterisation of fasted state gastric and intestinal fluids collected from children","volume":"158","author":"Pawar","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2025.107355_bib0040","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.ejpb.2013.05.007","article-title":"Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities","volume":"85","author":"Pedersen","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2025.107355_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2023.106505","article-title":"Leveraging the use of in vitro and computational methods to support the development of enabling oral drug products: an InPharma commentary","volume":"188","author":"Reppas","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0042","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jcis.2017.03.109","article-title":"Characterization of colloidal structures during intestinal lipolysis using small-angle neutron scattering","volume":"499","author":"Rezhdo","year":"2017","journal-title":"J. Colloid. Interface Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0043","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jconrel.2016.07.050","article-title":"Lipid-associated oral delivery: mechanisms and analysis of oral absorption enhancement","volume":"240","author":"Rezhdo","year":"2016","journal-title":"J. Control Release"},{"key":"10.1016\/j.ejps.2025.107355_bib0044","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jps.24603","article-title":"Characterization of Human duodenal fluids in fasted and fed State conditions","volume":"105","author":"Riethorst","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0045","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1021\/acs.molpharmaceut.8b00865","article-title":"Gastric and duodenal diclofenac concentrations in healthy volunteers after intake of the FDA standard meal: in vivo observations and in vitro explorations","volume":"16","author":"Rubbens","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2025.107355_bib0046","series-title":"The Analysis of Variance","author":"Scheff\u00e9","year":"1999"},{"key":"10.1016\/j.ejps.2025.107355_bib0047","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1211\/0022357021771896","article-title":"Evaluation of the in-vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products","volume":"54","author":"Sek","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejps.2025.107355_bib0048","series-title":"Handbook of Parametric and Nonparametric Statistical Procedures: Second Edition","author":"Sheskin","year":"2000"},{"key":"10.1016\/j.ejps.2025.107355_bib0049","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3390\/molecules27010191","article-title":"Melting, crystallization, and In vitro digestion properties of fats containing stearoyl-rich triacylglycerols","volume":"27","author":"Shin","year":"2021","journal-title":"Molecules."},{"key":"10.1016\/j.ejps.2025.107355_bib0050","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1007\/s11095-014-1367-6","article-title":"Pharmacokinetics of paracetamol in G\u00f6ttingen minipigs: in vivo studies and modeling to elucidate physiological determinants of absorption","volume":"31","author":"Suenderhauf","year":"2014","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2025.107355_bib0051","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1124\/dmd.118.083311","article-title":"Porcine prediction of pharmacokinetic parameters in people: a pig in a poke?","volume":"46","author":"Tang","year":"2018","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2025.107355_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122758","article-title":"Assessment of food effects during clinical development","volume":"635","author":"Vinarov","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2025.107355_bib0053","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1002\/jps.23205","article-title":"Toward the establishment of standardized In vitro tests for lipid-based formulations, part 1: method parameterization and comparison of In vitro digestion profiles across a range of representative formulations","volume":"101","author":"Williams","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0054","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1080\/00949655.2010.520163","article-title":"Comparisons of various types of normality tests","volume":"81","author":"Yap","year":"2011","journal-title":"J. Stat. Comput. Simul."},{"key":"10.1016\/j.ejps.2025.107355_bib0055","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0928-0987(01)00182-8","article-title":"A dynamic in vitro lipolysis model: II: evaluation of the model","volume":"14","author":"Zangenberg","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2025.107355_bib0056","series-title":"Biostatistical Analysis","author":"Zar","year":"2010"}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098725003525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098725003525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:11:58Z","timestamp":1763662318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098725003525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":56,"alternative-id":["S0928098725003525"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2025.107355","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of solid and liquid lipids and their lipolysis on griseofulvin bioavailability. In vitro dissolution, in vivo and ex vivo porcine model study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2025.107355","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107355"}}