{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:59:13Z","timestamp":1780405153538,"version":"3.54.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020410","name":"T\u00dcSEB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ejps.2025.107400","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:08:42Z","timestamp":1765210122000},"page":"107400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The relationship between PDE4 and AQP5 in lung tissue under inflammatory conditions: An experimental study"],"prefix":"10.1016","volume":"217","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-949X","authenticated-orcid":false,"given":"Ayse","family":"Bozkurt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4324-5943","authenticated-orcid":false,"given":"Zafer","family":"Bayraktutan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0715-2707","authenticated-orcid":false,"given":"Erdem","family":"Toktay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5766-6116","authenticated-orcid":false,"given":"Adem","family":"Kara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-6059","authenticated-orcid":false,"given":"Zekai","family":"Halici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0836-7205","authenticated-orcid":false,"given":"Elif","family":"Cadirci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ejps.2025.107400_bib0044","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.acthis.2015.07.006","article-title":"The protective effects of beta-carotene against ischemia\/reperfusion injury in rat ovarian tissue","volume":"117","author":"Aksak Karamese","year":"2015","journal-title":"Acta Histochem."},{"issue":"5","key":"10.1016\/j.ejps.2025.107400_bib0030","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00408-022-00564-9","article-title":"Avanafil as a novel therapeutic agent against LPS-induced acute lung injury via increasing CGMP to downregulate the TLR4-NF-\u03bab-NLRP3 inflammasome signaling pathway","volume":"200","author":"Aydin","year":"2022","journal-title":"Lung"},{"issue":"10","key":"10.1016\/j.ejps.2025.107400_bib0019","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41573-019-0033-4","article-title":"Therapeutic targeting of 3\u2032,5\u2032-cyclic nucleotide phosphodiesterases: inhibition and beyond","volume":"18","author":"Baillie","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4","key":"10.1016\/j.ejps.2025.107400_bib0020","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1152\/physrev.1995.75.4.725","article-title":"Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms","volume":"75","author":"Beavo","year":"1995","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.ejps.2025.107400_bib0002","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1056\/NEJMp1706595","article-title":"Acute lung failure \u2014 Our evolving understanding of ARDS","volume":"377","author":"Bernard","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.ejps.2025.107400_bib0065","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1007\/s43032-024-01496-w","article-title":"Targeting aquaporin-5 by phosphodiesterase 4 inhibition offers new therapeutic opportunities for ovarian ischemia reperfusion injury in rats","volume":"31","author":"Bozkurt","year":"2024","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0016","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nbt.1598","article-title":"Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety","volume":"28","author":"Burgin","year":"2010","journal-title":"Nat. Biotechnol."},{"issue":"10","key":"10.1016\/j.ejps.2025.107400_bib0041","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.imbio.2013.04.012","article-title":"Peripheral 5-HT7 receptors as a new target for prevention of lung injury and mortality in septic rats","volume":"218","author":"Cadirci","year":"2013","journal-title":"Immunobiology"},{"issue":"2","key":"10.1016\/j.ejps.2025.107400_bib0042","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00210-018-1571-8","article-title":"Urotensin receptors as a new target for CLP induced septic lung injury in mice","volume":"392","author":"Cadirci","year":"2019","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejps.2025.107400_bib0039","first-page":"438","article-title":"[Effect of qidong huoxue decoction on inflammatory factors and TLR4 mRNA expression in acute lung injury rats]","volume":"35","author":"Cao","year":"2015","journal-title":"Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi Chin.J. Integr Tradit. West Med."},{"issue":"2","key":"10.1016\/j.ejps.2025.107400_bib0060","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.taap.2012.06.017","article-title":"Inhibition of chlorine-induced lung injury by the type 4 phosphodiesterase inhibitor Rolipram","volume":"263","author":"Chang","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"9","key":"10.1016\/j.ejps.2025.107400_bib0066","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1002\/glia.24572","article-title":"Inhibition of phosphodiesterase 4 attenuates aquaporin 4 expression and astrocyte swelling following cerebral ischemia\/reperfusion injury","volume":"72","author":"Chen","year":"2024","journal-title":"Glia"},{"key":"10.1016\/j.ejps.2025.107400_bib0069","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jare.2024.03.019","article-title":"Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome","volume":"62","author":"Chen","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ejps.2025.107400_bib0043","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.lfs.2019.02.039","article-title":"Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats","volume":"221","author":"Cinar","year":"2019","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.ejps.2025.107400_bib0071","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24031889","article-title":"Aquaporin-5 dynamic regulation","volume":"24","author":"D\u2019Agostino","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.ejps.2025.107400_bib0035","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1007\/s11011-022-01060-y","article-title":"Rolipram and pentoxifylline combination ameliorates experimental diabetic neuropathy through inhibition of oxidative stress and inflammatory pathways in the dorsal root ganglion neurons","volume":"37","author":"Dastgheib","year":"2022","journal-title":"Metab. Brain Dis."},{"issue":"3","key":"10.1016\/j.ejps.2025.107400_bib0026","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1183\/09031936.00071307","article-title":"Phosphodiesterase-4 inhibition attenuates pulmonary inflammation in neonatal lung injury","volume":"31","author":"de Visser","year":"2008","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0022","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00408-025-00787-6","article-title":"PDE4B Modulates phosphorylation of p65 (Ser468) via cAMP\/PKA in acute lung injury","volume":"203","author":"Dhar","year":"2025","journal-title":"Lung"},{"issue":"4","key":"10.1016\/j.ejps.2025.107400_bib0072","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.pupt.2010.12.011","article-title":"PDE4-inhibitors: a novel, targeted therapy for obstructive airways disease","volume":"24","author":"Diamant","year":"2011","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.ejps.2025.107400_bib0021","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/SHK.0000000000000152","article-title":"Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions and microcirculation in a rodent model of polymicrobial sepsis","volume":"41","author":"Flemming","year":"2014","journal-title":"Shock"},{"issue":"4","key":"10.1016\/j.ejps.2025.107400_bib0001","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1007\/s10753-019-01010-4","article-title":"Acute lung injury: iL-17A-mediated inflammatory pathway and its regulation by curcumin","volume":"42","author":"Gouda","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.ejps.2025.107400_bib0052","doi-asserted-by":"crossref","unstructured":"Hachez C., Chaumont F. Aquaporins: a Family of highly regulated multifunctional channels. In; 2010:1\u201317. doi:10.1007\/978-1-4419-6315-4_1.","DOI":"10.1007\/978-1-4419-6315-4_1"},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0036","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3340\/jkns.2012.52.1.32","article-title":"Electrophysiological and behavioral changes by phosphodiesterase 4 inhibitor in a rat model of alcoholic neuropathy","volume":"52","author":"Han","year":"2012","journal-title":"J. Korean Neurosurg. Soc."},{"key":"10.1016\/j.ejps.2025.107400_bib0006","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.resp.2014.05.008","article-title":"Expression of aquaporins in the lungs of mice with acute injury caused by LPS treatment","volume":"200","author":"Hasan","year":"2014","journal-title":"Respir. Physiol. Neurobiol."},{"issue":"8","key":"10.1016\/j.ejps.2025.107400_bib0015","first-page":"619","article-title":"[Effects of selective phosphodiesterase 4 inhibitor on expression of aquaporin 5 in airway mucus hypersecretion model of rats]","volume":"93","author":"Jia","year":"2013","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"8","key":"10.1016\/j.ejps.2025.107400_bib0068","first-page":"619","article-title":"[Effects of selective phosphodiesterase 4 inhibitor on expression of aquaporin 5 in airway mucus hypersecretion model of rats]","volume":"93","author":"Jia","year":"2013","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"3","key":"10.1016\/j.ejps.2025.107400_bib0025","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1213\/ANE.0000000000000853","article-title":"The analgesic effect of Rolipram, a phosphodiesterase 4 inhibitor, on chemotherapy-induced neuropathic pain in rats","volume":"121","author":"Kim","year":"2015","journal-title":"Anesth. Analg."},{"issue":"3","key":"10.1016\/j.ejps.2025.107400_bib0023","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.21873\/invivo.13547","article-title":"The effect of Roflumilast on lipopolysaccharide-induced acute lung injury during neutropenia recovery in mice","volume":"38","author":"KIM","year":"2024","journal-title":"In. Vivo (Brooklyn)"},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0029","article-title":"Qidonghuoxue decoction ameliorates pulmonary edema in acute lung injury mice through the upregulation of epithelial sodium channel and aquaporin-1. Santafe M, ed","volume":"2020","author":"Ma","year":"2020","journal-title":"Evidence Complement Altern. Med."},{"issue":"10","key":"10.1016\/j.ejps.2025.107400_bib0031","doi-asserted-by":"crossref","first-page":"6899","DOI":"10.21037\/jtd-24-700","article-title":"Ameliorating lipopolysaccharide induced acute lung injury with Lianhua Qingke: focus on pulmonary endothelial barrier protection","volume":"16","author":"Ma","year":"2024","journal-title":"J. Thorac. Dis."},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0058","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1517\/13543784.11.1.1","article-title":"Update on the therapeutic potential of PDE4 inhibitors","volume":"11","author":"Montana","year":"2002","journal-title":"Expert. Opin. Investig. Drugs"},{"issue":"3","key":"10.1016\/j.ejps.2025.107400_bib0013","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1254\/jphs.FMJ04004X7","article-title":"Molecular mechanisms and drug development in aquaporin water channel diseases: aquaporin superfamily (Superaquaporins): expansion of aquaporins restricted to multicellular organisms","volume":"96","author":"Morishita","year":"2004","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ejps.2025.107400_bib0073","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107911","article-title":"Rationale design and synthesis of new roflumilast analogues as preferential selective and potent PDE-4B inhibitors","volume":"153","author":"Moussa","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"3","key":"10.1016\/j.ejps.2025.107400_bib0053","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bbrc.2004.10.216","article-title":"Lipopolysaccharide changes the subcellular distribution of aquaporin 5 and increases plasma membrane water permeability in mouse lung epithelial cells","volume":"326","author":"Ohinata","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.ejps.2025.107400_bib0051","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166184","article-title":"The expression of water and ion channels in diffuse alveolar damage is not dependent on DAD etiology","volume":"11","author":"Pires-Neto","year":"2016","journal-title":"PLoS. One"},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0033","article-title":"Astragalus membranaceus and salvia miltiorrhiza ameliorate lipopolysaccharide-induced acute lung injury in rats by regulating the toll-like receptor 4\/nuclear factor-kappa B signaling pathway","volume":"2018","author":"Qin","year":"2018","journal-title":"Evidence Complement Altern. Med."},{"key":"10.1016\/j.ejps.2025.107400_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116880","article-title":"Rolipram optimizes therapeutic effect of bevacizumab by enhancing proapoptotic, antiproliferative signals in a glioblastoma heterotopic model","volume":"239","author":"Ramezani","year":"2019","journal-title":"Life Sci."},{"issue":"14","key":"10.1016\/j.ejps.2025.107400_bib0003","doi-asserted-by":"crossref","DOI":"10.21037\/atm.2017.06.62","article-title":"Definition and epidemiology of acute respiratory distress syndrome","volume":"5","author":"Rezoagli","year":"2017","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.ejps.2025.107400_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1495206","article-title":"Aquaporins in sepsis- an update","volume":"15","author":"Rump","year":"2024","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.ejps.2025.107400_bib0050","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.bjp.0707428","article-title":"Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability","volume":"152","author":"Sanz","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejps.2025.107400_bib0045","first-page":"187","article-title":"Expressions of CK-19, NF-kappaB, E-cadherin, beta-catenin and EGFR as diagnostic and prognostic markers by immunohistochemical analysis in thyroid carcinoma","volume":"9","author":"Sethi","year":"2011","journal-title":"J. Exp. Ther. Oncol."},{"issue":"5","key":"10.1016\/j.ejps.2025.107400_bib0038","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.3390\/ijms22052573","article-title":"Small immunomodulatory molecules as potential therapeutics in experimental murine models of acute lung injury (ALI)\/acute Respiratory distress syndrome (ARDS)","volume":"22","author":"Shah","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejps.2025.107400_bib0048","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3109\/13880209.2013.867451","article-title":"Protective effects and mechanisms of mogroside V on LPS-induced acute lung injury in mice","volume":"52","author":"Shi","year":"2014","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0018","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13641","article-title":"Local cyclic adenosine monophosphate signalling cascades\u2014Roles and targets in chronic kidney disease","volume":"232","author":"Sholokh","year":"2021","journal-title":"Acta Physiol."},{"issue":"5","key":"10.1016\/j.ejps.2025.107400_bib0064","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1074\/jbc.M411038200","article-title":"cAMP has distinct acute and chronic effects on aquaporin-5 in lung epithelial cells","volume":"280","author":"Sidhaye","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.ejps.2025.107400_bib0014","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1469-7793.2000.00771.x","article-title":"Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice","volume":"525","author":"Song","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejps.2025.107400_bib0004","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/bs.ctm.2022.07.001","article-title":"Endothelial TRPV4 channels in lung edema and injury","volume":"89","author":"Sonkusare","year":"2022","journal-title":"Curr. Top. Membr."},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0067","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1681\/ASN.2006020132","article-title":"Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells","volume":"18","author":"Stefan","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0049","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/JLB.3MR0321-545RR","article-title":"Effects of mesenchymal stromal cell-derived extracellular vesicles in acute respiratory distress syndrome (ARDS): current understanding and future perspectives","volume":"110","author":"Su","year":"2021","journal-title":"J. Leukoc. Biol."},{"issue":"8","key":"10.1016\/j.ejps.2025.107400_bib0063","first-page":"1467","article-title":"Effect of dobutamine on lung aquaporin 5 in endotoxine shock-induced acute lung injury rabbit","volume":"7","author":"Sun","year":"2015","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.ejps.2025.107400_bib0047","series-title":"Using Multivariate Statistics","author":"Tabachnick","year":"2013"},{"issue":"4","key":"10.1016\/j.ejps.2025.107400_bib0034","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.intimp.2010.01.003","article-title":"Action of a Novel PDE4 inhibitor ZL-n-91 on lipopolysaccharide-induced acute lung injury","volume":"10","author":"Tang","year":"2010","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.ejps.2025.107400_bib0046","first-page":"1603","article-title":"Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity","volume":"23","author":"Toktay","year":"2020","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"22","key":"10.1016\/j.ejps.2025.107400_bib0055","doi-asserted-by":"crossref","first-page":"18657","DOI":"10.1074\/jbc.M100322200","article-title":"Tumor necrosis factor-\u03b1 inhibits aquaporin 5 expression in mouse lung epithelial cells","volume":"276","author":"Towne","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.ejps.2025.107400_bib0040","doi-asserted-by":"crossref","first-page":"156","DOI":"10.7555\/JBR.31.20170024","article-title":"Fasudil alleviates LPS-induced lung injury by restoring aquaporin 5 expression and inhibiting inflammation in lungs","volume":"33","author":"Wang","year":"2019","journal-title":"J. Biomed. Res."},{"issue":"3","key":"10.1016\/j.ejps.2025.107400_bib0054","doi-asserted-by":"crossref","first-page":"156","DOI":"10.7555\/JBR.31.20170024","article-title":"Fasudil alleviates LPS-induced lung injury by restoring aquaporin 5 expression and inhibiting inflammation in lungs","volume":"33","author":"Wang","year":"2019","journal-title":"J. Biomed. Res."},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0027","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13020-021-00562-8","article-title":"Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1\/M2 polarization through the VIP\/cAMP\/PKA pathway","volume":"17","author":"Wang","year":"2022","journal-title":"Chin. Med."},{"key":"10.1016\/j.ejps.2025.107400_bib0009","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-981-19-7415-1_9","article-title":"Aquaporins in Respiratory system","volume":"1398","author":"Wang","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.ejps.2025.107400_bib0008","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00424-018-2232-y","article-title":"Aquaporins in the lung","volume":"471","author":"Wittekindt","year":"2019","journal-title":"Pfl\u00fcgers Arch. Eur. J. Physiol."},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0061","doi-asserted-by":"crossref","DOI":"10.4238\/gmr.15017377","article-title":"Cyclic adenosine monophosphate-protein kinase A signal pathway may be involved in pulmonary aquaporin-5 expression in ischemia\/reperfusion rats following deep hypothermia cardiac arrest","volume":"15","author":"Wu","year":"2016","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.ejps.2025.107400_bib0032","article-title":"Simvastatin attenuates acute lung injury by activation of A2B adenosine receptor","volume":"422","author":"xia","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"7","key":"10.1016\/j.ejps.2025.107400_bib0059","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1172\/JCI136908","article-title":"IL-1\u03b2 suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury","volume":"130","author":"Xiong","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ejps.2025.107400_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2020.106193","article-title":"Aquaporins in lung health and disease: emerging roles, regulation, and clinical implications","volume":"174","author":"Yadav","year":"2020","journal-title":"Respir. Med."},{"issue":"1","key":"10.1016\/j.ejps.2025.107400_bib0024","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12950-023-00359-6","article-title":"IgG immune complex-induced acute lung injury is ameliorated by cAMP via down-regulation of C\/EBP- and AP-1-mediated transcriptions","volume":"20","author":"Yan","year":"2023","journal-title":"J. Inflamm."},{"issue":"34","key":"10.1016\/j.ejps.2025.107400_bib0062","doi-asserted-by":"crossref","first-page":"32173","DOI":"10.1074\/jbc.M305149200","article-title":"Cyclic AMP regulates aquaporin 5 expression at both transcriptional and post-transcriptional levels through a protein kinase A pathway","volume":"278","author":"Yang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2025.107400_bib0070","article-title":"Ibudilast, a phosphodiesterase-4 inhibitor, ameliorates acute Respiratory distress syndrome in neonatal mice by alleviating inflammation and apoptosis","volume":"26","author":"Yang","year":"2020","journal-title":"Med. Sci. Monit."},{"issue":"2","key":"10.1016\/j.ejps.2025.107400_bib0056","doi-asserted-by":"crossref","first-page":"724","DOI":"10.2353\/ajpath.2010.090282","article-title":"Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-\u03bab and p-c-Jun\/c-fos","volume":"177","author":"Yao","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"20","key":"10.1016\/j.ejps.2025.107400_bib0037","first-page":"1582","article-title":"[Effects and mechanism of fecal transplantation on acute lung injury induced by lipopolysaccharide in rats]","volume":"99","author":"Yin","year":"2019","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.ejps.2025.107400_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.603863","article-title":"Inhibition of inflammation and regulation of AQPs\/ENaCs\/Na+-K+-ATPase mediated alveolar fluid transport by total flavonoids extracted from nervilia fordii in lipopolysaccharide-induced acute lung injury","volume":"12","author":"Yin","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.ejps.2025.107400_bib0007","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1097\/MBC.0000000000000133","article-title":"miR-96 and miR-330 overexpressed and targeted AQP5 in lipopolysaccharide-induced rat lung damage of disseminated intravascular coagulation","volume":"25","author":"Zhang","year":"2014","journal-title":"Blood Coagul. Fibrinol."},{"issue":"10","key":"10.1016\/j.ejps.2025.107400_bib0028","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20187579","article-title":"Saquinavir plus methylprednisolone ameliorates experimental acute lung injury","volume":"51","author":"Zhang","year":"2018","journal-title":"Brazilian J. Med. Biol. Res."},{"issue":"14","key":"10.1016\/j.ejps.2025.107400_bib0012","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1055\/s-0041-1724001","article-title":"Influence of alveolar fluid on aquaporins and Na+\/K+-ATPase and its possible theoretical or clinical significance","volume":"29","author":"Zong","year":"2022","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.ejps.2025.107400_bib0017","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.pharmthera.2019.02.002","article-title":"Phosphodiesterases as therapeutic targets for respiratory diseases","volume":"197","author":"Zuo","year":"2019","journal-title":"Pharmacol. Ther."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098725003975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098725003975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:57:20Z","timestamp":1768384640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098725003975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":73,"alternative-id":["S0928098725003975"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2025.107400","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The relationship between PDE4 and AQP5 in lung tissue under inflammatory conditions: An experimental study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2025.107400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107400"}}