{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:31:38Z","timestamp":1793028698749,"version":"4.5.0"},"reference-count":168,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ejps.2026.107506","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:24:42Z","timestamp":1773854682000},"page":"107506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Smart lipid-based nanocarrier system for the topical delivery of ocular therapeutics bio-interfacing, physicochemical diversity, and routing barriers"],"prefix":"10.1016","volume":"225","author":[{"given":"Manisha","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Punya","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rbanshi","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandini","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashi","family":"Rajput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Dua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Chitranshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2026.107506_bib0105","article-title":"In vitro optimization, characterization and anti-tumor evaluation against colorectal cancer of a novel 5-fluorouracil oral nanosuspension using soy protein, polysaccharides-protein complexation, and in-situ gel formation","volume":"67","author":"Abdullah","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"Pt B","key":"10.1016\/j.ejps.2026.107506_bib0124","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ejpb.2015.01.026","article-title":"Biopharmaceutical profile of pranoprofen-loaded PLGA nanoparticles containing hydrogels for ocular administration","volume":"95","author":"Abrego","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"6","key":"10.1016\/j.ejps.2026.107506_bib0013","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/jbm.a.34453","article-title":"Part I: development and optimization of solid-lipid nanoparticles using Box-Behnken statistical design for ocular delivery of gatifloxacin","volume":"101","author":"Abul Kalam","year":"2013","journal-title":"J. Biomed. Mater. Res. a"},{"key":"10.1016\/j.ejps.2026.107506_bib0139","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.msec.2019.03.060","article-title":"Optimization by design of etoposide loaded solid lipid nanoparticles for ocular delivery: characterization, pharmacokinetic and deposition study","volume":"100","author":"Ahmad","year":"2019","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl."},{"issue":"13","key":"10.1016\/j.ejps.2026.107506_bib0001","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.3390\/jcm11133643","article-title":"Prevalence of comorbidity between dry eye and allergic conjunctivitis: a systematic review and meta-analysis","volume":"11","author":"Akasaki","year":"2022","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.ejps.2026.107506_bib0002","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/gels8020082","article-title":"Drug delivery challenges and current progress in nanocarrier-based ocular therapeutic system","volume":"8","author":"Akhter","year":"2022","journal-title":"Gels."},{"issue":"2","key":"10.1016\/j.ejps.2026.107506_bib0120","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15020681","article-title":"Recent progress in Chitosan-based nanomedicine for its ocular application in Glaucoma","volume":"15","author":"Albarqi","year":"2023","journal-title":"Pharmaceutics."},{"issue":"2","key":"10.1016\/j.ejps.2026.107506_bib0043","doi-asserted-by":"crossref","DOI":"10.3390\/ph16020258","article-title":"Fabrication of Celecoxib PVP microparticles stabilized by Gelucire 48\/16 via electrospraying for enhanced anti-inflammatory action","volume":"16","author":"Alshawwa","year":"2023","journal-title":"Pharmaceuticals. (Basel)"},{"issue":"9","key":"10.1016\/j.ejps.2026.107506_bib0091","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1016\/j.xphs.2016.03.006","article-title":"\u03b1-lipoic acid in soluplus(\u00ae) polymeric nanomicelles for ocular treatment of diabetes-associated corneal diseases","volume":"105","author":"Alvarez-Rivera","year":"2016","journal-title":"J. Pharm. Sci."},{"issue":"20","key":"10.1016\/j.ejps.2026.107506_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012102","article-title":"Lipid-based nanoparticulate systems for the ocular delivery of bioactives with anti-inflammatory properties","volume":"23","author":"Ana","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejps.2026.107506_bib0048","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/ICO.0000000000000825","article-title":"Voriconazole-loaded nanostructured lipid carriers for ocular drug delivery","volume":"35","author":"Andrade","year":"2016","journal-title":"Cornea"},{"issue":"1\u20132","key":"10.1016\/j.ejps.2026.107506_bib0173","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ijpharm.2014.02.038","article-title":"A novel gene therapy vector based on hyaluronic acid and solid lipid nanoparticles for ocular diseases","volume":"465","author":"Apaolaza","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0093","article-title":"Piperine loaded drug delivery systems for improved biomedical applications: current status and future directions","volume":"9","author":"Arora","year":"2023","journal-title":"Health Sci. Rev."},{"key":"10.1016\/j.ejps.2026.107506_bib0047","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jconrel.2020.05.017","article-title":"Design of ocular drug delivery platforms and in vitro - in vivo evaluation of riboflavin to the cornea by non-interventional (epi-on) technique for keratoconus treatment","volume":"324","author":"Aytekin","year":"2020","journal-title":"J. Control Release"},{"issue":"1","key":"10.1016\/j.ejps.2026.107506_bib0027","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/02652040902846883","article-title":"Cyclosporine-A incorporated cationic solid lipid nanoparticles for ocular delivery","volume":"27","author":"Ba\u015faran","year":"2010","journal-title":"J. Microencapsul."},{"issue":"11","key":"10.1016\/j.ejps.2026.107506_bib0089","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s13205-024-04116-1","article-title":"Augmentation of antifungal activity of fluconazole using a clove oil nanoemulgel formulation optimized by factorial randomized D-optimal design","volume":"14","author":"Badr-Eldin","year":"2024","journal-title":"3. Biotech."},{"issue":"1","key":"10.1016\/j.ejps.2026.107506_bib0063","doi-asserted-by":"crossref","DOI":"10.3390\/gels11010019","article-title":"Layer-by-Layer biopolymer-coated deformable liposomes-In situ gel: a hybrid strategy for enhanced ocular delivery of itraconazole: in vitro and In vivo appraisal","volume":"11","author":"Badran","year":"2024","journal-title":"Gels."},{"key":"10.1016\/j.ejps.2026.107506_bib0012","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijbiomac.2015.12.077","article-title":"Application of Box-Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: optimization, in vitro release, ocular tolerance, and antibacterial activity","volume":"85","author":"Baig","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejps.2026.107506_bib0025","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejpb.2016.10.015","article-title":"Topical ophthalmic lipid nanoparticle formulations (SLN, NLC) of indomethacin for delivery to the posterior segment ocular tissues","volume":"109","author":"Balguri","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1\u20132","key":"10.1016\/j.ejps.2026.107506_bib0053","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijpharm.2017.06.042","article-title":"Ocular disposition of ciprofloxacin from topical, PEGylated nanostructured lipid carriers: effect of molecular weight and density of poly (ethylene) glycol","volume":"529","author":"Balguri","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0094","article-title":"Native\/modified dextran-based nanogel in delivering drug and management of ocular complications: a review","author":"Basu","year":"2025","journal-title":"Z. Naturforsch. C. J. Biosci."},{"issue":"4","key":"10.1016\/j.ejps.2026.107506_bib0151","doi-asserted-by":"crossref","DOI":"10.1016\/j.jscs.2024.101896","article-title":"Antimicrobial nanoemulsion: a futuristic approach in antibacterial drug delivery system","volume":"28","author":"Begum Jp","year":"2024","journal-title":"J. Saudi Chem. Soc."},{"issue":"22","key":"10.1016\/j.ejps.2026.107506_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e38777","article-title":"Ciprofloxacin hydrochloride-loaded ocular silk fibroin liposomes: formulation, characterisation, in vitro cytotoxicity, and antimicrobial activity","volume":"10","author":"Bhat","year":"2024","journal-title":"Heliyon."},{"issue":"4","key":"10.1016\/j.ejps.2026.107506_bib0156","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s13346-022-01266-8","article-title":"Cationic liposomes as promising vehicles for timolol\/brimonidine combination ocular delivery in glaucoma: formulation development and in vitro\/in vivo evaluation","volume":"13","author":"Bigdeli","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ejps.2026.107506_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124222","article-title":"Novel nanostructured lipid carriers loading apigenin for anterior segment ocular pathologies","volume":"658","author":"Bonilla-Vidal","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.125160","article-title":"Combination of Apigenin and Melatonin with nanostructured lipid carriers as anti-inflammatory ocular treatment","volume":"670","author":"Bonilla-Vidal","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.ejps.2026.107506_bib0134","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1089\/jop.2022.0030","article-title":"Pharmacokinetics of Sirolimus in a novel liposome delivery system in selected ocular tissues and plasma following a single subconjunctival injection in Dutch belted rabbits","volume":"38","author":"Brooks","year":"2022","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2026.107506_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2024.105785","article-title":"Insights into ocular therapeutics: a comprehensive review of anatomy, barriers, diseases and nanoscale formulations for targeted drug delivery","author":"Chandel","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejps.2026.107506_bib0126","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106327","article-title":"Corrigendum to 'A novel sustained release fluoride strip based poly (propylene carbonate) for preventing caries' [European Journal of Pharmaceutical Sciences 171 (2022)106128]","volume":"181","author":"Chen","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2026.107506_bib0170","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ejpb.2023.04.012","article-title":"Ocular permeability, intraocular biodistribution of lipid nanocapsule formulation intended for retinal drug delivery","volume":"187","author":"Christensen","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124300","article-title":"In vitro and in vivo studies of ocular topically administered NLC for the treatment of uveal melanoma","volume":"660","author":"Cimino","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.ejps.2026.107506_bib0099","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s10096-015-2344-7","article-title":"Potential chitosan-coated alginate nanoparticles for ocular delivery of daptomycin","volume":"34","author":"Costa","year":"2015","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ejps.2026.107506_bib0092","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.112274","article-title":"Electrografted anthraquinone to monitor pH at the biofilm-anode interface in a wastewater microbial fuel cell","volume":"210","author":"Costa","year":"2022","journal-title":"Colloids. Surf. B Biointerfaces."},{"key":"10.1016\/j.ejps.2026.107506_bib0102","article-title":"Lipid-based nanocarriers for ocular drug delivery: an updated review","volume":"76","author":"Das","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"7","key":"10.1016\/j.ejps.2026.107506_bib0113","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/17435889.2025.2463867","article-title":"Polyol-modified deformable liposomes fortified contact lenses for improved ocular permeability","volume":"20","author":"Dave","year":"2025","journal-title":"Nanomedicine (Lond)"},{"issue":"17","key":"10.1016\/j.ejps.2026.107506_bib0096","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.3390\/polym14173580","article-title":"Current advances in nano-based and polymeric stimuli-responsive drug delivery targeting the ocular microenvironment: a review and envisaged future perspectives","volume":"14","author":"Dludla","year":"2022","journal-title":"Polymers. (Basel)"},{"key":"10.1016\/j.ejps.2026.107506_bib0107","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.ijbiomac.2020.07.306","article-title":"Polypeptide and glycosaminoglycan polysaccharide as stabilizing polymers in nanocrystals for a safe ocular hypotensive effect","volume":"162","author":"Donia","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.ejps.2026.107506_bib0082","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2478\/acph-2019-0054","article-title":"In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery","volume":"69","author":"Dukovski","year":"2019","journal-title":"Acta Pharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-019-1371-6","article-title":"Development, optimization, and in vitro\/in vivo characterization of enhanced lipid nanoparticles for ocular delivery of ofloxacin: the influence of pegylation and chitosan coating","volume":"20","author":"Eid","year":"2019","journal-title":"AAPS. PharmSciTech."},{"issue":"5","key":"10.1016\/j.ejps.2026.107506_bib0015","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1208\/s12249-019-1371-6","article-title":"Development, optimization, and In vitro\/In vivo characterization of enhanced lipid nanoparticles for ocular delivery of ofloxacin: the influence of pegylation and chitosan coating","volume":"20","author":"Eid","year":"2019","journal-title":"AAPS. PharmSciTech."},{"key":"10.1016\/j.ejps.2026.107506_bib0028","doi-asserted-by":"crossref","first-page":"7775","DOI":"10.2147\/IJN.S335482","article-title":"Formulation and pathohistological study of mizolastine-solid lipid nanoparticles-loaded ocular hydrogels","volume":"16","author":"El-Emam","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejps.2026.107506_bib0056","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124508","article-title":"Augmented ocular uptake and anti-inflammatory efficacy of decorated Genistein-loaded NLCs incorporated in in situ gel","volume":"662","author":"Elmanawy","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"9","key":"10.1016\/j.ejps.2026.107506_bib0032","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jsps.2021.07.015","article-title":"Nanostructured lipid carriers (NLCs) as drug delivery platform: advances in formulation and delivery strategies","volume":"29","author":"Elmowafy","year":"2021","journal-title":"Saudi. Pharm. J."},{"issue":"10","key":"10.1016\/j.ejps.2026.107506_bib0149","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1177\/08853282251324619","article-title":"Dexamethasone loaded blend poly hydroxybutyrate-stearic acid nanoparticles for ocular inflammation","volume":"39","author":"Erdal","year":"2025","journal-title":"J. Biomater. Appl."},{"issue":"8","key":"10.1016\/j.ejps.2026.107506_bib0070","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1167\/tvst.12.8.20","article-title":"Active transport and ocular distribution of intravitreally injected liposomes","volume":"12","author":"Eriksen","year":"2023","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.ejps.2026.107506_bib0069","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.2147\/IJN.S452134","article-title":"Microfluidic fabricated liposomes for Nutlin-3a ocular delivery as potential candidate for proliferative vitreoretinal diseases treatment","volume":"19","author":"Esposito","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejps.2026.107506_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121938","article-title":"Customized cationic nanoemulsions loading triamcinolone acetonide for corneal neovascularization secondary to inflammatory processes","volume":"623","author":"Fernandes","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.ejps.2026.107506_bib0010","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/08982104.2016.1224899","article-title":"Ocular amphotericin B delivery by chitosan-modified nanostructured lipid carriers for fungal keratitis-targeted therapy","volume":"27","author":"Fu","year":"2017","journal-title":"J. Liposome Res."},{"issue":"3","key":"10.1016\/j.ejps.2026.107506_bib0046","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/08982104.2016.1224899","article-title":"Ocular amphotericin B delivery by chitosan-modified nanostructured lipid carriers for fungal keratitis-targeted therapy","volume":"27","author":"Fu","year":"2017","journal-title":"J. Liposome Res."},{"issue":"11","key":"10.1016\/j.ejps.2026.107506_bib0162","doi-asserted-by":"crossref","first-page":"996","DOI":"10.3109\/02713680903261405","article-title":"Cyclosporine a-loaded solid lipid nanoparticles: ocular tolerance and in vivo drug release in rabbit eyes","volume":"34","author":"G\u00f6k\u00e7e","year":"2009","journal-title":"Curr. Eye Res."},{"issue":"7","key":"10.1016\/j.ejps.2026.107506_bib0143","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.3390\/pharmaceutics15071862","article-title":"Innovative strategies for drug delivery to the ocular posterior segment","volume":"15","author":"Gabai","year":"2023","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.ejps.2026.107506_bib0011","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1007\/s13346-020-00843-z","article-title":"Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives","volume":"11","author":"Gaballa","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"issue":"5","key":"10.1016\/j.ejps.2026.107506_bib0042","doi-asserted-by":"crossref","DOI":"10.3390\/gels8050255","article-title":"Formulation and evaluation of nano lipid carrier-based ocular gel system: optimization to antibacterial activity","volume":"8","author":"Gilani","year":"2022","journal-title":"Gels."},{"issue":"15","key":"10.1016\/j.ejps.2026.107506_bib0160","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.2174\/1389201021666200519133350","article-title":"Formulation and evaluation of atorvastatin calcium-poly-\u03b5-caprolactone nanoparticles loaded ocular inserts for sustained release and antiinflammatory efficacy","volume":"21","author":"Girgis","year":"2020","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.ejps.2026.107506_bib0101","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jconrel.2022.07.021","article-title":"Nano-sponge-like liposomes remove cholesterol crystals for antiatherosclerosis","volume":"349","author":"Gong","year":"2022","journal-title":"J. Control Release"},{"key":"10.1016\/j.ejps.2026.107506_bib0103","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114770","article-title":"Polymer- and lipid-based nanocarriers for ocular drug delivery: current status and future perspectives","volume":"196","author":"Han","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.ejps.2026.107506_bib0024","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1089\/jop.2012.0069","article-title":"Indomethacin-loaded solid lipid nanoparticles for ocular delivery: development, characterization, and in vitro evaluation","volume":"29","author":"Hippalgaonkar","year":"2013","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2026.107506_bib0114","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jconrel.2024.02.043","article-title":"Mucoadhesive liposomal delivery system synergizing anti-inflammation and anti-oxidation for enhanced treatment against dry eye disease","volume":"368","author":"Huang","year":"2024","journal-title":"J. Controll. Release"},{"key":"10.1016\/j.ejps.2026.107506_bib0006","doi-asserted-by":"crossref","first-page":"7579","DOI":"10.2147\/IJN.S518643","article-title":"Recent achievements and perspectives in smart nano-in-micro platforms for ocular disease treatment","author":"Huang","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejps.2026.107506_bib0132","article-title":"Nanomedicine in glaucoma treatment; current challenges and future perspectives","volume":"28","author":"Iqbal","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.ejps.2026.107506_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119402","article-title":"Nanoemulsion as a feasible and biocompatible carrier for ocular delivery of travoprost: improved pharmacokinetic\/pharmacodynamic properties","volume":"583","author":"Ismail","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0079","first-page":"6133","article-title":"Nanoemulsions based therapeutic strategies: enhancing targeted drug delivery against breast cancer cells","author":"Izadiyan","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejps.2026.107506_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120701","article-title":"Niclosamide inhalation powder made by thin-film freezing: multi-dose tolerability and exposure in rats and pharmacokinetics in hamsters","volume":"603","author":"Jara","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0158","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jconrel.2021.05.017","article-title":"Oral delivery of topotecan in polymeric nanoparticles: lymphatic distribution and pharmacokinetics","volume":"335","author":"Jeong","year":"2021","journal-title":"J. Control Release"},{"issue":"6","key":"10.1016\/j.ejps.2026.107506_bib0067","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1167\/iovs.66.6.56","article-title":"Liposome encapsulation enhances Ripasudil therapeutic efficacy against proliferative vitreoretinal diseases: implications in advanced ocular treatment","volume":"66","author":"Ji","year":"2025","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"12","key":"10.1016\/j.ejps.2026.107506_bib0075","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1007\/s13346-023-01376-x","article-title":"Nano-composite system of traditional Chinese medicine for ocular applications: molecular docking and three-dimensional modeling insight for intelligent drug evaluation","volume":"13","author":"Jiao","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"issue":"8","key":"10.1016\/j.ejps.2026.107506_bib0118","article-title":"Gatifloxacin loaded nano lipid carriers for the management of bacterial conjunctivitis","volume":"12","author":"Joshi","year":"2023","journal-title":"Antibiotics. (Basel)"},{"key":"10.1016\/j.ejps.2026.107506_bib0167","doi-asserted-by":"crossref","DOI":"10.1080\/17425247.2025.2516668","article-title":"Tyrosine kinase inhibitors and their promising role in treating diabetic retinopathy and other retinal vascular diseases: overview of their routes of administration, pharmacokinetics, formulations, and drug delivery applications","author":"Kadavil","year":"2025","journal-title":"Expert. Opin. Drug Deliv."},{"issue":"1","key":"10.1016\/j.ejps.2026.107506_bib0110","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ijpharm.2015.08.088","article-title":"Lipid-polyethylene glycol based nano-ocular formulation of ketoconazole","volume":"495","author":"Kakkar","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.ejps.2026.107506_bib0017","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1080\/1061186X.2020.1871483","article-title":"Lipo-PEG nano-ocular formulation successfully encapsulates hydrophilic fluconazole and traverses corneal and non-corneal path to reach posterior eye segment","volume":"29","author":"Kakkar","year":"2021","journal-title":"J. Drug Target."},{"issue":"3","key":"10.1016\/j.ejps.2026.107506_bib0014","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/10611860903338462","article-title":"Preparation, characterization, and evaluation of gatifloxacin loaded solid lipid nanoparticles as colloidal ocular drug delivery system","volume":"18","author":"Kalam","year":"2010","journal-title":"J. Drug Target."},{"issue":"3","key":"10.1016\/j.ejps.2026.107506_bib0097","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1007\/s13346-020-00810-8","article-title":"Topical instillation of triamcinolone acetonide-loaded emulsomes for posterior ocular delivery: statistical optimization and in vitro-in vivo studies","volume":"11","author":"Kapadia","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ejps.2026.107506_bib0020","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.2147\/IJN.S190502","article-title":"Natamycin solid lipid nanoparticles - sustained ocular delivery system of higher corneal penetration against deep fungal keratitis: preparation and optimization","volume":"14","author":"Khames","year":"2019","journal-title":"Int. J. Nanomed."},{"issue":"13","key":"10.1016\/j.ejps.2026.107506_bib0144","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.2174\/1381612824666180403115106","article-title":"Systematic development and optimization of an in-situ gelling system for moxifloxacin ocular nanosuspension using high-pressure homogenization with an improved encapsulation efficiency","volume":"24","author":"Khurana","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejps.2026.107506_bib0066","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jtos.2022.03.003","article-title":"Non-invasive high-contrast imaging of conjunctival goblet cells for the precision diagnosis of ocular surface diseases","volume":"24","author":"Kim","year":"2022","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.ejps.2026.107506_bib0164","doi-asserted-by":"crossref","DOI":"10.2169\/internalmedicine.4657-24","article-title":"Disseminated fusariosis successfully treated with empirical liposomal amphotericin B and voriconazole combination followed by ocular therapy in an allogenic hematopoietic stem cell transplant recipient","author":"Kishida","year":"2025","journal-title":"Intern. Med."},{"key":"10.1016\/j.ejps.2026.107506_bib0169","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejps.2017.10.023","article-title":"Development of copolymeric nanoparticles of hypocrellin B: enhanced phototoxic effect and ocular distribution","volume":"116","author":"Krishnaswami","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"issue":"7","key":"10.1016\/j.ejps.2026.107506_bib0019","doi-asserted-by":"crossref","first-page":"A613","DOI":"10.1016\/j.jval.2014.08.2153","article-title":"Fabrication of voriconazole solid lipid nanoparticles for effective ocular delivery","volume":"17","author":"Kumar","year":"2014","journal-title":"Value Health"},{"issue":"12","key":"10.1016\/j.ejps.2026.107506_bib0018","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1080\/03639045.2016.1185437","article-title":"Solid lipid nanoparticle: an efficient carrier for improved ocular permeation of voriconazole","volume":"42","author":"Kumar","year":"2016","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"3","key":"10.1016\/j.ejps.2026.107506_bib0029","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1208\/s12249-016-0575-2","article-title":"Lipid nanocarrier: an efficient approach towards ocular delivery of hydrophilic drug (Valacyclovir)","volume":"18","author":"Kumar","year":"2017","journal-title":"AAPS. PharmSciTech."},{"issue":"3","key":"10.1016\/j.ejps.2026.107506_bib0007","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ddr.21758","article-title":"Surface receptor-mediated targeted drug delivery systems for enhanced cancer treatment: a state-of-the-art review","volume":"82","author":"Kunjiappan","year":"2021","journal-title":"Drug Dev. Res."},{"issue":"7","key":"10.1016\/j.ejps.2026.107506_bib0059","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/17425247.2021.1872542","article-title":"Liposomes as vehicles for topical ophthalmic drug delivery and ocular surface protection","volume":"18","author":"L\u00f3pez-Cano","year":"2021","journal-title":"Expert. Opin. Drug Deliv."},{"issue":"3","key":"10.1016\/j.ejps.2026.107506_bib0106","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3109\/10837450.2012.705298","article-title":"Preparation and characterization of polymeric and lipid nanoparticles of pilocarpine HCl for ocular application","volume":"18","author":"L\u00fctfi","year":"2013","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.ejps.2026.107506_bib0041","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jddst.2018.07.010","article-title":"Curcumin-loaded nanostructured lipid carriers for ocular drug delivery: design optimization and characterization","volume":"47","author":"Lakhani","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejps.2026.107506_bib0138","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118771","article-title":"Optimization, stabilization, and characterization of amphotericin B loaded nanostructured lipid carriers for ocular drug delivery","volume":"572","author":"Lakhani","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ejps.2026.107506_bib0068","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0279462","article-title":"Nanoparticle ocular immunotherapy for herpesvirus surface eye infections evaluated in cat infection model","volume":"18","author":"Lappin","year":"2023","journal-title":"PLoS. One"},{"issue":"1\u20132","key":"10.1016\/j.ejps.2026.107506_bib0104","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijpharm.2014.04.061","article-title":"Influence of different surfactants on the technological properties and in vivo ocular tolerability of lipid nanoparticles","volume":"470","author":"Leonardi","year":"2014","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ejps.2026.107506_bib0154","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijpharm.2014.11.032","article-title":"Cationic solid lipid nanoparticles enhance ocular hypotensive effect of melatonin in rabbit","volume":"478","author":"Leonardi","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.ejps.2026.107506_bib0146","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3109\/03639045.2013.795582","article-title":"Preparation and evaluation of charged solid lipid nanoparticles of tetrandrine for ocular drug delivery system: pharmacokinetics, cytotoxicity and cellular uptake studies","volume":"40","author":"Li","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0052","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejpb.2017.08.013","article-title":"Transport mechanism of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan decorated coumarin-6 loaded nanostructured lipid carriers across the rabbit ocular","volume":"120","author":"Li","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0051","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.ijbiomac.2020.04.115","article-title":"Trimethyl chitosan nanoparticles for ocular baicalein delivery: preparation, optimization, in vitro evaluation, in vivo pharmacokinetic study and molecular dynamics simulation","volume":"156","author":"Li","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.ejps.2026.107506_bib0161","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/APO.0000000000000352","article-title":"A review of local therapy for the management of cystoid macular edema in uveitis","volume":"10","author":"Li","year":"2021","journal-title":"Asia-Pac. J. Ophthalmol."},{"key":"10.1016\/j.ejps.2026.107506_bib0022","doi-asserted-by":"crossref","first-page":"7847","DOI":"10.2147\/IJN.S340068","article-title":"Assessment to the antifungal effects in vitro and the ocular pharmacokinetics of solid-lipid nanoparticle in rabbits","volume":"16","author":"Liang","year":"2021","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"10.1016\/j.ejps.2026.107506_bib0031","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3109\/03639045.2010.522193","article-title":"Preparation and evaluation of solid lipid nanoparticles of baicalin for ocular drug delivery system in vitro and in vivo","volume":"37","author":"Liu","year":"2011","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121969","article-title":"Effective suppression of triple negative breast cancer by paclitaxel nanoparticles conjugated with transmembrane TNF-\u03b1 monoclonal antibody","volume":"624","author":"Liu","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0071","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120960","article-title":"In vitro and in vivo assessment of structural integrity for HPCD complex@liposome nanocomposites from ocular surface to the posterior segment of the eye","volume":"315","author":"Lu","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"9","key":"10.1016\/j.ejps.2026.107506_bib0062","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1080\/20415990.2024.2379756","article-title":"A novel liposomal formulation for ocular delivery of caspofungin: an experimental study by quality by design-based approach","volume":"15","author":"Macwan","year":"2024","journal-title":"Ther. Deliv."},{"issue":"2","key":"10.1016\/j.ejps.2026.107506_bib0004","doi-asserted-by":"crossref","first-page":"88","DOI":"10.18231\/j.jpbs.2021.012","article-title":"Ocular drug delivery system (ODDS): exploration the challenges and approaches to improve ODDS","volume":"9","author":"Mandal","year":"2021","journal-title":"J. Pharmaceut. Biol. Sci."},{"key":"10.1016\/j.ejps.2026.107506_bib0148","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2025.114739","article-title":"Poloxamer407\/gellan gum-based in situ hydrogels for ocular co-delivery of antibiotics and corticosteroids","volume":"213","author":"Marandi","year":"2025","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"8","key":"10.1016\/j.ejps.2026.107506_bib0145","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.2174\/1567201813666160325131831","article-title":"Quality by design applied to ocular solid lipid nanoparticles containing a hydrophilic peptide prepared via hot high pressure homogeniser","volume":"13","author":"Mercuri","year":"2016","journal-title":"Curr. Drug Deliv."},{"issue":"4","key":"10.1016\/j.ejps.2026.107506_bib0021","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3109\/10837450.2014.882935","article-title":"Development and characterization of itraconazole-loaded solid lipid nanoparticles for ocular delivery","volume":"20","author":"Mohanty","year":"2015","journal-title":"Pharm. Dev. Technol."},{"issue":"45","key":"10.1016\/j.ejps.2026.107506_bib0112","doi-asserted-by":"crossref","first-page":"13870","DOI":"10.1021\/acs.langmuir.2c02086","article-title":"Maleimide-decorated PEGylated mucoadhesive liposomes for ocular drug delivery","volume":"38","author":"Moiseev","year":"2022","journal-title":"Langmuir."},{"issue":"4","key":"10.1016\/j.ejps.2026.107506_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13040523","article-title":"Clarithromycin solid lipid nanoparticles for topical ocular therapy: optimization, evaluation and In vivo studies","volume":"13","author":"Nair","year":"2021","journal-title":"Pharmaceutics."},{"issue":"6","key":"10.1016\/j.ejps.2026.107506_bib0159","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/02652048.2023.2215326","article-title":"Enhancement of ocular anti-glaucomic activity of agomelatine through fabrication of hyaluronic acid modified-elastosomes: formulation, statistical optimisation, in vitro characterisation, histopathological study, and in vivo assessment","volume":"40","author":"Nemr","year":"2023","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.ejps.2026.107506_bib0165","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.2147\/OPTH.S360929","article-title":"Liposomal ozonated oil in ocular infections: a review of preclinical and clinical studies, focusing on its antiseptic and regenerative properties","volume":"16","author":"P\u00e9rez-Santonja","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.ejps.2026.107506_bib0117","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119095","article-title":"Chitosan oligosaccharide enhances binding of nanostructured lipid carriers to ocular mucins: effect on ocular disposition","volume":"577","author":"Pai","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0057","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jconrel.2019.07.037","article-title":"Exploring molecular dynamics simulation to predict binding with ocular mucin: an in silico approach for screening mucoadhesive materials for ocular retentive delivery systems","volume":"309","author":"Pai","year":"2019","journal-title":"J. Control Release"},{"issue":"8","key":"10.1016\/j.ejps.2026.107506_bib0045","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1016\/j.xphs.2018.04.014","article-title":"Formulation development, optimization, and In Vitro-In vivo characterization of natamycin-loaded PEGylated nano-lipid carriers for ocular applications","volume":"107","author":"Patil","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2026.107506_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113560","article-title":"mPEG-CS-modified flexible liposomes-reinforced thermosensitive sol-gel reversible hydrogels for ocular delivery of multiple drugs with enhanced synergism","volume":"231","author":"Peng","year":"2023","journal-title":"Colloids. Surf. B Biointerfaces."},{"key":"10.1016\/j.ejps.2026.107506_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112805","article-title":"Enhanced and sustained transdermal delivery of primaquine from polymeric thermoresponsive hydrogels in combination with Dermarollers\u00ae","volume":"219","author":"Permana","year":"2022","journal-title":"Colloids. Surf. B Biointerfaces."},{"key":"10.1016\/j.ejps.2026.107506_bib0086","article-title":"Porous alumina as potential nanostructures for drug delivery applications, synthesis and characteristics","volume":"77","author":"Pourmadadi","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"1","key":"10.1016\/j.ejps.2026.107506_bib0109","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/acsomega.2c05976","article-title":"Surface modification of lipid-based nanocarriers: a potential approach to enhance targeted drug delivery","volume":"8","author":"Priya","year":"2022","journal-title":"ACS. Omega"},{"issue":"2","key":"10.1016\/j.ejps.2026.107506_bib0141","doi-asserted-by":"crossref","DOI":"10.3390\/nano10020287","article-title":"Ocular formulation based on palmitoylethanolamide-loaded nanostructured lipid carriers: technological and pharmacological profile","volume":"10","author":"Puglia","year":"2020","journal-title":"Nanomaterials. (Basel)"},{"issue":"6","key":"10.1016\/j.ejps.2026.107506_bib0122","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1208\/s12249-016-0672-2","article-title":"Ocular disposition of \u2206(8)-tetrahydrocannabinol from various topical ophthalmic formulations","volume":"18","author":"Punyamurthula","year":"2017","journal-title":"AAPS. PharmSciTech."},{"key":"10.1016\/j.ejps.2026.107506_bib0157","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121886","article-title":"Improved dissolution of an enteric polymer and its amorphous solid dispersions by polymer salt formation","volume":"622","author":"Qi","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"8","key":"10.1016\/j.ejps.2026.107506_bib0152","article-title":"Advancing ocular medication delivery with nano-engineered solutions: a comprehensive review of innovations, obstacles, and clinical impact","volume":"16","author":"Rajan","year":"2024","journal-title":"Cureus."},{"key":"10.1016\/j.ejps.2026.107506_bib0168","article-title":"Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: a promising approach towards treating diabetic retinopathy","volume":"7","author":"Ramadan","year":"2024","journal-title":"Int. J. Pharm. X."},{"issue":"7","key":"10.1016\/j.ejps.2026.107506_bib0005","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.3390\/pharmaceutics15071944","article-title":"Lipid-based delivery systems for flavonoids and flavonolignans: liposomes, nanoemulsions, and solid lipid nanoparticles","volume":"15","author":"Ranjbar","year":"2023","journal-title":"Pharmaceutics."},{"issue":"5","key":"10.1016\/j.ejps.2026.107506_bib0111","doi-asserted-by":"crossref","DOI":"10.1002\/asia.202400933","article-title":"Antibacterial lecithin\/chitosan nanoparticles for the sustained release of ciprofloxacin to treat ocular bacterial infections","volume":"20","author":"Rasool","year":"2025","journal-title":"Chem. Asian J."},{"issue":"3","key":"10.1016\/j.ejps.2026.107506_bib0055","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/03639045.2020.1724135","article-title":"Systematic implementation of quality-by-design (QbD) to develop NSAID-loaded nanostructured lipid carriers for ocular application: preformulation screening studies and statistical hybrid-design for optimization of variables","volume":"46","author":"Rathod","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"2","key":"10.1016\/j.ejps.2026.107506_bib0081","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/1872213X12666180730115225","article-title":"Impact of ocular compatible lipoids and Castor oil in fabrication of brimonidine tartrate nanoemulsions by 3(3) full factorial design","volume":"12","author":"Rimple","year":"2018","journal-title":"Recent. Pat. Inflamm. Allergy Drug Discov."},{"issue":"13","key":"10.1016\/j.ejps.2026.107506_bib0119","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11133719","article-title":"Lipid, aqueous and mucin tear film layer stability and permanence within 0.15% liposome crosslinked hyaluronic acid versus 0.15% non-crosslinked hyaluronic acid measured with a novel non-invasive ocular surface analyzer","volume":"11","author":"S\u00e1nchez-Gonz\u00e1lez","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ejps.2026.107506_bib0061","article-title":"Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires","volume":"11","author":"S\u00e1nchez-Gonz\u00e1lez","year":"2024","journal-title":"Front. Med. (Lausanne)"},{"issue":"3","key":"10.1016\/j.ejps.2026.107506_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.clae.2025.102368","article-title":"Diversity and composition of ocular microbiota in contact lens wearers: efficacy of liposomal ozonated oil","volume":"48","author":"S\u00e1nchez-Gonz\u00e1lez","year":"2025","journal-title":"Cont. Lens. Anterior. Eye"},{"issue":"3","key":"10.1016\/j.ejps.2026.107506_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15030951","article-title":"Nanostructured lipid carriers aimed to the ocular delivery of mangiferin: in vitro evidence","volume":"15","author":"Santonocito","year":"2023","journal-title":"Pharmaceutics."},{"issue":"10","key":"10.1016\/j.ejps.2026.107506_bib0073","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1039\/D4NA01086H","article-title":"Development and in vitro and ex vivo characterization of a twin nanoparticulate system to enhance ocular absorption and prolong retention of dexamethasone in the eye: from lab to pilot scale optimization","volume":"7","author":"Sarfraz","year":"2025","journal-title":"Nanoscale Adv."},{"issue":"7","key":"10.1016\/j.ejps.2026.107506_bib0153","doi-asserted-by":"crossref","DOI":"10.3390\/ph16071001","article-title":"Ocular delivery of bimatoprost-loaded solid lipid nanoparticles for effective management of glaucoma","volume":"16","author":"Satyanarayana","year":"2023","journal-title":"Pharmaceuticals. (Basel)"},{"issue":"4","key":"10.1016\/j.ejps.2026.107506_bib0050","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1089\/adt.2018.898","article-title":"Repositioning of itraconazole for the management of ocular neovascularization through surface-modified nanostructured lipid carriers","volume":"17","author":"Selvaraj","year":"2019","journal-title":"Assay. Drug Dev. Technol."},{"issue":"4","key":"10.1016\/j.ejps.2026.107506_bib0030","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3109\/03639045.2012.665460","article-title":"Development of solid lipid nanoparticles and nanostructured lipid carriers for improving ocular delivery of acyclovir","volume":"39","author":"Seyfoddin","year":"2013","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"5","key":"10.1016\/j.ejps.2026.107506_bib0087","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11050230","article-title":"Nanoemulsion based vehicle for effective ocular delivery of moxifloxacin using experimental design and pharmacokinetic study in rabbits","volume":"11","author":"Shah","year":"2019","journal-title":"Pharmaceutics."},{"issue":"9","key":"10.1016\/j.ejps.2026.107506_bib0023","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1080\/10717544.2016.1183720","article-title":"Fabrication and evaluation of lipid nanoparticulates for ocular delivery of a COX-2 inhibitor","volume":"23","author":"Sharma","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejps.2026.107506_bib0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124762","article-title":"Strategic development of aceclofenac loaded organosomes for topical application: an explorative ex-vivo and in-vivo investigation for arthritis","volume":"666","author":"Sharma","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2026.107506_bib0137","article-title":"Nanostructured drug delivery systems for posterior segment eye diseases: strategies to defy ocular barriers","author":"Shen","year":"2025","journal-title":"BMEMat"},{"issue":"6","key":"10.1016\/j.ejps.2026.107506_bib0036","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2174\/1566523218666171129205626","article-title":"Fabrication and characterization of timolol maleate and brinzolamide loaded nanostructured lipid carrier system for ocular drug delivery","volume":"15","author":"Shrivastava","year":"2018","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.ejps.2026.107506_bib0088","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112957","article-title":"Fabrication of n-p \u03b2-Bi(2)O(3)@BiOI core\/shell photocatalytic heterostructure for the removal of bacteria and bisphenol A under LED light","volume":"221","author":"Shu","year":"2023","journal-title":"Colloids. Surf. B Biointerfaces."},{"issue":"7","key":"10.1016\/j.ejps.2026.107506_bib0115","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15071855","article-title":"Chitosan-coated SLN: a potential system for ocular delivery of metronidazole","volume":"15","author":"Sikhondze","year":"2023","journal-title":"Pharmaceutics."},{"issue":"4","key":"10.1016\/j.ejps.2026.107506_bib0123","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2217\/nnm-2018-0278","article-title":"Solid lipid nanoparticles for ocular delivery of isoniazid: evaluation, proof of concept and in vivo safety & kinetics","volume":"14","author":"Singh","year":"2019","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.ejps.2026.107506_bib0147","doi-asserted-by":"crossref","DOI":"10.2174\/0126673878339109250219072409","article-title":"Formulation development and permeation studies of Vancomycin hydrochloride-loaded nanostructured lipid carrier incorporated thermoresponsive In-situ gel: a Box-Behnken design implemented approach for ocular delivery in endophthalmitis","author":"Singh","year":"2025","journal-title":"Recent. Adv. Drug Deliv. Formul."},{"issue":"11","key":"10.1016\/j.ejps.2026.107506_bib0074","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1080\/03639045.2022.2070198","article-title":"Formulation design and optimization of cationic-charged liposomes of brimonidine tartrate for effective ocular drug delivery by design of experiment (DoE) approach","volume":"47","author":"Soni","year":"2021","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"6","key":"10.1016\/j.ejps.2026.107506_bib0084","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14061240","article-title":"Treatment of neuronopathic mucopolysaccharidoses with blood-brain barrier-crossing enzymes: clinical application of receptor-mediated transcytosis","volume":"14","author":"Sonoda","year":"2022","journal-title":"Pharmaceutics."},{"issue":"7","key":"10.1016\/j.ejps.2026.107506_bib0163","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3109\/02713681003760168","article-title":"Feasibility of lipid nanoparticles for ocular delivery of anti-inflammatory drugs","volume":"35","author":"Souto","year":"2010","journal-title":"Curr. Eye Res."},{"issue":"12","key":"10.1016\/j.ejps.2026.107506_bib0131","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1097\/j.jcrs.0000000000000672","article-title":"Effectiveness of liposomal ozonized oil in reducing ocular microbial flora in patients undergoing cataract surgery","volume":"47","author":"Spadea","year":"2021","journal-title":"J. Cataract. Refract. Surg."},{"issue":"5","key":"10.1016\/j.ejps.2026.107506_bib0035","doi-asserted-by":"crossref","DOI":"10.3390\/ph16050675","article-title":"Guanidines: synthesis of novel histamine H(3)R antagonists with additional breast anticancer activity and cholinesterases inhibitory effect","volume":"16","author":"Staszewski","year":"2023","journal-title":"Pharmaceuticals. (Basel)"},{"key":"10.1016\/j.ejps.2026.107506_bib0026","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2147\/DDDT.S287721","article-title":"Preparation and characterization of Tacrolimus-loaded SLNs in situ gel for ocular drug delivery for the treatment of immune conjunctivitis","volume":"15","author":"Sun","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejps.2026.107506_bib0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121725","article-title":"Liposomal sunitinib for ocular drug delivery: a potential treatment for choroidal neovascularization","volume":"620","author":"Tavakoli","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.ejps.2026.107506_bib0121","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1089\/adt.2023.058","article-title":"Determination of the toxicity preferences of ocular drug delivery system by comparing two different toxicity bioassays","volume":"21","author":"Uner","year":"2023","journal-title":"Assay. Drug Dev. Technol."},{"issue":"11","key":"10.1016\/j.ejps.2026.107506_bib0058","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1517\/17425247.2015.1059419","article-title":"Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis","volume":"12","author":"\u00dcst\u00fcnda\u011f-Okur","year":"2015","journal-title":"Expert. Opin. Drug Deliv."},{"key":"10.1016\/j.ejps.2026.107506_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122014","article-title":"Design of nanostructured lipid carriers and solid lipid nanoparticles for enhanced cellular uptake","volume":"624","author":"Veider","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.ejps.2026.107506_bib0108","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s40123-022-00518-7","article-title":"Effects of a new formulation of multiple-action tear substitute on objective ocular surface parameters and ocular discomfort symptoms in patients with dry eye disease","volume":"11","author":"Vigo","year":"2022","journal-title":"Ophthalmol. Ther."},{"key":"10.1016\/j.ejps.2026.107506_bib0065","article-title":"Polymeric solid dispersion vs co-amorphous technology: a critical comparison","volume":"78","author":"Vullendula","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ejps.2026.107506_bib0172","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3390\/jfb6020379","article-title":"Lipid nanoparticles for ocular gene delivery","volume":"6","author":"Wang","year":"2015","journal-title":"J. Funct. Biomater."},{"issue":"5","key":"10.1016\/j.ejps.2026.107506_bib0116","first-page":"411","article-title":"Preparation, optimization, and characterization of chitosan-coated solid lipid nanoparticles for ocular drug delivery","volume":"32","author":"Wang","year":"2018","journal-title":"J. Biomed. Res."},{"key":"10.1016\/j.ejps.2026.107506_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111854","article-title":"Sucrose-modified iron nanoparticles for highly efficient microbial production of hyaluronic acid by Streptococcus zooepidemicus","volume":"205","author":"Wang","year":"2021","journal-title":"Colloids. Surf. B Biointerfaces."},{"issue":"7","key":"10.1016\/j.ejps.2026.107506_bib0133","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/1061186X.2021.1878366","article-title":"A review of nanocarrier-mediated drug delivery systems for posterior segment eye disease: challenges analysis and recent advances","volume":"29","author":"Wang","year":"2021","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ejps.2026.107506_bib0136","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106213","article-title":"Effects of itraconazole and rifampicin on the pharmacokinetics and safety of youkenafil, a novel phosphodiesterase type 5 inhibitor, in healthy Chinese subjects","volume":"175","author":"Wang","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.ejps.2026.107506_bib0174","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00262-022-03321-2","article-title":"Novel ocular immunotherapy induces tumor regression in an equine model of ocular surface squamous neoplasia","volume":"72","author":"Wotman","year":"2023","journal-title":"Cancer Immunol. Immunther."},{"key":"10.1016\/j.ejps.2026.107506_bib0083","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120405","article-title":"Cell penetrating peptide TAT-functionalized liposomes for efficient ophthalmic delivery of flurbiprofen: penetration and its underlying mechanism, retention, anti-inflammation and biocompatibility","volume":"598","author":"Wu","year":"2021","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.ejps.2026.107506_bib0166","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.aopr.2024.11.003","article-title":"Nano-based drug delivery systems for the treatment of non-infectious uveitis","volume":"5","author":"Wu","year":"2025","journal-title":"Adv. Ophthalmol. Pract. Res."},{"key":"10.1016\/j.ejps.2026.107506_bib0034","first-page":"2483","article-title":"Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide","volume":"7","author":"Youshia","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejps.2026.107506_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2021.105887","article-title":"Gamma sterilization and in vivo evaluation of cationic nanostructured lipid carriers as potential ocular delivery systems for antiglaucoma drugs","volume":"163","author":"Youshia","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2026.107506_bib0044","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.2147\/IJN.S360740","article-title":"Dual drug loaded lipid nanocarrier formulations for topical ocular applications","volume":"17","author":"Youssef","year":"2022","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"10.1016\/j.ejps.2026.107506_bib0098","first-page":"423","article-title":"A hybrid genipin-crosslinked dual-sensitive hydrogel\/nanostructured lipid carrier ocular drug delivery platform","volume":"14","author":"Yu","year":"2019","journal-title":"Asian J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.ejps.2026.107506_bib0054","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1021\/acsbiomaterials.9b01800","article-title":"A hybrid genipin-cross-linked hydrogel\/nanostructured lipid carrier for ocular drug delivery: cellular, ex vivo, and in vivo evaluation","volume":"6","author":"Yu","year":"2020","journal-title":"ACS. Biomater. Sci. Eng."},{"key":"10.1016\/j.ejps.2026.107506_bib0171","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114965","article-title":"Recent advances and prospects for lipid-based nanoparticles as drug carriers in the treatment of human retinal diseases","volume":"199","author":"Zeng","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"9","key":"10.1016\/j.ejps.2026.107506_bib0077","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13091500","article-title":"Iterative upgrading of small molecular tyrosine kinase inhibitors for EGFR mutation in NSCLC: necessity and perspective","volume":"13","author":"Zhu","year":"2021","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.ejps.2026.107506_bib0072","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.jconrel.2024.11.079","article-title":"FRET-based analysis on the fate of liposome and cyclodextrin@liposome nanocomposites from ocular surface to the posterior segment of the eye","volume":"377","author":"Zhu","year":"2025","journal-title":"J. Control Release"},{"issue":"9","key":"10.1016\/j.ejps.2026.107506_bib0037","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14091961","article-title":"Optimization of lipid nanoparticles by response surface methodology to improve the ocular delivery of diosmin: characterization and In-vitro anti-inflammatory assessment","volume":"14","author":"Zingale","year":"2022","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.ejps.2026.107506_bib0100","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.ijbiomac.2022.07.184","article-title":"Sargassum fusiforme fucoidan ameliorates diet-induced obesity through enhancing thermogenesis of adipose tissues and modulating gut microbiota","volume":"216","author":"Zuo","year":"2022","journal-title":"Int. J. Biol. Macromol."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098726000801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098726000801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T02:41:22Z","timestamp":1787107282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098726000801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":168,"alternative-id":["S0928098726000801"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2026.107506","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Smart lipid-based nanocarrier system for the topical delivery of ocular therapeutics bio-interfacing, physicochemical diversity, and routing barriers","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2026.107506","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107506"}}