{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:09:39Z","timestamp":1784750979498,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001636","name":"University College Cork","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejps.2026.107601","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:16:14Z","timestamp":1783178174000},"page":"107601","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Design and process parameter evaluation of bilayer capsule systems for targeted ileal drug delivery"],"prefix":"10.1016","volume":"224","author":[{"given":"Elisa","family":"Millet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-3696","authenticated-orcid":false,"given":"Sofie S.T.","family":"Vandenbroucke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P","family":"O\u2019Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan T","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1630-2807","authenticated-orcid":false,"given":"Vincent","family":"Jannin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2026.107601_bib0001","article-title":"Towards a novel pullulan and pullulan-enteric hard capsules: study of drug release and crucial capsule features","volume":"92","author":"Aghajannataj Ahangarkola","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejps.2026.107601_bib0002","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.1021\/acssuschemeng.5c13894","article-title":"Tailoring the properties of ethyl cellulose membranes using hydrophobic deep eutectic solvents","volume":"14","author":"Alke","year":"2026","journal-title":"ACS. Sustain. Chem. Eng."},{"key":"10.1016\/j.ejps.2026.107601_bib0003","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ijpharm.2014.12.029","article-title":"Moisture diffusion and permeability characteristics of hydroxypropylmethylcellulose and hard gelatin capsules","volume":"478","author":"Barham","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2026.107601_bib0004","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.2147\/DDDT.S383138","article-title":"Insights on Nefecon\u00ae, a targeted-release formulation of budesonide and its selective immunomodulatory effects in patients with IgA nephropathy","volume":"18","author":"Barratt","year":"2024","journal-title":"Drug. Devel. Ther."},{"key":"10.1016\/j.ejps.2026.107601_bib0005","first-page":"98","article-title":"A review on manufacturing and evaluation of capsules","author":"Begum","year":"2018","journal-title":"World J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2026.107601_bib0006","series-title":"Polymer Handbook","article-title":"Polymer Handbook","author":"Brandrup","year":"1999"},{"key":"10.1016\/j.ejps.2026.107601_bib0007","unstructured":"Choudhary, L., Jain, A., Agarwal, D., 2020. Colon-targeted oral drug delivery systems: a review."},{"key":"10.1016\/j.ejps.2026.107601_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2026.108638","article-title":"Polysaccharides from medicine and food homology species used in China: a comprehensive review of extraction, bioactivities structure-activity relationship and applications","volume":"79","author":"Dong","year":"2026","journal-title":"Food Biosci."},{"key":"10.1016\/j.ejps.2026.107601_bib0009","series-title":"Biopolymers Online","article-title":"Alginates from Algae","author":"Draget","year":"2005"},{"key":"10.1016\/j.ejps.2026.107601_bib0011","article-title":"Colon targeting in rats, dogs and IBD patients with species-independent film coatings","volume":"7","author":"Ferraro","year":"2024","journal-title":"Int. J. Pharm.: X"},{"key":"10.1016\/j.ejps.2026.107601_bib0012","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.3390\/nu15061352","article-title":"Isolation of alginate-degrading bacteria from the Human gut microbiota and discovery of Bacteroides xylanisolvens AY11-1 as a novel anti-colitis probiotic bacterium","volume":"15","author":"Fu","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.ejps.2026.107601_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.126521","article-title":"Assessment of pectin-ethyl cellulose coated pellets for bacterially enhanced colonic drug delivery in progressively complex in vitro and in vivo models","volume":"690","author":"Giakoumis","year":"2026","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2026.107601_bib0014","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0014-5793(73)80770-7","article-title":"Biological interactions between polysaccharides and divalent cations: the egg-box model","volume":"32","author":"Grant","year":"1973","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejps.2026.107601_bib0015","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.3390\/pharmaceutics15112576","article-title":"In vivo evaluation of a gastro-resistant Enprotect\u00ae capsule under postprandial conditions","volume":"15","author":"Grimm","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2026.107601_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2025.107237","article-title":"Evaluating drug absorption from enteric capsules in pigs: impact of capsule size on gastric emptying","volume":"213","author":"Hoffmann","year":"2025","journal-title":"Eur. J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.ejps.2026.107601_bib0017","article-title":"Development of a novel drug delivery system to deliver drugs directly to the colonic mucosa, resulting in improved efficacy and reduced systemic exposure for the treatment of ulcerative colitis","volume":"360","author":"Huntsman","year":"2021","journal-title":"Crohn\u2019s Colitis"},{"key":"10.1016\/j.ejps.2026.107601_bib0018","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3109\/03639045.2014.917657","article-title":"Alginate drug delivery systems: application in context of pharmaceutical and biomedical research","volume":"40","author":"Jain","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2026.107601_bib40","series-title":"Capsule Shell Manufacture. Pharmaceutical Dosage Forms","author":"Jones","year":"2017"},{"key":"10.1016\/j.ejps.2026.107601_bib0019","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3109\/03639040902882314","article-title":"Effect of unconventional curing conditions and storage on pellets coated with Aquacoat ECD","volume":"36","author":"K\u00f6rber","year":"2010","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2026.107601_bib0020","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.addr.2018.06.021","article-title":"Bioresponsive drug delivery systems in intestinal inflammation: state-of-the-art and future perspectives","volume":"146","author":"Kotla","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejps.2026.107601_bib39","series-title":"Etude Et Elaboration de Films \u00e0 Base De Polysaccharides Pour La Fabrication De G\u00e9lules Pharmaceutiques (Thesis: G\u00e9nie des Proc\u00e9d\u00e9s)","author":"Lafargue","year":"2020"},{"key":"10.1016\/j.ejps.2026.107601_bib0021","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/pharmaceutics12010068","article-title":"Strategic approaches for colon targeted drug delivery: an overview of recent advancements","volume":"12","author":"Lee","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2026.107601_bib0022","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3390\/polym18101146","article-title":"Enzyme-responsive polymeric drug delivery systems for the treatment of inflammatory bowel diseases: a review","volume":"18","author":"Li","year":"2026","journal-title":"Polym. (Basel)"},{"key":"10.1016\/j.ejps.2026.107601_bib0023","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3390\/pharmaceutics17070877","article-title":"Comparative evaluation of gelatin and HPMC inhalation capsule shells exposed to simulated humidity conditions","volume":"17","author":"Magramane","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2026.107601_bib0025","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1038\/s41598-018-26104-1","article-title":"Ancient acquisition of \u201calginate utilization loci\u201d by human gut microbiota","volume":"8","author":"Mathieu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejps.2026.107601_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2025.107277","article-title":"Next generation capsules: Emerging technologies in capsule fabrication and targeted oral drug delivery","volume":"214","author":"Millet","year":"2025","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2026.107601_bib0026","doi-asserted-by":"crossref","first-page":"10022","DOI":"10.1039\/D5RA05194K","article-title":"Formulation approaches for colon-specific drug delivery: conventional to nanocarrier systems","volume":"16","author":"Mishra","year":"2026","journal-title":"RSC. Adv."},{"key":"10.1016\/j.ejps.2026.107601_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125538","article-title":"Unraveling the role of pectin biodegradability and blend composition on the permeability of ethylcellulose-based blend films designed for colon targeting","volume":"675","author":"Ouyang","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejps.2026.107601_bib0028","doi-asserted-by":"crossref","DOI":"10.1038\/srep40248","article-title":"A fibrolytic potential in the human ileum mucosal microbiota revealed by functional metagenomic","volume":"7","author":"Patrascu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejps.2026.107601_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107596","article-title":"Action and cooperation in alginate degradation by three enzymes from the human gut bacterium Bacteroides eggerthii DSM 20697","volume":"300","author":"R\u00f8nne","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejps.2026.107601_bib0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1042\/EBC20220123","article-title":"Gut bacterial alginate degrading enzymes","volume":"67","author":"R\u00f8nne","year":"2023","journal-title":"Essays Biochem."},{"key":"10.1016\/j.ejps.2026.107601_bib0031","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.3390\/pharmaceutics14101999","article-title":"In vivo evaluation of a gastro-resistant HPMC-based \u201cNext Generation Enteric\u201d capsule","volume":"14","author":"Rump","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2026.107601_bib0032","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.memsci.2015.07.003","article-title":"Effect of citrate-based non-toxic solvents on poly(vinylidene fluoride) membrane preparation via thermally induced phase separation","volume":"493","author":"Sawada","year":"2015","journal-title":"J. Memb. Sci."},{"key":"10.1016\/j.ejps.2026.107601_bib0033","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ejps.2026.107601_bib0034","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ejpb.2006.12.003","article-title":"Swelling, erosion and release behavior of alginate-based matrix tablets","volume":"66","author":"Sriamornsak","year":"2007","journal-title":"Eur. J. Pharm. Biopharm. : Off. J. Arbeitsgemeinschaft Pharm. Verfahrenstechnik E.V."},{"key":"10.1016\/j.ejps.2026.107601_bib0035","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1081\/DDC-120003853","article-title":"Alginate in drug delivery systems","volume":"28","author":"T\u00f8nnesen","year":"2002","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ejps.2026.107601_bib0037","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/j.apt.2016.07.027","article-title":"Sustained drug release from electrostatic powder coated tablets with ultrafine ethylcellulose powders","volume":"27","author":"Yang","year":"2016","journal-title":"Adv. Powder Technol."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098726001752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098726001752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:24:14Z","timestamp":1784748254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098726001752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":37,"alternative-id":["S0928098726001752"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2026.107601","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and process parameter evaluation of bilayer capsule systems for targeted ileal drug delivery","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2026.107601","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107601"}}