{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:10:45Z","timestamp":1784751045670,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejps.2026.107604","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:58:40Z","timestamp":1783781920000},"page":"107604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["AdipoRon ameliorates synovial inflammatory lesions and joint destruction in experimental arthritis by downregulating KRT7"],"prefix":"10.1016","volume":"224","author":[{"given":"Chen","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanmei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengli","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weirong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renpeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-3732","authenticated-orcid":false,"given":"Yingjie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ejps.2026.107604_bib0001","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/s41591-020-0939-8","article-title":"Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis","volume":"26","author":"Alivernini","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejps.2026.107604_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115871","article-title":"AdipoRon and ADP355, adiponectin receptor agonists, in Metabolic-associated fatty liver disease (MAFLD) and Nonalcoholic Steatohepatitis (NASH): a systematic review","volume":"218","author":"Barbalho","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejps.2026.107604_bib0003","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.bone.2004.06.008","article-title":"Adiponectin and its receptors are expressed in bone-forming cells","volume":"35","author":"Berner","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.ejps.2026.107604_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113687","article-title":"Secretory phosphoprotein 1 secreted by fibroblast-like synoviocytes promotes osteoclasts formation via PI3K\/AKT signaling in collagen-induced arthritis","volume":"155","author":"Cai","year":"2022","journal-title":"Biomed. PharmacOther"},{"issue":"11","key":"10.1016\/j.ejps.2026.107604_bib0005","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1158\/0008-5472.CAN-20-3779","article-title":"N(6) -Methyladenosine regulates mRNA stability and translation efficiency of KRT7 to promote breast cancer lung metastasis","volume":"81","author":"Chen","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejps.2026.107604_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108875","article-title":"Metformin inhibits the proliferation of rheumatoid arthritis fibroblast-like synoviocytes through IGF-IR\/PI3K\/AKT\/m-TOR pathway","volume":"115","author":"Chen","year":"2019","journal-title":"Biomed. PharmacOther"},{"issue":"3","key":"10.1016\/j.ejps.2026.107604_bib0007","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/19490976.2019.1695494","article-title":"Fusobacterium nucleatum promotes colorectal cancer metastasis by modulating KRT7-AS\/KRT7","volume":"11","author":"Chen","year":"2020","journal-title":"Gut. Microbes."},{"issue":"17","key":"10.1016\/j.ejps.2026.107604_bib0008","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ejps.2026.107604_bib0009","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.omtm.2020.05.008","article-title":"Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion","volume":"17","author":"Chen","year":"2020","journal-title":"Mol. Ther. Methods Clin. Dev."},{"issue":"7760","key":"10.1016\/j.ejps.2026.107604_bib0010","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41586-019-1263-7","article-title":"Distinct fibroblast subsets drive inflammation and damage in arthritis","volume":"570","author":"Croft","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ejps.2026.107604_bib0011","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13578-025-01503-w","article-title":"From pathogenesis to therapeutic targeting: new insight into TAM receptors in rheumatoid arthritis","volume":"15","author":"Dai","year":"2025","journal-title":"Cell Biosci."},{"issue":"2","key":"10.1016\/j.ejps.2026.107604_bib0012","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jaci.2007.10.018","article-title":"Adiponectin and inflammation: consensus and controversy","volume":"121","author":"Fantuzzi","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.ejps.2026.107604_bib0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/endrev\/bnae021","article-title":"Adiponectin and Adiponectin Receptors in Atherosclerosis","volume":"46","author":"Gianopoulos","year":"2025","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejps.2026.107604_bib0014","article-title":"Emerging insights into keratin 7 roles in tumor progression and metastasis of cancers","volume":"13","author":"Hosseinalizadeh","year":"2023","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.ejps.2026.107604_bib0015","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.cmet.2013.04.009","article-title":"Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1","volume":"17","author":"Kajimura","year":"2013","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.ejps.2026.107604_bib0016","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/ard-2022-223365","article-title":"Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis","volume":"82","author":"Kerschbaumer","year":"2023","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.ejps.2026.107604_bib0017","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.ejps.2026.107604_bib0018","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1681\/ASN.2017060627","article-title":"The adiponectin receptor agonist adiporon ameliorates diabetic nephropathy in a model of type 2 diabetes","volume":"29","author":"Kim","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejps.2026.107604_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102823","article-title":"The therapeutic potential of adiponectin and extracellular vesicles for promoting improved healthspan","volume":"111","author":"Lei","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.ejps.2026.107604_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-020-00122-0","article-title":"Adiponectin signalling in bone homeostasis, with age and in disease","volume":"9","author":"Lewis","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.ejps.2026.107604_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.178468","article-title":"AdipoRon ameliorates anxiety- and depression-like behaviors in chronic restraint-stressed mice via AMPK-PPARalpha-BDNF-TrkB signaling","volume":"1011","author":"Li","year":"2026","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107604_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111933","article-title":"TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCalpha-HuR axis in rheumatoid arthritis","volume":"132","author":"Lin","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.ejps.2026.107604_bib0023","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1007\/s00125-021-05473-9","article-title":"Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo","volume":"64","author":"Lindfors","year":"2021","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejps.2026.107604_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115082","article-title":"Role of leptin and adiponectin in immune response and inflammation","volume":"161","author":"Liu","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.ejps.2026.107604_bib0025","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00428-017-2074-6","article-title":"In hepatic venous outflow obstruction, alcoholic liver disease, and nonalcoholic fatty liver disease, centrilobular scars, CD34+ vessels, and keratin 7+ hepatocytes are in close proximity","volume":"470","author":"Matsukuma","year":"2017","journal-title":"Virchows Arch."},{"issue":"21","key":"10.1016\/j.ejps.2026.107604_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115883","article-title":"Aberrant Activation of Immune and Non-Immune Cells Contributes to Joint Inflammation and Bone Degradation in Rheumatoid Arthritis","volume":"24","author":"Nandakumar","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejps.2026.107604_bib0027","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41584-020-0413-5","article-title":"Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes","volume":"16","author":"Nygaard","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"issue":"7","key":"10.1016\/j.ejps.2026.107604_bib0028","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.tem.2014.03.009","article-title":"Role of anti-inflammatory adipokines in obesity-related diseases","volume":"25","author":"Ohashi","year":"2014","journal-title":"Trends. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.ejps.2026.107604_bib0029","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24108566","article-title":"Anti-inflammatory effects of adiponectin receptor agonist adiporon against intervertebral disc degeneration","volume":"24","author":"Ohnishi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"7477","key":"10.1016\/j.ejps.2026.107604_bib0030","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature12656","article-title":"A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity","volume":"503","author":"Okada-Iwabu","year":"2013","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.ejps.2026.107604_bib0031","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24129841","article-title":"Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: from Pathogenesis to Therapeutics","volume":"24","author":"Ouyang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejps.2026.107604_bib0032","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/clr.14070","article-title":"AdipoAI suppresses osteoclastogenesis by activating AdipoR1\/APPL1: an in vivo experimental study in diabetes-associated peri-implantitis","volume":"34","author":"Qiu","year":"2023","journal-title":"Clin. Oral Implants Res."},{"issue":"1","key":"10.1016\/j.ejps.2026.107604_bib0033","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hep.31252","article-title":"Regional differences in human biliary tissues and corresponding in vitro-derived organoids","volume":"73","author":"Rimland","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.ejps.2026.107604_bib0034","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/978-1-59745-401-8_24","article-title":"Acquisition, culture, and phenotyping of synovial fibroblasts","volume":"135","author":"Rosengren","year":"2007","journal-title":"Methods Mol. Med."},{"issue":"5","key":"10.1016\/j.ejps.2026.107604_bib0035","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cmet.2016.04.011","article-title":"Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk","volume":"23","author":"Stern","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejps.2026.107604_bib0036","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jare.2024.02.015","article-title":"AdipoRon ameliorates the progression of heart failure with preserved ejection fraction via mitigating lipid accumulation and fibrosis","volume":"68","author":"Tan","year":"2025","journal-title":"J. Adv. Res."},{"issue":"11","key":"10.1016\/j.ejps.2026.107604_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS. One"},{"key":"10.1016\/j.ejps.2026.107604_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107762","article-title":"Targeting overexpressed HSPA8 by halofuginone suppresses aberrant proliferation and invasion of rheumatoid arthritis fibroblast-like synoviocytes","volume":"216","author":"Tang","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.ejps.2026.107604_bib0039","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nri1937","article-title":"Adipocytokines: mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"Tilg","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejps.2026.107604_bib0040","article-title":"The relationship between clinical disease activity, synovial inflammatory profile, and treatment response in rheumatoid arthritis","author":"Triaille","year":"2025","journal-title":"Lancet Rheumatol."},{"key":"10.1016\/j.ejps.2026.107604_bib0041","article-title":"GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis","author":"Yang","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.ejps.2026.107604_bib0042","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140214","article-title":"Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss","volume":"131","author":"Yu","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.ejps.2026.107604_bib0043","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12967-019-1805-7","article-title":"Adiponectin regulates bone mass in AIS osteopenia via RANKL\/OPG and IL6 pathway","volume":"17","author":"Zhang","year":"2019","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.ejps.2026.107604_bib0044","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11914-025-00933-2","article-title":"Bone marrow adipoq-lineage progenitors: an emerging osteoclast niche cell population","volume":"23","author":"Zhao","year":"2025","journal-title":"Curr. Osteoporos. Rep."},{"issue":"3","key":"10.1016\/j.ejps.2026.107604_bib0045","doi-asserted-by":"crossref","first-page":"518","DOI":"10.4049\/jimmunol.1900552","article-title":"Tolerogenic dendritic cells generated by BAFF silencing ameliorate collagen-induced arthritis by modulating the Th17\/regulatory T cell balance","volume":"204","author":"Zhao","year":"2020","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.ejps.2026.107604_bib0046","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41419-023-05802-3","article-title":"The long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers","volume":"14","author":"Zhao","year":"2023","journal-title":"Cell Death. Dis."},{"key":"10.1016\/j.ejps.2026.107604_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102411","article-title":"TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCalpha-NOX4 axis","volume":"55","author":"Zhou","year":"2022","journal-title":"Redox. Biol."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098726001788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098726001788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:25:32Z","timestamp":1784748332000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098726001788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"alternative-id":["S0928098726001788"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2026.107604","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AdipoRon ameliorates synovial inflammatory lesions and joint destruction in experimental arthritis by downregulating KRT7","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2026.107604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107604"}}