{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T03:25:49Z","timestamp":1787109949936,"version":"build-2736575974"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404769"],"award-info":[{"award-number":["82404769"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ5465"],"award-info":[{"award-number":["2024JJ5465"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ50576"],"award-info":[{"award-number":["2025JJ50576"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ejps.2026.107623","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:41:53Z","timestamp":1785253313000},"page":"107623","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evaluation of transplacental clearance prediction methods in maternal-fetal PBPK modeling: Implications for predicting fetal drug exposure"],"prefix":"10.1016","volume":"225","author":[{"given":"Qiufen","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanwang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejps.2026.107623_bib0001","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1208\/s12248-025-01031-y","article-title":"Application of a physiologically based pharmacokinetic approach to predict Tenofovir pharmacokinetics during pregnancy","volume":"27","author":"Abduljalil","year":"2025","journal-title":"AAPS J."},{"key":"10.1016\/j.ejps.2026.107623_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.840710","article-title":"Application of a physiologically based pharmacokinetic approach to predict theophylline pharmacokinetics using virtual non-pregnant, pregnant, fetal, breast-feeding, and neonatal populations","volume":"10","author":"Abduljalil","year":"2022","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.ejps.2026.107623_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16040474","article-title":"An application of a physiologically based pharmacokinetic approach to predict ceftazidime pharmacokinetics in a pregnant population","volume":"16","author":"Abduljalil","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejps.2026.107623_bib0004","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1124\/dmd.121.000711","article-title":"Prediction of maternal and fetoplacental concentrations of cefazolin, cefuroxime, and amoxicillin during pregnancy using bottom-up physiologically based pharmacokinetic models","volume":"50","author":"Abduljalil","year":"2022","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2026.107623_bib0005","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s40262-021-01103-0","article-title":"Prediction of maternal and fetal acyclovir, emtricitabine, lamivudine, and metformin concentrations during pregnancy using a physiologically based pharmacokinetic modeling approach","volume":"61","author":"Abduljalil","year":"2022","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2026.107623_bib0006","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/ajmg.c.30313","article-title":"Evolving knowledge of the teratogenicity of medications in human pregnancy","volume":"157","author":"Adam","year":"2011","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.ejps.2026.107623_bib0007","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12871-015-0144-3","article-title":"Paracetamol pharmacokinetics and metabolism in young women","volume":"15","author":"Allegaert","year":"2015","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.ejps.2026.107623_bib0008","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/psp4.12674","article-title":"Estimating fetal exposure to the P-gp substrates, corticosteroids, by PBPK modeling to inform prevention of neonatal respiratory distress syndrome","volume":"10","author":"Anoshchenko","year":"2021","journal-title":"CPT Pharmacometr. Syst. Pharmacol."},{"issue":"Suppl 1","key":"10.1016\/j.ejps.2026.107623_bib0009","first-page":"S94","article-title":"Predicting Human fetal drug exposure through maternal-fetal PBPK modeling and In vitro or ex vivo studies","volume":"62","author":"Balhara","year":"2022","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0010","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/BF00191910","article-title":"Paracetamol pharmacokinetics during the first trimester of human pregnancy","volume":"46","author":"Beaulac-Baillargeon","year":"1994","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0011","first-page":"46","article-title":"Effect of piperine on the metabolism and pharmacokinetics of carbamazepine in healthy volunteers","volume":"67","author":"Bedada","year":"2017","journal-title":"Drug Res. (Stuttg)"},{"key":"10.1016\/j.ejps.2026.107623_bib0012","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1128\/AAC.05244-11","article-title":"Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women","volume":"56","author":"Benaboud","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0013","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s40262-022-01127-0","article-title":"Prediction of maternal and fetal doravirine exposure by integrating physiologically based pharmacokinetic modeling and Human placenta perfusion experiments","volume":"61","author":"Bukkems","year":"2022","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2026.107623_bib0014","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/01.ftd.0000184161.52573.0e","article-title":"Population pharmacokinetics of metformin in late pregnancy","volume":"28","author":"Charles","year":"2006","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.ejps.2026.107623_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2024.106707","article-title":"Physiologically based pharmacokinetic modeling to predict maternal pharmacokinetics and fetal carbamazepine exposure during pregnancy","volume":"194","author":"Chen","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2026.107623_bib0016","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/BF00608228","article-title":"Pharmacokinetics of cimetidine after subchronic administration","volume":"30","author":"Chin","year":"1986","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115318","article-title":"Assessing the impacts on fetal dosimetry of the modelling of the placental transfers of xenobiotics in a pregnancy physiologically based pharmacokinetic model","volume":"409","author":"Codaccioni","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0018","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/QAD.0b013e32835c208b","article-title":"The pharmacokinetics, safety and efficacy of tenofovir and emtricitabine in HIV-1-infected pregnant women","volume":"27","author":"Colbers","year":"2013","journal-title":"Aids"},{"issue":"Suppl 1","key":"10.1016\/j.ejps.2026.107623_bib0019","first-page":"S129","article-title":"The use of pregnancy physiologically based pharmacokinetic modeling for renally cleared drugs","volume":"62","author":"Coppola","year":"2022","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0020","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/BF00561065","article-title":"The pharmacokinetics of carbamazepine","volume":"12","author":"Cotter","year":"1977","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0021","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01686-18","article-title":"Tenofovir exposure during pregnancy and postpartum in women receiving Tenofovir disoproxil fumarate for the prevention of mother-to-child transmission of Hepatitis B virus","volume":"62","author":"Cressey","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0022","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s40262-017-0594-5","article-title":"A physiologically based pharmacokinetic model for pregnant women to predict the pharmacokinetics of drugs metabolized via several enzymatic pathways","volume":"57","author":"Dallmann","year":"2018","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2026.107623_bib0023","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s40268-019-00285-0","article-title":"Are standard doses of renally-excreted antiretrovirals in older patients appropriate: a PBPK study comparing exposures in the elderly population with those in renal impairment","volume":"19","author":"De Sousa Mendes","year":"2019","journal-title":"Drugs R&D"},{"key":"10.1016\/j.ejps.2026.107623_bib0024","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/bcp.12685","article-title":"Physiologically-based pharmacokinetic modeling of renally excreted antiretroviral drugs in pregnant women","volume":"80","author":"De Sousa Mendes","year":"2015","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0025","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/bcp.12815","article-title":"Prediction of human fetal pharmacokinetics using ex vivo human placenta perfusion studies and physiologically based models","volume":"81","author":"De Sousa Mendes","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0026","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s40262-016-0457-5","article-title":"A physiologically-based pharmacokinetic model to predict human fetal exposure for a drug metabolized by several CYP450 pathways","volume":"56","author":"De Sousa Mendes","year":"2017","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2026.107623_bib0027","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1128\/AAC.42.9.2380","article-title":"Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults","volume":"42","author":"Deeks","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0028","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.2165\/00003088-200645100-00005","article-title":"Development and evaluation of a generic physiologically based pharmacokinetic model for children","volume":"45","author":"Edginton","year":"2006","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2026.107623_bib0029","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02168-20","article-title":"Population pharmacokinetics of Tenofovir in pregnant and postpartum women using Tenofovir disoproxil fumarate","volume":"65","author":"Eke","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0030","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1124\/dmd.109.031245","article-title":"Pharmacokinetics of metformin during pregnancy","volume":"38","author":"Eyal","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2026.107623_bib0031","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.1128\/AAC.00544-11","article-title":"Pharmacokinetics and safety of single-dose tenofovir disoproxil fumarate and emtricitabine in HIV-1-infected pregnant women and their infants","volume":"55","author":"Flynn","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0032","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/jac\/dkw412","article-title":"Single-dose pharmacokinetics and pharmacodynamics of oral tenofovir and emtricitabine in blood, saliva and rectal tissue: a sub-study of the ANRS IPERGAY trial","volume":"72","author":"Fonsart","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0033","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0002-9378(88)80010-3","article-title":"Steady-state cord and amniotic fluid ceftizoxime levels continuously surpass maternal levels","volume":"159","author":"Fortunato","year":"1988","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ejps.2026.107623_bib0034","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF01064556","article-title":"Pharmacokinetics of carbamazepine in normal humans after single and repeated oral doses","volume":"4","author":"G\u00e9radin","year":"1976","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.ejps.2026.107623_bib0035","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1528-1157.1990.tb05384.x","article-title":"Absolute bioavailability of carbamazepine after oral administration of a 2% syrup","volume":"31","author":"G\u00e9rardin","year":"1990","journal-title":"Epilepsia"},{"key":"10.1016\/j.ejps.2026.107623_bib0036","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/BF00605632","article-title":"Bioavailability and pharmacokinetics of cimetidine","volume":"16","author":"Grahn\u00e9n","year":"1979","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0037","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/clpt.1989.41","article-title":"Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo","volume":"45","author":"Greenblatt","year":"1989","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2026.107623_bib0038","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1128\/AAC.01377-10","article-title":"Plasma and intracellular tenofovir pharmacokinetics in the neonate (ANRS 12109 trial, step 2)","volume":"55","author":"Hirt","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0039","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/clpt.2008.201","article-title":"Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109)","volume":"85","author":"Hirt","year":"2009","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2026.107623_bib0040","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1128\/AAC.00860-08","article-title":"Population pharmacokinetics of emtricitabine in human immunodeficiency virus type 1-infected pregnant women and their neonates","volume":"53","author":"Hirt","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0041","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00007691-198503000-00005","article-title":"Simultaneous plasma carbamazepine and carbamazepine-epoxide concentrations in pharmacokinetic and bioavailability studies","volume":"7","author":"Hooper","year":"1985","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.ejps.2026.107623_bib0042","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2044.1981.tb10240.x","article-title":"The placental transfer of cimetidine","volume":"36","author":"Howe","year":"1981","journal-title":"Anaesthesia"},{"key":"10.1016\/j.ejps.2026.107623_bib0043","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1111601","article-title":"Drug exposure during pregnancy: current understanding and approaches to measure maternal-fetal drug exposure","volume":"14","author":"Hudson","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0044","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1093\/jac\/dkr201","article-title":"Reutericyclin and related analogues kill stationary phase Clostridium difficile at achievable colonic concentrations","volume":"66","author":"Hurdle","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0045","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/clpt.2011.66","article-title":"The human placental perfusion model: a systematic review and development of a model to predict in vivo transfer of therapeutic drugs","volume":"90","author":"Hutson","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2026.107623_bib0046","first-page":"1155","article-title":"[Pharmacokinetic and clinical studies of ceftizoxime in obstetrical and gynecological field (2)]","volume":"41","author":"Ito","year":"1988","journal-title":"Jpn. J. Antibiot."},{"key":"10.1016\/j.ejps.2026.107623_bib0047","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1021\/acs.molpharmaceut.3c00502","article-title":"The comparison of machine learning and mechanistic in vitro-in vivo extrapolation models for the prediction of human intrinsic clearance","volume":"20","author":"Keefer","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ejps.2026.107623_bib0048","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1128\/AAC.24.2.151","article-title":"Pharmacokinetics of ceftizoxime in subjects with various degrees of renal function","volume":"24","author":"Kowalsky","year":"1983","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0049","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/j.1365-2125.2012.04402.x","article-title":"Pharmacokinetics of paracetamol and its metabolites in women at delivery and post-partum","volume":"75","author":"Kulo","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0050","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/jac\/12.2.147","article-title":"Effect of probenecid on the pharmacokinetics of ceftizoxime","volume":"12","author":"LeBel","year":"1983","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0051","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/clpt.1981.201","article-title":"Ranitidine kinetics and dynamics. II. Intravenous dose studies and comparison with cimetidine","volume":"30","author":"Lebert","year":"1981","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2026.107623_bib0052","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/bcp.15589","article-title":"Foetal and neonatal exposure prediction and dosing evaluation for ampicillin using a physiologically-based pharmacokinetic modelling approach","volume":"89","author":"Li","year":"2023","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0053","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1124\/dmd.119.088435","article-title":"Effects of pregnancy on the pharmacokinetics of metformin","volume":"48","author":"Liao","year":"2020","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2026.107623_bib0054","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/cpt.1714","article-title":"Inhibitory effects of probenecid on pharmacokinetics of Tenofovir disoproxil fumarate and emtricitabine for on-demand HIV preexposure prophylaxis","volume":"107","author":"Liu","year":"2020","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2026.107623_bib0055","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/jcph.1515","article-title":"Physiologically based pharmacokinetic models to predict maternal pharmacokinetics and fetal exposure to emtricitabine and acyclovir","volume":"60","author":"Liu","year":"2020","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0056","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1068153","article-title":"PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia","volume":"14","author":"Macente","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0057","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0773.1979.tb02365.x","article-title":"Absorption of diazepam in man following rectal and parenteral administration","volume":"45","author":"Magnussen","year":"1979","journal-title":"Acta Pharmacol. Toxicol. (Copenh)"},{"key":"10.1016\/j.ejps.2026.107623_bib0058","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/cpt1975175564","article-title":"Placental transfer to diazepam and its disposition in the newborn","volume":"17","author":"Mandelli","year":"1975","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2026.107623_bib0059","first-page":"1129","article-title":"[Pharmacokinetic and clinical studies of ceftizoxime in the perinatal period. The chemotherapy research group for mothers and children]","volume":"41","author":"Matsuda","year":"1988","journal-title":"Jpn. J. Antibiot."},{"key":"10.1016\/j.ejps.2026.107623_bib0060","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s40262-020-00861-7","article-title":"Integration of placental transfer in a fetal-maternal physiologically based pharmacokinetic model to characterize acetaminophen exposure and metabolic clearance in the fetus","volume":"59","author":"Mian","year":"2020","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2026.107623_bib0061","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2021.733520","article-title":"Mechanistic coupling of a novel in silico cotyledon perfusion model and a physiologically based pharmacokinetic model to predict fetal acetaminophen pharmacokinetics at delivery","volume":"9","author":"Mian","year":"2021","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.ejps.2026.107623_bib0062","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s40262-019-00799-5","article-title":"Physiologically based pharmacokinetic modeling to characterize acetaminophen pharmacokinetics and N-acetyl-p-benzoquinone imine (NAPQI) formation in non-pregnant and pregnant women","volume":"59","author":"Mian","year":"2020","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2026.107623_bib0063","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/QAI.0b013e3182a921eb","article-title":"Pharmacokinetics and safety of tenofovir in HIV-infected women during labor and their infants during the first week of life","volume":"65","author":"Mirochnick","year":"2014","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.ejps.2026.107623_bib0064","doi-asserted-by":"crossref","first-page":"51.e1","DOI":"10.1016\/j.ajog.2011.02.029","article-title":"Medication use during pregnancy, with particular focus on prescription drugs: 1976\u20132008","volume":"205","author":"Mitchell","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ejps.2026.107623_bib0065","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/clpt.1983.127","article-title":"Effects of oral contraceptive steroids on acetaminophen metabolism and elimination","volume":"34","author":"Mitchell","year":"1983","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2026.107623_bib0066","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/BF00716363","article-title":"The disposition kinetics of diazepam in pregnant women at parturition","volume":"13","author":"Moore","year":"1978","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0067","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1128\/AAC.20.3.366","article-title":"Pharmacology of ceftizoxime compared with that of cefamandole","volume":"20","author":"Neu","year":"1981","journal-title":"Antimicrob. Agents Chemother."},{"issue":"Suppl 1","key":"10.1016\/j.ejps.2026.107623_bib0068","first-page":"5s","article-title":"Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality","volume":"53","author":"Nichols","year":"2002","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0069","first-page":"541","article-title":"Transplacental passage of acetaminophen in term pregnancy","volume":"34","author":"Nitsche","year":"2017","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.ejps.2026.107623_bib0070","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1128\/AAC.22.5.878","article-title":"Pharmacokinetics, protein binding, and extravascular distribution of ceftizoxime in normal subjects","volume":"22","author":"Peterson","year":"1982","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejps.2026.107623_bib0071","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s40262-025-01574-5","article-title":"Prediction of maternal and fetal exposure to escitalopram, sertraline, and paroxetine by combining human ex vivo placenta perfusion data and physiologically based pharmacokinetic modeling","volume":"64","author":"Preta","year":"2025","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejps.2026.107623_bib0072","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1600-0773.1977.tb02145.x","article-title":"Carbamazepine: placental transport, tissue concentrations in foetus and newborn, and level in milk","volume":"41","author":"Pynn\u00f6nen","year":"1977","journal-title":"Acta Pharmacol. Toxicol. (Copenh)"},{"key":"10.1016\/j.ejps.2026.107623_bib0073","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1600-0773.1977.tb02157.x","article-title":"The pharmacokinetics of carbamazepine in plasma and saliva of man","volume":"41","author":"Pynn\u00f6nen","year":"1977","journal-title":"Acta Pharmacol. Toxicol. (Copenh)"},{"key":"10.1016\/j.ejps.2026.107623_bib0074","first-page":"63s","article-title":"Comparative pharmacokinetics of cefotaxime and ceftizoxime and the role of desacetylcefotaxime in the antibacterial activity of cefotaxime","volume":"2","author":"Quintiliani","year":"1984","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.ejps.2026.107623_bib0075","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/clpt.1989.65","article-title":"The disposition and placental transfer of diazepam in cesarean section","volume":"45","author":"Ridd","year":"1989","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2026.107623_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2022.105471","article-title":"Predicting fetal exposure of crizotinib during pregnancy: combining human ex vivo placenta perfusion data with physiologically-based pharmacokinetic modeling","volume":"85","author":"Roelofsen","year":"2022","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.ejps.2026.107623_bib0077","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/jcph.283","article-title":"Effects of a protein-rich drink or a standard meal on the pharmacokinetics of elvitegravir, cobicistat, emtricitabine and tenofovir in healthy Japanese male subjects: a randomized, three-way crossover study","volume":"54","author":"Shiomi","year":"2014","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.ejps.2026.107623_bib0078","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1023\/A:1020483911355","article-title":"Comparison of human duodenum and caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs","volume":"19","author":"Sun","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ejps.2026.107623_bib0079","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ejps.2009.10.014","article-title":"The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta","volume":"39","author":"Tertti","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ejps.2026.107623_bib0080","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00592-014-0570-6","article-title":"The degree of fetal metformin exposure does not influence fetal outcome in gestational diabetes mellitus","volume":"51","author":"Tertti","year":"2014","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.ejps.2026.107623_bib0081","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ajog.2020.01.025","article-title":"Safety and efficacy of sildenafil citrate to reduce operative birth for intrapartum fetal compromise at term: a phase 2 randomized controlled trial","volume":"222","author":"Turner","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ejps.2026.107623_bib0082","article-title":"Pharmacometrics: a new era of pharmacotherapy and drug development in low- and middle-income countries","volume":"2023","author":"Usman","year":"2023","journal-title":"Adv. Pharmacol. Pharm. Sci."},{"key":"10.1016\/j.ejps.2026.107623_bib0083","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0016-5085(78)90762-X","article-title":"Bioavailability of cimetidine in man","volume":"74","author":"Walkenstein","year":"1978","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejps.2026.107623_bib0084","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/cpt.2981","article-title":"Patterns of prescription medication use during the first trimester of pregnancy in the United States, 1997-2018","volume":"114","author":"Werler","year":"2023","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejps.2026.107623_bib0085","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1021\/jm9810102","article-title":"Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach","volume":"41","author":"Winiwarter","year":"1998","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejps.2026.107623_bib0086","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/cpdd.365","article-title":"Effects of a nutritional protein-rich drink on the pharmacokinetics of Elvitegravir, Cobicistat, Emtricitabine, tenofovir alafenamide, and Tenofovir compared with a standard meal in healthy Japanese male subjects","volume":"7","author":"Yamada","year":"2018","journal-title":"Clin. Pharmacol. Drug Dev."},{"key":"10.1016\/j.ejps.2026.107623_bib0087","first-page":"1164","article-title":"Pharmacokinetic and clinical studies on ceftizoxime in the perinatal period]","volume":"41","author":"Yamamoto","year":"1988","journal-title":"Jpn. J. Antibiot."},{"key":"10.1016\/j.ejps.2026.107623_bib0089","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1124\/dmd.117.075192","article-title":"Development of a novel maternal-fetal physiologically based pharmacokinetic model I: insights into factors that determine fetal drug exposure through simulations and sensitivity analyses","volume":"45","author":"Zhang","year":"2017","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejps.2026.107623_bib0090","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1124\/dmd.116.073957","article-title":"Development of a novel maternal-fetal physiologically based pharmacokinetic model II: verification of the model for passive placental permeability drugs","volume":"45","author":"Zhang","year":"2017","journal-title":"Drug Metab. Dispos."}],"container-title":["European Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098726001971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0928098726001971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T02:40:13Z","timestamp":1787107213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0928098726001971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":89,"alternative-id":["S0928098726001971"],"URL":"https:\/\/doi.org\/10.1016\/j.ejps.2026.107623","relation":{},"ISSN":["0928-0987"],"issn-type":[{"value":"0928-0987","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of transplacental clearance prediction methods in maternal-fetal PBPK modeling: Implications for predicting fetal drug exposure","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejps.2026.107623","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107623"}}