{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:46:28Z","timestamp":1791135988599,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.ejrad.2007.06.028","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T12:21:05Z","timestamp":1186662065000},"page":"335-350","source":"Crossref","is-referenced-by-count":174,"title":["Dynamic contrast enhanced MRI in prostate cancer"],"prefix":"10.1016","volume":"63","author":[{"given":"Roberto","family":"Alonzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar R.","family":"Padhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejrad.2007.06.028_bib1","first-page":"13","article-title":"The prostate gland morphology and pathobiology","author":"McNeal","year":"1983","journal-title":"Monogr Urol"},{"issue":"6","key":"10.1016\/j.ejrad.2007.06.028_bib2","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/S0022-5347(01)64774-8","article-title":"Vascular endothelial growth factor (VEGF) expression in prostate cancer and benign prostatic hyperplasia","volume":"157","author":"Jackson","year":"1997","journal-title":"J Urol"},{"issue":"12 Pt 1","key":"10.1016\/j.ejrad.2007.06.028_bib3","first-page":"2507","article-title":"Androgens regulate vascular endothelial growth factor content in normal and malignant prostatic tissue","volume":"3","author":"Joseph","year":"1997","journal-title":"Clin Cancer Res"},{"issue":"18","key":"10.1016\/j.ejrad.2007.06.028_bib4","doi-asserted-by":"crossref","first-page":"10820","DOI":"10.1073\/pnas.95.18.10820","article-title":"Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor","volume":"95","author":"Jain","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.ejrad.2007.06.028_bib5","first-page":"155","article-title":"Expression of vascular endothelial growth factor (VEGF) and association with microvessel density in benign prostatic hyperplasia and prostate cancer","volume":"18","author":"Stefanou","year":"2004","journal-title":"In Vivo"},{"issue":"2","key":"10.1016\/j.ejrad.2007.06.028_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.yexmp.2004.04.005","article-title":"Microvessel density as a molecular marker for identifying high-grade prostatic intraepithelial neoplasia precursors to prostate cancer","volume":"77","author":"Sinha","year":"2004","journal-title":"Exp Mol Pathol"},{"issue":"2","key":"10.1016\/j.ejrad.2007.06.028_bib7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0046-8177(93)90304-Y","article-title":"Comparison of microscopic vascularity in benign and malignant prostate tissue","volume":"24","author":"Bigler","year":"1993","journal-title":"Hum Pathol"},{"issue":"2","key":"10.1016\/j.ejrad.2007.06.028_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0022-5347(01)62925-2","article-title":"CD34 immunohistochemical assessment of angiogenesis as a prognostic marker for prostate cancer recurrence after radical prostatectomy","volume":"160","author":"Bettencourt","year":"1998","journal-title":"J Urol"},{"issue":"7","key":"10.1016\/j.ejrad.2007.06.028_bib9","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/bjc.1998.605","article-title":"Microvessel density predicts survival in prostate cancer patients subjected to watchful waiting","volume":"78","author":"Borre","year":"1998","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1016\/j.ejrad.2007.06.028_bib10","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0090-4295(94)80173-8","article-title":"Significance of tumor angiogenesis in clinically localized prostate carcinoma treated with external beam radiotherapy","volume":"44","author":"Hall","year":"1994","journal-title":"Urology"},{"issue":"3","key":"10.1016\/j.ejrad.2007.06.028_bib11","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0090-4295(98)00561-5","article-title":"Microvessel density in prostate cancer: lack of correlation with tumor grade, pathologic stage, and clinical outcome","volume":"53","author":"Rubin","year":"1999","journal-title":"Urology"},{"issue":"1","key":"10.1016\/j.ejrad.2007.06.028_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1148\/radiology.186.1.8416557","article-title":"Evaluation of the prostate and prostatic carcinoma with gadolinium-enhanced endorectal coil MR imaging","volume":"186","author":"Mirowitz","year":"1993","journal-title":"Radiology"},{"issue":"2","key":"10.1016\/j.ejrad.2007.06.028_bib13","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1148\/radiology.190.2.8284376","article-title":"MR imaging of prostate cancer with an endorectal surface coil technique: correlation with whole-mount specimens","volume":"190","author":"Quinn","year":"1994","journal-title":"Radiology"},{"issue":"9","key":"10.1016\/j.ejrad.2007.06.028_bib14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0009-9260(05)83288-X","article-title":"The role of intravenous contrast enhancement in magnetic resonance imaging of prostatic carcinoma","volume":"50","author":"Brown","year":"1995","journal-title":"Clin Radiol"},{"issue":"2","key":"10.1016\/j.ejrad.2007.06.028_bib15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00004728-199503000-00013","article-title":"Contrast-enhanced endorectal coil MRI in local staging of prostate carcinoma","volume":"19","author":"Huch Boni","year":"1995","journal-title":"J Comput Assist Tomogr"},{"issue":"4","key":"10.1016\/j.ejrad.2007.06.028_bib16","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mrm.1910400406","article-title":"Quantification of the extraction fraction for gadopentetate across breast cancer capillaries","volume":"40","author":"Daldrup","year":"1998","journal-title":"Magn Reson Med"},{"issue":"9","key":"10.1016\/j.ejrad.2007.06.028_bib17","first-page":"1603","article-title":"Effects of three different doses of a bolus injection of gadodiamide: assessment of regional cerebral blood volume maps in a blinded reader study","volume":"21","author":"Bruening","year":"2000","journal-title":"AJNR Am J Neuroradiol"},{"issue":"6","key":"10.1016\/j.ejrad.2007.06.028_bib18","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/mrm.1910400602","article-title":"NMR imaging of changes in vascular morphology due to tumor angiogenesis","volume":"40","author":"Dennie","year":"1998","journal-title":"Magn Reson Med"},{"issue":"5","key":"10.1016\/j.ejrad.2007.06.028_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1109\/MEMB.2004.1360410","article-title":"Dynamic magnetic resonance imaging of tumor perfusion Approaches and biomedical challenges.","volume":"23","author":"Collins","year":"2004","journal-title":"IEEE Eng Med Biol Mag"},{"key":"10.1016\/j.ejrad.2007.06.028_bib20","series-title":"Proceedings of the UK Radiological Congress","first-page":"53","article-title":"Diagnostic utility of perfusion weighted imaging of the prostate","author":"Gibbs","year":"2001"},{"key":"10.1016\/j.ejrad.2007.06.028_bib21","first-page":"2148","article-title":"Comparison of normal and cancerous prostate using dynamic Tl and T2* weighted MRI","volume":"7","author":"Noseworthy","year":"2000","journal-title":"Proc Intl Soc Mag Reson Med"},{"issue":"4","key":"10.1016\/j.ejrad.2007.06.028_bib22","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.ijrobp.2007.01.018","article-title":"Hypoxia in prostate cancer: correlation of BOLD-MRI with pimonidazole immunohistochemistry","volume":"68","author":"Hoskin","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ejrad.2007.06.028_bib23","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1148\/radiology.203.3.9169683","article-title":"Dynamic TurboFLASH subtraction technique for contrast-enhanced MR imaging of the prostate: correlation with histopathologic results","volume":"203","author":"Jager","year":"1997","journal-title":"Radiology"},{"issue":"5","key":"10.1016\/j.ejrad.2007.06.028_bib24","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/mrm.1910320514","article-title":"Quantitative analysis of multi-slice Gd-DTPA enhanced dynamic MR images using an automated simplex minimization procedure","volume":"32","author":"Buckley","year":"1994","journal-title":"Magn Reson Med"},{"issue":"1","key":"10.1016\/j.ejrad.2007.06.028_bib25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/mrm.1910320110","article-title":"Studies of Gd-DTPA relaxivity and proton exchange rates in tissue","volume":"32","author":"Donahue","year":"1994","journal-title":"Magn Reson Med"},{"issue":"3","key":"10.1016\/j.ejrad.2007.06.028_bib26","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0360-3016(99)00040-1","article-title":"Evaluating the effect of rectal distension and rectal movement on prostate gland position using cine MRI","volume":"44","author":"Padhani","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"10.1016\/j.ejrad.2007.06.028_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S","article-title":"Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols","volume":"10","author":"Tofts","year":"1999","journal-title":"J Magn Reson Imaging"},{"issue":"1","key":"10.1016\/j.ejrad.2007.06.028_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jmri.1880070113","article-title":"Modeling tracer kinetics in dynamic Gd-DTPA MR imaging","volume":"7","author":"Tofts","year":"1997","journal-title":"J Magn Reson Imaging"},{"issue":"3","key":"10.1016\/j.ejrad.2007.06.028_bib29","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/mrm.10080","article-title":"Uncertainty in the analysis of tracer kinetics using dynamic contrast-enhanced T1-weighted MRI","volume":"47","author":"Buckley","year":"2002","journal-title":"Magn Reson Med"},{"issue":"3a","key":"10.1016\/j.ejrad.2007.06.028_bib30","first-page":"1651","article-title":"Expression of different vascular endothelial markers in prostate cancer and BPH tissue: an immunohistochemical and clinical evaluation","volume":"24","author":"Trojan","year":"2004","journal-title":"Anticancer Res"},{"issue":"4","key":"10.1016\/j.ejrad.2007.06.028_bib31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/jmri.10176","article-title":"Dynamic contrast-enhanced MRI in clinical oncology: current status and future directions","volume":"16","author":"Padhani","year":"2002","journal-title":"J Magn Reson Imaging"},{"issue":"1","key":"10.1016\/j.ejrad.2007.06.028_bib32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1148\/radiol.2291020200","article-title":"Discrimination of prostate cancer from normal peripheral zone and central gland tissue by using dynamic contrast-enhanced MR imaging","volume":"229","author":"Engelbrecht","year":"2003","journal-title":"Radiology"},{"issue":"2","key":"10.1016\/j.ejrad.2007.06.028_bib33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/crad.1999.0327","article-title":"Dynamic contrast enhanced MRI of prostate cancer: correlation with morphology and tumour stage, histological grade and PSA","volume":"55","author":"Padhani","year":"2000","journal-title":"Clin Radiol"},{"issue":"2","key":"10.1016\/j.ejrad.2007.06.028_bib34","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/pros.20124","article-title":"Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a useful modality for the precise detection and staging of early prostate cancer","volume":"62","author":"Hara","year":"2005","journal-title":"Prostate"},{"issue":"1","key":"10.1016\/j.ejrad.2007.06.028_bib35","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jmri.20626","article-title":"Combined diffusion-weighted and dynamic contrast-enhanced MRI for prostate cancer diagnosis\u2014correlation with biopsy and histopathology","volume":"24","author":"Kozlowski","year":"2006","journal-title":"J Magn Reson Imaging"},{"issue":"3","key":"10.1016\/j.ejrad.2007.06.028_bib36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0895-6111(98)00022-6","article-title":"The value of dynamic MR imaging for hypointensity lesions of the peripheral zone of the prostate","volume":"22","author":"Namimoto","year":"1998","journal-title":"Comput Med Imaging Graph"},{"key":"10.1016\/j.ejrad.2007.06.028_bib37","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.2412051866","article-title":"Prostate cancer localization with dynamic contrast-enhanced MR imaging and proton MR spectroscopic Imaging","author":"Futterer","year":"2006","journal-title":"Radiology"},{"issue":"2","key":"10.1016\/j.ejrad.2007.06.028_bib38","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1148\/radiol.2372041724","article-title":"Staging prostate cancer with dynamic contrast-enhanced endorectal MR imaging prior to radical prostatectomy: experienced versus less experienced readers","volume":"237","author":"Futterer","year":"2005","journal-title":"Radiology"},{"issue":"3","key":"10.1016\/j.ejrad.2007.06.028_bib39","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0360-3016(00)00467-3","article-title":"Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality","volume":"47","author":"Ling","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.ejrad.2007.06.028_bib40","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ijrobp.2005.12.046","article-title":"IMRT boost dose planning on dominant intraprostatic lesions: gold marker-based three-dimensional fusion of CT with dynamic contrast-enhanced and 1H-spectroscopic MRI","volume":"65","author":"van Lin","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.ejrad.2007.06.028_bib41","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0022-5347(05)68352-8","article-title":"Castration induces acute vasoconstriction of blood vessels in the rat prostate concomitant with a reduction of prostatic nitric oxide synthase activity","volume":"162","author":"Hayek","year":"1999","journal-title":"J Urol"},{"issue":"3","key":"10.1016\/j.ejrad.2007.06.028_bib42","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1097-0045(19980801)36:3<201::AID-PROS9>3.0.CO;2-J","article-title":"Rapid reduction in blood flow to the rat ventral prostate gland after castration: preliminary evidence that androgens influence prostate size by regulating blood flow to the prostate gland and prostatic endothelial cell survival","volume":"36","author":"Shabsigh","year":"1998","journal-title":"Prostate"},{"issue":"2","key":"10.1016\/j.ejrad.2007.06.028_bib43","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1148\/radiology.218.2.r01ja04365","article-title":"Effects of androgen deprivation on prostatic morphology and vascular permeability evaluated with MR imaging","volume":"218","author":"Padhani","year":"2001","journal-title":"Radiology"},{"issue":"suppl. 1","key":"10.1016\/j.ejrad.2007.06.028_bib44","first-page":"s445","article-title":"Functional MRI to investigate changes in oxygenation and vascularity of the prostate gland caused by androgen deprivation.","volume":"81","author":"Alonzi","year":"2006","journal-title":"Radiother. Oncol."},{"issue":"suppl. 1","key":"10.1016\/j.ejrad.2007.06.028_bib45","first-page":"s315","article-title":"The effect of radiotherapy and combretastatin A-4 phosphate (CA4P) on prostate gland vascularity","volume":"81","author":"Mandeville","year":"2006","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.ejrad.2007.06.028_bib46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00004728-200101000-00008","article-title":"Functional CT imaging of the acute hyperemic response to radiation therapy of the prostate gland: early experience","volume":"25","author":"Harvey","year":"2001","journal-title":"J Comput Assist Tomogr"},{"issue":"1","key":"10.1016\/j.ejrad.2007.06.028_bib47","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/(SICI)1097-0215(19990702)82:1<84::AID-IJC15>3.0.CO;2-N","article-title":"Synergistic interaction of ultrasonic shock waves and hyperthermia in the Dunning prostate tumor R3327-AT1","volume":"82","author":"Huber","year":"1999","journal-title":"Int J Cancer"},{"issue":"suppl.","key":"10.1016\/j.ejrad.2007.06.028_bib48","first-page":"s97","article-title":"Value of multi-sectional fast contrast-enhanced MR imaging in patients with elevated PSA levels after radical prostatectomy","volume":"178","author":"Takeda","year":"2002","journal-title":"Am J Roentgenol"},{"issue":"5","key":"10.1016\/j.ejrad.2007.06.028_bib49","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.urology.2003.12.017","article-title":"Recurrent prostate cancer after external beam radiotherapy: value of contrast-enhanced dynamic MRI in localizing intraprostatic tumor\u2014correlation with biopsy findings","volume":"63","author":"Rouviere","year":"2004","journal-title":"Urology"},{"key":"10.1016\/j.ejrad.2007.06.028_bib50","first-page":"2094","article-title":"Dynamic contrast enhanced MRI of prostate cancer for predicting patient outcome","volume":"10","author":"Padhani","year":"2002","journal-title":"Proc Intl Soc Mag Reson Med"},{"issue":"2","key":"10.1016\/j.ejrad.2007.06.028_bib51","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1148\/rg.262045187","article-title":"Leach M: informatics in radiology (infoRAD): magnetic resonance imaging workbench: analysis and visualization of dynamic contrast-enhanced MR imaging data","volume":"26","author":"d\u2019Arcy","year":"2006","journal-title":"Radiographics"}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X07003245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X07003245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,5]],"date-time":"2019-01-05T07:54:20Z","timestamp":1546674860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X07003245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0720048X07003245"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2007.06.028","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}