{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:06:05Z","timestamp":1760853965872},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["ejradiology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.ejrad.2017.07.006","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T14:01:09Z","timestamp":1500300069000},"page":"18-23","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Altered spontaneous brain activity pattern in cognitively normal young adults carrying mutations of APP, presenilin-1\/2 and APOE \u03b54"],"prefix":"10.1016","volume":"95","author":[{"given":"Li Juan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Yan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhui","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang Ming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long Jiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejrad.2017.07.006_bib0005","first-page":"1","article-title":"REvIEWS epidemiology of Alzheimer disease","volume":"7","author":"Reitz","year":"2011","journal-title":"Nat. Publ. Gr."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cortex.2015.10.014","article-title":"Early-onset and late-onset Alzheimer\u2019s disease are associated with distinct patterns of memory impairment","volume":"74","author":"Joubert","year":"2015","journal-title":"Cortex"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0015","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1212\/WNL.0000000000000154","article-title":"APOE e4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory","volume":"82","author":"Kerchner","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0020","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/alzrt182","article-title":"Comprehensive behavioral characterization of an APP\/PS-1 double knock-in mouse model of Alzheimer\u2019s disease","volume":"5","author":"Webster","year":"2013","journal-title":"Alzheimers. Res. Ther."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0025","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1474-4422(12)70228-4","article-title":"Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer\u2019s disease in the presenilin 1 E280A kindred: a case-control study","volume":"11","author":"Reiman","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0030","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1136\/jnnp-2013-305858","article-title":"Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients","volume":"85","author":"Lehmann","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0035","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/j.neurobiolaging.2012.01.014","article-title":"Gray matter network associated with risk for Alzheimer\u2019s disease in young to middle-aged adults","volume":"33","author":"Alexander","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0040","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/1573405054038726","article-title":"Voxel-based morphometry of the human brain: methods and applications","volume":"1","author":"Mechelli","year":"2005","journal-title":"Curr. Med. Imaging Rev."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-015-0027-z","article-title":"Voxel-based meta-analysis of grey matter changes in Alzheimer\u2019s disease","volume":"4","author":"Wang","year":"2015","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0050","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11065-007-9025-y","article-title":"Use of functional magnetic resonance imaging in the early identification of Alzheimer\u2019s disease","volume":"17","author":"Wierenga","year":"2007","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0055","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuroimage.2003.12.030","article-title":"Regional homogeneity approach to fMRI data analysis","volume":"22","author":"Zang","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0060","article-title":"Different hippocampus functional connectivity patterns in healthy young adults with mutations of APP\/Presenilin-1\/2 and APOE\u03b54","author":"Zheng","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0065","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1093\/cercor\/bhu237","article-title":"Opposite neural trajectories of apolipoprotein e 4 and 2 alleles with aging associated with different risks of alzheimer\u2019s disease","volume":"26","author":"Shu","year":"2014","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0070","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.neuroimage.2010.05.010","article-title":"Selective aberrant functional connectivity of resting state networks in social anxiety disorder","volume":"52","author":"Liao","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0075","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/WAD.0b013e31819cb8a2","article-title":"Cardiorespiratory fitness and preserved medial temporal lobe volume in Alzheimer disease","volume":"23","author":"Honea","year":"2009","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0080","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.neuropsychologia.2008.01.027","article-title":"Regional homogeneity, functional connectivity and imaging markers of Alzheimer\u2019s disease: a review of resting-state fMRI studies","volume":"46","author":"Liu","year":"2008","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/907464","article-title":"Assessment of functional characteristics of amnestic mild cognitive impairment and alzheimer\u2019s disease using various methods of resting-state FMRI analysis","volume":"2015","author":"Cha","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0090","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1152\/jn.1972.35.1.96","article-title":"Visual properties of neurons in inferotemporal cortex of the Macaque","volume":"35","author":"Gross","year":"1972","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0095","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1523\/JNEUROSCI.4293-12.2013","article-title":"Global similarity and pattern separation in the human medial temporal lobe predict subsequent memory","volume":"33","author":"LaRocque","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0100","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1093\/brain\/aws113","article-title":"Amyloid burden and metabolic function in early-onset Alzheimer\u2019s disease: parietal lobe involvement","volume":"135","author":"Ossenkoppele","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0105","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.arcmed.2012.11.009","article-title":"Early-onset alzheimer\u2019s disease: nonamnestic subtypes and type 2 CE","volume":"43","author":"Mendez","year":"2012","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0110","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3233\/JAD-142451","article-title":"I. Alzheimer\u2019s Disease Neuroimaging, Cognition, brain atrophy, and cerebrospinal fluid biomarkers changes from preclinical to dementia stage of alzheimer\u2019s disease and the influence of apolipoprotein E","volume":"45","author":"Susanto","year":"2015","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0115","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuroimage.2016.05.051","article-title":"Exploring the role of the posterior middle temporal gyrus in semantic cognition: integration of anterior temporal lobe with goal-oriented cognition","volume":"137","author":"Davey","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2013.01.001","article-title":"Longitudinal changes of cortical thickness in early- versus late-onset Alzheimer\u2019s disease","volume":"34","author":"Cho","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0125","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.neuron.2009.08.028","article-title":"Intention, action planning, and decision making in parietal-frontal circuits","volume":"63","author":"Andersen","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0130","first-page":"1","article-title":"Effects of apolipoprotein e genotype on the off-line memory consolidation","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0135","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1002\/hbm.22570","article-title":"Temporo-frontal functional connectivity during auditory change detection is altered in Alzheimer\u2019s disease","volume":"35","author":"Hsiao","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.ejrad.2017.07.006_bib0140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00234-012-1077-x","article-title":"Regional cerebral perfusion in patients with Alzheimer\u2019s disease and mild cognitive impairment: effect of APOE Epsilon4 allele","volume":"55","author":"Kim","year":"2012","journal-title":"Neuroradiology"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0145","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2147\/CIA.S58879","article-title":"Pattern of cerebral hyperperfusion in Alzheimer\u2019s disease and amnestic mild cognitive impairment using voxel-based analysis of 3D arterial spin-labeling imaging: initial experience","volume":"9","author":"Ding","year":"2014","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.ejrad.2017.07.006_bib0150","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/jnnp-2011-302087","article-title":"Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer\u2019s disease mutations","volume":"84","author":"Lee","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X17302905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X17302905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T07:16:13Z","timestamp":1536304573000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X17302905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":30,"alternative-id":["S0720048X17302905"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2017.07.006","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered spontaneous brain activity pattern in cognitively normal young adults carrying mutations of APP, presenilin-1\/2 and APOE \u03b54","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2017.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}