{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:51:07Z","timestamp":1784253067728,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"intramural research program of the Center for Cancer Research, National Cancer Institute"},{"name":"Intramural Research Program of the National Cancer Institute","award":["1ZIA BCO1127507"],"award-info":[{"award-number":["1ZIA BCO1127507"]}]}],"content-domain":{"domain":["ejradiology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ejrad.2018.11.023","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T18:55:11Z","timestamp":1542912911000},"page":"130-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["The utility of 68Gallium-DOTATATE PET\/CT in the detection of von Hippel-Lindau disease associated tumors"],"prefix":"10.1016","volume":"112","author":[{"given":"Jasmine","family":"Shell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-9634","authenticated-orcid":false,"given":"Amit","family":"Tirosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Millo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira M.","family":"Sadowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Assadipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patience","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaval","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naris","family":"Nilubol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Electron","family":"Kebebew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejrad.2018.11.023_bib0005","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0140-6736(03)13643-4","article-title":"von Hippel-Lindau disease","volume":"361","author":"Lonser","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ejrad.2018.11.023_bib0010","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","article-title":"Identification of the von Hippel-Lindau disease tumor suppressor gene","volume":"260","author":"Latif","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.ejrad.2018.11.023_bib0015","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/jama.1995.03520310062031","article-title":"Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer","volume":"273","author":"Linehan","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.ejrad.2018.11.023_bib0020","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1007\/s11605-012-1847-0","article-title":"Pancreatic lesions in von Hippel\u2013Lindau disease? A systematic review and meta-synthesis of the literature","volume":"16","author":"Charlesworth","year":"2012","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0025","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/SLA.0000000000000856","article-title":"Long-term prognosis of resected pancreatic neuroendocrine tumors in von hippel-lindau disease is favorable and not influenced by small tumors left in place","volume":"262","author":"de Mestier","year":"2015","journal-title":"Ann. Surg."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0030","article-title":"Association of VHL genotype with pancreatic neuroendocrine tumor phenotype in patients with von Hippel-Lindau disease","author":"Tirosh","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12672-013-0134-1","article-title":"Altered PTEN, ATRX, CHGA, CHGB, and TP53 expression are associated with aggressive VHL-associated pancreatic neuroendocrine tumors","volume":"4","author":"Weisbrod","year":"2013","journal-title":"Horm. Cancer"},{"key":"10.1016\/j.ejrad.2018.11.023_bib0040","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1245\/s10434-012-2276-8","article-title":"Association of type O blood with pancreatic neuroendocrine tumors in Von Hippel\u2013Lindau syndrome","volume":"19","author":"Weisbrod","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0045","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.surg.2007.09.012","article-title":"Clinical, genetic and radiographic analysis of 108 patients with von Hippel-Lindau disease (VHL) manifested by pancreatic neuroendocrine neoplasms (PNETs)","volume":"142","author":"Blansfield","year":"2007","journal-title":"Surgery"},{"key":"10.1016\/j.ejrad.2018.11.023_bib0050","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrclinonc.2016.37","article-title":"Evaluation and management of pancreatic lesions in patients with von Hippel\u2013Lindau disease","volume":"13","author":"Keutgen","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0055","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.surg.2011.09.048","article-title":"Comparison of 6-18F-Fluoro-l-DOPA, 18F-2-deoxy-d-glucose, CT, and MRI in patients with pancreatic neuroendocrine neoplasms with von Hippel-Lindau disease","volume":"150","author":"Kitano","year":"2011","journal-title":"Surgery"},{"key":"10.1016\/j.ejrad.2018.11.023_bib0060","first-page":"17","article-title":"Functional assessment in the multimodality imaging of pancreatic neuro-endocrine tumours","volume":"35","author":"Bhate","year":"2010","journal-title":"Minerva Endocrinol."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0065","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.bpg.2012.12.004","article-title":"Radiological and nuclear medicine imaging of gastroenteropancreatic neuroendocrine tumours","volume":"26","author":"Sundin","year":"2012","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0070","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.jamcollsurg.2014.01.004","article-title":"Prospective evaluation of the clinical utility of 18-fluorodeoxyglucose PET CT scanning in patients with Von Hippel-Lindau\u2013associated pancreatic lesions","volume":"218","author":"Sadowski","year":"2014","journal-title":"J. Am. Coll. Surg."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0075","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.2967\/jnumed.110.075002","article-title":"68Ga-DOTATATE PET\/CT for the early prediction of response to somatostatin receptor-mediated radionuclide therapy in patients with well-differentiated neuroendocrine tumors","volume":"51","author":"Haug","year":"2010","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0080","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1245\/s10434-014-3981-2","article-title":"Impact of (68)Ga-DOTATATE PET\/CT on the surgical management of primary neuroendocrine tumors of the pancreas or ileum","volume":"22","author":"Ilhan","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0085","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.2967\/jnumed.111.101675","article-title":"The role of 68Ga-DOTATATE PET\/CT in suspected neuroendocrine tumors","volume":"53","author":"Haug","year":"2012","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0090","first-page":"426","article-title":"The value of (68)Ga-DOTATATE PET\/CT in diagnosis and management of neuroendocrine tumors compared to current FDA approved imaging modalities: a review of literature","volume":"4","author":"Mojtahedi","year":"2014","journal-title":"Am. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.ejrad.2018.11.023_bib0095","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1754-9485.2011.02327.x","article-title":"High management impact of Ga-68 DOTATATE (GaTate) PET\/CT for imaging neuroendocrine and other somatostatin expressing tumours","volume":"56","author":"Hofman","year":"2012","journal-title":"J. Med. Imaging Radiat. Oncol."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0100","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00259-013-2371-5","article-title":"Comparison of abdominal MRI with diffusion-weighted imaging to 68Ga-DOTATATE PET\/CT in detection of neuroendocrine tumors of the pancreas","volume":"40","author":"Schmid-Tannwald","year":"2013","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.ejrad.2018.11.023_bib0105","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1200\/JCO.2015.64.0987","article-title":"Prospective study of 68Ga-DOTATATE positron emission tomography\/computed tomography for detecting gastro-entero-pancreatic neuroendocrine tumors and unknown primary sites","volume":"34","author":"Sadowski","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0110","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1007\/s00259-016-3421-6","article-title":"Potential role of 68Ga-DOTATOC PET\/CT in screening for pancreatic neuroendocrine tumour in patients with von Hippel-Lindau disease","volume":"43","author":"Prasad","year":"2016","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.ejrad.2018.11.023_bib0115","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/RLU.0000000000001315","article-title":"Endolymphatic sac tumor showing increased activity on 68Ga DOTATATE PET\/CT","volume":"41","author":"Papadakis","year":"2016","journal-title":"Clin. Nucl. Med."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0120","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/RLU.0000000000001314","article-title":"Epididymal cystadenomas in von Hippel-Lindau disease showing increased activity on 68Ga DOTATATE PET\/CT","volume":"41","author":"Papadakis","year":"2016","journal-title":"Clin. Nucl. Med."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/RLU.0000000000001511","article-title":"18F-FDG and 68Ga-DOTATATE PET\/CT in von Hippel-Lindau disease\u2013associated retinal hemangioblastoma","volume":"42","author":"Papadakis","year":"2017","journal-title":"Clin. Nucl. Med."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0130","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1097\/RLU.0000000000001393","article-title":"Kidney tumor in a von hippel-lindau (VHL) patient with intensely increased activity on 68Ga-DOTA-TATE PET\/CT","volume":"41","author":"Papadakis","year":"2016","journal-title":"Clin. Nucl. Med."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0135","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2967\/jnumed.112.114165","article-title":"Measured human dosimetry of 68Ga-DOTATATE","volume":"54","author":"Walker","year":"2013","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0140","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1001\/archinternmed.2009.427","article-title":"Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of Cancer","volume":"169","author":"Smith-Bindman","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0145","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1007\/s00330-017-4803-2","article-title":"Evaluation of (68)Ga-DOTATOC PET\/MRI for whole-body staging of neuroendocrine tumours in comparison with (68)Ga-DOTATOC PET\/CT","volume":"27","author":"Sawicki","year":"2017","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.ejrad.2018.11.023_bib0150","doi-asserted-by":"crossref","DOI":"10.1007\/s11547-018-0917-0","article-title":"Fast non-enhanced abdominal examination protocols in PET\/MRI for patients with neuroendocrine tumors (NET): comparison to multiphase contrast-enhanced PET\/CT","author":"Seith","year":"2018","journal-title":"Radiol. Med."}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X18304182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X18304182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T17:32:24Z","timestamp":1550251944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X18304182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":30,"alternative-id":["S0720048X18304182"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2018.11.023","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The utility of 68Gallium-DOTATATE PET\/CT in the detection of von Hippel-Lindau disease associated tumors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2018.11.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}