{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T20:00:24Z","timestamp":1771617624463,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004830","name":"Siemens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004830","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ejradiology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.ejrad.2019.01.017","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T11:48:48Z","timestamp":1547639328000},"page":"136-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Iodine quantification based on rest \/ stress perfusion dual energy CT to differentiate ischemic, infarcted and normal myocardium"],"prefix":"10.1016","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-4426","authenticated-orcid":false,"given":"Marly","family":"van Assen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Lavra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-5641","authenticated-orcid":false,"given":"U. Joseph","family":"Schoepf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian E.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baxter T.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2781-7462","authenticated-orcid":false,"given":"Akos","family":"Varga-Szemes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balazs","family":"Ruzsics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthijs","family":"Oudkerk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rozemarijn","family":"Vliegenthart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo N.","family":"De Cecco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejrad.2019.01.017_bib0005","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.ejrad.2016.06.023","article-title":"Myocardial perfusion imaging with dual energy CT","volume":"85","author":"Jin","year":"2016","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0010","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ejrad.2008.09.010","article-title":"Dual-energy CT of the heart-Principles and protocols","volume":"68","author":"Schwarz","year":"2008","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0015","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s00330-013-3040-6","article-title":"Protocols: validation in a phantom model","volume":"24","author":"Koonce","year":"2014","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0020","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2214\/AJR.11.7082","article-title":"CT of coronary heart disease: part 1, CT of myocardial infarction, ischemia, and viability","volume":"198","author":"Vliegenthart","year":"2012","journal-title":"Am. J. Roentgenol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0025","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1161\/CIRCULATIONAHA.107.745711","article-title":"Myocardial ischemia diagnosed by dual-energy computed tomography: correlation with single-photon emission computed tomography","volume":"117","author":"Ruzsics","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.ejrad.2019.01.017_bib0030","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/RTI.0000000000000284","article-title":"Quantitative analysis of iodine image of dual-energy computed tomography at rest: comparison with 99mTc-tetrofosmin stress-rest single-photon emission computed tomography myocardial perfusion imaging as the reference standard","volume":"33","author":"Nakahara","year":"2018","journal-title":"J. Thorac. Imaging"},{"key":"10.1016\/j.ejrad.2019.01.017_bib0035","first-page":"1","article-title":"Accuracy of iodine quantification using dual energy CT in latest generation dual source and dual layer CT","author":"Pelgrim","year":"2017","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0040","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/RTI.0000000000000259","article-title":"Monoenergetic dual-energy computed tomographic imaging: cardiothoracic applications","volume":"32","author":"Lenga","year":"2017","journal-title":"J. Thorac. Imaging"},{"key":"10.1016\/j.ejrad.2019.01.017_bib0045","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/RTI.0000000000000258","article-title":"Recent advances in computed tomographic technology: cardiopulmonary imaging applications","volume":"32","author":"Tabari","year":"2017","journal-title":"J. Thorac. Imaging"},{"key":"10.1016\/j.ejrad.2019.01.017_bib0050","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00330-010-1897-1","article-title":"Myocardial perfusion imaging using adenosine-induced stress dual-energy computed tomography of the heart: comparison with cardiac magnetic resonance imaging and conventional coronary angiography","volume":"21","author":"Ko","year":"2011","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0055","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.amjcard.2009.03.051","article-title":"Comparison of dual-energy computed tomography of the heart with single photon emission computed tomography for assessment of coronary artery stenosis and of the myocardial blood supply","volume":"104","author":"Ruzsics","year":"2009","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0060","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10554-014-0410-3","article-title":"Direct comparison of stress- and rest-dual-energy computed tomography for detection of myocardial perfusion defect","volume":"30","author":"Ko","year":"2014","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ejrad.2019.01.017_bib0065","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1007\/s00330-015-4128-y","article-title":"Quantitative myocardial perfusion with stress dual-energy CT: iodine concentration differences between normal and ischemic or necrotic myocardium. Initial experience","volume":"26","author":"Delgado Sanchez-Gracian","year":"2016","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0070","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1001\/jamacardio.2017.2471","article-title":"Comparison of coronary CT angiography, SPECT, PET, and hybrid imaging for diagnosis of ischemic heart disease determined by fractional flow reserve","volume":"2","author":"Danad","year":"2017","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0075","first-page":"131183","article-title":"First-arterial-pass dual-energy CT for assessment of myocardial blood supply: do we need rest, stress, and delayed acquisition? Comparison with SPECT","volume":"270","author":"Meinel","year":"2013","journal-title":"Radiology"},{"key":"10.1016\/j.ejrad.2019.01.017_bib0080","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.jacc.2006.08.012","article-title":"Computed tomography coronary angiography","volume":"48","author":"Achenbach","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/RLI.0b013e31823fd42b","article-title":"Accuracy of dynamic computed tomography adenosine stress myocardial perfusion imaging in estimating myocardial blood flow at various degrees of coronary artery stenosis using a porcine animal model","volume":"47","author":"Bamberg","year":"2012","journal-title":"Invest. Radiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0090","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.jacc.2011.12.040","article-title":"Diagnostic performance of noninvasive myocardial perfusion imaging using single-photon emission computed tomography, cardiac magnetic resonance, and positron emission tomography imaging for the detection of obstructive coronary artery disease","volume":"59","author":"Jaarsma","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0095","doi-asserted-by":"crossref","first-page":"e446","DOI":"10.1016\/j.crvasa.2015.09.010","article-title":"Myocardial perfusion imaging in coronary artery disease","volume":"57","author":"Kostkiewicz","year":"2015","journal-title":"Cor Vasa"},{"key":"10.1016\/j.ejrad.2019.01.017_bib0100","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jcmg.2015.08.018","article-title":"Adenosine stress and rest T1 mapping can differentiate between ischemic, infarcted, remote, and normal myocardium without the need for gadolinium contrast agents","volume":"9","author":"Liu","year":"2016","journal-title":"JACC-Cardiovasc. Imag."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0105","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/0735-1097(93)90172-W","article-title":"Altered coronary vasodilator reserve and metabolism in myocardium subtended by normal arteries in patients with coronary artery disease","volume":"22","author":"Uren","year":"1993","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0110","first-page":"75","article-title":"Myocardial blood flow measurement by PET: technical aspects and clinical applications","volume":"46","author":"Kaufmann","year":"2005","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ejrad.2019.01.017_bib0115","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/CIRCIMAGING.109.854893","article-title":"Noninvasive assessment of myocardial perfusion","volume":"2","author":"Salerno","year":"2009","journal-title":"Circ. Cardiovasc. Imaging"}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X19300178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X19300178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T10:02:06Z","timestamp":1573725726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X19300178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":23,"alternative-id":["S0720048X19300178"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2019.01.017","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iodine quantification based on rest \/ stress perfusion dual energy CT to differentiate ischemic, infarcted and normal myocardium","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2019.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}