{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:36:20Z","timestamp":1783643780545,"version":"3.55.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.ejrad.2020.109047","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T21:30:07Z","timestamp":1590010207000},"page":"109047","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors"],"prefix":"10.1016","volume":"129","author":[{"given":"Takeshi","family":"Kamitani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Sagiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Togao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Hida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Yasumatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetake","family":"Yabuuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejrad.2020.109047_bib0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/jmre.1999.1956","article-title":"A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST)","volume":"143","author":"Ward","year":"2000","journal-title":"J Magn Reson."},{"key":"10.1016\/j.ejrad.2020.109047_bib0010","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1039\/b509907m","article-title":"Paramagnetic lanthanide complexes as PARACEST agents for medical imaging","volume":"35","author":"Woods","year":"2006","journal-title":"Chem Soc Rev."},{"key":"10.1016\/j.ejrad.2020.109047_bib0015","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/mrm.22761","article-title":"Chemical exchange saturation transfer (CEST): what is in a name and what isn\u2019t?","volume":"65","author":"van Zijl","year":"2001","journal-title":"Magn Reson Med."},{"key":"10.1016\/j.ejrad.2020.109047_bib0020","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/neuonc\/not158","article-title":"Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades","volume":"16","author":"Togao","year":"2014","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ejrad.2020.109047_bib0025","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/nm907","article-title":"Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI","volume":"9","author":"Zhou","year":"2003","journal-title":"Nat Med."},{"key":"10.1016\/j.ejrad.2020.109047_bib0030","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/mrm.10651","article-title":"Amide proton transfer (APT) contrast for imaging of brain tumors","volume":"50","author":"Zhou","year":"2003","journal-title":"Magn Reson Med."},{"key":"10.1016\/j.ejrad.2020.109047_bib0035","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/mrm.21712","article-title":"Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging","volume":"60","author":"Zhou","year":"2008","journal-title":"Magn Reson Med."},{"key":"10.1016\/j.ejrad.2020.109047_bib0040","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1148\/radiol.2017170349","article-title":"Amide proton transfer MR imaging of endometrioid endometrial adenocarcinoma: association with histologic grade","volume":"286","author":"Takayama","year":"2018","journal-title":"Radiology"},{"key":"10.1016\/j.ejrad.2020.109047_bib0045","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mri.2018.04.017","article-title":"Amide proton transfer imaging can predict tumor grade in rectal cancer","volume":"51","author":"Nishie","year":"2018","journal-title":"Magn Reson Image"},{"key":"10.1016\/j.ejrad.2020.109047_bib0050","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1148\/radiol.2015151161","article-title":"Chemical exchange saturation transfer MR imaging: preliminary results for differentiation of malignant and benign thoracic lesions","volume":"279","author":"Ohno","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.ejrad.2020.109047_bib0055","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1007\/s00330-016-4261-2","article-title":"Added value of amide proton transfer imaging to conventional and perfusion MR imaging for evaluating the treatment response of newly diagnosed glioblastoma","volume":"26","author":"Park","year":"2016","journal-title":"Eur Radiol"},{"key":"10.1016\/j.ejrad.2020.109047_bib0060","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/mrm.24450","article-title":"Amide proton transfer imaging of the breast at 3 T: establishing reproducibility and possible feasibility assessing chemotherapy response","volume":"70","author":"Dula","year":"2013","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.ejrad.2020.109047_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155925","article-title":"Amide proton transfer imaging of diffuse gliomas: effect of saturation pulse length in parallel transmission-based technique","volume":"11","author":"Togao","year":"2016","journal-title":"PLos One"},{"key":"10.1016\/j.ejrad.2020.109047_bib0070","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1109\/83.650848","article-title":"A pyramid approach to subpixel registration based on intensity","volume":"7","author":"Thevenaz","year":"1998","journal-title":"IEEE Trans Image Process."},{"key":"10.1016\/j.ejrad.2020.109047_bib0075","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s10334-016-0537-4","article-title":"Amide proton transfer (APT) magnetic resonance imaging of prostate cancer: comparison with Gleason scores","volume":"29","author":"Takayama","year":"2016","journal-title":"Magn Reson Mater Phy"},{"key":"10.1016\/j.ejrad.2020.109047_bib0080","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/nbm.3184","article-title":"Amide proton transfer-weighted imaging of the head and neck at 3 T: a feasibility study on healthy human subjects and patients with head and neck cancer","volume":"27","author":"Yuan","year":"2014","journal-title":"NMR Biomed"},{"key":"10.1016\/j.ejrad.2020.109047_bib0085","series-title":"World Health Organization Classification of Tumours, Pathology and Genetics of Head and Neck Tumours, IARC","first-page":"254","article-title":"Pleomorphic adenoma","author":"Eveson","year":"2003"},{"key":"10.1016\/j.ejrad.2020.109047_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2019.108656","article-title":"Amide proton transfer imaging for differentiating benign ovarian cystic lesions: potential of first time right","volume":"120","author":"Ishimatsu","year":"2019","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.ejrad.2020.109047_bib0095","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1148\/radiol.2493072045","article-title":"Parotid gland tumors: can addition of diffusion-weighted MR imaging to dynamic contrast-enhanced MR imaging improve diagnostic accuracy in characterization?","volume":"249","author":"Yabuuchi","year":"2008","journal-title":"Radiology"}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X20302369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X20302369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:16:47Z","timestamp":1759994207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X20302369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":19,"alternative-id":["S0720048X20302369"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2020.109047","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2020.109047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109047"}}