{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:40:03Z","timestamp":1790300403733,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.ejrad.2020.109394","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T18:04:46Z","timestamp":1604340286000},"page":"109394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Iron deposition in Parkinsonisms: A Quantitative Susceptibility Mapping study in the deep grey matter"],"prefix":"10.1016","volume":"133","author":[{"given":"Maria Paola","family":"Fedeli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8922-657X","authenticated-orcid":false,"given":"Valeria Elisa","family":"Contarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Siggillino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Samoylova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Calloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Melazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Conte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Sacilotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Pezzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Maria","family":"Triulzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Scola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejrad.2020.109394_bib0005","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ejrad.2020.109394_bib0010","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejrad.2018.10.032","article-title":"Multiparametric MR imaging of Parkinsonisms at 3 tesla: its role in the differentiation of idiopathic Parkinson\u2019s disease versus atypical Parkinsonian disorders","volume":"109","author":"Calloni","year":"2018","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.ejrad.2020.109394_bib0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00004728-198701000-00002","article-title":"Clinical magnetic susceptibility mapping of the brain","volume":"11","author":"Young","year":"1987","journal-title":"J. Comput. Assist. Tomogr."},{"key":"10.1016\/j.ejrad.2020.109394_bib0020","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3174\/ajnr.A2765","article-title":"Different iron-deposition patterns of multiple system atrophy with predominant parkinsonism and idiopathetic Parkinson diseases demonstrated by phase-corrected susceptibility-weighted imaging","volume":"33","author":"Wang","year":"2012","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.ejrad.2020.109394_bib0025","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.parkreldis.2013.08.011","article-title":"Motor phenotype and magnetic resonance measures of basal ganglia iron levels in Parkinson\u2019s disease","volume":"19","author":"Bunzeck","year":"2013","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.ejrad.2020.109394_bib0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jns.2018.01.008","article-title":"Quantifying iron deposition within the substantia nigra of Parkinson\u2019s disease by quantitative susceptibility mapping","volume":"386","author":"An","year":"2018","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ejrad.2020.109394_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0162460","article-title":"Quantitative susceptibility mapping in Parkinson\u2019s disease","volume":"11","author":"Langkammer","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejrad.2020.109394_bib0040","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.mri.2015.02.021","article-title":"Quantifying brain iron deposition in patients with Parkinson\u2019s disease using quantitative susceptibility mapping, R2 and R2*","volume":"33","author":"Barbosa","year":"2015","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.ejrad.2020.109394_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101999","article-title":"Quantitative susceptibility mapping in atypical Parkinsonisms","volume":"24","author":"Mazzucchi","year":"2019","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.ejrad.2020.109394_bib0050","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.parkreldis.2017.08.029","article-title":"Quantitative susceptibility mapping differentiates between parkinsonian disorders","volume":"44","author":"Sj\u00f6str\u00f6m","year":"2017","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.ejrad.2020.109394_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-42565-4","article-title":"Mapping of apparent susceptibility yields promising diagnostic separation of progressive supranuclear palsy from other causes of parkinsonism","volume":"9","author":"Sj\u00f6str\u00f6m","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejrad.2020.109394_bib0060","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00234-017-1870-7","article-title":"Differential diagnosis of parkinsonism by a combined use of diffusion kurtosis imaging and quantitative susceptibility mapping","volume":"59","author":"Ito","year":"2017","journal-title":"Neuroradiology"},{"issue":"Suppl","key":"10.1016\/j.ejrad.2020.109394_bib0065","first-page":"1","article-title":"Clinical features differentiating patients with postmortem confirmed progressive supranuclear palsy and corticobasal degeneration","volume":"246","author":"Litvan","year":"1999","journal-title":"J. Neurol."},{"key":"10.1016\/j.ejrad.2020.109394_bib0070","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00401-003-0711-4","article-title":"Distribution of astrocytic plaques in the corticobasal degeneration brain and comparison with tuft-shaped astrocytes in the progressive supranuclear palsy brain","volume":"106","author":"Hattori","year":"2003","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ejrad.2020.109394_bib0075","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/brain\/123.7.1410","article-title":"Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson\u2019s disease: clinical and therapeutic implications","volume":"123","author":"Henderson","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.ejrad.2020.109394_bib0080","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jns.2012.11.009","article-title":"Topographical differences of brain iron deposition between progressive supranuclear palsy and parkinsonian variant multiple system atrophy","volume":"325","author":"Han","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ejrad.2020.109394_bib0085","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1212\/WNL.57.8.1497","article-title":"What features improve the accuracy of clinical diagnosis in Parkinson\u2019s disease: a clinicopathologic study","volume":"57","author":"Hughes","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.ejrad.2020.109394_bib0090","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","article-title":"Second consensus statement on the diagnosis of multiple system atrophy background: a consensus conference on multiple system atrophy (MSA) in 1998 established","volume":"71","author":"Gilman","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.ejrad.2020.109394_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.47.1.1","article-title":"Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP International Workshop","volume":"47","author":"Litvan","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.ejrad.2020.109394_bib0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/jmri.24768","article-title":"Susceptibility-weighted imaging and quantitative susceptibility mapping in the brain","volume":"42","author":"Liu","year":"2015","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.ejrad.2020.109394_bib0105","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.neuroimage.2010.11.088","article-title":"Quantitative susceptibility mapping of human brain reflects spatial variation in tissue composition","volume":"55","author":"Li","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.ejrad.2020.109394_bib0110","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1016\/j.neuroimage.2010.10.070","article-title":"Quantitative imaging of intrinsic magnetic tissue properties using MRI signal phase: An approach to in vivo brain iron metabolism?","volume":"54","author":"Schweser","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.ejrad.2020.109394_bib0115","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/nbm.3383","article-title":"Streaking artifact reduction for quantitative susceptibility mapping of sources with large dynamic range","volume":"28","author":"Wei","year":"2015","journal-title":"NMR Biomed."},{"key":"10.1016\/j.ejrad.2020.109394_bib0120","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/brain\/114.4.1953","article-title":"Alterations in the levels of iron, ferritin and other trace metals in parkinson\u2019s disease and other neurodegenerative diseases affecting the basal ganglia","volume":"114","author":"Dexter","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.ejrad.2020.109394_bib0125","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3174\/ajnr.A3832","article-title":"Changes in the thalamus in atypical Parkinsonism detected using shape analysis and diffusion tensor imaging","volume":"39","author":"Hess","year":"2014","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.ejrad.2020.109394_bib0130","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/nan.12362","article-title":"Progression of alpha-synuclein pathology in MSA of the cerebellar type","volume":"43","author":"Brettschneider","year":"2018","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.ejrad.2020.109394_bib0135","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1093\/brain\/awm104","article-title":"Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson\u2019s syndrome","volume":"130","author":"Williams","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.ejrad.2020.109394_bib0140","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.neuroimage.2017.08.003","article-title":"Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer\u2019s disease","volume":"159","author":"O\u2019Callaghan","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.ejrad.2020.109394_bib0145","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.3174\/ajnr.A1615","article-title":"Diffusion tensor imaging shows different topographic involvement of the thalamus in progressive supranuclear palsy and corticobasal degeneration","volume":"30","author":"Erbetta","year":"2009","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.ejrad.2020.109394_bib0150","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/mds.24968","article-title":"Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy","volume":"27","author":"Massey","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ejrad.2020.109394_bib0155","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00723-017-0877-x","article-title":"Quantitative susceptibility mapping of the substantia nigra in Parkinson\u2019s disease","volume":"48","author":"Zhao","year":"2017","journal-title":"Appl. Magn. Reson."},{"key":"10.1016\/j.ejrad.2020.109394_bib0160","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuroimage.2012.09.055","article-title":"Toward in vivo histology: a comparison of quantitative susceptibility mapping (QSM) with magnitude-, phase-, and R2*-imaging at ultra-high magnetic field strength","volume":"65","author":"Deistung","year":"2013","journal-title":"Neuroimage"}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X20305842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X20305842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:21:17Z","timestamp":1759994477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X20305842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":32,"alternative-id":["S0720048X20305842"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2020.109394","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iron deposition in Parkinsonisms: A Quantitative Susceptibility Mapping study in the deep grey matter","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2020.109394","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109394"}}