{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:30:34Z","timestamp":1788489034071,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.ejrad.2022.110356","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T04:54:36Z","timestamp":1652417676000},"page":"110356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["A gadoxetic acid\u2013enhanced MRI\u2013based multivariable model using LI-RADS v2018 and other imaging features for preoperative prediction of macrotrabecular\u2013massive hepatocellular carcinoma"],"prefix":"10.1016","volume":"153","author":[{"given":"Yingying","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejrad.2022.110356_b0005","doi-asserted-by":"crossref","unstructured":"Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, Washington KM, Carneiro F, Cree IA, Board WHOCoTE. The 2019 WHO classification of tumours of the digestive system. Histopathology 76 (2020) 182-188.","DOI":"10.1111\/his.13975"},{"key":"10.1016\/j.ejrad.2022.110356_b0010","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/hep.29762","article-title":"Macrotrabecular-massive hepatocellular carcinoma: A distinctive histological subtype with clinical relevance","volume":"68","author":"Ziol","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.ejrad.2022.110356_b0015","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jhep.2017.05.014","article-title":"Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification","volume":"67","author":"Calderaro","year":"2017","journal-title":"J. Hepatol."},{"issue":"10","key":"10.1016\/j.ejrad.2022.110356_b0020","doi-asserted-by":"crossref","first-page":"7696","DOI":"10.1007\/s00330-021-07898-7","article-title":"Macrotrabecular-massive hepatocellular carcinoma: imaging identification and prediction based on gadoxetic acid-enhanced magnetic resonance imaging","volume":"31","author":"Chen","year":"2021","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.ejrad.2022.110356_b0025","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1148\/radiol.2021203614","article-title":"Preoperative CT for Characterization of Aggressive Macrotrabecular-Massive Subtype and Vessels That Encapsulate Tumor Clusters Pattern in Hepatocellular Carcinoma","volume":"300","author":"Feng","year":"2021","journal-title":"Radiology"},{"key":"10.1016\/j.ejrad.2022.110356_b0030","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1148\/radiol.2020192230","article-title":"Multiphase Liver MRI for Identifying the Macrotrabecular-Massive Subtype of Hepatocellular Carcinoma","volume":"295","author":"Mule","year":"2020","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.ejrad.2022.110356_b0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jhep.2020.08.013","article-title":"Gadoxetic acid-enhanced MRI of macrotrabecular-massive hepatocellular carcinoma and its prognostic implications","volume":"74","author":"Rhee","year":"2021","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.ejrad.2022.110356_b0040","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1007\/s00261-021-02989-x","article-title":"A radiomics nomogram based on contrast-enhanced MRI for preoperative prediction of macrotrabecular-massive hepatocellular carcinoma","volume":"46","author":"Zhu","year":"2021","journal-title":"Abdom Radiol (NY)"},{"key":"10.1016\/j.ejrad.2022.110356_b0045","doi-asserted-by":"crossref","unstructured":"Kim TH, Kim SY, Tang A, Lee JM. Comparison of international guidelines for noninvasive diagnosis of hepatocellular carcinoma: 2018 update. Clin Mol Hepatol 25 (2019) 245-263.","DOI":"10.3350\/cmh.2018.0090"},{"key":"10.1016\/j.ejrad.2022.110356_b0050","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/hep.27304","article-title":"LI-RADS (Liver Imaging Reporting and Data System): summary, discussion, and consensus of the LI-RADS Management Working Group and future directions","volume":"61","author":"Mitchell","year":"2015","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.ejrad.2022.110356_b0055","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/jmri.26640","article-title":"Diagnostic performance of MR for hepatocellular carcinoma based on LI-RADS v2018, compared with v2017","volume":"50","author":"Ren","year":"2019","journal-title":"J. Magn. Reson. Imaging"},{"issue":"1","key":"10.1016\/j.ejrad.2022.110356_b0060","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1148\/radiol.2019181995","article-title":"Hepatocellular Carcinoma versus Other Hepatic Malignancy in Cirrhosis: Performance of LI-RADS Version 2018","volume":"291","author":"Kim","year":"2019","journal-title":"Radiology"},{"issue":"4","key":"10.1016\/j.ejrad.2022.110356_b0065","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1053\/j.gastro.2018.11.020","article-title":"Accuracy of the Liver Imaging Reporting and Data System in Computed Tomography and Magnetic Resonance Image Analysis of Hepatocellular Carcinoma or Overall Malignancy-A Systematic Review","volume":"156","author":"van der Pol","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejrad.2022.110356_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2020.109404","article-title":"Diagnostic performance of LI-RADS for MRI and CT detection of HCC: A systematic review and diagnostic meta-analysis","volume":"134","author":"Liang","year":"2021","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.ejrad.2022.110356_b0075","doi-asserted-by":"crossref","unstructured":"Cannella R, Dioguardi Burgio M, Beaufrere A, Trapani L, Paradis V, Hobeika C, Cauchy F, Bouattour M, Vilgrain V, Sartoris R, Ronot M. Imaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS. JHEP Rep 3 (2021) 100380.","DOI":"10.1016\/j.jhepr.2021.100380"},{"key":"10.1016\/j.ejrad.2022.110356_b0080","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.745085","article-title":"A Non-Invasive Nomogram for Preoperative Prediction of Microvascular Invasion Risk in Hepatocellular Carcinoma","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejrad.2022.110356_b0085","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000449336","article-title":"Surgery for Intermediate and Advanced Hepatocellular Carcinoma: A Consensus Report from the 5th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2014)","volume":"5","author":"Ho","year":"2016","journal-title":"Liver Cancer"},{"key":"10.1016\/j.ejrad.2022.110356_b0090","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.ejrad.2008.02.021","article-title":"Radiological detectability of minute hepatic venous invasion in hepatocellular carcinoma","volume":"70","author":"Nishie","year":"2009","journal-title":"Eur. J. Radiol."},{"issue":"5","key":"10.1016\/j.ejrad.2022.110356_b0095","doi-asserted-by":"crossref","first-page":"646","DOI":"10.21037\/hbsn.2020.03.20","article-title":"Liver resection versus intensity-modulated radiation therapy for treatment of hepatocellular carcinoma with hepatic vein tumor thrombus: a propensity score matching analysis","volume":"10","author":"Chen","year":"2021","journal-title":"Hepatobiliary Surg Nutr"},{"key":"10.1016\/j.ejrad.2022.110356_b0100","doi-asserted-by":"crossref","first-page":"782","DOI":"10.21037\/hbsn-19-810","article-title":"A new staging system for hepatocellular carcinoma associated with portal vein tumor thrombus","volume":"10","author":"Lau","year":"2021","journal-title":"Hepatobiliary Surg Nutr"},{"key":"10.1016\/j.ejrad.2022.110356_b0105","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1148\/radiol.2501071702","article-title":"Hepatocellular carcinoma with a pseudocapsule on gadolinium-enhanced MR images: correlation with histopathologic findings","volume":"250","author":"Ishigami","year":"2009","journal-title":"Radiology"},{"key":"10.1016\/j.ejrad.2022.110356_b0110","doi-asserted-by":"crossref","unstructured":"Tang A, Bashir MR, Corwin MT, Cruite I, Dietrich CF, Do RKG, Ehman EC, Fowler KJ, Hussain HK, Jha RC, Karam AR, Mamidipalli A, Marks RM, Mitchell DG, Morgan TA, Ohliger MA, Shah A, Vu KN, Sirlin CB, Group L-REW. Evidence Supporting LI-RADS Major Features for CT- and MR Imaging-based Diagnosis of Hepatocellular Carcinoma: A Systematic Review. Radiology 286 (2018) 29-48.","DOI":"10.1148\/radiol.2017170554"},{"key":"10.1016\/j.ejrad.2022.110356_b0115","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jmri.27570","article-title":"LI-RADS Major Features on MRI for Diagnosing Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis","volume":"54","author":"Shin","year":"2021","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.ejrad.2022.110356_b0120","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.diii.2021.06.004","article-title":"Enhancing capsule in hepatocellular carcinoma: intra-individual comparison between CT and MRI with extracellular contrast agent","volume":"102","author":"Cannella","year":"2021","journal-title":"Diagn Interv Imaging"},{"key":"10.1016\/j.ejrad.2022.110356_b0125","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jhep.2019.12.011","article-title":"Comparison of extracellular and hepatobiliary MR contrast agents for the diagnosis of small HCCs","volume":"72","author":"Paisant","year":"2020","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejrad.2022.110356_b0130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.hepres.2004.01.001","article-title":"Elasticity of small artery in patient with spontaneous rupture of hepatocellular carcinoma","volume":"29","author":"Zhu","year":"2004","journal-title":"Hepatol Res"},{"key":"10.1016\/j.ejrad.2022.110356_b0135","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1015-9584(09)60166-4","article-title":"Ultrastructural study of the vascular endothelium of patients with spontaneous rupture of hepatocellular carcinoma","volume":"25","author":"Zhu","year":"2002","journal-title":"Asian J Surg"},{"key":"10.1016\/j.ejrad.2022.110356_b0140","doi-asserted-by":"crossref","unstructured":"Cerny M, Chernyak V, Olivie D, Billiard JS, Murphy-Lavallee J, Kielar AZ, Elsayes KM, Bourque L, Hooker JC, Sirlin CB, Tang A. LI-RADS Version 2018 Ancillary Features at MRI. Radiographics 38 (2018) 1973-2001.","DOI":"10.1148\/rg.2018180052"},{"issue":"6","key":"10.1016\/j.ejrad.2022.110356_b0145","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1007\/s00330-020-07488-z","article-title":"Diagnosis of LI-RADS M lesions on gadoxetate-enhanced MRI: identifying cholangiocarcinoma-containing tumor with serum markers and imaging features","volume":"31","author":"Jiang","year":"2021","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.ejrad.2022.110356_b0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.clinimag.2021.01.022","article-title":"Peritumoral edema in preoperative magnetic resonance imaging is an independent prognostic factor for hepatocellular carcinoma","volume":"75","author":"He","year":"2021","journal-title":"Clin. Imaging"},{"key":"10.1016\/j.ejrad.2022.110356_b0155","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/hep.23485","article-title":"A meta-analysis of survival rates of untreated patients in randomized clinical trials of hepatocellular carcinoma","volume":"51","author":"Cabibbo","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.ejrad.2022.110356_b0160","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1148\/radiol.2021210379","article-title":"CT Characterization of Aggressive Macrotrabecular-Massive Hepatocellular Carcinoma: A Step Forward to Personalized Medicine","volume":"300","author":"Yoon","year":"2021","journal-title":"Radiology"}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X22002066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X22002066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:29:12Z","timestamp":1759994952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X22002066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":32,"alternative-id":["S0720048X22002066"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2022.110356","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A gadoxetic acid\u2013enhanced MRI\u2013based multivariable model using LI-RADS v2018 and other imaging features for preoperative prediction of macrotrabecular\u2013massive hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2022.110356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110356"}}