{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:40:48Z","timestamp":1792813248755,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771825"],"award-info":[{"award-number":["81771825"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1307900"],"award-info":[{"award-number":["2017YFC1307900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.ejrad.2023.111208","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T19:42:19Z","timestamp":1700250139000},"page":"111208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Atherosclerotic plaque characteristics in extracranial carotid artery may indicate closer association with white matter hyperintensities than intracranial arteries: A CARE-II study"],"prefix":"10.1016","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1416-0964","authenticated-orcid":false,"given":"Rui","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-1724","authenticated-orcid":false,"given":"Xihai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ejrad.2023.111208_b0005","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1474-4422(02)00190-4","article-title":"Subcortical ischaemic vascular dementia","volume":"1","author":"Rom\u00e1n","year":"2002","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.ejrad.2023.111208_b0010","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"Pantoni","year":"2010","journal-title":"Lancet Neurol."},{"issue":"24","key":"10.1016\/j.ejrad.2023.111208_b0015","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1212\/WNL.0000000000007654","article-title":"CNS small vessel disease: A clinical review","volume":"92","author":"Cannistraro","year":"2019","journal-title":"Neurology."},{"key":"10.1016\/j.ejrad.2023.111208_b0020","doi-asserted-by":"crossref","unstructured":"I.A. Awad, R.F. Spetzler, J.A. Hodak, C.A. Awad, R. Carey, Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors, Stroke. 17(6) (1986) 1084-1089, https:\/\/doi.org\/10.1161\/01.str.17.6.1084.","DOI":"10.1161\/01.STR.17.6.1084"},{"issue":"1036","key":"10.1016\/j.ejrad.2023.111208_b0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/postgradmedj-2011-130307","article-title":"Age-related cerebral white matter disease (leukoaraiosis): a review","volume":"88","author":"Grueter","year":"2012","journal-title":"Postgrad Med J."},{"issue":"8","key":"10.1016\/j.ejrad.2023.111208_b0030","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.3174\/ajnr.A3015","article-title":"Severity of leukoaraiosis in large vessel atherosclerotic disease","volume":"33","author":"Chutinet","year":"2012","journal-title":"AJNR Am J Neuroradiol."},{"issue":"15","key":"10.1016\/j.ejrad.2023.111208_b0035","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1212\/WNL.0000000000000312","article-title":"Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities","volume":"82","author":"Wardlaw","year":"2014","journal-title":"Neurology."},{"issue":"7","key":"10.1016\/j.ejrad.2023.111208_b0040","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1212\/WNL.0b013e318281ccc2","article-title":"Large-vessel correlates of cerebral small-vessel disease","volume":"80","author":"Brisset","year":"2013","journal-title":"Neurology."},{"key":"10.1016\/j.ejrad.2023.111208_b0045","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.ijcard.2016.08.234","article-title":"Carotid atherosclerosis, silent ischemic brain damage and brain atrophy: A systematic review and meta-analysis","volume":"223","author":"Moroni","year":"2016","journal-title":"Int J Cardiol."},{"key":"10.1016\/j.ejrad.2023.111208_b0050","unstructured":"M. Ouhlous, H.Z. Flach, de T.T. Weert, et al, Carotid plaque composition and cerebral infarction: MR imaging study, AJNR Am J Neuroradiol. 26(5) (2005) 1044-1049, PMID: 15891157."},{"issue":"1","key":"10.1016\/j.ejrad.2023.111208_b0055","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.11.007","article-title":"Carotid stenosis: a risk factor for cerebral white-matter disease","volume":"23","author":"Kandiah","year":"2014","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"10.1016\/j.ejrad.2023.111208_b0060","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.atherosclerosis.2019.04.230","article-title":"Progression of brain white matter hyperintensities in asymptomatic patients with carotid atherosclerotic plaques and no indication for revascularization","volume":"287","author":"Ammirati","year":"2019","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.ejrad.2023.111208_b0065","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3389\/fnagi.2020.00163","article-title":"The Asymmetry of White Matter Hyperintensity Burden Between Hemispheres Is Associated With Intracranial Atherosclerotic Plaque Enhancement Grade","volume":"12","author":"Ni","year":"2020","journal-title":"Front Aging Neurosci."},{"issue":"1","key":"10.1016\/j.ejrad.2023.111208_b0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/ene.12431","article-title":"Association of intracranial atherosclerotic stenosis with severity of white matter hyperintensities","volume":"22","author":"Park","year":"2015","journal-title":"Eur J Neurol."},{"issue":"5","key":"10.1016\/j.ejrad.2023.111208_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106406","article-title":"Association Between Intracranial Pulsatility and White Matter Hyperintensities in Asymptomatic Intracranial Arterial Stenosis: A Population-Based Study in Shandong, China","volume":"31","author":"Zhao","year":"2022","journal-title":"J Stroke Cerebrovasc Dis."},{"issue":"1","key":"10.1016\/j.ejrad.2023.111208_b0080","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/svn-2016-000053","volume":"2","author":"Zhao","year":"2017","journal-title":"Stroke Vasc. Neurol."},{"issue":"8","key":"10.1016\/j.ejrad.2023.111208_b0085","article-title":"Prevalence and Characteristics of Carotid Artery High-Risk Atherosclerotic Plaques in Chinese Patients With Cerebrovascular Symptoms: A Chinese Atherosclerosis Risk Evaluation II Study","volume":"6","author":"Zhao","year":"2017","journal-title":"J. Am. Hear.t Assoc."},{"issue":"17","key":"10.1016\/j.ejrad.2023.111208_b0090","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1161\/hc4201.097839","article-title":"In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques","volume":"104","author":"Yuan","year":"2001","journal-title":"Circulation."},{"issue":"9","key":"10.1016\/j.ejrad.2023.111208_b0095","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1161\/01.CIR.102.9.959","article-title":"Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging","volume":"102","author":"Hatsukami","year":"2000","journal-title":"Circulation."},{"issue":"1","key":"10.1016\/j.ejrad.2023.111208_b0100","first-page":"e3","article-title":"Images in cardiovascular medicine","volume":"112","author":"Chu","year":"2005","journal-title":"Detection of Carotid Atherosclerotic Plaque Ulceration, Calcification, and Thrombosis by Multicontrast Weighted Magnetic Resonance Imaging, Circulation."},{"issue":"3","key":"10.1016\/j.ejrad.2023.111208_b0105","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s00270-013-0711-2","article-title":"Imaging of the carotid artery vulnerable plaque","volume":"37","author":"Saba","year":"2014","journal-title":"Cardiovasc Intervent Radiol."},{"issue":"20","key":"10.1016\/j.ejrad.2023.111208_b0110","first-page":"1415","article-title":"Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis","volume":"339","author":"Barnett","year":"1998","journal-title":"North American Symptomatic Carotid Endarterectomy Trial Collaborators, N Engl J Med."},{"issue":"13","key":"10.1016\/j.ejrad.2023.111208_b0115","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1056\/NEJMoa043033","article-title":"Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis","volume":"352","author":"Chimowitz","year":"2005","journal-title":"N Engl J Med."},{"issue":"2","key":"10.1016\/j.ejrad.2023.111208_b0120","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1.5 T in Alzheimer\u2019s dementia and normal aging","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am. J. Roentgenol."},{"issue":"2","key":"10.1016\/j.ejrad.2023.111208_b0125","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1161\/STROKEAHA.113.003004","article-title":"Extensive leukoaraiosis is associated with high early risk of recurrence after ischemic stroke","volume":"45","author":"Kim","year":"2014","journal-title":"Stroke."},{"issue":"10","key":"10.1016\/j.ejrad.2023.111208_b0130","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1161\/STROKEAHA.116.013982","article-title":"White Matter Hyperintensity-Adjusted Critical Infarct Thresholds to Predict a Favorable 90-Day Outcome","volume":"47","author":"Patti","year":"2016","journal-title":"Stroke."},{"issue":"1","key":"10.1016\/j.ejrad.2023.111208_b0135","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1148\/radiol.2481070300","article-title":"Brain white matter hyperintensities are associated with carotid intraplaque hemorrhage","volume":"248","author":"Altaf","year":"2008","journal-title":"Radiology."},{"issue":"2","key":"10.1016\/j.ejrad.2023.111208_b0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017070","article-title":"Association between carotid plaque characteristics and cerebral white matter lesions: one-year follow-up study by MRI","volume":"6","author":"Kwee","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ejrad.2023.111208_b0145","first-page":"872","article-title":"Cavernous carotid artery calcification and white matter ischemia","volume":"24","author":"Babiarz","year":"2003","journal-title":"AJNR Am J Neuroradiol."},{"issue":"4","key":"10.1016\/j.ejrad.2023.111208_b0150","doi-asserted-by":"crossref","first-page":"378","DOI":"10.5114\/fn.2021.112007","article-title":"Risk factors for ischemic stroke: differences between cerebral small vessel and large artery atherosclerosis aetiologies","volume":"59","author":"Shi","year":"2021","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.ejrad.2023.111208_b0155","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.atherosclerosis.2017.12.015","article-title":"Morphometric measurements of extracranial and intracranial atherosclerotic disease: A population-based autopsy study","volume":"270","author":"Suemoto","year":"2018","journal-title":"Atherosclerosis."},{"issue":"1","key":"10.1016\/j.ejrad.2023.111208_b0160","doi-asserted-by":"crossref","first-page":"21562","DOI":"10.1038\/s41598-022-25654-9","article-title":"Association of cerebral white matter hyperintensities with coronary artery calcium in a healthy population: a cross-sectional study","volume":"12","author":"Choi","year":"2022","journal-title":"Sci Rep."},{"issue":"2","key":"10.1016\/j.ejrad.2023.111208_b0165","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.1016\/j.archger.2010.07.008","article-title":"White matter hyperintensities (WMH) are associated with intracranial atherosclerosis rather than extracranial atherosclerosis","volume":"53","author":"Lee","year":"2011","journal-title":"Arch. Gerontol. Geriatr."},{"issue":"2","key":"10.1016\/j.ejrad.2023.111208_b0170","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5551\/jat.26054","article-title":"Progression of intracranial major artery stenosis is associated with baseline carotid and intracranial atherosclerosis","volume":"22","author":"Mizukami","year":"2015","journal-title":"J Atheroscler Thromb."}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X23005223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X23005223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:37:08Z","timestamp":1759995428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X23005223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":34,"alternative-id":["S0720048X23005223"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2023.111208","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atherosclerotic plaque characteristics in extracranial carotid artery may indicate closer association with white matter hyperintensities than intracranial arteries: A CARE-II study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2023.111208","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111208"}}