{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:08:32Z","timestamp":1767704912176,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272064"],"award-info":[{"award-number":["82272064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008081","name":"Southeast University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013085","name":"Program for Jiangsu Excellent Scientific and Technological Innovation Team","doi-asserted-by":"publisher","award":["KYCX23_0323","KYCX22_0297"],"award-info":[{"award-number":["KYCX23_0323","KYCX22_0297"]}],"id":[{"id":"10.13039\/501100013085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ejrad.2025.112203","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T02:41:08Z","timestamp":1748313668000},"page":"112203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Longitudinal T1\u03c1 quantification in chronic hepatitis B: from fibrosis staging to pegylated interferon-\u03b1 therapeutic response tracking"],"prefix":"10.1016","volume":"190","author":[{"given":"Xin-Gui","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyue","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.ejrad.2025.112203_b0005","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41575-023-00760-9","article-title":"Global burden of hepatitis B virus: current status, missed opportunities and a call for action","volume":"20","author":"Hsu","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"10381","key":"10.1016\/j.ejrad.2025.112203_b0010","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0140-6736(22)01468-4","article-title":"Hepatitis B","volume":"401","author":"Jeng","year":"2023","journal-title":"Lancet (London, England)"},{"issue":"8","key":"10.1016\/j.ejrad.2025.112203_b0015","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S2468-1253(22)00050-4","article-title":"Worldwide prevalence of hepatitis B virus and hepatitis C virus among patients with cirrhosis at country, region, and global levels: a systematic review","volume":"7","author":"Alberts","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112203_b0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jhep.2023.09.011","article-title":"PAGE-B incorporating moderate HBV DNA levels predicts risk of HCC among patients entering into HBeAg-positive chronic hepatitis B","volume":"80","author":"Chun","year":"2024","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.ejrad.2025.112203_b0025","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.cld.2007.08.010","article-title":"Interferon therapy for chronic hepatitis B","volume":"11","author":"Asselah","year":"2007","journal-title":"Clin. Liver Dis."},{"issue":"4","key":"10.1016\/j.ejrad.2025.112203_b0030","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11901-010-0055-1","article-title":"The role of interferon in hepatitis B therapy","volume":"9","author":"Rijckborst","year":"2010","journal-title":"Curr. Hepat. Rep."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112203_b0035","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.jhep.2020.05.017","article-title":"The risk-benefit assessment of liver biopsy in times of non-invasive screening for liver fibrosis","volume":"73","author":"Ilic","year":"2020","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.ejrad.2025.112203_b0040","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1053\/j.gastro.2016.03.008","article-title":"Biopsy and noninvasive methods to assess progression of nonalcoholic fatty liver disease","volume":"150","author":"Bedossa","year":"2016","journal-title":"Gastroenterology."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112203_b0045","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jhepr.2019.02.006","article-title":"Anticoagulation in the cirrhotic patient","volume":"1","author":"Turco","year":"2019","journal-title":"JHEP Rep."},{"issue":"22","key":"10.1016\/j.ejrad.2025.112203_b0050","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1056\/NEJMra1914900","article-title":"Acute-on-chronic liver failure","volume":"382","author":"Arroyo","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejrad.2025.112203_b0055","unstructured":"WHO Guidelines Approved by the Guidelines Review Committee. Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection. World Health Organization Copyright \u00a9 World Health Organization 2015, 2015."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112203_b0060","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jhep.2015.04.006","article-title":"Non-invasive tests for evaluation of liver disease severity and prognosis","volume":"63","author":"EASL-ALEH Clinical Practice Guidelines","year":"2015","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.ejrad.2025.112203_b0065","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jhep.2015.11.012","article-title":"Evaluation of APRI and FIB-4 scoring systems for non-invasive assessment of hepatic fibrosis in chronic hepatitis B patients","volume":"64","author":"Kim","year":"2016","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.ejrad.2025.112203_b0070","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/00004728-198511000-00002","article-title":"A method for T1 rho imaging","volume":"9","author":"Sepponen","year":"1985","journal-title":"J. Comput. Assist. Tomogr."},{"issue":"6","key":"10.1016\/j.ejrad.2025.112203_b0075","doi-asserted-by":"crossref","first-page":"898","DOI":"10.3348\/kjr.2017.18.6.898","article-title":"Impact of liver fibrosis and fatty liver on T1rho measurements: a prospective study","volume":"18","author":"Xie","year":"2017","journal-title":"Korean J. Radiol."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112203_b0080","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/jmri.27822","article-title":"Staging liver fibrosis: comparison of native T1 mapping, T2 mapping, and T1\u03c1: an experimental study in rats with bile duct ligation and carbon tetrachloride at 11.7 T MRI","volume":"55","author":"Lu","year":"2022","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.ejrad.2025.112203_b0085","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.mri.2022.01.002","article-title":"Diagnostic potential of T1\u03c1 and T2 relaxations in assessing the severity of liver fibrosis and necro-inflammation","volume":"87","author":"Takayama","year":"2022","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.ejrad.2025.112203_b0090","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mri.2017.10.009","article-title":"Quantitative assessment of liver function with whole-liver T1rho mapping at 3.0T","volume":"46","author":"Chen","year":"2018","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.ejrad.2025.112203_b0095","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12967-015-0648-0","article-title":"T1\u03c1 MRI of healthy and fibrotic human livers at 1.5 T","volume":"13","author":"Singh","year":"2015","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112203_b0100","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/jmri.28308","article-title":"Detecting early-stage liver fibrosis using macromolecular proton fraction mapping based on spin-lock MRI: preliminary observations","volume":"57","author":"Hou","year":"2023","journal-title":"J. Magn. Reson. Imaging"},{"issue":"1","key":"10.1016\/j.ejrad.2025.112203_b0105","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ajg.2016.517","article-title":"ACG clinical guideline: evaluation of abnormal liver chemistries","volume":"112","author":"Kwo","year":"2017","journal-title":"Am. J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112203_b0110","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0168-8278(02)00406-3","article-title":"Assessment of liver biopsies in chronic hepatitis: how is it best done?","volume":"38","author":"Scheuer","year":"2003","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112203_b0115","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0168-8278(02)00357-4","article-title":"Histopathological study of chronic hepatitis B and C: a comparison of two scoring systems","volume":"38","author":"Rozario","year":"2003","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112203_b0120","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/hep.22742","article-title":"Liver biopsy","volume":"49","author":"Rockey","year":"2009","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.ejrad.2025.112203_b0125","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/jmri.21876","article-title":"Diffusion-weighted imaging of the liver: comparison of navigator triggered and breathhold acquisitions","volume":"30","author":"Taouli","year":"2009","journal-title":"J. Magn. Reson. Imaging"},{"issue":"12","key":"10.1016\/j.ejrad.2025.112203_b0130","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.crad.2016.07.017","article-title":"Semi-quantitative assessment of the presence and Child-Pugh class of hepatitis B related cirrhosis by using liver lobe-based dynamic contrast-enhanced MRI","volume":"71","author":"Zhou","year":"2016","journal-title":"Clin. Radiol."},{"issue":"8","key":"10.1016\/j.ejrad.2025.112203_b0135","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00330-012-2419-0","article-title":"MR T1\u03c1 as an imaging biomarker for monitoring liver injury progression and regression: an experimental study in rats with carbon tetrachloride intoxication","volume":"22","author":"Zhao","year":"2012","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.ejrad.2025.112203_b0140","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mri.2017.12.017","article-title":"Gd-EOB-DTPA-enhanced T1\u03c1 imaging vs diffusion metrics for assessment liver inflammation and early stage fibrosis of nonalcoholic steatohepatitis in rabbits","volume":"48","author":"Xie","year":"2018","journal-title":"Magn. Reson. Imaging"},{"issue":"7","key":"10.1016\/j.ejrad.2025.112203_b0145","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00261-017-1381-3","article-title":"Liver fibrosis detection and staging: a comparative study of T1\u03c1 MR imaging and 2D real-time shear-wave elastography","volume":"43","author":"Li","year":"2018","journal-title":"Abdom Radiol (NY)"},{"issue":"6","key":"10.1016\/j.ejrad.2025.112203_b0150","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3348\/kjr.2012.13.6.736","article-title":"Experimental evaluation of accelerated T1rho relaxation quantification in human liver using limited spin-lock times","volume":"13","author":"Zhao","year":"2012","journal-title":"Korean J. Radiol."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112203_b0155","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1148\/radiol.13130342","article-title":"Evaluation of fibrotic liver disease with whole-liver T1\u03c1 MR imaging: a feasibility study at 1.5 T","volume":"271","author":"Allkemper","year":"2014","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.ejrad.2025.112203_b0160","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12876-020-1161-3","article-title":"Liver injury monitoring, fibrosis staging and inflammation grading using T1rho magnetic resonance imaging: an experimental study in rats with carbon tetrachloride intoxication","volume":"20","author":"Xie","year":"2020","journal-title":"BMC Gastroenterol."},{"issue":"12","key":"10.1016\/j.ejrad.2025.112203_b0165","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.21037\/qims-20-651","article-title":"Collagen deposition in the liver is strongly and positively associated with T1rho elongation while fat deposition is associated with T1rho shortening: an experimental study of methionine and choline-deficient (MCD) diet rat model","volume":"10","author":"Zhao","year":"2020","journal-title":"Quant. Imaging Med. Surg."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112203_b0170","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1148\/radiol.11101638","article-title":"T1rho MR imaging is sensitive to evaluate liver fibrosis: an experimental study in a rat biliary duct ligation model","volume":"259","author":"Wang","year":"2011","journal-title":"Radiology"},{"issue":"3","key":"10.1016\/j.ejrad.2025.112203_b0175","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/jmri.25424","article-title":"Comparison of T2, T1rho, and diffusion metrics in assessment of liver fibrosis in rats","volume":"45","author":"Zhang","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"issue":"4","key":"10.1016\/j.ejrad.2025.112203_b0180","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3350\/cmh.2013.19.4.360","article-title":"The MR imaging diagnosis of liver diseases using gadoxetic acid: emphasis on hepatobiliary phase","volume":"19","author":"Jeong","year":"2013","journal-title":"Clin. Mol. Hepatol."},{"issue":"10","key":"10.1016\/j.ejrad.2025.112203_b0185","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1007\/s00330-019-06110-1","article-title":"Detection of liver metastases on gadobenate dimeglumine-enhanced MRI: systematic review, meta-analysis, and similarities with gadoxetate-enhanced MRI","volume":"29","author":"Zhang","year":"2019","journal-title":"Eur. Radiol."},{"issue":"4","key":"10.1016\/j.ejrad.2025.112203_b0190","doi-asserted-by":"crossref","first-page":"514.e1","DOI":"10.1016\/j.cmi.2018.06.002","article-title":"Gamma-glutamyl transpeptidase to cholinesterase and platelet ratio in predicting significant liver fibrosis and cirrhosis of chronic hepatitis B","volume":"25","author":"Liu","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"issue":"5 Suppl","key":"10.1016\/j.ejrad.2025.112203_b0195","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1002\/hep.22930","article-title":"Liver biopsy findings in chronic hepatitis B","volume":"49","author":"Mani","year":"2009","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.ejrad.2025.112203_b0200","article-title":"Limitations of non-invasive tests for assessment of liver fibrosis","volume":"2","author":"Patel","year":"2020","journal-title":"JHEP Rep"},{"issue":"2","key":"10.1016\/j.ejrad.2025.112203_b0205","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/2472630317747198","article-title":"Age- and gender-associated liver physiological T1rho dynamics demonstrated with a clinically applicable single-breathhold acquisition","volume":"23","author":"W\u00e1ng","year":"2018","journal-title":"SLAS Technol."}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X2500289X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X2500289X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:11:27Z","timestamp":1762308687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X2500289X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":41,"alternative-id":["S0720048X2500289X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2025.112203","relation":{},"ISSN":["0720-048X"],"issn-type":[{"type":"print","value":"0720-048X"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal T1\u03c1 quantification in chronic hepatitis B: from fibrosis staging to pegylated interferon-\u03b1 therapeutic response tracking","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2025.112203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112203"}}