{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:26:38Z","timestamp":1788848798521,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["82301299"],"award-info":[{"award-number":["82301299"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009076","name":"University of Science and Technology of China","doi-asserted-by":"publisher","award":["2022xjyxm065"],"award-info":[{"award-number":["2022xjyxm065"]}],"id":[{"id":"10.13039\/501100009076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ejrad.2025.112382","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T23:42:56Z","timestamp":1756165376000},"page":"112382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Quantitative study of vestibular endolymphatic hydrops in Meniere\u2019s disease based on Three-Dimensional real Inversion Recovery (3D-real IR) sequence"],"prefix":"10.1016","volume":"192","author":[{"given":"Jiajia","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejrad.2025.112382_b0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/WCO.0000000000001227","article-title":"Epidemiology and genetics of Meniere\u2019s disease","volume":"37","author":"Lopez-Escamez","year":"2024","journal-title":"Curr. Opin. Neurol."},{"issue":"7","key":"10.1016\/j.ejrad.2025.112382_b0010","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/lary.21827","article-title":"Otologic diagnoses in the elderly: current utilization and predicted workload increase","volume":"121","author":"Lin","year":"2011","journal-title":"Laryngoscope"},{"issue":"Pt 1","key":"10.1016\/j.ejrad.2025.112382_b0015","article-title":"Meniere\u2019s disease: Pathogenesis, treatments, and emerging approaches for an idiopathic bioenvironmental disorder","volume":"238","author":"Mohseni-Dargah","year":"2023","journal-title":"Environ. Res."},{"issue":"10","key":"10.1016\/j.ejrad.2025.112382_b0020","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1080\/00016489.2020.1776385","article-title":"Current status on researches of Meniere\u2019s disease: a review","volume":"140","author":"Liu","year":"2020","journal-title":"Acta Otolaryngol (stockh)"},{"issue":"1","key":"10.1016\/j.ejrad.2025.112382_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for Meni\u00e8re\u2019s disease","volume":"25","author":"Lopez-Escamez","year":"2015","journal-title":"J Vestib Res Equilib Orientat"},{"issue":"3","key":"10.1016\/j.ejrad.2025.112382_b0030","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/MLG.0b013e31802c300c","article-title":"Visualization of endolymphatic hydrops in patients with Meniere\u2019s disease","volume":"117","author":"Nakashima","year":"2007","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.ejrad.2025.112382_b0035","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.anl.2020.10.009","article-title":"Diagnostic and therapeutic strategies for Meniere\u2019s disease of the Japan Society for Equilibrium Research","volume":"48","author":"Iwasaki","year":"2021","journal-title":"Auris Nasus Larynx"},{"issue":"10","key":"10.1016\/j.ejrad.2025.112382_b0040","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1007\/s00330-023-09651-8","article-title":"Delayed post gadolinium MRI descriptors for Meniere\u2019s disease: a systematic review and meta-analysis","volume":"33","author":"Connor","year":"2023","journal-title":"Eur. Radiol."},{"issue":"6","key":"10.1016\/j.ejrad.2025.112382_b0045","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3109\/00016480903382808","article-title":"Long-term course of Meni\u00e8re's disease revisited","volume":"130","author":"Huppert","year":"2010","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.ejrad.2025.112382_b0050","first-page":"1","article-title":"Hearing loss rather than vestibular loss identifies patient subgroups with different outcomes in Meniere's disease","volume":"13","author":"Zhang","year":"2025","journal-title":"Int. J. Audiol."},{"issue":"6","key":"10.1016\/j.ejrad.2025.112382_b0055","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/coa.12844","article-title":"Meniere's disease Consortium (MeDiC). Extended phenotype and clinical subgroups in unilateral Meniere disease: a cross-sectional study with cluster analysis","volume":"42","author":"Frejo","year":"2017","journal-title":"Clin. Otolaryngol."},{"issue":"8","key":"10.1016\/j.ejrad.2025.112382_b0060","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.3389\/fimmu.2017.01739","article-title":"Regulation of Fn14 Receptor and NF-\u03baB Underlies Inflammation in Meniere's Disease","volume":"13","author":"Frejo","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejrad.2025.112382_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.110413","article-title":"Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease: a longitudinal study","volume":"271","author":"Frejo","year":"2025","journal-title":"Clin. Immunol."},{"issue":"2\u20133","key":"10.1016\/j.ejrad.2025.112382_b0070","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3233\/VES-180646","article-title":"Systematic review of magnetic resonance imaging for diagnosis of Meniere disease","volume":"29","author":"Lopez-Escamez","year":"2019","journal-title":"J. Vestib. Res."},{"key":"10.1016\/j.ejrad.2025.112382_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1128942","article-title":"Comparison between audio-vestibular findings and contrast-enhanced MRI of inner ear in patients with unilateral M\u00e9ni\u00e8re's disease","volume":"17","author":"Leng","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejrad.2025.112382_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2022.110614","article-title":"Comparison of an optimized 3D-real IR and a 3D-FLAIR with a constant flip angle in the evaluation of endolymphatic hydrops","volume":"158","author":"Zhao","year":"2023","journal-title":"Eur. J. Radiol."},{"issue":"4","key":"10.1016\/j.ejrad.2025.112382_b0085","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00234-019-02155-7","article-title":"The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Meni\u00e8re\u2019s disease on MRI","volume":"61","author":"Bernaerts","year":"2019","journal-title":"Neuroradiology"},{"issue":"4","key":"10.1016\/j.ejrad.2025.112382_b0090","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1177\/000348948709600418","article-title":"Localization, frequency, and severity of endolymphatic hydrops and the pathology of the labyrinthine membrane in Meni\u00e8re\u2019s disease","volume":"96","author":"Okuno","year":"1987","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112382_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120357","article-title":"Semi-quantitative vs. volumetric determination of endolymphatic space in Meni\u00e8re\u2019s disease using endolymphatic hydrops 3T-HR-MRI after intravenous gadolinium injection","volume":"10","author":"Homann","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ejrad.2025.112382_b0100","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.otc.2010.05.001","article-title":"Current epidemiology of Meniere\u2019s syndrome","volume":"43","author":"Alexander","year":"2010","journal-title":"Otolaryngol. Clin. North Am."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112382_b0105","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/MAO.0000000000002502","article-title":"On the Relationship between Meni\u00e8re\u2019s Disease and Endolymphatic Hydrops","volume":"41","author":"Gluth","year":"2020","journal-title":"Otol. Neurotol."},{"issue":"7","key":"10.1016\/j.ejrad.2025.112382_b0110","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/MAO.0b013e31829e83df","article-title":"Endolymphatic hydrops in M\u00e9ni\u00e8re\u2019s disease: cause, consequence, or epiphenomenon?","volume":"34","author":"Foster","year":"2013","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.ejrad.2025.112382_b0115","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/00016480902729827","article-title":"Grading of endolymphatic hydrops using magnetic resonance imaging","volume":"560","author":"Nakashima","year":"2009","journal-title":"Acta Oto-Laryngol., Suppl."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112382_b0120","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00330-005-0046-8","article-title":"Observation of contrast enhancement in the cochlear fluid space of healthy subjects using a 3D-FLAIR sequence at 3 Tesla","volume":"16","author":"Naganawa","year":"2006","journal-title":"Eur. Radiol."},{"issue":"5","key":"10.1016\/j.ejrad.2025.112382_b0125","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.otc.2010.06.001","article-title":"Magnetic resonance imaging of the inner ear in Meniere\u2019s disease","volume":"43","author":"Pyykk\u00f6","year":"2010","journal-title":"Otolaryngol. Clin. North Am."},{"issue":"5","key":"10.1016\/j.ejrad.2025.112382_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bjorl.2023.101314","article-title":"Evaluation of the relationship between endolymphatic hydrops and hearing loss in Meniere\u2019s disease based on three-dimensional real inversion recovery sequence","volume":"89","author":"Huang","year":"2023","journal-title":"Braz. J. Otorhinolaryngol."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112382_b0135","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/MAO.0000000000001675","article-title":"Correlations between the Degree of Endolymphatic Hydrops and Symptoms and Audiological Test results in patients with Meni\u00e8re\u2019s Disease: a Reevaluation","volume":"39","author":"Yang","year":"2018","journal-title":"Otol. Neurotol."},{"issue":"9","key":"10.1016\/j.ejrad.2025.112382_b0140","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.1007\/s00330-024-10620-y","article-title":"Correlation of endolymphatic hydrops and perilymphatic enhancement with the clinical features of M\u00e9ni\u00e8re\u2019s disease","volume":"34","author":"Li","year":"2024","journal-title":"Eur. Radiol."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112382_b0145","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00441-015-2147-2","article-title":"Structural changes in thestrial blood-labyrinth barrier of aged C57BL\/6 mice","volume":"361","author":"Neng","year":"2015","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ejrad.2025.112382_b0150","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2009.02.079","article-title":"Mechanisms and genes in human strial presbycusis from animal models","volume":"1277","author":"Ohlemiller","year":"2009","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112382_b0155","first-page":"72","article-title":"Blood-labyrinth barrier and fluid dynamics of the inner ear","volume":"7","author":"Juhn","year":"2001","journal-title":"Int. Tinnitus J."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112382_b0160","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/lio2.1047","article-title":"The value of 3D quantitative scoring of endolymphatic hydrops in the diagnosis and differential diagnosis of M\u00e9ni\u00e8re\u2019s disease","volume":"8","author":"Xiao","year":"2023","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"9","key":"10.1016\/j.ejrad.2025.112382_b0165","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1007\/s00405-023-07899-w","article-title":"Endolymphatic hydrops imaging and correlation with clinical characteristics, audiovestibular function and mental impairment in patients with Meniere\u2019s disease","volume":"280","author":"Hu","year":"2023","journal-title":"Eur. Arch. Otorhinolaryngol."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112382_b0170","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13005-024-00455-9","article-title":"The relationship between endolymphatic hydrops features and hearing loss in Bilateral Meniere\u2019s disease","volume":"20","author":"Liu","year":"2024","journal-title":"Head Face Med."},{"issue":"4","key":"10.1016\/j.ejrad.2025.112382_b0175","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/lary.25576","article-title":"The correlation between symptoms of definite Meniere\u2019s disease and endolymphatic hydrops visualized by magnetic resonance imaging","volume":"126","author":"Wu","year":"2016","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1016\/j.ejrad.2025.112382_b0180","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00330-014-3414-4","article-title":"MR volumetric assessment of endolymphatic hydrops","volume":"25","author":"G\u00fcrkov","year":"2015","journal-title":"Eur. Radiol."},{"issue":"6","key":"10.1016\/j.ejrad.2025.112382_b0185","doi-asserted-by":"crossref","first-page":"536","DOI":"10.5152\/iao.2021.21317","article-title":"Magnetic Resonance 3D Measurement of the Endolymphatic Space in 100 Control Human Subjects","volume":"17","author":"Inui","year":"2021","journal-title":"J Int Adv Otol"},{"issue":"9","key":"10.1016\/j.ejrad.2025.112382_b0190","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3109\/00016489.2016.1168940","article-title":"Volumetric measurements of the inner ear in patients with Meniere\u2019s disease using three-dimensional magnetic resonance imaging","volume":"136","author":"Inui","year":"2016","journal-title":"Acta Otolaryngol (stockh)"},{"issue":"18","key":"10.1016\/j.ejrad.2025.112382_b0195","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.3390\/jcm12185965","article-title":"Magnetic Resonance Volumetric Quantification of Vestibular Endolymphatic Hydrops in patients with Unilateral Definite Meniere\u2019s Disease using 3D Inversion Recovery with Real Reconstruction (3D-REAL-IR) Sequence","volume":"12","author":"Su\u00e1rez-Vega","year":"2023","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.ejrad.2025.112382_b0200","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/lio2.313","article-title":"Endolymphatic volume in patients with meniere\u2019s disease and healthy controls: Three-dimensional analysis with magnetic resonance imaging","volume":"4","author":"Ito","year":"2019","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"3","key":"10.1016\/j.ejrad.2025.112382_b0205","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3109\/00016489.2011.637232","article-title":"Comparison of noninvasive evaluation of endolymphatic hydrops in Meniere\u2019s disease and endolymphatic space in healthy volunteers using magnetic resonance imaging","volume":"132","author":"Liu","year":"2012","journal-title":"Acta Otolaryngol (stockh)"},{"issue":"12","key":"10.1016\/j.ejrad.2025.112382_b0210","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1080\/00016489.2016.1204663","article-title":"Magnetic resonance volumetric measurement of endolymphatic space in patients without vertiginous or cochlear symptoms","volume":"136","author":"Inui","year":"2016","journal-title":"Acta Otolaryngol (stockh)"}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X25004681?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X25004681?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:40:32Z","timestamp":1771256432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X25004681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":42,"alternative-id":["S0720048X25004681"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2025.112382","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative study of vestibular endolymphatic hydrops in Meniere\u2019s disease based on Three-Dimensional real Inversion Recovery (3D-real IR) sequence","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2025.112382","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112382"}}