{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:46:32Z","timestamp":1773690392325,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ejrad.2025.112522","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T15:59:33Z","timestamp":1764431973000},"page":"112522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Time-dependent diffusion MRI derived microstructure parameters to predict differentiation degree and Ki-67 expression in rectal cancer"],"prefix":"10.1016","volume":"195","author":[{"given":"Fulin","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuide","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yisha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meining","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3464-1088","authenticated-orcid":false,"given":"Hang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejrad.2025.112522_b0005","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112522_b0010","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"issue":"6","key":"10.1016\/j.ejrad.2025.112522_b0015","doi-asserted-by":"crossref","first-page":"664","DOI":"10.5858\/arpa.2019-0665-RA","article-title":"What is New in the 2019 World Health Organization (WHO) Classification of Tumors of the Digestive System: Review of selected Updates on Neuroendocrine Neoplasms, Appendiceal Tumors, and Molecular Testing","volume":"145","author":"Assarzadegan","year":"2021","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112522_b0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/cas.14223","article-title":"Ki67 expression and localization of T cells after neoadjuvant therapies as reliable predictive markers in rectal cancer","volume":"111","author":"Imaizumi","year":"2020","journal-title":"Cancer Sci."},{"issue":"8","key":"10.1016\/j.ejrad.2025.112522_b0025","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/sj.bjc.6605333","article-title":"Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis","volume":"101","author":"Fluge","year":"2009","journal-title":"Br. J. Cancer"},{"issue":"11","key":"10.1016\/j.ejrad.2025.112522_b0030","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1158\/1078-0432.CCR-10-2779","article-title":"Biological function and prognostic significance of peroxisome proliferator-activated receptor delta in rectal cancer","volume":"17","author":"Yang","year":"2011","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112522_b0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0846537119885666","article-title":"Value of apparent diffusion coefficient for assessing preoperative T Staging of low rectal cancer and whether this is correlated with Ki-67 expression","volume":"71","author":"Ao","year":"2020","journal-title":"Can. Assoc. Radiol. J."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112522_b0040","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jmri.23643","article-title":"Diffusion-weighted MRI of the abdomen: current value in clinical routine","volume":"37","author":"Schmid-Tannwald","year":"2013","journal-title":"J. Magn. Reson. Imaging"},{"issue":"3","key":"10.1016\/j.ejrad.2025.112522_b0045","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.critrevonc.2014.07.002","article-title":"Diffusion-weighted MR imaging of the rectum: clinical applications","volume":"92","author":"Nguyen","year":"2014","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"4","key":"10.1016\/j.ejrad.2025.112522_b0050","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.ijrobp.2017.12.280","article-title":"Short diffusion time diffusion-weighted imaging with oscillating gradient preparation as an early magnetic resonance imaging biomarker for radiation therapy response monitoring in glioblastoma: a preclinical feasibility study","volume":"102","author":"Bongers","year":"2018","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112522_b0055","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/jmri.29106","article-title":"Oscillating gradient diffusion-weighted MRI for risk stratification of uterine endometrial cancer","volume":"60","author":"Ejima","year":"2024","journal-title":"J. Magn. Reson. Imaging"},{"issue":"3","key":"10.1016\/j.ejrad.2025.112522_b0060","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1148\/radiol.211180","article-title":"Time-dependent diffusion MRI for quantitative microstructural mapping of prostate cancer","volume":"303","author":"Wu","year":"2022","journal-title":"Radiology"},{"issue":"9","key":"10.1016\/j.ejrad.2025.112522_b0065","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1007\/s00330-023-09623-y","article-title":"Diffusion-time dependent diffusion MRI: effect of diffusion-time on microstructural mapping and prediction of prognostic features in breast cancer","volume":"33","author":"Ba","year":"2023","journal-title":"Eur. Radiol."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112522_b0070","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jmri.26578","article-title":"Time-dependent diffusion MRI to distinguish malignant from benign head and neck tumors","volume":"50","author":"Iima","year":"2019","journal-title":"J. Magn. Reson. Imaging"},{"issue":"5","key":"10.1016\/j.ejrad.2025.112522_b0075","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.2214\/AJR.08.1298","article-title":"MRI for detection of extramural vascular invasion in rectal cancer","volume":"191","author":"Smith","year":"2008","journal-title":"AJR Am. J. Roentgenol."},{"issue":"4","key":"10.1016\/j.ejrad.2025.112522_b0080","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00330-017-5026-2","article-title":"Magnetic resonance imaging for clinical management of rectal cancer: Updated recommendations from the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting","volume":"28","author":"Beets-Tan","year":"2018","journal-title":"Eur. Radiol."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112522_b0085","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/mrm.26356","article-title":"In vivo imaging of cancer cell size and cellularity using temporal diffusion spectroscopy","volume":"78","author":"Jiang","year":"2017","journal-title":"Magn. Reson. Med."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112522_b0090","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/jmri.25376","article-title":"Stimulated echo diffusion tensor imaging (STEAM-DTI) with varying diffusion times as a probe of breast tissue","volume":"45","author":"Teruel","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"issue":"8","key":"10.1016\/j.ejrad.2025.112522_b0095","first-page":"4693","article-title":"Independent correlation between Ki67 index and circulating Tumor Cells in the diagnosis of colorectal cancer","volume":"37","author":"Yang","year":"2017","journal-title":"Anticancer Res"},{"issue":"6","key":"10.1016\/j.ejrad.2025.112522_b0100","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1002\/mrm.26309","article-title":"Impact of transcytolemmal water exchange on estimates of tissue microstructural properties derived from diffusion MRI","volume":"77","author":"Li","year":"2017","journal-title":"Magn. Reson. Med."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112522_b0105","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A Guideline of selecting and reporting intraclass correlation coefficients for reliability research","volume":"15","author":"Koo","year":"2016","journal-title":"J. Chiropr. Med."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112522_b0110","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40644-021-00403-9","article-title":"Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization","volume":"21","author":"Qiu","year":"2021","journal-title":"Cancer Imaging"},{"issue":"3","key":"10.1016\/j.ejrad.2025.112522_b0115","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/mrm.25684","article-title":"Quantification of cell size using temporal diffusion spectroscopy","volume":"75","author":"Jiang","year":"2016","journal-title":"Magn. Reson. Med."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112522_b0120","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/jmri.28831","article-title":"In vivo microstructure imaging in oropharyngeal squamous cell carcinoma using the random walk with barriers model","volume":"59","author":"Cao","year":"2024","journal-title":"J. Magn. Reson. Imaging"},{"issue":"1","key":"10.1016\/j.ejrad.2025.112522_b0125","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1186\/s12885-023-11130-8","article-title":"Deep learning-based radiomic nomograms for predicting Ki67 expression in prostate cancer","volume":"23","author":"Deng","year":"2023","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.ejrad.2025.112522_b0130","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41598-019-57094-3","article-title":"The prognostic and predictive potential of Ki-67 in triple-negative breast cancer","volume":"10","author":"Zhu","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112522_b0135","doi-asserted-by":"crossref","first-page":"20334","DOI":"10.1038\/s41598-024-71275-9","article-title":"A nomogram with Ki-67 in the prediction of postoperative recurrence and death for glioma","volume":"14","author":"Li","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejrad.2025.112522_b0140","article-title":"Association of Ki-67 Change Pattern after Core Needle Biopsy and Prognosis in HR+\/HER2- Early Breast Cancer patients","volume":"9","author":"Li","year":"2022","journal-title":"Front. Surg."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112522_b0145","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1470-2045(09)70262-1","article-title":"Ki67 in breast cancer: prognostic and predictive potential","volume":"11","author":"Yerushalmi","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ejrad.2025.112522_b0150","article-title":"\u201cExploration and validation of the Ki67, Her-2, and mutant P53 protein-based risk model, nomogram and lymph node metastasis model for predicting colorectal cancer progression and prognosis\u201d. Front","volume":"13","author":"Yuan","year":"2023","journal-title":"Oncol"},{"key":"10.1016\/j.ejrad.2025.112522_b0155","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.humpath.2017.07.014","article-title":"Prognostic value of programmed death ligand 1, p53, and Ki-67 in patients with advanced-stage colorectal cancer","volume":"71","author":"Wang","year":"2018","journal-title":"Hum. Pathol."},{"issue":"5","key":"10.1016\/j.ejrad.2025.112522_b0160","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/PAI.0000000000000315","article-title":"Intratumoral heterogeneity for Ki-67 index in invasive breast carcinoma: a study on 131 consecutive cases","volume":"25","author":"Boros","year":"2017","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"issue":"6","key":"10.1016\/j.ejrad.2025.112522_b0165","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/jmri.23589","article-title":"Diffusion-weighted MRI in rectal cancer: apparent diffusion coefficient as a potential noninvasive marker of tumor aggressiveness","volume":"35","author":"Curvo-Semedo","year":"2012","journal-title":"J. Magn. Reson. Imaging"},{"issue":"8","key":"10.1016\/j.ejrad.2025.112522_b0170","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1245\/s10434-011-1607-5","article-title":"Diffusion-weighted MRI for selection of complete responders after chemoradiation for locally advanced rectal cancer: a multicenter study","volume":"18","author":"Lambregts","year":"2011","journal-title":"Ann. Surg. Oncol."},{"issue":"8","key":"10.1016\/j.ejrad.2025.112522_b0175","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3390\/curroncol32080431","article-title":"A Multimodal MRI - based model for colorectal liver metastasis prediction: integrating radiomics, deep learning, and clinical features with SHAP interpretation","volume":"32","author":"Yan","year":"2025","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.ejrad.2025.112522_b0180","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1057841","article-title":"Multiparametric MRI radiomics fusion for predicting the response and shrinkage pattern to neoadjuvant chemotherapy in breast cancer","volume":"13","author":"Fan","year":"2023","journal-title":"Front. Oncol."}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X25006084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X25006084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:50:57Z","timestamp":1770382257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X25006084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":36,"alternative-id":["S0720048X25006084"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2025.112522","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Time-dependent diffusion MRI derived microstructure parameters to predict differentiation degree and Ki-67 expression in rectal cancer","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2025.112522","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112522"}}