{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:09:44Z","timestamp":1771492184419,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFB4702700"],"award-info":[{"award-number":["2022YFB4702700"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012149","name":"National Key Scientific Instrument and Equipment Development Projects of China","doi-asserted-by":"publisher","award":["32427801"],"award-info":[{"award-number":["32427801"]}],"id":[{"id":"10.13039\/501100012149","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ejrad.2025.112632","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T06:44:37Z","timestamp":1767249877000},"page":"112632","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evaluation of Age-Related compositional changes in the infrapatellar fat pad using MRI-Derived PDFF and T2* at 1.5\u00a0T"],"prefix":"10.1016","volume":"196","author":[{"given":"Kecheng","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiantai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penghui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-7378","authenticated-orcid":false,"given":"Bensheng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejrad.2025.112632_b0005","doi-asserted-by":"crossref","unstructured":"Hunter, D. and S. Bierma-Zeinstra. Osteoarthritis Lancet. 2019; 393 (10182): 1745\u201359. In. CAS.","DOI":"10.1016\/S0140-6736(19)30417-9"},{"issue":"6","key":"10.1016\/j.ejrad.2025.112632_b0010","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.ejrad.2025.112632_b0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/ar4422","article-title":"An emerging player in knee osteoarthritis: the infrapatellar fat pad","volume":"15","author":"Ioan-Facsinay","year":"2013","journal-title":"Arthritis Res. Ther."},{"issue":"7","key":"10.1016\/j.ejrad.2025.112632_b0020","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.joca.2010.03.014","article-title":"The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review","volume":"18","author":"Clockaerts","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"4","key":"10.1016\/j.ejrad.2025.112632_b0025","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s00167-004-0592-7","article-title":"The infrapatellar fat pad: anatomy and clinical correlations","volume":"13","author":"Gallagher","year":"2005","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112632_b0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1148\/radiol.212009","article-title":"MRI-based Texture Analysis of Infrapatellar Fat Pad to Predict knee Osteoarthritis Incidence","volume":"304","author":"Li","year":"2022","journal-title":"Radiology"},{"issue":"1 Suppl","key":"10.1016\/j.ejrad.2025.112632_b0035","first-page":"17","article-title":"Synovial fluid levels of adipokines in osteoarthritis: Association with local factors of inflammation and cartilage maintenance","volume":"24","author":"Gross","year":"2014","journal-title":"Biomed. Mater. Eng."},{"issue":"11","key":"10.1016\/j.ejrad.2025.112632_b0040","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1002\/art.24881","article-title":"The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin\u20106 and its soluble receptor","volume":"60","author":"Distel","year":"2009","journal-title":"Arthritis & Rheumatism: Official Journal of the American College of Rheumatology"},{"issue":"5","key":"10.1016\/j.ejrad.2025.112632_b0045","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/ard.2010.140046","article-title":"The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype","volume":"70","author":"Klein-Wieringa","year":"2011","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112632_b0050","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/joa.12820","article-title":"The infrapatellar fat pad and the synovial membrane: an anatomo-functional unit","volume":"233","author":"Macchi","year":"2018","journal-title":"J. Anat."},{"issue":"6","key":"10.1016\/j.ejrad.2025.112632_b0055","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrrheum.2017.53","article-title":"Osteoarthritis: Inflammation and fibrosis in adipose tissue of osteoarthritic joints","volume":"13","author":"Ioan-Facsinay","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112632_b0060","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s10753-021-01604-x","article-title":"Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in patients with Osteoarthritis or Rheumatoid Arthritis","volume":"45","author":"Nieminen","year":"2022","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.ejrad.2025.112632_b0065","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/acr.21898","article-title":"Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US","volume":"65","author":"Losina","year":"2013","journal-title":"Arthritis Care Res (hoboken)"},{"key":"10.1016\/j.ejrad.2025.112632_b0070","doi-asserted-by":"crossref","unstructured":"Franceschi, C., M. Bonaf\u00e8, S. Valensin, et al., Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci, 2000. 908: p. 244-54.","DOI":"10.1111\/j.1749-6632.2000.tb06651.x"},{"issue":"9","key":"10.1016\/j.ejrad.2025.112632_b0075","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/jor.21125","article-title":"Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI","volume":"28","author":"Chuckpaiwong","year":"2010","journal-title":"J. Orthop. Res."},{"issue":"8","key":"10.1016\/j.ejrad.2025.112632_b0080","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1016\/j.acra.2024.02.013","article-title":"Qualitative and Quantitative measures in the Infrapatellar Fat Pad in older adults: Associations with knee Pain, Radiographic Osteoarthritis, Kinematics, and Kinetics of the knee","volume":"31","author":"Wang","year":"2024","journal-title":"Acad. Radiol."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112632_b0085","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/mrm.20624","article-title":"Iterative decomposition of water and fat with echo asymmetry and least\u2010squares estimation (IDEAL): application with fast spin\u2010echo imaging","volume":"54","author":"Reeder","year":"2005","journal-title":"Magnetic Resonance in Medicine: an Official Journal of the International Society for Magnetic Resonance in Medicine"},{"issue":"3","key":"10.1016\/j.ejrad.2025.112632_b0090","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.mric.2010.08.013","article-title":"Quantification of liver fat with magnetic resonance imaging","volume":"18","author":"Reeder","year":"2010","journal-title":"Magn. Reson. Imaging Clin. N. Am."},{"issue":"7","key":"10.1016\/j.ejrad.2025.112632_b0095","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.1007\/s00330-022-08561-5","article-title":"Quantitative MR evaluation of the infrapatellar fat pad for knee osteoarthritis: using proton density fat fraction and T2* relaxation based on DIXON","volume":"32","author":"Chen","year":"2022","journal-title":"Eur. Radiol."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112632_b0100","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s13018-025-05687-2","article-title":"Correlation analysis between the mDIXON-quant fat quantification parameters of the infrapatellar fat pad and the severity of knee osteoarthritis","volume":"20","author":"Zhao","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"issue":"5","key":"10.1016\/j.ejrad.2025.112632_b0105","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/mrm.22925","article-title":"T1-corrected fat quantification using chemical shift-based water\/fat separation: application to skeletal muscle","volume":"66","author":"Karampinos","year":"2011","journal-title":"Magn. Reson. Med."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112632_b0110","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/mrm.21301","article-title":"Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise","volume":"58","author":"Liu","year":"2007","journal-title":"Magn. Reson. Med."},{"issue":"11","key":"10.1016\/j.ejrad.2025.112632_b0115","doi-asserted-by":"crossref","DOI":"10.1002\/mp.70101","article-title":"A robust MRI water-fat separation algorithm based on field map and fat fraction map smoothness","volume":"52","author":"Yuan","year":"2025","journal-title":"Med. Phys."},{"issue":"12","key":"10.1016\/j.ejrad.2025.112632_b0120","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy","year":"1988","journal-title":"J. Rheumatol."},{"issue":"3","key":"10.1016\/j.ejrad.2025.112632_b0125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.joca.2003.11.003","article-title":"Whole-Organ magnetic Resonance Imaging score (WORMS) of the knee in osteoarthritis","volume":"12","author":"Peterfy","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.ejrad.2025.112632_b0130","first-page":"34","article-title":"The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis. npj","volume":"10","author":"Wang","year":"2024","journal-title":"Aging"},{"issue":"4","key":"10.1016\/j.ejrad.2025.112632_b0135","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/ten.teb.2013.0377","article-title":"The roles of catabolic factors in the development of osteoarthritis","volume":"20","author":"Blasioli","year":"2014","journal-title":"Tissue Eng. B Rev."},{"issue":"4","key":"10.1016\/j.ejrad.2025.112632_b0140","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1161\/01.ATV.20.4.1057","article-title":"C-reactive protein, cardiovascular risk factors, and mortality in a prospective study in the elderly","volume":"20","author":"Strandberg","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.ejrad.2025.112632_b0145","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s42492-022-00121-4","article-title":"Two fully automated data-driven 3D whole-breast segmentation strategies in MRI for MR-based breast density using image registration and U-Net with a focus on reproducibility","volume":"5","author":"Ying","year":"2022","journal-title":"Visual Comput. Ind., Biomed., Art"},{"issue":"1","key":"10.1016\/j.ejrad.2025.112632_b0150","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41598-021-04125-7","article-title":"Degenerative joint disease induced by repeated intra-articular injections of monosodium urate crystals in rats as investigated by translational imaging","volume":"12","author":"Accart","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejrad.2025.112632_b0155","doi-asserted-by":"crossref","unstructured":"Collins, K.H., K.L. Lenz, H.D. Welhaven, et al., Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain. Science Advances, 2025. 11(17): p. eadt5915.","DOI":"10.1126\/sciadv.adt5915"},{"issue":"12","key":"10.1016\/j.ejrad.2025.112632_b0160","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1007\/s00198-024-07220-3","article-title":"Association of proton-density fat fraction with osteoporosis: a systematic review and meta-analysis","volume":"35","author":"Yuan","year":"2024","journal-title":"Osteoporos Int."},{"issue":"12","key":"10.1016\/j.ejrad.2025.112632_b0165","doi-asserted-by":"crossref","DOI":"10.21037\/apm-21-3479","article-title":"Systematic review and meta-analysis: the value of MRI chemical-shift imaging in the evaluation of bone quality in patients with osteoporosis","volume":"10","author":"Wang","year":"2021","journal-title":"Annals of Palliative Medicine"},{"issue":"3","key":"10.1016\/j.ejrad.2025.112632_b0170","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.crad.2013.10.005","article-title":"Quantitative evaluation of vertebral marrow adipose tissue in postmenopausal female using MRI chemical shift-based water\u2013fat separation","volume":"69","author":"Li","year":"2014","journal-title":"Clin. Radiol."},{"issue":"10","key":"10.1016\/j.ejrad.2025.112632_b0175","doi-asserted-by":"crossref","first-page":"5180","DOI":"10.1007\/s00330-019-06071-5","article-title":"Diagnostic accuracy of hepatic proton density fat fraction measured by magnetic resonance imaging for the evaluation of liver steatosis with histology as reference standard: a meta-analysis","volume":"29","author":"Qu","year":"2019","journal-title":"Eur. Radiol."},{"issue":"7","key":"10.1016\/j.ejrad.2025.112632_b0180","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1007\/s00330-019-06072-4","article-title":"Diagnostic value of MRI-PDFF for hepatic steatosis in patients with non-alcoholic fatty liver disease: a meta-analysis","volume":"29","author":"Gu","year":"2019","journal-title":"Eur. Radiol."},{"issue":"11","key":"10.1016\/j.ejrad.2025.112632_b0185","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1016\/j.acra.2025.05.051","article-title":"Diagnostic Accuracy of Hepatic MRI-PDFF and R2* for the Evaluation of Liver Steatosis and Liver Iron Overload: aMeta-analysis","volume":"32","author":"Yuan","year":"2025","journal-title":"Acad. Radiol."},{"issue":"4","key":"10.1016\/j.ejrad.2025.112632_b0190","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.21037\/qims-24-2021","article-title":"Quantification of infrapatellar fat pad fibrosis using magnetic resonance imaging-derived proton density fat fraction: a pathology-controlled study","volume":"15","author":"Zhou","year":"2025","journal-title":"Quant. Imaging Med. Surg."},{"issue":"2","key":"10.1016\/j.ejrad.2025.112632_b0195","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/mrm.23016","article-title":"On the performance of T2* correction methods for quantification of hepatic fat content","volume":"67","author":"Reeder","year":"2012","journal-title":"Magn. Reson. Med."}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X25007181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X25007181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:10:16Z","timestamp":1771488616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X25007181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":39,"alternative-id":["S0720048X25007181"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2025.112632","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of Age-Related compositional changes in the infrapatellar fat pad using MRI-Derived PDFF and T2* at 1.5\u00a0T","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2025.112632","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112632"}}