{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:50:44Z","timestamp":1782100244829,"version":"3.54.5"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS112274"],"award-info":[{"award-number":["R01NS112274"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014842","name":"Race to Erase MS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH123550"],"award-info":[{"award-number":["R01MH123550"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ejrad.2026.112707","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T16:01:18Z","timestamp":1769702478000},"page":"112707","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comparison of central FLAIR hypointensity and central vein sign on FLAIR* in a diagnostic cohort"],"prefix":"10.1016","volume":"196","author":[{"given":"Karlo","family":"Toljan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moein","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Daboul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunio","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Sicotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell T.","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Sati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-9148","authenticated-orcid":false,"given":"Daniel","family":"Ontaneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejrad.2026.112707_b0005","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1177\/13524585221097560","article-title":"Lesion size and shape in central vein sign assessment for multiple sclerosis diagnosis: an in vivo and postmortem MRI study","volume":"28","author":"Al-Louzi","year":"2022","journal-title":"Mult. Scler."},{"key":"10.1016\/j.ejrad.2026.112707_b0010","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrneurol.2016.166","article-title":"The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative","volume":"12","author":"Sati","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejrad.2026.112707_b0015","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1148\/radiol.12120208","article-title":"FLAIR*: A combined MR contrast technique for visualizing white matter lesions and parenchymal veins","volume":"265","author":"Sati","year":"2012","journal-title":"Radiology"},{"key":"10.1016\/j.ejrad.2026.112707_b0020","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2214\/AJR.22.27731","article-title":"Effect of GBCA use on detection and diagnostic performance of the central vein sign: evaluation using a 3-T FLAIR* sequence in patients with suspected multiple sclerosis","volume":"220","author":"Daboul","year":"2023","journal-title":"Am. J. Roentgenol."},{"key":"10.1016\/j.ejrad.2026.112707_b0025","doi-asserted-by":"crossref","DOI":"10.1111\/jon.70011","article-title":"Reliability of central vein sign imaging With 3T FLAIR* in a multicenter study","volume":"35","author":"Martin","year":"2025","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.ejrad.2026.112707_b0030","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3390\/diagnostics10121025","article-title":"The use of the central vein sign in the diagnosis of multiple sclerosis: a systematic review and meta-analysis","volume":"10","author":"Castellaro","year":"2020","journal-title":"Diagnostics"},{"key":"10.1016\/j.ejrad.2026.112707_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.crad.2025.106984","article-title":"Central vein sign and paramagnetic rim lesion abbreviated counting methods for diagnosis of multiple sclerosis: a systematic review and meta-analysis","author":"Toljan","year":"2025","journal-title":"Clin. Radiol."},{"issue":"2025","key":"10.1016\/j.ejrad.2026.112707_b0040","first-page":"850","article-title":"Diagnosis of multiple sclerosis revisions of the McDonald criteria","volume":"24","author":"Montalban","year":"2024","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.ejrad.2026.112707_b0045","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.3174\/ajnr.A5819","article-title":"The central vein: FLAIR signal abnormalities associated with developmental venous anomalies in patients with multiple sclerosis","volume":"39","author":"Rogers","year":"2018","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.ejrad.2026.112707_b0050","doi-asserted-by":"crossref","unstructured":"F. Gaillard, Multiple sclerosis with central vein sign, in: Radiopaedia.Org, Radiopaedia.org, 2024. DOI: 10.53347\/rID-198248.","DOI":"10.53347\/rID-198248"},{"key":"10.1016\/j.ejrad.2026.112707_b0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/13524585231214360","article-title":"A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis","volume":"30","author":"Daboul","year":"2024","journal-title":"Mult. Scler."},{"key":"10.1016\/j.ejrad.2026.112707_b0060","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1177\/1352458514525868","article-title":"Rapid, high-resolution, whole-brain, susceptibility-based MRI of multiple sclerosis","volume":"20","author":"Sati","year":"2014","journal-title":"Mult. Scler."},{"key":"10.1016\/j.ejrad.2026.112707_b0065","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1177\/13524585241271988","article-title":"Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis","volume":"30","author":"Toljan","year":"2024","journal-title":"Mult. Scler."},{"key":"10.1016\/j.ejrad.2026.112707_b0070","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","article-title":"User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability","volume":"31","author":"Yushkevich","year":"2006","journal-title":"Neuroimage"},{"issue":"2025","key":"10.1016\/j.ejrad.2026.112707_b0075","first-page":"866","article-title":"MAGNIMS\u2013CMSC\u2013NAIMS consensus recommendations on the use of MRI for the diagnosis of multiple sclerosis","volume":"24","author":"Barkhof","year":"2024","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.ejrad.2026.112707_b0080","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1177\/1352458520910496","article-title":"Challenges in multiple sclerosis diagnosis: misunderstanding and misapplication of the McDonald criteria","volume":"27","author":"Solomon","year":"2021","journal-title":"Mult. Scler."},{"key":"10.1016\/j.ejrad.2026.112707_b0085","doi-asserted-by":"crossref","unstructured":"Y.E. Senturk, A. Peker, H. Ozen Atalay, A. Altintas, A.Y. Oner, Assessing the central vein sign in multiple sclerosis using contrast-enhanced isotropic FLAIR* on a 1.5T System: A prospective observational study, Mult Scler Relat Disord 102 (2025) 106628. DOI: 10.1016\/j.msard.2025.106628.","DOI":"10.1016\/j.msard.2025.106628"},{"key":"10.1016\/j.ejrad.2026.112707_b0090","article-title":"Central vein sign: A diagnostic biomarker in multiple sclerosis (CAVS-MS) study protocol for a prospective multicenter trial","volume":"32","author":"Ontaneda","year":"2021","journal-title":"NeuroImage: Clinical"}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X26000550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X26000550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:41:09Z","timestamp":1782099669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X26000550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":18,"alternative-id":["S0720048X26000550"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2026.112707","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of central FLAIR hypointensity and central vein sign on FLAIR* in a diagnostic cohort","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2026.112707","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112707"}}