{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:28:53Z","timestamp":1792265333096,"version":"4.4.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ejrad.2026.112709","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:29:29Z","timestamp":1769844569000},"page":"112709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Diagnostic performance of iodine map for differentiating colorectal cancer from benign colorectal wall thickening"],"prefix":"10.1016","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9287-7058","authenticated-orcid":false,"given":"Sonaz","family":"Malekzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Rotas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Hiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floryn","family":"Cherbanyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Staudenmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cannella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Widmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejrad.2026.112709_b0005","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ejrad.2026.112709_b0010","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1148\/radiographics.20.2.g00mc14419","article-title":"Spiral CT of colon cancer: imaging features and role in management","volume":"20","author":"Horton","year":"2000","journal-title":"Radiographics"},{"key":"10.1016\/j.ejrad.2026.112709_b0015","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.crad.2017.06.007","article-title":"Pitfalls in diagnosing colon cancer on abdominal CT","volume":"72","author":"Klang","year":"2017","journal-title":"Clin. Radiol."},{"key":"10.1016\/j.ejrad.2026.112709_b0020","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/flgastro-2018-100966","article-title":"Systematic review and meta-analysis: does colonic mural thickening on CT correlate with endoscopic findings at colonoscopy?","volume":"9","author":"Chandrapalan","year":"2018","journal-title":"Frontline Gastroenterol"},{"key":"10.1016\/j.ejrad.2026.112709_b0025","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s10140-009-0806-x","article-title":"Correlation of incidental colorectal wall thickening at CT compared to colonoscopy","volume":"16","author":"Eskaros","year":"2009","journal-title":"Emerg. Radiol."},{"key":"10.1016\/j.ejrad.2026.112709_b0030","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/tomography9010017","article-title":"Pros and Cons of Dual-Energy CT Systems: \u201cone does not Fit all\u201d","volume":"9","author":"Borges","year":"2023","journal-title":"Tomography"},{"key":"10.1016\/j.ejrad.2026.112709_b0035","first-page":"299","volume":"10","author":"Foti","year":"2024","journal-title":"Dual-Energy CT in Oncologic Imaging. Tomography"},{"key":"10.1016\/j.ejrad.2026.112709_b0040","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1053\/j.sult.2023.03.006","article-title":"Dual Energy CT in Oncology: Benefits for both patients and Radiologists from an Emerging Quantitative and Functional Diagnostic Technique","volume":"44","author":"Guerrini","year":"2023","journal-title":"Semin. Ultrasound CT MR"},{"key":"10.1016\/j.ejrad.2026.112709_b0045","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3390\/diagnostics10100814","article-title":"Gastrointestinal applications of Iodine Quantification using Dual-Energy CT: a Systematic Review","volume":"10","author":"Xu","year":"2020","journal-title":"Diagnostics (basel)"},{"key":"10.1016\/j.ejrad.2026.112709_b0050","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13244-023-01593-5","article-title":"Performance of dual-layer spectrum CT virtual monoenergetic images to assess early rectal adenocarcinoma T-stage: comparison with MR","volume":"15","author":"Jia","year":"2024","journal-title":"Insights Imaging"},{"key":"10.1016\/j.ejrad.2026.112709_b0055","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5152\/dir.2017.16225","article-title":"Dual-energy CT characteristics of colon and rectal cancer allows differentiation from stool by dual-source CT","volume":"23","author":"Ozdeniz","year":"2017","journal-title":"Diagn. Interv. Radiol."},{"key":"10.1016\/j.ejrad.2026.112709_b0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147756","article-title":"Dual Energy Spectral CT Imaging for Colorectal Cancer Grading: a Preliminary Study","volume":"11","author":"Gong","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejrad.2026.112709_b0065","doi-asserted-by":"crossref","first-page":"10539","DOI":"10.1038\/s41598-024-61000-x","article-title":"Differential expression of angiogenesis-related genes 'VEGF' and 'angiopoietin-1' in metastatic and EMAST-positive colorectal cancer patients","volume":"14","author":"Torshizi Esfahani","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejrad.2026.112709_b0070","first-page":"3558","article-title":"Angiogenesis in primary colorectal cancer and matched metastatic tissues: Biological and clinical implications for anti-angiogenic therapies","volume":"19","author":"Yin","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.ejrad.2026.112709_b0075","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1007\/s00330-018-5502-3","article-title":"Can quantitative iodine parameters on DECT replace perfusion CT parameters in colorectal cancers?","volume":"28","author":"Kang","year":"2018","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.ejrad.2026.112709_b0080","first-page":"15","article-title":"Correlation of Spectral CT-Based Iodine Concentration Parameters with LI-RADS Classification of Suspected Hepatocellular Carcinoma Nodules in Cirrhotic patients","author":"Celestino","year":"2025","journal-title":"Diagnostics (basel)"},{"key":"10.1016\/j.ejrad.2026.112709_b0085","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejrad.2018.05.019","article-title":"Iodine quantification to distinguish hepatic neuroendocrine tumor metastasis from hepatocellular carcinoma at dual-source dual-energy liver CT","volume":"105","author":"Kaltenbach","year":"2018","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.ejrad.2026.112709_b0090","doi-asserted-by":"crossref","first-page":"e643","DOI":"10.5114\/pjr.2018.80347","article-title":"Improved imaging of colorectal liver metastases using single-source, fast kVp-switching, dual-energy CT: preliminary results","volume":"83","author":"Ratajczak","year":"2018","journal-title":"Pol. J. Radiol."},{"key":"10.1016\/j.ejrad.2026.112709_b0095","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13244-022-01297-2","article-title":"Dual-energy CT with virtual monoenergetic images and iodine maps improves tumor conspicuity in patients with pancreatic ductal adenocarcinoma","volume":"13","author":"Liang","year":"2022","journal-title":"Insights Imaging"},{"key":"10.1016\/j.ejrad.2026.112709_b0100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2214\/AJR.18.20574","article-title":"Detection and Characterization of Atypical Renal Cysts and Solid Renal Masses in Kidney Transplant patients by use of Dual-Energy CT Iodine Maps","volume":"213","author":"L'Hostis","year":"2019","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1016\/j.ejrad.2026.112709_b0105","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20221079","article-title":"Accumulation of iodine or other similar K-edge equivalent element within renal cysts mimics enhancing masses at single-phase dual-energy CT","volume":"96","author":"Magnetta","year":"2023","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.ejrad.2026.112709_b0110","doi-asserted-by":"crossref","first-page":"W17","DOI":"10.2214\/AJR.18.20843","article-title":"Preoperative Diagnosis of Regional Lymph Node Metastasis of Colorectal Cancer with Quantitative Parameters from Dual-Energy CT","volume":"213","author":"Yang","year":"2019","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1016\/j.ejrad.2026.112709_b0115","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12880-023-01060-z","article-title":"Preoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual-energy spectral CT","volume":"23","author":"Yuan","year":"2023","journal-title":"BMC Med. Imaging"},{"key":"10.1016\/j.ejrad.2026.112709_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2022.110618","article-title":"Association between extramural vascular invasion and iodine quantification using dual-energy computed tomography of rectal cancer: a preliminary study","volume":"158","author":"Gao","year":"2023","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.ejrad.2026.112709_b0125","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/JCMA.0000000000000706","article-title":"Application of dual-layer spectral detector computed tomography to evaluate the expression of Ki-67 in colorectal cancer","volume":"85","author":"Wang","year":"2022","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.ejrad.2026.112709_b0130","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.crad.2013.03.005","article-title":"The feasibility of colorectal cancer detection using dual-energy computed tomography with iodine mapping","volume":"68","author":"Boellaard","year":"2013","journal-title":"Clin. Radiol."},{"key":"10.1016\/j.ejrad.2026.112709_b0135","first-page":"13","article-title":"Biomarkers of Angiogenesis in Colorectal Cancer","volume":"7","author":"Mousa","year":"2015","journal-title":"Biomark Cancer"},{"key":"10.1016\/j.ejrad.2026.112709_b0140","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1007\/s00330-018-5736-0","article-title":"How accurate and precise are CT based measurements of iodine concentration? a comparison of the minimum detectable concentration difference among single source and dual source dual energy CT in a phantom study","volume":"4","author":"Euler","year":"2019","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.ejrad.2026.112709_b0145","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1002\/mp.16583","article-title":"Quantitative performance of photon-counting CT at low dose: Virtual monochromatic imaging and iodine quantification","volume":"9","author":"Vrbaski","year":"2023","journal-title":"Med. Phys."}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X26000574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X26000574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:08:31Z","timestamp":1771488511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X26000574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":29,"alternative-id":["S0720048X26000574"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2026.112709","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic performance of iodine map for differentiating colorectal cancer from benign colorectal wall thickening","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2026.112709","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112709"}}