{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:05:20Z","timestamp":1776085520191,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["SFB 1118"],"award-info":[{"award-number":["SFB 1118"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["SFB 1158"],"award-info":[{"award-number":["SFB 1158"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ejrad.2026.112783","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:49:42Z","timestamp":1773301782000},"page":"112783","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Magnetization transfer ratio is decreased in the sciatic nerve of patients with relapsing-remitting multiple sclerosis"],"prefix":"10.1016","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5378-2778","authenticated-orcid":false,"given":"Kira","family":"G\u00f6ldner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Korporal-Kuhnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Vieh\u00f6ver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Weiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Wildemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Sam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"F\u00f6sleitner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anysia","family":"Poncelet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Heiland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bendszus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6254-9192","authenticated-orcid":false,"given":"Jennifer C.","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejrad.2026.112783_b0005","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1212\/WNL.0000000000000560","article-title":"Defining the clinical course of multiple sclerosis: the 2013 revisions","volume":"83","author":"Lublin","year":"2014","journal-title":"Neurology"},{"issue":"Pt 6","key":"10.1016\/j.ejrad.2026.112783_b0010","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1093\/brain\/112.6.1419","article-title":"The natural history of multiple sclerosis: a geographically based study. 2. Predictive value of the early clinical course","volume":"112","author":"Weinshenker","year":"1989","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.ejrad.2026.112783_b0015","first-page":"672","article-title":"Peripheral neuropathy in multiple sclerosis","volume":"79","author":"Drake","year":"1987","journal-title":"J. Natl Med. Assoc."},{"issue":"5","key":"10.1016\/j.ejrad.2026.112783_b0020","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1468-1331.2010.03149.x","article-title":"Peripheral nervous system involvement in multiple sclerosis","volume":"18","author":"Gartzen","year":"2011","journal-title":"Eur. J. Neurol."},{"issue":"7","key":"10.1016\/j.ejrad.2026.112783_b0025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1212\/WNL.8.7.503","article-title":"Peripheral neuropathy in multiple sclerosis","volume":"8","author":"Hasson","year":"1958","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.ejrad.2026.112783_b0030","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.mehy.2008.07.066","article-title":"Peripheral nerves are progressively involved in multiple sclerosis\u2013a hypothesis from a pilot study of temperature sensitized electroneurographic screening","volume":"72","author":"Hidasi","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.ejrad.2026.112783_b0035","article-title":"Die sogenannte akute multiple Sklerose (Encephalomyelitis periaxialis scleroticans)","author":"Marburg","year":"1906","journal-title":"Franz Deuticke"},{"issue":"5","key":"10.1016\/j.ejrad.2026.112783_b0040","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/1352458517693469","article-title":"Peripheral nervous system involvement in multiple sclerosis","volume":"23","author":"Rovira","year":"2017","journal-title":"Mult. Scler."},{"issue":"4","key":"10.1016\/j.ejrad.2026.112783_b0045","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/brain\/100.4.755","article-title":"'Onion bulb' formations in the central and peripheral nervous system in association with multiple sclerosis and hypertrophic polyneuropathy","volume":"100","author":"Schoene","year":"1977","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.ejrad.2026.112783_b0050","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/j.clinph.2008.04.010","article-title":"Peripheral nerve demyelination in multiple sclerosis","volume":"119","author":"Misawa","year":"2008","journal-title":"Clin. Neurophysiol."},{"issue":"1","key":"10.1016\/j.ejrad.2026.112783_b0055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ana.410020107","article-title":"Peripheral nerve abnormality in multiple sclerosis","volume":"2","author":"Pollock","year":"1977","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.ejrad.2026.112783_b0060","first-page":"349","article-title":"Peripheral sensory and motor abnormalities in patients with multiple sclerosis","volume":"43","author":"Anlar","year":"2003","journal-title":"Electromyogr. Clin. Neurophysiol."},{"issue":"5","key":"10.1016\/j.ejrad.2026.112783_b0065","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/ana.25068","article-title":"Peripheral nerve involvement in multiple sclerosis: demonstration by magnetic resonance neurography","volume":"82","author":"Jende","year":"2017","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.ejrad.2026.112783_b0070","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/RLI.0000000000000915","article-title":"Peripheral nerve involvement at first diagnosis of multiple sclerosis: a prospective MR neurography study","volume":"58","author":"Foesleitner","year":"2023","journal-title":"Invest. Radiol."},{"key":"10.1016\/j.ejrad.2026.112783_b0075","article-title":"Quantification and proximal-to-distal distribution pattern of Tibial nerve lesions in relapsing-remitting multiple sclerosis : assessment by MR neurography","author":"Pietsch","year":"2022","journal-title":"Clin. Neuroradiol."},{"issue":"2","key":"10.1016\/j.ejrad.2026.112783_b0080","doi-asserted-by":"crossref","DOI":"10.1111\/ene.16126","article-title":"Microstructural changes of peripheral nerves in early multiple sclerosis: a prospective magnetic resonance neurography study","volume":"31","author":"Foesleitner","year":"2024","journal-title":"Eur. J. Neurol."},{"issue":"4 Suppl","key":"10.1016\/j.ejrad.2026.112783_b0085","first-page":"58s","article-title":"Magnetization transfer imaging in multiple sclerosis","volume":"15","author":"Horsfield","year":"2005","journal-title":"J. Neuroimaging"},{"issue":"9","key":"10.1016\/j.ejrad.2026.112783_b0090","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0730-725X(98)00139-8","article-title":"Multi-component T1 relaxation and magnetisation transfer in peripheral nerve","volume":"16","author":"Does","year":"1998","journal-title":"Magn. Reson. Imaging"},{"issue":"1","key":"10.1016\/j.ejrad.2026.112783_b0095","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/mrm.1910100113","article-title":"Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo","volume":"10","author":"Wolff","year":"1989","journal-title":"Magn. Reson. Med."},{"issue":"7","key":"10.1016\/j.ejrad.2026.112783_b0100","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/RLI.0000000000000455","article-title":"Magnetization transfer ratio in peripheral nerve tissue: does it depend on age or location?","volume":"53","author":"Kollmer","year":"2018","journal-title":"Invest. Radiol."},{"issue":"2","key":"10.1016\/j.ejrad.2026.112783_b0105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0022-510X(98)00162-2","article-title":"Magnetization transfer ratios of multiple sclerosis lesions with variable durations of enhancement","volume":"159","author":"Filippi","year":"1998","journal-title":"J. Neurol. Sci."},{"issue":"6","key":"10.1016\/j.ejrad.2026.112783_b0110","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/ana.410430616","article-title":"Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis","volume":"43","author":"Filippi","year":"1998","journal-title":"Ann. Neurol."},{"issue":"11","key":"10.1016\/j.ejrad.2026.112783_b0115","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00415-003-0192-3","article-title":"High field MRI correlates of myelin content and axonal density in multiple sclerosis\u2013a post-mortem study of the spinal cord","volume":"250","author":"Mottershead","year":"2003","journal-title":"J. Neurol."},{"key":"10.1016\/j.ejrad.2026.112783_b0120","doi-asserted-by":"crossref","unstructured":"J.H. van Waesberghe, W. Kamphorst, C.J. De Groot, M.A. van Walderveen, J.A. Castelijns, R. Ravid, G.J. Lycklama \u00e0 Nijeholt, P. van der Valk, C.H. Polman, A.J. Thompson, F. Barkhof, Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights into substrates of disability, Ann Neurol 46(5) (1999) 747-54.","DOI":"10.1002\/1531-8249(199911)46:5<747::AID-ANA10>3.0.CO;2-4"},{"key":"10.1016\/j.ejrad.2026.112783_b0125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuroimage.2012.10.059","article-title":"Segmentation of magnetization transfer ratio lesions for longitudinal analysis of demyelination and remyelination in multiple sclerosis","volume":"66","author":"Brown","year":"2013","journal-title":"Neuroimage"},{"issue":"17","key":"10.1016\/j.ejrad.2026.112783_b0130","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1212\/WNL.0000000000000919","article-title":"Proximal nerve magnetization transfer MRI relates to disability in Charcot-Marie-Tooth diseases","volume":"83","author":"Dortch","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.ejrad.2026.112783_b0135","doi-asserted-by":"crossref","DOI":"10.1111\/ene.15841","article-title":"Peripheral nerve involvement in hereditary spastic paraplegia characterized by quantitative magnetic resonance neurography","author":"Jacobi","year":"2023","journal-title":"Eur. J. Neurol."},{"issue":"5","key":"10.1016\/j.ejrad.2026.112783_b0140","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/acn3.51049","article-title":"Magnetization transfer ratio quantifies polyneuropathy in hereditary transthyretin amyloidosis","volume":"7","author":"Kollmer","year":"2020","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"1","key":"10.1016\/j.ejrad.2026.112783_b0145","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/ene.14528","article-title":"Magnetization transfer ratio: a quantitative imaging biomarker for 5q spinal muscular atrophy","volume":"28","author":"Kollmer","year":"2021","journal-title":"Eur. J. Neurol."},{"issue":"6","key":"10.1016\/j.ejrad.2026.112783_b0150","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1111\/ene.15305","article-title":"Quantitative magnetic resonance neurographic characterization of peripheral nerve involvement in manifest and pre-ataxic spinocerebellar ataxia type 3","volume":"29","author":"Kollmer","year":"2022","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.ejrad.2026.112783_b0155","doi-asserted-by":"crossref","unstructured":"J. Cabana, GU Y, Boudreau M, et al., Quantitative magnetization transfer imaging made easy with qMTLab: Software for data simulation, analysis, and visualization., Concept Magn Reson (44A) (2016) 263-277.","DOI":"10.1002\/cmr.a.21357"},{"issue":"2","key":"10.1016\/j.ejrad.2026.112783_b0160","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.ejrad.2026.112783_b0165","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00062-022-01219-1","article-title":"Quantification and proximal-to-distal distribution pattern of Tibial nerve lesions in relapsing-remitting multiple sclerosis : assessment by MR neurography","volume":"33","author":"Pietsch","year":"2023","journal-title":"Clin. Neuroradiol."},{"issue":"Suppl 2","key":"10.1016\/j.ejrad.2026.112783_b0170","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00062-015-0412-0","article-title":"Diagnostic imaging in the PNS","volume":"25","author":"Kollmer","year":"2015","journal-title":"Clin. Neuroradiol."},{"issue":"7","key":"10.1016\/j.ejrad.2026.112783_b0175","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1007\/s00415-017-8543-7","article-title":"Large coverage MR neurography in CIDP: diagnostic accuracy and electrophysiological correlation","volume":"264","author":"Kronlage","year":"2017","journal-title":"J. Neurol."},{"issue":"2","key":"10.1016\/j.ejrad.2026.112783_b0180","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00062-021-01067-5","article-title":"Magnetization transfer ratio of peripheral nerve and Skeletal muscle : correlation with demographic variables in healthy volunteers","volume":"32","author":"F\u00f6sleitner","year":"2022","journal-title":"Clin. Neuroradiol."},{"issue":"2","key":"10.1016\/j.ejrad.2026.112783_b0185","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1001\/jamaneurol.2022.4156","article-title":"Time to change the current clinical classification of multiple sclerosis?","volume":"80","author":"Granziera","year":"2023","journal-title":"JAMA Neurol."},{"issue":"1","key":"10.1016\/j.ejrad.2026.112783_b0190","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nic.2008.09.004","article-title":"Magnetization transfer MR imaging in multiple sclerosis","volume":"19","author":"Ropele","year":"2009","journal-title":"Neuroimaging Clin. N. Am."},{"key":"10.1016\/j.ejrad.2026.112783_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2022.103012","article-title":"Periventricular magnetisation transfer abnormalities in early multiple sclerosis","volume":"34","author":"Pirpamer","year":"2022","journal-title":"Neuroimage Clin"},{"issue":"3","key":"10.1016\/j.ejrad.2026.112783_b0200","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1148\/radiology.215.3.r00jn02824","article-title":"Multiple sclerosis: magnetization transfer MR imaging of white matter before lesion appearance on T2-weighted images","volume":"215","author":"Pike","year":"2000","journal-title":"Radiology"},{"issue":"6","key":"10.1016\/j.ejrad.2026.112783_b0205","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1177\/1352458510364630","article-title":"Lesional magnetization transfer ratio: a feasible outcome for remyelinating treatment trials in multiple sclerosis","volume":"16","author":"van den Elskamp","year":"2010","journal-title":"Mult. Scler."},{"key":"10.1016\/j.ejrad.2026.112783_b0210","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.763143","article-title":"Assessing lumbar plexus and sciatic nerve damage in relapsing-remitting multiple sclerosis using magnetisation transfer ratio","volume":"12","author":"Boonsuth","year":"2021","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.ejrad.2026.112783_b0215","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/mus.22240","article-title":"Magnetic resonance imaging of peripheral nerves: differences in magnetization transfer","volume":"45","author":"Gambarota","year":"2012","journal-title":"Muscle Nerve"},{"issue":"5","key":"10.1016\/j.ejrad.2026.112783_b0220","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/jmri.23828","article-title":"Magnetization transfer-based 3D visualization of foot peripheral nerves","volume":"37","author":"Mekle","year":"2013","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.ejrad.2026.112783_b0225","doi-asserted-by":"crossref","unstructured":"P. G., Anatomy of the peripheral nerve system, in: B.J. Penkert G, and Schelle (Ed.), Focal Peripheral Neuropathies, Springer, Berlin, Heidelberg, 2015, pp. 3-9.","DOI":"10.1007\/978-3-642-54780-5_2"},{"issue":"5","key":"10.1016\/j.ejrad.2026.112783_b0230","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1177\/1352458516687401","article-title":"Involvement of peripheral III nerve in multiple sclerosis patient: report of a new case and discussion of the underlying mechanism","volume":"23","author":"Shor","year":"2017","journal-title":"Mult. Scler."},{"issue":"8","key":"10.1016\/j.ejrad.2026.112783_b0235","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1212\/WNL.37.8.1287","article-title":"Combined central and peripheral myelinopathy","volume":"37","author":"Rubin","year":"1987","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.ejrad.2026.112783_b0240","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/CND.0b013e31816f18e3","article-title":"Chronic inflammatory demyelinating polyradiculoneuropathy associated with multiple sclerosis","volume":"9","author":"Sharma","year":"2008","journal-title":"J. Clin. Neuromuscul. Dis."},{"issue":"9","key":"10.1016\/j.ejrad.2026.112783_b0245","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1136\/jnnp.2006.108290","article-title":"Relapsing demyelinating disease affecting both the central and peripheral nervous systems","volume":"79","author":"Zephir","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"3","key":"10.1016\/j.ejrad.2026.112783_b0250","first-page":"135","article-title":"Multiple sclerosis associated with peripheral demyelinating neuropathy","volume":"15","author":"Di Trapani","year":"1996","journal-title":"Clin. Neuropathol."}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X26001312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X26001312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:28:01Z","timestamp":1776083281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X26001312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":50,"alternative-id":["S0720048X26001312"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2026.112783","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnetization transfer ratio is decreased in the sciatic nerve of patients with relapsing-remitting multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2026.112783","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112783"}}