{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:02:45Z","timestamp":1776124965631,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Liaoning Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015226","name":"Shengjing Hospital of China Medical University","doi-asserted-by":"publisher","award":["M1358"],"award-info":[{"award-number":["M1358"]}],"id":[{"id":"10.13039\/501100015226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015226","name":"Shengjing Hospital of China Medical University","doi-asserted-by":"publisher","award":["M1357"],"award-info":[{"award-number":["M1357"]}],"id":[{"id":"10.13039\/501100015226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejradiology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ejrad.2026.112822","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:38:42Z","timestamp":1774543122000},"page":"112822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Early prediction via PET\/CT for skeletal-related events in osteoporotic men with metastatic prostate cancer undergoing androgen deprivation therapy"],"prefix":"10.1016","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5908-8619","authenticated-orcid":false,"given":"Yiying","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronghui","family":"Ju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-9567","authenticated-orcid":false,"given":"Bitian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3431-7423","authenticated-orcid":false,"given":"Shen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejrad.2026.112822_b0005","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41585-021-00442-8","article-title":"Epidemiology and genomics of prostate cancer in asian men","volume":"18","author":"Zhu","year":"2021","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.ejrad.2026.112822_b0010","doi-asserted-by":"crossref","first-page":"482","DOI":"10.21037\/atm.2020.03.55","article-title":"Incidence of patients with bone metastases at diagnosis of solid tumors in adults: a large population-based study","volume":"8","author":"Huang","year":"2020","journal-title":"Annals of Translational Medicine"},{"key":"10.1016\/j.ejrad.2026.112822_b0015","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1038\/s41598-020-64073-6","article-title":"Prognosis of prostate cancer and bone metastasis pattern of patients: a SEER-based study and a local hospital based study from China","volume":"10","author":"Liu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejrad.2026.112822_b0020","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.2467","article-title":"Bone-Modifying agents in patients with high-risk metastatic castration-sensitive prostate cancer treated with abiraterone acetate","volume":"7","author":"Fukuokaya","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.ejrad.2026.112822_b0025","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1210\/jc.2011-3058","article-title":"Risk factors for low bone mass-related fractures in men: a systematic review and meta-analysis","volume":"97","author":"Drake","year":"2012","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.ejrad.2026.112822_b0030","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41391-020-00296-y","article-title":"Bone health effects of androgen-deprivation therapy and androgen receptor inhibitors in patients with nonmetastatic castration-resistant prostate cancer","volume":"24","author":"Hussain","year":"2021","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.ejrad.2026.112822_b0035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tem.2020.12.004","article-title":"Effects of medical treatment of prostate cancer on bone health","volume":"32","author":"Formenti","year":"2021","journal-title":"Trends in Endocrinol. Metab."},{"key":"10.1016\/j.ejrad.2026.112822_b0040","article-title":"Alkaline phosphatase (alp) levels in multiple myeloma and solid cancers with bone lesions: is there any difference?","volume":"26","author":"Annibali","year":"2020","journal-title":"J. Bone Oncol."},{"key":"10.1016\/j.ejrad.2026.112822_b0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228447","article-title":"Prediction of metastatic prostate cancer by prostate-specific antigen in combination with T stage and Gleason Grade: Nationwide, population-based register study","volume":"15","author":"Thomsen","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ejrad.2026.112822_b0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fendo.2018.00247","article-title":"Multifaceted roles for macrophages in prostate cancer skeletal metastasis","volume":"9","author":"Lo","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejrad.2026.112822_b0055","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8580043","article-title":"The roles of tumor-associated macrophages in prostate cancer","volume":"2022","author":"Han","year":"2022","journal-title":"J. Oncol."},{"key":"10.1016\/j.ejrad.2026.112822_b0060","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41419-020-2435-y","article-title":"CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating \u03b2-catenin\/STAT3 signaling","volume":"11","author":"Huang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejrad.2026.112822_b0065","first-page":"180","article-title":"Role of prostate and bone stromal cells on prostate cancer progression","volume":"10","author":"Karkampouna","year":"2022","journal-title":"Am. J. Clin. Experimental Urol."},{"key":"10.1016\/j.ejrad.2026.112822_b0070","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.21037\/tau.2019.09.20","article-title":"Current techniques of prostate biopsy: an update from past to present","volume":"9","author":"Noureldin","year":"2020","journal-title":"Translational Androl. Urol."},{"key":"10.1016\/j.ejrad.2026.112822_b0075","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.urolonc.2009.12.022","article-title":"Limitations of a contemporary prostate biopsy: the blind march forward","volume":"28","author":"Wei","year":"2010","journal-title":"Urol. Oncol."},{"key":"10.1016\/j.ejrad.2026.112822_b0080","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/s00259-019-04625-9","article-title":"Radiomics of 18F-FDG PET\/CT images predicts clinical benefit of advanced NSCLC patients to checkpoint blockade immunotherapy","volume":"47","author":"Mu","year":"2020","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.ejrad.2026.112822_b0085","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41571-021-00560-7","article-title":"Predicting cancer outcomes with radiomics and artificial intelligence in radiology","volume":"19","author":"Bera","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ejrad.2026.112822_b0090","article-title":"mpMRI-based interpretable machine learning model for predicting castration-resistant prostate cancer risk","volume":"195","author":"Shen","year":"2025","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.ejrad.2026.112822_b0095","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/eus.0000000000000113","article-title":"The role of artificial intelligence and deep learning in determining the histopathological grade of pancreatic neuroendocrine tumors by using EUS images","volume":"14","author":"Kiremitci","year":"2025","journal-title":"Endosc. Ultrasound"},{"key":"10.1016\/j.ejrad.2026.112822_b0100","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/eus.0000000000000079","article-title":"Computed tomography-based radial endobronchial ultrasound image simulation of peripheral pulmonary lesions using deep learning","volume":"13","author":"Zhang","year":"2024","journal-title":"Endosc. Ultrasound"},{"key":"10.1016\/j.ejrad.2026.112822_b0105","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/eus.0000000000000071","volume":"13","author":"M\u00f6ller","year":"2024","journal-title":"Endosc. Ultrasound"},{"key":"10.1016\/j.ejrad.2026.112822_b0110","doi-asserted-by":"crossref","DOI":"10.1002\/acm2.70189","article-title":"CT Imaging-based radiomics predicts the pain relief of Strontium-89 in treating tumor-induced bone metastases","volume":"26","author":"Fang","year":"2025","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"10.1016\/j.ejrad.2026.112822_b0115","first-page":"12","article-title":"Clinical practice guideline: the diagnosis and treatment of osteoporosis","volume":"122","author":"Thomasius","year":"2025","journal-title":"Deutsches Arzteblatt International"},{"key":"10.1016\/j.ejrad.2026.112822_b0120","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1093\/jnci\/94.19.1458","article-title":"A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma","volume":"94","author":"Saad","year":"2002","journal-title":"JNCI J. National Cancer Institute"},{"key":"10.1016\/j.ejrad.2026.112822_b0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/bco2.46","article-title":"A novel prognostic model for Japanese patients with newly diagnosed bone\u2010metastatic hormone\u2010na\u00efve prostate cancer","volume":"2","author":"Miyoshi","year":"2021","journal-title":"BJUI Compass"},{"key":"10.1016\/j.ejrad.2026.112822_b0130","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v036.i11","article-title":"Feature selection with the Boruta package","volume":"36","author":"Kursa","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.ejrad.2026.112822_b0135","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1109\/TPAMI.2005.159","article-title":"Feature selection based on mutual information: criteria of max-dependency, max-relevance, and min-redundancy","volume":"27","author":"Peng","year":"2005","journal-title":"IEEE Trans. Pattern Anal. Mach. Intell."},{"key":"10.1016\/j.ejrad.2026.112822_b0140","unstructured":"I. Guyon, J. Weston, S. Barnhill. Gene Selection for Cancer Classification using Support Vector Machines."},{"key":"10.1016\/j.ejrad.2026.112822_b0145","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1613\/jair.953","article-title":"SMOTE: Synthetic Minority Over-sampling Technique","volume":"16","author":"Chawla","year":"2002","journal-title":"J. Artif. Intell. Res."},{"key":"10.1016\/j.ejrad.2026.112822_b0150","doi-asserted-by":"crossref","DOI":"10.1245\/s10434-025-18981-4","article-title":"Intratumoral and Peritumoral Fat CT\u2011Based radiomics for predicting recurrence risk in non-muscle-invasive bladder cancer: a two-center study","author":"Jiang","year":"2026","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.ejrad.2026.112822_b0155","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.juro.2010.03.034","article-title":"Skeletal related events, bone metastasis and survival of prostate cancer: a population based cohort study in Denmark (1999 to 2007)","volume":"184","author":"N\u00f8rgaard","year":"2010","journal-title":"J. Urol."},{"key":"10.1016\/j.ejrad.2026.112822_b0160","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.3390\/cancers15205047","article-title":"Castration-resistant prostate cancer: from uncovered resistance mechanisms to current treatments","volume":"15","author":"Le","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.ejrad.2026.112822_b0165","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0022-5347(17)38491-4","article-title":"Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate","volume":"145","author":"Oesterling","year":"1991","journal-title":"J. Urol."},{"key":"10.1016\/j.ejrad.2026.112822_b0170","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1186\/s12967-023-04320-2","article-title":"The heterogeneity and clonal evolution analysis of the advanced prostate cancer with castration resistance","volume":"21","author":"Liu","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejrad.2026.112822_b0175","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.3390\/ijms20102587","article-title":"Prostate cancer and bone metastases: the underlying mechanisms","volume":"20","author":"Wong","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejrad.2026.112822_b0180","doi-asserted-by":"crossref","DOI":"10.1007\/s00259-021-05221-6","article-title":"The added value of18 F-FDG PET\/CT compared to68 Ga-PSMA PET\/CT in patients with castration-resistant prostate cancer","author":"Chen","year":"2021","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ejrad.2026.112822_b0185","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.euo.2018.06.010","article-title":"The metabolic landscape of prostate cancer","volume":"2","author":"Giunchi","year":"2019","journal-title":"Europ. Urol. Oncol."},{"key":"10.1016\/j.ejrad.2026.112822_b0190","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coemr.2020.02.003","article-title":"Metabolic alterations in tissues and biofluids of patients with prostate cancer","volume":"10","author":"Andersen","year":"2020","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"key":"10.1016\/j.ejrad.2026.112822_b0195","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.3390\/curroncol28050290","article-title":"Current overview of treatment for metastatic bone disease","volume":"28","author":"Tsukamoto","year":"2021","journal-title":"Curr. Oncol."}],"container-title":["European Journal of Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X26001701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0720048X26001701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:14:18Z","timestamp":1776122058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0720048X26001701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":39,"alternative-id":["S0720048X26001701"],"URL":"https:\/\/doi.org\/10.1016\/j.ejrad.2026.112822","relation":{},"ISSN":["0720-048X"],"issn-type":[{"value":"0720-048X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early prediction via PET\/CT for skeletal-related events in osteoporotic men with metastatic prostate cancer undergoing androgen deprivation therapy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejrad.2026.112822","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112822"}}