{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:32:19Z","timestamp":1787589139509,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T00:00:00Z","timestamp":1781395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004092","name":"Kuopio University Hospital","doi-asserted-by":"publisher","award":["5772789"],"award-info":[{"award-number":["5772789"]}],"id":[{"id":"10.13039\/501100004092","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejropen.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Radiology Open"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ejro.2026.100779","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:34:39Z","timestamp":1781764479000},"page":"100779","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Imaging-to-recanalization delay influences perfusion CT threshold calibration for follow-up infarct volume estimation"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0971-9332","authenticated-orcid":false,"given":"Simo","family":"Karhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Palm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Taina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"J\u00e4k\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Manninen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhana","family":"Hakum\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritva","family":"Vanninen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejro.2026.100779_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1411587","article-title":"A randomized trial of intraarterial treatment for acute ischemic stroke","volume":"372","author":"Berkhemer","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejro.2026.100779_bib2","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1056\/NEJMoa1414905","article-title":"Randomized assessment of rapid endovascular treatment of ischemic stroke","volume":"372","author":"Goyal","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejro.2026.100779_bib3","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1056\/NEJMoa1415061","article-title":"Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke","volume":"372","author":"Saver","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejro.2026.100779_bib4","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1056\/NEJMoa1414792","article-title":"Endovascular therapy for ischemic stroke with perfusion-imaging selection","volume":"372","author":"Campbell","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejro.2026.100779_bib5","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1056\/NEJMoa1713973","article-title":"Thrombectomy for stroke at 6\u201316\u2009h with selection by perfusion imaging","volume":"378","author":"Albers","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejro.2026.100779_bib6","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1056\/NEJMoa1503780","article-title":"Thrombectomy within 8\u2009h after symptom onset in ischemic stroke","volume":"372","author":"Jovin","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejro.2026.100779_bib7","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ejro.2026.100779_bib8","article-title":"2026 guideline for the early management of patients with acute ischemic stroke: a guideline from the American heart association\/American stroke association","author":"Prabhakaran","year":"2026","journal-title":"Stroke"},{"key":"10.1016\/j.ejro.2026.100779_bib9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1706442","article-title":"Thrombectomy 6\u201324\u2009h after stroke with a mismatch between deficit and infarct","volume":"378","author":"Nogueira","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejro.2026.100779_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ana.24543","article-title":"Ischemic core and hypoperfusion volumes predict infarct size in SWIFT PRIME","volume":"79","author":"Albers","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejro.2026.100779_bib11","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/neurintsurg-2016-012494","article-title":"Admission CT perfusion may overestimate initial infarct core: the ghost infarct core concept","volume":"9","author":"Boned","year":"2017","journal-title":"J. Neurointerv. Surg."},{"key":"10.1016\/j.ejro.2026.100779_bib12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/jon.12692","article-title":"Infarct core reliability by CT perfusion is a time-dependent phenomenon","volume":"30","author":"Rotem","year":"2020","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.ejro.2026.100779_bib13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3174\/ajnr.A8113","article-title":"Prevalence of \"ghost infarct core\" after endovascular thrombectomy","volume":"45","author":"Ospel","year":"2024","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.ejro.2026.100779_bib14","article-title":"Does the ischemic core really matter? An updated systematic review and meta-analysis of large core trials after TESLA, TENSION, and LASTE","volume":"4","author":"AlMajali","year":"2024","journal-title":"Stroke Vasc. Interv. Neurol."},{"key":"10.1016\/j.ejro.2026.100779_bib15","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/S0140-6736(23)02032-9","article-title":"Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial","volume":"402","author":"Bendszus","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.ejro.2026.100779_bib16","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1056\/NEJMoa2314063","article-title":"Trial of thrombectomy for stroke with a large infarct of unrestricted size","volume":"390","author":"Costalat","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejro.2026.100779_bib17","doi-asserted-by":"crossref","first-page":"e349","DOI":"10.1136\/jnis-2022-019777","article-title":"Updated estimates of large and medium vessel strokes, mechanical thrombectomy trends, and future projections indicate a relative flattening of the growth curve but highlight opportunities for expanding endovascular stroke care","volume":"15","author":"Rai","year":"2023","journal-title":"J. Neurointerv. Surg."},{"key":"10.1016\/j.ejro.2026.100779_bib18","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1161\/STROKEAHA.116.013147","article-title":"Comparison of perfusion CT software to predict the final infarct volume after thrombectomy","volume":"47","author":"Austein","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.ejro.2026.100779_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188891","article-title":"patients with suspected acute stroke, CT perfusion-based cerebral blood flow maps cannot substitute for DWI in measuring the ischemic core","volume":"12","author":"Copen","year":"2017","journal-title":"PLOS One"},{"key":"10.1016\/j.ejro.2026.100779_bib20","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1161\/STROKEAHA.110.610618","article-title":"CT cerebral blood flow maps optimally correlate with admission diffusion-weighted imaging in acute stroke but thresholds vary by postprocessing platform","volume":"42","author":"Kamalian","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.ejro.2026.100779_bib21","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1161\/STROKEAHA.111.618355","article-title":"Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core","volume":"42","author":"Campbell","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.ejro.2026.100779_bib22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.neurad.2013.11.006","article-title":"Defining acute ischemic stroke tissue pathophysiology with whole brain CT perfusion","volume":"41","author":"Bivard","year":"2014","journal-title":"J. Neuroradiol."},{"key":"10.1016\/j.ejro.2026.100779_bib23","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1136\/neurintsurg-2019-014822","article-title":"Comparison of three commonly used CT perfusion software packages in patients with acute ischemic stroke","volume":"11","author":"Koopman","year":"2019","journal-title":"J. Neurointerv. Surg."},{"key":"10.1016\/j.ejro.2026.100779_bib24","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1136\/neurintsurg-2020-015827","article-title":"Comparing the outcomes of two independent computed tomography perfusion softwares and their impact on therapeutic decisions in acute ischemic stroke","volume":"12","author":"Bathla","year":"2020","journal-title":"J. Neurointerv. Surg."},{"key":"10.1016\/j.ejro.2026.100779_bib25","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1136\/neurintsurg-2019-014810","article-title":"Achieving comparable perfusion results across vendors. The next step in standardizing stroke care: a technical report","volume":"11","author":"Bathla","year":"2019","journal-title":"J. Neurointerv. Surg."},{"key":"10.1016\/j.ejro.2026.100779_bib26","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.3174\/ajnr.A2151","article-title":"Perfusion CT in acute ischemic stroke: a qualitative and quantitative comparison of deconvolution and maximum slope approach","volume":"31","author":"Abels","year":"2010","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.ejro.2026.100779_bib27","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1161\/STROKEAHA.121.035626","article-title":"Comparison of two automated computed tomography perfusion applications to predict the final infarct volume after thrombolysis in cerebral infarction 3 recanalization","volume":"53","author":"Muehlen","year":"2022","journal-title":"Stroke"},{"key":"10.1016\/j.ejro.2026.100779_bib28","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1161\/01.CIR.47.1.144","article-title":"Right ventricular volume determinations in children. Normal values and observations with volume or pressure overload","volume":"47","author":"Graham","year":"1973","journal-title":"Circulation"},{"key":"10.1016\/j.ejro.2026.100779_bib29","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1161\/STROKEAHA.113.001972","article-title":"Recommendations on angiographic revascularization grading standards for acute ischemic stroke: a consensus statement","volume":"44","author":"Zaidat","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.ejro.2026.100779_bib30","doi-asserted-by":"crossref","first-page":"e193","DOI":"10.1161\/STROKEAHA.120.029892","article-title":"Effects of collateral status on infarct distribution following endovascular therapy in large vessel occlusion stroke","volume":"51","author":"Al-Dasuqi","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.ejro.2026.100779_bib31","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1161\/STROKEAHA.119.025809","article-title":"Clinical and imaging parameters associated with hyperacute infarction growth in large vessel occlusion stroke","volume":"50","author":"Puhr-Westerheide","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.ejro.2026.100779_bib32","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.3174\/ajnr.A6744","article-title":"Perfusion parameter thresholds that discriminate ischemic core vary with time from onset in acute ischemic stroke","volume":"41","author":"Yoshie","year":"2020","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.ejro.2026.100779_bib33","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/ana.27169","article-title":"Optimal cerebral blood flow thresholds for ischemic core estimation using computed tomography perfusion and diffusion-weighted imaging","volume":"97","author":"Kim","year":"2025","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejro.2026.100779_bib34","doi-asserted-by":"crossref","first-page":"e2084","DOI":"10.1212\/WNL.0000000000200269","article-title":"Accuracy of CT perfusion-based core estimation of follow-up infarction: effects of time since last known well","volume":"98","author":"Sarraj","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.ejro.2026.100779_bib35","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1161\/STROKEAHA.115.009250","article-title":"Time-dependent computed tomographic perfusion thresholds for patients with acute ischemic stroke","volume":"46","author":"d'Esterre","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.ejro.2026.100779_bib36","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1161\/STROKEAHA.119.026281","article-title":"Confirmatory study of time-dependent computed tomographic perfusion thresholds for use in acute ischemic stroke","volume":"50","author":"Qiu","year":"2019","journal-title":"Stroke"}],"container-title":["European Journal of Radiology Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352047726000560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352047726000560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:57:56Z","timestamp":1787587076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352047726000560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":36,"alternative-id":["S2352047726000560"],"URL":"https:\/\/doi.org\/10.1016\/j.ejro.2026.100779","relation":{},"ISSN":["2352-0477"],"issn-type":[{"value":"2352-0477","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imaging-to-recanalization delay influences perfusion CT threshold calibration for follow-up infarct volume estimation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Radiology Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejro.2026.100779","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100779"}}