{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:52:27Z","timestamp":1764996747087},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Surgical Oncology (EJSO)"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.ejso.2004.12.010","type":"journal-article","created":{"date-parts":[[2005,2,5]],"date-time":"2005-02-05T12:35:20Z","timestamp":1107606920000},"page":"259-264","source":"Crossref","is-referenced-by-count":21,"title":["CDH1 associated gastric cancer: a report of a family and review of the literature"],"prefix":"10.1016","volume":"31","author":[{"given":"C.J.","family":"Moran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.J.","family":"McAnena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejso.2004.12.010_bib1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/32918","article-title":"E-cadherin germline mutations in familial gastric cancer","volume":"392","author":"Guilford","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ejso.2004.12.010_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/(SICI)1098-1004(1999)14:3<249::AID-HUMU8>3.0.CO;2-9","article-title":"E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer","volume":"14","author":"Guilford","year":"1999","journal-title":"Human Mutat"},{"key":"10.1016\/j.ejso.2004.12.010_bib3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/hmg\/8.4.607","article-title":"Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer","volume":"8","author":"Richards","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ejso.2004.12.010_bib4","first-page":"873","article-title":"Familial gastric cancer: overview and guidelines for management","volume":"36","author":"Caldas","year":"1999","journal-title":"J Med Genet"},{"key":"10.1016\/j.ejso.2004.12.010_bib5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/cncr.10680","article-title":"Prophylactic bilateral mastectomy; patterns of practice","volume":"95","author":"Metcalfe","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ejso.2004.12.010_bib6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/gyno.2002.6731","article-title":"Prophylactic oopherectomy comes of age","volume":"85","author":"Rubin","year":"2002","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejso.2004.12.010_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1072-7515(02)01220-6","article-title":"Prophylactic thyroidectomy in MEN2A syndrome","volume":"195","author":"Rodriguez","year":"2002","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.ejso.2004.12.010_bib8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D","article-title":"Mutations of the human E-cadherin (CDH1) gene","volume":"12","author":"Berx","year":"1998","journal-title":"Human Mutat"},{"key":"10.1016\/j.ejso.2004.12.010_bib9","first-page":"4086","article-title":"Identification of germline E-cadherin mutations in gastric cancer families of European origin","volume":"58","author":"Gayther","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejso.2004.12.010_bib10","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1056\/NEJM200106213442504","article-title":"Early gastric cancer in young asymptomatic carriers of germline E-cadherin mutations","volume":"344","author":"Huntsman","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ejso.2004.12.010_bib11","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/humu.10067","article-title":"Novel germline CDH1 mutations in hereditary diffuse gastric cancer families","volume":"19","author":"Humar","year":"2002","journal-title":"Hum Mutat"},{"key":"10.1016\/j.ejso.2004.12.010_bib12","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/ijc.10633","article-title":"E-cadherin variants in gastric cancer families whose probands were diagnosed with diffuse gastric cancer","volume":"101","author":"Yabuta","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejso.2004.12.010_bib13","first-page":"287","article-title":"Familial gastric cancer","volume":"63","author":"Jones","year":"1964","journal-title":"NZ Med J"},{"key":"10.1016\/j.ejso.2004.12.010_bib14","first-page":"3845","article-title":"E-cadherin gene mutations provide clues to diffuse gastric carcinomas","volume":"54","author":"Becker","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.ejso.2004.12.010_bib15","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1053\/srao.2002.30815","article-title":"Molecular biology of gastric cancer","volume":"12","author":"El-Rafai","year":"2002","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ejso.2004.12.010_bib16","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1038\/sj.onc.1204234","article-title":"E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma","volume":"20","author":"Machado","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.ejso.2004.12.010_bib17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/ijc.1386","article-title":"The E-cadherin gene is silenced by CpG methylation in human oral squamous cell carcinomas","volume":"93","author":"Nakayama","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejso.2004.12.010_bib18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1357-4310(99)01461-6","article-title":"E-cadherin down regulation in cancer: fuel on the fire ?","volume":"5","author":"Guilford","year":"1999","journal-title":"Mol Med Today"},{"issue":"Suppl","key":"10.1016\/j.ejso.2004.12.010_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1242\/jcs.1993.Supplement_17.22","article-title":"Catenins as mediators of the cytoplasmic functions of cadherins","volume":"17","author":"Gumbiner","year":"1993","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ejso.2004.12.010_bib20","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/32433","article-title":"A causal role for E-cadherin in the transition from adenoma to carcinoma","volume":"392","author":"Perl","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ejso.2004.12.010_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00004836-200207000-00009","article-title":"Expression of E-cadherin and catenins in early gastric cancer","volume":"35","author":"Joo","year":"2002","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.ejso.2004.12.010_bib22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1046\/j.1365-2168.2002.01985.x","article-title":"Abnormal expression of E-cadherin and beta-catenin may be a molecular marker of submucosal invasion and lymph-node metastasis in early gastric cancer","volume":"89","author":"Tanaka","year":"2002","journal-title":"Br J Surg"},{"key":"10.1016\/j.ejso.2004.12.010_bib23","first-page":"723","article-title":"Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract","volume":"148","author":"Hanby","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ejso.2004.12.010_bib24","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00125480-200105000-00005","article-title":"Loss of E-cadherin is the fundamental defect in diffuse type gastric carcinoma and infiltrating lobular carcinoma of breast","volume":"8","author":"Chan","year":"2001","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.ejso.2004.12.010_bib25","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1053\/gast.2001.29611","article-title":"Incidence of gastric cancer and breast cancer in CDH-1 (E-cadherin) mutation carriers from Hereditary Diffuse Gastric Cancer families","volume":"121","author":"Pharoah","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejso.2004.12.010_bib26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/hmg\/8.4.607","article-title":"Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer","volume":"8","author":"Richards","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.ejso.2004.12.010_bib27","first-page":"3465","article-title":"Association of E-cadherin germline mutations with prostate cancer","volume":"7","author":"Ikonen","year":"2001","journal-title":"Clin Cane Res"},{"key":"10.1016\/j.ejso.2004.12.010_bib28","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ng0594-98","article-title":"Mutations of the E-cadherin gene in human gynaecologic cancers","volume":"7","author":"Risinger","year":"1994","journal-title":"Nat Genet"},{"key":"10.1016\/j.ejso.2004.12.010_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/jama.279.3.179","article-title":"Genetic testing for cancer risk: how to reconcile the conflicts","volume":"279","author":"Kodish","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.ejso.2004.12.010_bib30","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1086\/302350","article-title":"BRCA1 and BRCA2 testing: weighing the demand against the benefits","volume":"64","author":"Devilee","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ejso.2004.12.010_bib31","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/bjs.1800841036","article-title":"Population based study of diagnosis, treatment and prognosis of gastric cancer","volume":"84","author":"Msika","year":"1997","journal-title":"Br J Surg"},{"key":"10.1016\/j.ejso.2004.12.010_bib32","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1093\/annonc\/mdg486","article-title":"The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice","volume":"14","author":"Graziano","year":"2003","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejso.2004.12.010_bib33","first-page":"158","article-title":"Chromoendoscopic surveillance in a Maori kindred genotypicaiiy predisposed to hereditary diffuse gastric cancer: an alternative to prophylactic gastrectomy","volume":"57","author":"Shaw","year":"2003","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.ejso.2004.12.010_bib34","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/1097-0142(20010701)92:1<181::AID-CNCR1307>3.0.CO;2-J","article-title":"Germline E-cadherin gene mutations: is prophylactic gastrectomy indicated ?","volume":"92","author":"Chun","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.ejso.2004.12.010_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000063162","article-title":"E-cadherin mutations and hereditary gastric cancer: prevention by resection ?","volume":"20","author":"Fitzgerald","year":"2002","journal-title":"Dig Dis"},{"key":"10.1016\/j.ejso.2004.12.010_bib36","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1067\/msy.2001.117099","article-title":"Prophylactic total gastrectomy for familial gastric cancer","volume":"130","author":"Lewis","year":"2001","journal-title":"Surgery"},{"key":"10.1016\/j.ejso.2004.12.010_bib37","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0016-5085(02)80140-8","article-title":"Hereditary diffuse gastric cancer: more answers or more questions?","volume":"122","author":"Grady","year":"2002","journal-title":"Gastroenteroiogy"},{"issue":"4","key":"10.1016\/j.ejso.2004.12.010_bib38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s10120-001-8007-7","article-title":"Surgery for gastric cancer: 10-year experience worldwide","author":"Adachi","year":"2001","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.ejso.2004.12.010_bib39","first-page":"773","article-title":"Improving survival in gastric cancer: review of operative mortality in English language publications from","volume":"78","author":"Maclntyre","year":"1970","journal-title":"Br J Surg"},{"key":"10.1016\/j.ejso.2004.12.010_bib40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/bjs.1800780325","article-title":"Improving results in the treatment of gastric cancer: an 11 year audit","volume":"78","author":"Akoh","year":"1991","journal-title":"Br J Surg"},{"key":"10.1016\/j.ejso.2004.12.010_bib41","first-page":"352","article-title":"Surgery for gastric cancer: the American view","volume":"23","author":"Brennan","year":"1996","journal-title":"Semin Oncol"},{"key":"10.1016\/j.ejso.2004.12.010_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1040-8428(00)00131-1","article-title":"The difference in gastric cancer between Japan, USA and Europe: what are the facts? What are the suggestions?","volume":"40","author":"Davis","year":"2001","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ejso.2004.12.010_bib43","first-page":"1742","article-title":"Gastrectomy circumstances that influence early postoperative outcome","volume":"49","author":"Schwarz","year":"2002","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.ejso.2004.12.010_bib44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000172226","article-title":"Laparoscopic wedge resection of the stomach for early gastric cancer using a lesion-lifting method","volume":"11","author":"Ohgami","year":"1994","journal-title":"Dig Surg"},{"key":"10.1016\/j.ejso.2004.12.010_bib45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000064209","article-title":"Laparoscopic wedge resection of gastric submucosal tumors","volume":"19","author":"Shimizu","year":"2002","journal-title":"Dig Surg"},{"key":"10.1016\/j.ejso.2004.12.010_bib46","first-page":"146","article-title":"Laparoscopic-assisted Billroth I gastrectomy","volume":"4","author":"Kitano","year":"1994","journal-title":"Surg Laparosc Endosc"},{"key":"10.1016\/j.ejso.2004.12.010_bib47","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1136\/gut.2002.010447","article-title":"Hereditary diffuse gastric cancer: predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone","volume":"53","author":"Charlton","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.ejso.2004.12.010_bib48","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1136\/jcp.51.5.410","article-title":"H pylori infection is associated with downregulation of E-cadherin, a molecule involved in epithelial cell adhesion and proliferation control","volume":"5","author":"Terres","year":"1998","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.ejso.2004.12.010_bib49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/sj.bjc.6600415","article-title":"Dietary factors and stomach cancer mortality","volume":"87","author":"Ngoan","year":"2002","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ejso.2004.12.010_bib50","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1038\/sj.bjc.6600321","article-title":"Serological identification and expression analysis of gastric cancer-associated genes","volume":"86","author":"Line","year":"2002","journal-title":"Br J Cancer"}],"container-title":["European Journal of Surgical Oncology (EJSO)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798304003555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798304003555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:41:41Z","timestamp":1682988101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798304003555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0748798304003555"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2004.12.010","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}