{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:41:44Z","timestamp":1781919704069,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ejso.2018.03.023","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T12:21:09Z","timestamp":1523449269000},"page":"1212-1219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Histopathologic patterns as markers of prognosis in patients undergoing hepatectomy for colorectal cancer liver metastases \u2013 Pushing growth as an independent risk factor for decreased survival"],"prefix":"10.1016","volume":"44","author":[{"given":"Daniela","family":"Falc\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique","family":"Alexandrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Caetano Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ser\u00f4dio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Guilherme","family":"Tralh\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Augusta","family":"Cipriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Castro e Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejso.2018.03.023_bib1","first-page":"10","article-title":"Cancer statistics, 2012","volume":"62","author":"Siegel","year":"2012","journal-title":"CA A Cancer J Clin"},{"issue":"3","key":"10.1016\/j.ejso.2018.03.023_bib2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.critrevonc.2010.08.001","article-title":"Chemotherapy for the conversion of unresectable colorectal cancer liver metastases to resection","volume":"79","author":"Power","year":"2011","journal-title":"Crit Rev Oncol-Hematol"},{"issue":"10","key":"10.1016\/j.ejso.2018.03.023_bib3","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1634\/theoncologist.2012-0121","article-title":"The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus","volume":"17","author":"Adam","year":"2012","journal-title":"Oncologist"},{"issue":"4","key":"10.1016\/j.ejso.2018.03.023_bib4","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/01.sla.0000141198.92114.f6","article-title":"Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival","volume":"240","author":"Adam","year":"2004","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.ejso.2018.03.023_bib5","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1097\/SLA.0b013e31816c405f","article-title":"Effect of postoperative morbidity on long-term survival after hepatic resection for metastatic colorectal cancer","volume":"247","author":"Ito","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2018.03.023_bib6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12957-015-0549-y","article-title":"Predictors of early recurrence after resection of colorectal liver metastases","volume":"13","author":"Bhogal","year":"2015","journal-title":"World J Surg Oncol"},{"issue":"9","key":"10.1016\/j.ejso.2018.03.023_bib7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/bjs.1800730917","article-title":"Determinants of survival in liver resection for colorectal secondaries","volume":"73","author":"Ekberg","year":"1986","journal-title":"Br J Surg"},{"issue":"2","key":"10.1016\/j.ejso.2018.03.023_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/SLA.0b013e31811ea962","article-title":"The impact of margins on outcome after hepatic resection for colorectal metastasis","volume":"246","author":"Are","year":"2007","journal-title":"Ann Surg"},{"issue":"11","key":"10.1016\/j.ejso.2018.03.023_bib9","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1007\/s00268-013-2186-3","article-title":"Prognostic impact of positive surgical margins after resection of colorectal cancer liver metastases: reappraisal in the era of modern chemotherapy","volume":"37","author":"Tranchart","year":"2013","journal-title":"World J Surg"},{"issue":"1","key":"10.1016\/j.ejso.2018.03.023_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1477-2574.2009.00121.x","article-title":"Hepatic resection for colorectal metastases: the impact of surgical margin status on outcome","volume":"12","author":"Poultsides","year":"2010","journal-title":"HPB"},{"issue":"9","key":"10.1016\/j.ejso.2018.03.023_bib11","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1097\/PAS.0b013e3181eb2f7b","article-title":"Tumor thickness at the tumor-normal interface: a novel pathologic indicator of chemotherapy response in hepatic colorectal metastases","volume":"34","author":"Maru","year":"2010","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.ejso.2018.03.023_bib12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/annonc\/mdl386","article-title":"Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery","volume":"18","author":"Rubbia-Brandt","year":"2007","journal-title":"Ann Oncol"},{"issue":"3","key":"10.1016\/j.ejso.2018.03.023_bib13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/path.966","article-title":"Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia","volume":"195","author":"Vermeulen","year":"2001","journal-title":"J\u00a0Pathol"},{"issue":"6","key":"10.1016\/j.ejso.2018.03.023_bib14","first-page":"818","article-title":"Spontaneous resolution of histologically proven liver metastases from colorectal cancer","volume":"84","author":"Francis","year":"1997","journal-title":"Br J Surg"},{"issue":"5","key":"10.1016\/j.ejso.2018.03.023_bib15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ejso.2016.02.017","article-title":"Sinusoidal dilation increases the risk of complications in hepatectomy for CRCLM - protective effect of bevacizumab and diabetes mellitus, serum gamma-glutamyltranspeptidase as predictive factor","volume":"42","author":"Martins","year":"2016","journal-title":"Eur J Surg Oncol"},{"issue":"2","key":"10.1016\/j.ejso.2018.03.023_bib16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.ejso.2018.03.023_bib17","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/01.sla.0000189131.90876.9e","article-title":"The \u201c50-50 criteria\u201d on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy","volume":"242","author":"Balzan","year":"2005","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.ejso.2018.03.023_bib18","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10585-012-9469-1","article-title":"The histological growth pattern of colorectal cancer liver metastases has prognostic value","volume":"29","author":"Van den Eynden","year":"2012","journal-title":"Clin Exp Metastasis"},{"issue":"9617","key":"10.1016\/j.ejso.2018.03.023_bib19","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0140-6736(08)60455-9","article-title":"Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial","volume":"371","author":"Nordlinger","year":"2008","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.ejso.2018.03.023_bib20","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S1470-2045(13)70447-9","article-title":"Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial","volume":"14","author":"Nordlinger","year":"2013","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.ejso.2018.03.023_bib21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00000658-199909000-00004","article-title":"Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases","volume":"230","author":"Fong","year":"1999","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.ejso.2018.03.023_bib22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejso.2011.10.013","article-title":"Prognostic models for outcome following liver resection for colorectal cancer metastases: a systematic review","volume":"38","author":"Spelt","year":"2012","journal-title":"Eur J Surg Oncol"},{"issue":"7","key":"10.1016\/j.ejso.2018.03.023_bib23","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1254::AID-CNCR5>3.0.CO;2-I","article-title":"Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Francaise de Chirurgie","volume":"77","author":"Nordlinger","year":"1996","journal-title":"Cancer"},{"issue":"12","key":"10.1016\/j.ejso.2018.03.023_bib24","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s00595-014-1108-9","article-title":"The clinical relevance of the Fong and the Nordlinger scores in the era of effective neoadjuvant chemotherapy for colorectal liver metastasis","volume":"45","author":"Schreckenbach","year":"2015","journal-title":"Surg Today"},{"issue":"10","key":"10.1016\/j.ejso.2018.03.023_bib25","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1245\/s10434-011-1819-8","article-title":"Is the clinical risk score for patients with colorectal liver metastases still useable in the era of effective neoadjuvant chemotherapy?","volume":"18","author":"Ayez","year":"2011","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10.1016\/j.ejso.2018.03.023_bib26","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.surg.2013.05.039","article-title":"Actual incidence and long-term consequences of posthepatectomy liver failure after hepatectomy for colorectal liver metastases","volume":"155","author":"Vibert","year":"2014","journal-title":"Surgery"},{"issue":"8","key":"10.1016\/j.ejso.2018.03.023_bib27","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1245\/s10434-013-2975-9","article-title":"Perioperative complications influence recurrence and survival after resection of hepatic colorectal metastases","volume":"20","author":"Correa-Gallego","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"10.1016\/j.ejso.2018.03.023_bib28","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/SLA.0b013e3182902b6e","article-title":"One-millimeter cancer-free margin is curative for colorectal liver metastases: a propensity score case-match approach","volume":"259","author":"Hamady","year":"2014","journal-title":"Ann Surg"},{"issue":"11","key":"10.1016\/j.ejso.2018.03.023_bib29","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1158\/1078-0432.CCR-10-3087","article-title":"Detection of tumor DNA at the margins of colorectal cancer liver metastasis","volume":"17","author":"Holdhoff","year":"2011","journal-title":"Clin Canc Res"},{"issue":"9","key":"10.1016\/j.ejso.2018.03.023_bib30","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.ejso.2016.02.013","article-title":"Impact of novel histopathological factors on the outcomes of liver surgery for colorectal cancer metastases","volume":"42","author":"Serrablo","year":"2016","journal-title":"Eur J Surg Oncol"},{"issue":"11","key":"10.1016\/j.ejso.2018.03.023_bib31","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1007\/s11605-016-3198-8","article-title":"Tumor biology rather than surgical technique dictates prognosis in colorectal cancer liver metastases","volume":"20","author":"Margonis","year":"2016","journal-title":"J\u00a0Gastrointest Surg"},{"issue":"15","key":"10.1016\/j.ejso.2018.03.023_bib32","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1002\/cncr.28097","article-title":"Multicenter validation study of pathologic response and tumor thickness at the tumor-normal liver interface as independent predictors of disease-free survival after preoperative chemotherapy and surgery for colorectal liver metastases","volume":"119","author":"Brouquet","year":"2013","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.ejso.2018.03.023_bib33","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/annonc\/mdi246","article-title":"Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates","volume":"16","author":"Folprecht","year":"2005","journal-title":"Ann Oncol"},{"issue":"4","key":"10.1016\/j.ejso.2018.03.023_bib34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10585-015-9715-4","article-title":"Growth pattern of colorectal liver metastasis as a marker of recurrence risk","volume":"32","author":"Eefsen","year":"2015","journal-title":"Clin Exp Metastasis"},{"issue":"7","key":"10.1016\/j.ejso.2018.03.023_bib35","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/sj.bjc.6603677","article-title":"The influence of invasive growth pattern and microvessel density on prognosis in colorectal cancer and colorectal liver metastases","volume":"96","author":"Rajaganeshan","year":"2007","journal-title":"Br J Canc"},{"issue":"7","key":"10.1016\/j.ejso.2018.03.023_bib36","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1038\/sj.bjc.6601727","article-title":"Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia","volume":"90","author":"Stessels","year":"2004","journal-title":"Br J Canc"},{"key":"10.1016\/j.ejso.2018.03.023_bib37","first-page":"907971","article-title":"Histopathological growth pattern, proteolysis and angiogenesis in chemonaive patients resected for multiple colorectal liver metastases","volume":"2012","author":"Eefsen","year":"2012","journal-title":"J\u00a0Oncol"},{"issue":"1","key":"10.1016\/j.ejso.2018.03.023_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2353\/ajpath.2007.060302","article-title":"Alternative vascularization mechanisms in cancer : pathology and therapeutic implications","volume":"170","author":"D\u00f6me","year":"2007","journal-title":"Am J Pathol"},{"issue":"7","key":"10.1016\/j.ejso.2018.03.023_bib39","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1158\/0008-5472.CAN-12-3931","article-title":"The multifaceted role of the microenvironment in liver metastasis: biology and clinical implications","volume":"73","author":"Van den Eynden","year":"2013","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.ejso.2018.03.023_bib40","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1124\/pr.56.4.3","article-title":"Vascular endothelial growth factor and angiogenesis","volume":"56","author":"Hoeben","year":"2004","journal-title":"Pharmacol Rev"},{"issue":"36","key":"10.1016\/j.ejso.2018.03.023_bib41","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1200\/JCO.2012.45.2854","article-title":"Optimal morphologic response to preoperative chemotherapy: an alternate outcome end point before resection of hepatic colorectal metastases","volume":"30","author":"Shindoh","year":"2012","journal-title":"J\u00a0Clin Oncol"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798318309922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798318309922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:26:44Z","timestamp":1760059604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798318309922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0748798318309922"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2018.03.023","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histopathologic patterns as markers of prognosis in patients undergoing hepatectomy for colorectal cancer liver metastases \u2013 Pushing growth as an independent risk factor for decreased survival","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2018.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.","name":"copyright","label":"Copyright"}]}}