{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:59:33Z","timestamp":1787317173864,"version":"build-2736575974"},"reference-count":27,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["ejso.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.ejso.2018.05.022","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T14:02:58Z","timestamp":1527256978000},"page":"1908-1913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of HPV-associated p16-expression and other clinical factors on therapeutic decision-making in patients with oropharyngeal cancer: A GETTEC multicentric study"],"prefix":"10.1016","volume":"44","author":[{"given":"Dorian","family":"Culi\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1367-363X","authenticated-orcid":false,"given":"Renaud","family":"Garrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Viotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-9507","authenticated-orcid":false,"given":"Renaud","family":"Schiappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Chamorey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7070-0780","authenticated-orcid":false,"given":"Nicolas","family":"Fakhry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Lallemant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Vergez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Dupret-Bories","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dassonville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Poissonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Santini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Peyrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Benezery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Sudaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Jourdan-Soulier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Chapel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Guelfucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bozec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejso.2018.05.022_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ejso.2018.05.022_bib2","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ctrv.2015.10.001","article-title":"Increased radiosensitivity of HPV-positive head and neck cancers: molecular basis and therapeutic perspectives","volume":"41","author":"Mirghani","year":"2015","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ejso.2018.05.022_bib3","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1470-2045(10)70017-6","article-title":"HPV-associated head and neck cancer: a virus-related cancer epidemic","volume":"11","author":"Marur","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejso.2018.05.022_bib4","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1200\/JCO.2014.55.1937","article-title":"Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma","volume":"32","author":"Fakhry","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ejso.2018.05.022_bib5","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1200\/JCO.2010.29.2904","article-title":"Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial","volume":"28","author":"Rischin","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ejso.2018.05.022_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djn011","article-title":"Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial","volume":"100","author":"Fakhry","year":"2008","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.ejso.2018.05.022_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.radonc.2011.02.010","article-title":"The influence of HPV-associated p16-expression on accelerated fractionated radiotherapy in head and neck cancer: evaluation of the randomised DAHANCA 6&7 trial","volume":"100","author":"Lassen","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ejso.2018.05.022_bib8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.6004\/jnccn.2017.0101","article-title":"NCCN Guidelines Insights: Head and Neck Cancers, Version 2.2017","volume":"15","author":"Adelstein","year":"2017","journal-title":"J Natl Compr Canc Netw"},{"issue":"S2","key":"10.1016\/j.ejso.2018.05.022_bib9","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1017\/S0022215116000505","article-title":"Oropharyngeal cancer: United Kingdom national multidisciplinary guidelines","volume":"130","author":"Mehanna","year":"2016","journal-title":"J\u00a0Laryngol Otol"},{"key":"10.1016\/j.ejso.2018.05.022_bib10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11864-015-0362-4","article-title":"Surgery versus radiotherapy for early oropharyngeal tumors: a never-ending debate","volume":"16","author":"Monnier","year":"2015","journal-title":"Curr Treat Options Oncol"},{"key":"10.1016\/j.ejso.2018.05.022_bib11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.prro.2015.11.006","article-title":"Analysis of decision-making at a multidisciplinary head and neck tumor board incorporating evidence-based National Cancer Comprehensive Network (NCCN) guidelines","volume":"6","author":"Shah","year":"2016","journal-title":"Pract Radiat Oncol"},{"key":"10.1016\/j.ejso.2018.05.022_bib12","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hed.20796","article-title":"Cystic lymph node metastasis in patients with head and neck cancer: an HPV-associated phenomenon","volume":"30","author":"Goldenberg","year":"2008","journal-title":"Head Neck"},{"key":"10.1016\/j.ejso.2018.05.022_bib13","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/ijc.28847","article-title":"Treatment de-escalation in HPV-positive oropharyngeal carcinoma: ongoing trials, critical issues and perspectives","volume":"136","author":"Mirghani","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejso.2018.05.022_bib14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejca.2016.09.006","article-title":"Treatment de-intensification strategies for head and neck cancer","volume":"68","author":"Kelly","year":"2016","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ejso.2018.05.022_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.oraloncology.2017.04.004","article-title":"Multidisciplinary management of head and neck cancer: first expert consensus using Delphi methodology from the Spanish Society for Head and Neck Cancer (part 1)","volume":"70","author":"Ma\u00f1\u00f3s","year":"2017","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ejso.2018.05.022_bib16","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","article-title":"Human papillomavirus and rising oropharyngeal cancer incidence in the United States","volume":"29","author":"Chaturvedi","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ejso.2018.05.022_bib17","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/ijc.29254","article-title":"A\u00a0high and increasing HPV prevalence in tonsillar cancers in Eastern Denmark, 2000-2010: the largest registry-based study to date","volume":"136","author":"Garnaes","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ejso.2018.05.022_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.14639\/0392-100X-853","article-title":"Human papillomavirus and head and neck carcinomas: focus on evidence in the babel of published data","volume":"36","author":"Morbini","year":"2016","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"10.1016\/j.ejso.2018.05.022_bib19","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1097\/PAS.0b013e3181e84652","article-title":"p16 positive oropharyngeal squamous cell carcinoma: an entity with a favorable prognosis regardless of tumor HPV status","volume":"34","author":"Lewis","year":"2010","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.ejso.2018.05.022_bib20","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/PAS.0b013e3182116a45","article-title":"Isolating p16-positive\/`HPV-negative oropharyngeal cancer\u202f: an effort worth making","volume":"35","author":"Perrone","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ejso.2018.05.022_bib21","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jnci\/djn025","article-title":"Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers","volume":"100","author":"Gillison","year":"2008","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.ejso.2018.05.022_bib22","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1634\/theoncologist.2016-0433","article-title":"p16, HPV, and cetuximab: what is the evidence?","volume":"22","author":"Bonner","year":"2017","journal-title":"Oncologist"},{"key":"10.1016\/j.ejso.2018.05.022_bib23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-3-319-43580-0_10","article-title":"Human Papillomavirus (HPV): a criterion for therapeutic decision in squamous cell carcinoma of the head and neck?","volume":"206","author":"Vermorken","year":"2017","journal-title":"Recent Results Cancer Res"},{"key":"10.1016\/j.ejso.2018.05.022_bib24","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/cncr.29938","article-title":"Increase in primary surgical treatment of T1 and T2 oropharyngeal squamous cell carcinoma and rates of adverse pathologic features: National Cancer Data Base","volume":"122","author":"Cracchiolo","year":"2016","journal-title":"Cancer"},{"key":"10.1016\/j.ejso.2018.05.022_bib25","article-title":"Minimally invasive surgery versus radiotherapy\/chemoradiotherapy for small-volume primary oropharyngeal carcinoma","volume":"12","author":"Howard","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejso.2018.05.022_bib26","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1007\/s00405-015-3744-0","article-title":"Treatment strategies in early-stage oropharyngeal squamous cell carcinoma: a French national survey","volume":"273","author":"Gorphe","year":"2016","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"key":"10.1016\/j.ejso.2018.05.022_bib27","article-title":"Primary surgery-versus primary radiation-based treatment for locally-advanced oropharyngeal cancer","author":"Kamran","year":"2017","journal-title":"Laryngoscope"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074879831831076X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074879831831076X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T02:20:39Z","timestamp":1661307639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S074879831831076X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S074879831831076X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2018.05.022","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of HPV-associated p16-expression and other clinical factors on therapeutic decision-making in patients with oropharyngeal cancer: A GETTEC multicentric study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2018.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.","name":"copyright","label":"Copyright"}]}}