{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:34:54Z","timestamp":1778319294596,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ejso.2019.01.013","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T06:42:55Z","timestamp":1548398575000},"page":"1061-1068","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Positive cystic duct margin at index cholecystectomy in incidental gallbladder cancer is an important negative prognosticator"],"prefix":"10.1016","volume":"45","author":[{"given":"Eduardo A.","family":"Vega","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Vinuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Sanhueza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemarie","family":"Mege","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Caracci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Joechle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Goumard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Shin","family":"Chun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Wei D.","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey E.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Nicolas","family":"Vauthey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudius","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejso.2019.01.013_bib1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.6004\/jnccn.2009.0027","article-title":"NCCN clinical practice guidelines in oncology: hepatobiliary cancers","volume":"7","author":"Benson","year":"2009","journal-title":"J\u00a0Natl Compr Canc Netw : J Natl Compr Canc Netw"},{"key":"10.1016\/j.ejso.2019.01.013_bib2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/hpb.12444","article-title":"Gallbladder cancer: expert consensus statement","volume":"17","author":"Aloia","year":"2015","journal-title":"HPB : Off J Int Hepato Pancreato Biliary Assoc"},{"key":"10.1016\/j.ejso.2019.01.013_bib3","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jamcollsurg.2014.01.069","article-title":"Residual disease predicts outcomes after definitive resection for incidental gallbladder cancer","volume":"219","author":"Butte","year":"2014","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.ejso.2019.01.013_bib4","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1007\/s11605-017-3436-8","article-title":"Predicting residual disease in incidental gallbladder cancer: risk stratification for modified treatment strategies","volume":"21","author":"Creasy","year":"2017","journal-title":"J\u00a0Gastrointest Surg : Off J Soc Surg Aliment Tract"},{"key":"10.1016\/j.ejso.2019.01.013_bib5","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1245\/s10434-016-5637-x","article-title":"A\u00a0novel pathology-based preoperative risk score to predict locoregional residual and distant disease and survival for incidental gallbladder cancer: a 10-institution study from the U.S. Extrahepatic Biliary Malignancy Consortium","volume":"24","author":"Ethun","year":"2017","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2019.01.013_bib6","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1477-2574.2012.00498.x","article-title":"Relevance of residual disease after liver resection for incidental gallbladder cancer","volume":"14","author":"Lendoire","year":"2012","journal-title":"HPB : Off J Int Hepato Pancreato Biliary Assoc"},{"key":"10.1016\/j.ejso.2019.01.013_bib7","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1007\/s11605-007-0309-6","article-title":"Incidence of finding residual disease for incidental gallbladder carcinoma: implications for re-resection","volume":"11","author":"Pawlik","year":"2007","journal-title":"J\u00a0Gastrointest Surg : Off J Soc Surg Aliment Tract"},{"key":"10.1016\/j.ejso.2019.01.013_bib8","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1245\/s10434-017-5859-6","article-title":"Incidental gallbladder cancer: residual cancer discovered at oncologic extended resection determines outcome: a report from high- and low-incidence countries","volume":"24","author":"Vinuela","year":"2017","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2019.01.013_bib9","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/jso.21681","article-title":"Incidental gallbladder cancer: analysis of surgical findings and survival","volume":"102","author":"Butte","year":"2010","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.ejso.2019.01.013_bib10","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.3748\/wjg.v21.i4.1315","article-title":"Clinical characteristics of incidental or unsuspected gallbladder cancers diagnosed during or after cholecystectomy: a systematic review and meta-analysis","volume":"21","author":"Choi","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ejso.2019.01.013_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11605-017-3507-x","article-title":"Extended lymphadenectomy is required for incidental gallbladder cancer independent of cystic duct lymph node status","volume":"22","author":"Vega","year":"2018","journal-title":"J\u00a0Gastrointest Surg : Off J Soc Surg Aliment Tract"},{"key":"10.1016\/j.ejso.2019.01.013_bib12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/00000478-200405000-00009","article-title":"In situ and invasive adenocarcinomas of the gallbladder extending into or arising from Rokitansky-Aschoff sinuses: a clinicopathologic study of 49 cases","volume":"28","author":"Albores-Saavedra","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ejso.2019.01.013_bib13","doi-asserted-by":"crossref","first-page":"6554","DOI":"10.3748\/wjg.v11.i41.6554","article-title":"Peroral cholangioscopy for non-invasive papillary cholangiocarcinoma with extensive superficial ductal spread","volume":"11","author":"Wakai","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ejso.2019.01.013_bib14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00534-005-1096-7","article-title":"Local recurrence at hepaticojejunostomy 9 years after resection of bile duct cancer with superficial flat spread","volume":"13","author":"Sasaki","year":"2006","journal-title":"J\u00a0Hepato-Biliary-Pancreatic Surg"},{"key":"10.1016\/j.ejso.2019.01.013_bib15","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","article-title":"The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM","volume":"17","author":"Edge","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2019.01.013_bib16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.01.013_bib17","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/SLA.0000000000001048","article-title":"Ninety-day postoperative mortality is a legitimate measure of hepatopancreatobiliary surgical quality","volume":"262","author":"Mise","year":"2015","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.01.013_bib18","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00268-007-9324-8","article-title":"New classification of cystic duct carcinoma","volume":"32","author":"Yokoyama","year":"2008","journal-title":"World J Surg"},{"key":"10.1016\/j.ejso.2019.01.013_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00268-006-0118-1","article-title":"Impact of tumor spread to the cystic duct on the prognosis of patients with gallbladder carcinoma","volume":"31","author":"Nakata","year":"2007","journal-title":"World J Surg"},{"key":"10.1016\/j.ejso.2019.01.013_bib20","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1477-2574.2011.00388.x","article-title":"High-grade dysplasia of the cystic duct margin in the absence of malignancy after cholecystectomy","volume":"13","author":"Bickenbach","year":"2011","journal-title":"HPB : Off J Int Hepato Pancreato Biliary Assoc"},{"key":"10.1016\/j.ejso.2019.01.013_bib21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00000658-196207000-00021","article-title":"Carcinoma of the gallbladder: a study of its modes of spread","volume":"156","author":"Fahim","year":"1962","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.01.013_bib22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/00000658-199803000-00013","article-title":"The pattern of infiltration at the proximal border of hilar bile duct carcinoma: a histologic analysis of 62 resected cases","volume":"227","author":"Sakamoto","year":"1998","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.01.013_bib23","first-page":"545","article-title":"Early carcinoma of the gallbladder","volume":"158","author":"Shirai","year":"1992","journal-title":"Eur J Surg\u00a0= Acta chirurgica"},{"key":"10.1016\/j.ejso.2019.01.013_bib24","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/jso.24283","article-title":"Assessing the impact of common bile duct resection in the surgical management of gallbladder cancer","volume":"114","author":"Gani","year":"2016","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.ejso.2019.01.013_bib25","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1245\/s10434-008-0189-3","article-title":"Analysis of the extent of resection for adenocarcinoma of the gallbladder","volume":"16","author":"D'Angelica","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2019.01.013_bib26","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/01.sla.0000160817.94472.fd","article-title":"Papillary phenotype confers improved survival after resection of hilar cholangiocarcinoma","volume":"241","author":"Jarnagin","year":"2005","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.01.013_bib27","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/1097-0142(20000801)89:3<508::AID-CNCR5>3.0.CO;2-D","article-title":"Noninvasive and minimally invasive papillary carcinomas of the extrahepatic bile ducts","volume":"89","author":"Albores-Saavedra","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ejso.2019.01.013_bib28","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/SLA.0b013e318190a647","article-title":"Clinicopathologic study of cholangiocarcinoma with superficial spread","volume":"249","author":"Igami","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.01.013_bib29","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s11605-017-3440-z","article-title":"Gallbladder cancer presenting with jaundice: uniformly fatal or still potentially curable?","volume":"21","author":"Tran","year":"2017","journal-title":"J\u00a0Gastrointest Surg : Off J Soc Surg Aliment Tract"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798319300368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798319300368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:28:29Z","timestamp":1760059709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798319300368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0748798319300368"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2019.01.013","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Positive cystic duct margin at index cholecystectomy in incidental gallbladder cancer is an important negative prognosticator","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2019.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}