{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:45:37Z","timestamp":1791585937519,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.ejso.2019.03.005","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T21:20:22Z","timestamp":1552080022000},"page":"1225-1231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pathological complete response may underestimate distant metastasis in locally advanced rectal cancer following neoadjuvant chemoradiotherapy and radical surgery: Incidence, metastatic pattern, and risk factors"],"prefix":"10.1016","volume":"45","author":[{"given":"Yanwu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingrong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejso.2019.03.005_bib1","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMoa040694","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer","volume":"351","author":"Sauer","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ejso.2019.03.005_bib2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1470-2045(11)70097-3","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial","volume":"12","author":"van Gijn","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejso.2019.03.005_bib3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S1470-2045(13)70599-0","article-title":"Fluorouracilbased adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study","volume":"15","author":"Bosset","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.ejso.2019.03.005_bib4","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S1470-2045(10)70172-8","article-title":"Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data","volume":"11","author":"Maas","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejso.2019.03.005_bib5","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1245\/s10434-011-2209-y","article-title":"Complete pathologic response after combined modality treatment for rectal cancer and long-term survival: a meta-analysis","volume":"19","author":"Zorcolo","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2019.03.005_bib6","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/01.sla.0000141194.27992.32","article-title":"Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results","volume":"240","author":"Habr-Gama","year":"2004","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.03.005_bib7","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1200\/JCO.2011.37.7176","article-title":"Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer","volume":"29","author":"Maas","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ejso.2019.03.005_bib8","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1245\/s10434-011-1933-7","article-title":"A\u00a0phase II trial of neoadjuvant chemoradiation and local excision for T2N0 rectal cancer: preliminary results of the ACOSOG Z6041 trial","volume":"19","author":"Garcia-Aguilar","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2019.03.005_bib9","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0140-6736(17)31056-5","article-title":"Organ preservation for rectal cancer (GRECCAR 2): a prospective, randomised, open-label, multicentre, phase 3 trial","volume":"390","author":"Rullier","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ejso.2019.03.005_bib10","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00384-018-3116-5","article-title":"'Watch and wait' in rectal cancer: summary of the current evidence","volume":"33","author":"On","year":"2018","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.ejso.2019.03.005_bib11","first-page":"291","article-title":"Predictors of pathologic complete response after neoadjuvant treatment for rectal cancer: a multicenter study","volume":"14","author":"Armstrong","year":"2015","journal-title":"Clin Colorectal Cancer"},{"key":"10.1016\/j.ejso.2019.03.005_bib12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/DCR.0000000000000558","article-title":"Pathologic complete response in rectal cancer: can we detect it? Lessons learned from a proposed randomized trial of Watch-and-Wait treatment of tectal cancer","volume":"59","author":"Nahas","year":"2016","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.ejso.2019.03.005_bib13","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s00432-017-2383-9","article-title":"Patterns of recurrence in patients achieving pathologic complete response after neoadjuvant chemoradiotherapy for rectal cancer","volume":"143","author":"Fan","year":"2017","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"key":"10.1016\/j.ejso.2019.03.005_bib14","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/DCR.0000000000000830","article-title":"Baseline T classification predicts early tumor regrowth after nonoperative management in distal rectal cancer after extended neoadjuvant chemoradiation and initial complete clinical response","volume":"60","author":"Habr-Gama","year":"2017","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.ejso.2019.03.005_bib15","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1200\/JCO.2011.40.1836","article-title":"Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO\/ARO\/AIO-94 randomized phase III trial after a median follow-up of 11 years","volume":"30","author":"Sauer","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ejso.2019.03.005_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00000478-200402000-00009","article-title":"Patterns of morphologic alteration in residual rectal carcinoma following preoperative chemoradiation and their association with long-term outcome","volume":"28","author":"Shia","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ejso.2019.03.005_bib17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/PAS.0b013e318200cf78","article-title":"Significance of acellular mucin pools in rectal carcinoma after neoadjuvant chemoradiotherapy","volume":"35","author":"Shia","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ejso.2019.03.005_bib18","first-page":"295","article-title":"Clinical significance of carcinoembryonic antigen expression of acellular mucin pools after preoperative chemoradiotherapy of rectal carcinoma","volume":"29","author":"Gurzu","year":"2014","journal-title":"Cancer Biother Radiopharm"},{"key":"10.1016\/j.ejso.2019.03.005_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/978-1-59745-324-0_26","article-title":"The avidin-biotin complex (ABC) method and other avidin-biotin binding methods","volume":"588","author":"Bratthauer","year":"2010","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.ejso.2019.03.005_bib20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.surg.2009.06.003","article-title":"Genetic and molecular diversity of colon cancer hepatic metastases","volume":"146","author":"Messick","year":"2009","journal-title":"Surgery"},{"key":"10.1016\/j.ejso.2019.03.005_bib21","first-page":"9","article-title":"Oncological and survival outcomes in watch and wait patients with a clinical complete response after neoadjuvant chemoradiotherapy for rectal cancer: a systematic review and pooled analysis","author":"Dattani","year":"2018","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.03.005_bib22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/SLA.0b013e31825b3a2b","article-title":"Pulmonary recurrence predominates after combined modality therapy for rectal cancer: an original retrospective study","volume":"256","author":"Ding","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.03.005_bib23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1748-717X-8-114","article-title":"Patterns of failure in patients with locally advanced rectal cancer receiving pre-operative or post-operative chemoradiotherapy","volume":"8","author":"Yeo","year":"2013","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.ejso.2019.03.005_bib24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/SLA.0b013e3181bdfc27","article-title":"Clinical significance of acellular mucin in rectal adenocarcinoma patients with a pathologic complete response to preoperative chemoradiation","volume":"251","author":"Smith","year":"2010","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.03.005_bib25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1463-1318.2010.02532.x","article-title":"Clinical implications of acellular mucin pools in resected rectal cancer with pathological complete response to neoadjuvant chemoradiation","volume":"14","author":"de Campos-Lobato","year":"2012","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.ejso.2019.03.005_bib26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/PAS.0b013e3182657186","article-title":"Prevalence and clinical significance of acellular mucin in locally advanced rectal cancer patients showing pathologic complete response to preoperative chemoradiotherapy","volume":"37","author":"Lim","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ejso.2019.03.005_bib27","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.ijsu.2014.07.267","article-title":"Impact of acellular mucin pools on survival in patients with complete pathological response to neoadjuvant treatment in rectal cancer","volume":"12","author":"Bhatti","year":"2014","journal-title":"Int J Surg"},{"key":"10.1016\/j.ejso.2019.03.005_bib28","doi-asserted-by":"crossref","first-page":"O10","DOI":"10.1111\/codi.13169","article-title":"Prevalence and clinical significance of cellular and acellular mucin in patients with locally advanced mucinous rectal cancer who underwent preoperative chemoradiotherapy followed by radical surgery","volume":"18","author":"Kang","year":"2016","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.ejso.2019.03.005_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s003840050072","article-title":"Pathological features of rectal cancer after preoperative radiochemotherapy","volume":"12","author":"Dworak","year":"1997","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.ejso.2019.03.005_bib30","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00595-016-1419-0","article-title":"Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy","volume":"47","author":"Kaneko","year":"2017","journal-title":"Surg Today"},{"key":"10.1016\/j.ejso.2019.03.005_bib31","first-page":"714","article-title":"Prognostic role of acellular mucin pools in patients with rectal cancer after pathological complete response to preoperative chemoradiation: systematic review and Meta-analysis","volume":"27","author":"Bhatti","year":"2017","journal-title":"J\u00a0Coll Phys Surg"},{"key":"10.1016\/j.ejso.2019.03.005_bib32","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.21873\/anticanres.12787","article-title":"Chemoradiotherapy-induced changes in mucinous components in rectal cancer tissue: evaluation on high iron diamine-alcian blue and Mucin 1 staining","volume":"38","author":"Miyakita","year":"2018","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ejso.2019.03.005_bib33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1477-7819-5-31","article-title":"The role of MUC1 and MUC3 in the biology and prognosis of colorectal cancer","volume":"5","author":"Duncan","year":"2007","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.ejso.2019.03.005_bib34","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/cas.12170","article-title":"Transmembrane mucin MUC1 overexpression and its association with CD10\u207a myeloid cells, transforming growth factor-\u03b21 expression, and tumor budding grade in colorectal cancer","volume":"104","author":"Khanh Do","year":"2013","journal-title":"Cancer Sci"},{"key":"10.1016\/j.ejso.2019.03.005_bib35","doi-asserted-by":"crossref","first-page":"e2286","DOI":"10.1097\/MD.0000000000002286","article-title":"Prognostic significance of Mucin antigen MUC1 in various human epithelial cancers: a Meta-analysis","volume":"94","author":"Xu","year":"2015","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.ejso.2019.03.005_bib36","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12664-015-0534-y","article-title":"Immunohistochemical study of MUC1, MUC2 and MUC5AC in colorectal carcinoma and review of literature","volume":"34","author":"Kesari","year":"2015","journal-title":"Indian J Gastroenterol"},{"key":"10.1016\/j.ejso.2019.03.005_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138049","article-title":"MUC1 predicts colorectal cancer metastasis: a systematic review and Meta-analysis of case controlled studies","volume":"10","author":"Zeng","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejso.2019.03.005_bib38","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1200\/JCO.2015.60.8554","article-title":"Adjuvant chemotherapy for locally advanced rectal cancer: is it a given?","volume":"33","author":"Hong","year":"2015","journal-title":"J\u00a0Clin Oncol"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798319303129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798319303129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:30:11Z","timestamp":1760059811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798319303129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0748798319303129"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2019.03.005","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathological complete response may underestimate distant metastasis in locally advanced rectal cancer following neoadjuvant chemoradiotherapy and radical surgery: Incidence, metastatic pattern, and risk factors","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2019.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.","name":"copyright","label":"Copyright"}]}}