{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:54:21Z","timestamp":1784289261265,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.ejso.2019.05.020","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T11:27:25Z","timestamp":1558351645000},"page":"1613-1618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Possible dose dependent effect of perioperative dexamethasone and laparoscopic surgery on the postoperative systemic inflammatory response and complications following surgery for colon cancer"],"prefix":"10.1016","volume":"45","author":[{"given":"Stephen T.","family":"McSorley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross D.","family":"Dolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Campbell SD.","family":"Roxburgh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Horgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham J.","family":"MacKay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"McMillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejso.2019.05.020_bib1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/SLA.0000000000000854","article-title":"Infectious postoperative complications decrease long-term survival in patients undergoing curative surgery for colorectal cancer","volume":"261","author":"Artinyan","year":"2015","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.05.020_bib2","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.1245\/s10434-012-2498-9","article-title":"C-reactive protein as a predictor of postoperative infective complications after curative resection in patients with colorectal cancer","volume":"19","author":"Platt","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.ejso.2019.05.020_bib3","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.surg.2014.09.009","article-title":"Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation: a systematic review","volume":"157","author":"Watt","year":"2015","journal-title":"Surgery"},{"key":"10.1016\/j.ejso.2019.05.020_bib4","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/bjs.9756","article-title":"Meta-analysis of the predictive value of C-reactive protein for infectious complications in abdominal surgery","volume":"102","author":"Adamina","year":"2015","journal-title":"Br J Surg"},{"issue":"9","key":"10.1016\/j.ejso.2019.05.020_bib5","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1245\/s10434-016-5204-5","article-title":"Postoperative systemic inflammatory response, complication severity, and survival following surgery for colorectal cancer","volume":"23","author":"McSorley","year":"2016","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2019.05.020_bib6","first-page":"j1455","article-title":"Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial)","volume":"357","author":"Magill","year":"2017","journal-title":"Br Med J"},{"key":"10.1016\/j.ejso.2019.05.020_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.critrevonc.2016.03.011","article-title":"The impact of preoperative corticosteroids on the systemic inflammatory response and postoperative complications following surgery for gastrointestinal cancer: a systematic review and meta-analysis","volume":"101","author":"McSorley","year":"2016","journal-title":"Crit Rev Oncol Hematol"},{"issue":"5","key":"10.1016\/j.ejso.2019.05.020_bib8","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/SLA.0000000000001883","article-title":"Perioperative hydrocortisone reduces major complications after pancreaticoduodenectomy: a randomized controlled trial","volume":"264","author":"Laaninen","year":"2016","journal-title":"Ann Surg"},{"issue":"8","key":"10.1016\/j.ejso.2019.05.020_bib9","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1245\/s10434-017-5817-3","article-title":"The impact of preoperative dexamethasone on the magnitude of the postoperative systemic inflammatory response and complications following surgery for colorectal cancer","volume":"24","author":"McSorley","year":"2017","journal-title":"Ann Surg Oncol"},{"issue":"S1","key":"10.1016\/j.ejso.2019.05.020_bib10","doi-asserted-by":"crossref","first-page":"i68","DOI":"10.1093\/bja\/aet577","article-title":"Association between pre-operative glucocorticoids and long-term survival and cancer recurrence after colectomy: follow-up analysis of a previously randomized trial","volume":"113","author":"Singh","year":"2014","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ejso.2019.05.020_bib11","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1245\/s10434-017-5987-z","article-title":"Clinicopathological determinants of an elevated systemic inflammatory response following elective potentially curative resection for colorectal cancer","volume":"24","author":"Watt","year":"2017","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"10.1016\/j.ejso.2019.05.020_bib12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ctrv.2012.08.003","article-title":"The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer","volume":"36","author":"McMillan","year":"2012","journal-title":"Cancer Treat Rev"},{"issue":"4","key":"10.1016\/j.ejso.2019.05.020_bib13","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1245\/s10434-016-5659-4","article-title":"A\u00a0postoperative systemic inflammation score predicts short- and long-term outcomes in patients undergoing surgery for colorectal cancer","volume":"24","author":"Watt","year":"2017","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2019.05.020_bib14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"issue":"5","key":"10.1016\/j.ejso.2019.05.020_bib15","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/SLA.0b013e3181856024","article-title":"The impact of prophylactic dexamethasone on nausea and vomiting after laparoscopic cholecystectomy: a systematic review and meta-analysis","volume":"248","author":"Karanicolas","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.ejso.2019.05.020_bib16","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/j.pain.0000000000001243","article-title":"Postoperative pain, analgesia, and recovery \u2013 bedfellows that cannot be ignored","volume":"159","author":"Kehlet","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.ejso.2019.05.020_bib17","first-page":"CD011940","article-title":"Adverse side effects of dexamethasone in surgical patients","volume":"11","author":"Polderman","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejso.2019.05.020_bib18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2013.10.008","article-title":"The cellular mechanisms of the antiemetic action of dexamethasone and related glucocorticoids against vomiting","volume":"722","author":"Chu","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.ejso.2019.05.020_bib19","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMra050541","article-title":"Anti-inflammatory action of glucocorticoids \u2013 new mechanisms for old drugs","volume":"353","author":"Rhen","year":"2005","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.ejso.2019.05.020_bib20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1067\/mai.2003.97","article-title":"Update on glucocorticoid action and resistance","volume":"111","author":"Leung","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.ejso.2019.05.020_bib21","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/anae.14306","article-title":"The early in-vivo effects of a single anti-emetic dose of dexamethasone on innate immune cell gene expression and activation in healthy volunteers","volume":"73","author":"Bain","year":"2018","journal-title":"Anaesthesia"},{"issue":"2","key":"10.1016\/j.ejso.2019.05.020_bib22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/bja\/aex154","article-title":"Intraoperative dexamethasone alters immune cell populations in patients undergoing elective laparoscopic gynaecological surgery","volume":"119","author":"Corcoran","year":"2017","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.ejso.2019.05.020_bib23","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.critrevonc.2015.08.013","article-title":"The impact of the type and severity of postoperative complications on long-term outcomes following surgery for colorectal cancer: a systematic review and meta-analysis","volume":"97","author":"McSorley","year":"2016","journal-title":"Crit Rev Oncol-Hematol"},{"issue":"8","key":"10.1016\/j.ejso.2019.05.020_bib24","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/ncb3015","article-title":"The tumour induced systemic environment as a critical regulator of cancer progression and metastasis","volume":"16","author":"McAllister","year":"2014","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.ejso.2019.05.020_bib25","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1245\/s10434-014-4065-z","article-title":"The impact of open versus laparoscopic resection for colon cancer on c-reactive protein concentrations as a predictor of postoperative infective complications","volume":"22","author":"Ramanathan","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2019.05.020_bib26","doi-asserted-by":"crossref","DOI":"10.1245\/s10434-018-6827-5","article-title":"Intraoperative dexamethasone decreases infectious complications after pancreaticoduodenectomy and is associated with long-term survival in pancreatic cancer","author":"Sandini","year":"2018","journal-title":"Ann Surg Oncol"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798319304585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798319304585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:30:45Z","timestamp":1760059845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798319304585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0748798319304585"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2019.05.020","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible dose dependent effect of perioperative dexamethasone and laparoscopic surgery on the postoperative systemic inflammatory response and complications following surgery for colon cancer","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2019.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.","name":"copyright","label":"Copyright"}]}}