{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:45:50Z","timestamp":1782229550892,"version":"3.54.5"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"am","delay-in-days":362,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"The Lacassagne Center"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.ejso.2020.07.034","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T11:35:16Z","timestamp":1599737716000},"page":"367-374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Upfront surgery or definitive radiotherapy for patients with p16-negative oropharyngeal squamous cell carcinoma. A GETTEC multicentric study"],"prefix":"10.1016","volume":"47","author":[{"given":"Dorian","family":"Culi\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Viotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-6454","authenticated-orcid":false,"given":"Anouchka","family":"Modesto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-9507","authenticated-orcid":false,"given":"Renaud","family":"Schiappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6841-4571","authenticated-orcid":false,"given":"Emmanuel","family":"Chamorey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dassonville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Poissonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Guelfucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6757-4330","authenticated-orcid":false,"given":"Alain","family":"Bizeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Vergez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Dupret-Bories","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Garrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Fakhry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Santini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Lallemant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Chambon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Sudaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Peyrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esma","family":"Saada-Bouzid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Benezery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Jourdan-Soulier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Chapel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Sophie","family":"Ramay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Roger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Galissier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Coste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aicha","family":"Ben Lakdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Guerlain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Temam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitham","family":"Mirghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-4964","authenticated-orcid":false,"given":"Phillipe","family":"Gorphe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bozec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ejso.2020.07.034_bib1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s11864-014-0309-1","article-title":"Human papillomavirus-associated oropharynx cancer (HPV-OPC): treatment options","volume":"15","author":"Chau","year":"2014","journal-title":"Curr Treat Options Oncol"},{"key":"10.1016\/j.ejso.2020.07.034_bib2","first-page":"1","article-title":"Recent advances in the understanding and management of oropharyngeal cancer [version 1; referees: 3 approved]","volume":"7","author":"Hay","year":"2018","journal-title":"F1000Research"},{"key":"10.1016\/j.ejso.2020.07.034_bib3","series-title":"NCCN clinical practice guidelines in oncology (NCCN guidelines) - head and neck cancers","author":"National Cancer Institute","year":"2018"},{"issue":"3","key":"10.1016\/j.ejso.2020.07.034_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/sj.bjc.6602696","article-title":"Surgery and adjuvant radiotherapy vs concurrent chemoradiotherapy in stage III\/IV nonmetastatic squamous cell head and neck cancer: a randomised comparison","volume":"93","author":"Soo","year":"2005","journal-title":"Br J Canc"},{"issue":"12","key":"10.1016\/j.ejso.2020.07.034_bib5","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1016\/j.ejso.2018.05.022","article-title":"Impact of HPV-associated p16-expression and other clinical factors on therapeutic decision-making in patients with oropharyngeal cancer: a GETTEC multicentric study","volume":"44","author":"Culi\u00e9","year":"2018","journal-title":"Eur J Surg Oncol"},{"issue":"10","key":"10.1016\/j.ejso.2020.07.034_bib6","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1093\/annonc\/mdx304","article-title":"Human papillomavirus-related oropharyngeal cancer","volume":"28","author":"Taberna","year":"2017","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ejso.2020.07.034_bib7","doi-asserted-by":"crossref","DOI":"10.1097\/CCO.0000000000000531","article-title":"Current role of primary surgical treatment in patients with head and neck squamous cell carcinoma","author":"Bozec","year":"2019","journal-title":"Curr Opin Oncol"},{"issue":"29","key":"10.1016\/j.ejso.2020.07.034_bib8","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1200\/JCO.2015.61.6995","article-title":"Epidemiology of human papillomavirus-positive head and neck squamous cell carcinoma","volume":"33","author":"Gillison","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"issue":"10","key":"10.1016\/j.ejso.2020.07.034_bib9","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1002\/lary.26566","article-title":"Influence of human papillomavirus on the clinical presentation of oropharyngeal carcinoma in the United States","volume":"127","author":"Stenmark","year":"2017","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.ejso.2020.07.034_bib10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jnci\/djn025","article-title":"Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers","volume":"100","author":"Gillison","year":"2008","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.ejso.2020.07.034_bib11","first-page":"1","article-title":"Primary surgery-versus primary radiation-based treatment for locally advanced oropharyngeal cancer","author":"Kamran","year":"2017","journal-title":"Laryngoscope"},{"issue":"12","key":"10.1016\/j.ejso.2020.07.034_bib12","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1038\/bjc.2017.132","article-title":"Human papillomavirus association is the most important predictor for surgically treated patients with oropharyngeal cancer","volume":"116","author":"Wagner","year":"2017","journal-title":"Br J Canc"},{"issue":"27","key":"10.1016\/j.ejso.2020.07.034_bib13","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1200\/JCO.2010.29.2904","article-title":"Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial","volume":"28","author":"Rischin","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"issue":"29","key":"10.1016\/j.ejso.2020.07.034_bib14","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1200\/JCO.2015.60.7804","article-title":"Human papillomavirus-negative pharyngeal cancer","volume":"33","author":"Dillon","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"issue":"8","key":"10.1016\/j.ejso.2020.07.034_bib15","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1001\/jamaoncol.2016.5769","article-title":"Comparison of survival outcomes among human papillomavirus\u2013negative cT1-2 N1-2b patients with oropharyngeal squamous cell cancer treated with upfront surgery vs definitive chemoradiation therapy: an observational study","volume":"3","author":"Kelly","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ejso.2020.07.034_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.oraloncology.2017.01.012","article-title":"Oropharyngeal cancer prognosis by tumour HPV status in France: the multicentric Papillophar study","volume":"67","author":"Lacau St Guily","year":"2017","journal-title":"Oral Oncol"},{"issue":"10166","key":"10.1016\/j.ejso.2020.07.034_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(18)32779-X","article-title":"Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial","volume":"393","author":"Gillison","year":"2019","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.ejso.2020.07.034_bib18","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S1470-2045(19)30410-3","article-title":"Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial","volume":"20","author":"Nichols","year":"2019","journal-title":"Lancet Oncol"},{"issue":"2","key":"10.1016\/j.ejso.2020.07.034_bib19","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/cncr.29022","article-title":"A\u00a0multi-institution pooled analysis of gastrostomy tube dependence in patients with oropharyngeal cancer treated with definitive intensity-modulated radiotherapy","volume":"121","author":"Setton","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.ejso.2020.07.034_bib20","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1200\/JCO.2014.55.3925","article-title":"Randomized phase III trial to test accelerated versus standard fractionation in combination with concurrent cisplatin for head and neck carcinomas in the radiation therapy oncology group 0129 trial: long-term report of efficacy and toxicity","volume":"32","author":"Felix Nguyen-Tan","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"issue":"February","key":"10.1016\/j.ejso.2020.07.034_bib21","first-page":"415","article-title":"Predictors of gastrostomy tube dependence in surgically managed oropharyngeal squamous cell carcinoma","author":"Varma","year":"2018","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.ejso.2020.07.034_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1742-7843.2006.pto_293.x","article-title":"Indications for propensity scores and review of their use in pharmacoepidemiology","volume":"98","author":"Glynn","year":"2006","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"24","key":"10.1016\/j.ejso.2020.07.034_bib23","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1002\/cncr.24595","article-title":"The role of salvage surgery in patients with recurrent squamous cell carcinoma of the oropharynx","volume":"115","author":"Zafereo","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.ejso.2020.07.034_bib24","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s10147-012-0449-x","article-title":"Salvage surgery for recurrent oropharyngeal cancer after chemoradiotherapy","volume":"18","author":"Kano","year":"2013","journal-title":"Int J Clin Oncol"},{"issue":"12","key":"10.1016\/j.ejso.2020.07.034_bib25","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3109\/00016489.2015.1066935","article-title":"Salvage surgery for recurrent oropharyngeal cancer: post-operative oncologic and functional outcomes","volume":"135","author":"Culi\u00e9","year":"2015","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.ejso.2020.07.034_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.oraloncology.2018.01.010","article-title":"Double positivity for HPV-DNA\/p16ink4a is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients","volume":"78","author":"Mena","year":"2018","journal-title":"Oral Oncol"},{"issue":"5","key":"10.1016\/j.ejso.2020.07.034_bib27","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/PAS.0b013e3182116a45","article-title":"Isolating p16-positive\/`HPV-negative oropharyngeal cancer\u00a0: an effort worth making","volume":"35","author":"Perrone","year":"2011","journal-title":"Am J Surg Pathol"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798320306612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798320306612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:34:43Z","timestamp":1760060083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798320306612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S0748798320306612"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2020.07.034","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upfront surgery or definitive radiotherapy for patients with p16-negative oropharyngeal squamous cell carcinoma. A GETTEC multicentric study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2020.07.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.","name":"copyright","label":"Copyright"}]}}