{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:12:17Z","timestamp":1760141537847,"version":"build-2065373602"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002345","name":"University of T\u00fcbingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ejso.2021.02.012","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T08:11:09Z","timestamp":1613549469000},"page":"1434-1440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Experimental evaluation of icodextrin delivery as pressurized aerosol (PIPAC): Antiadhesive and cytotoxic effects"],"prefix":"10.1016","volume":"47","author":[{"given":"Helen Salome","family":"Keck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank-J\u00fcrgen","family":"Weinreich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjita","family":"Shegokar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"K\u00f6nigsrainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc Andr\u00e9","family":"Reymond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgi","family":"Nadiradze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejso.2021.02.012_bib1","first-page":"CD000475","article-title":"Barrier agents for adhesion prevention after gynaecological surgery","volume":"3","author":"Ahmad","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejso.2021.02.012_bib2","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1097\/DCR.0000000000000191","article-title":"Strategies in the prevention of the formation of postoperative adhesions in digestive surgery: a systematic review of the literature","volume":"57","author":"Robb","year":"2014","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.ejso.2021.02.012_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0140-6736(13)61687-6","article-title":"Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis","volume":"383","author":"Ten Broek","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.ejso.2021.02.012_bib4","first-page":"CD007554","article-title":"Biocompatible dialysis fluids for peritoneal dialysis","volume":"10","author":"Htay","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ejso.2021.02.012_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2482-13-34","article-title":"Influence of 4% icodextrin solution on peritoneal tissue response and adhesion formation","volume":"13","author":"Klink","year":"2013","journal-title":"BMC Surg"},{"key":"10.1016\/j.ejso.2021.02.012_bib6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.surg.2004.06.001","article-title":"Icodextrin reduces postoperative adhesion formation in rats without affecting peritoneal metastasis","volume":"137","author":"van den Tol","year":"2005","journal-title":"Surgery"},{"key":"10.1016\/j.ejso.2021.02.012_bib7","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.lfs.2012.04.036","article-title":"Impacts of icodextrin on integrin-mediated wound healing of peritoneal mesothelial cells","volume":"90","author":"Matsumoto","year":"2012","journal-title":"Life Sci"},{"key":"10.1016\/j.ejso.2021.02.012_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/codi.13095","article-title":"Role of icodextrin in the prevention of small bowel obstruction. Safety randomized patients control of the first 300 in the ADEPT trial","volume":"18","author":"Sakari","year":"2016","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.ejso.2021.02.012_bib9","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1093\/humrep\/der135","article-title":"Gynaecological endoscopic evaluation of 4% icodextrin solution: a European, multicentre, double-blind, randomized study of the efficacy and safety in the reduction of de novo adhesions after laparoscopic gynaecological surgery","volume":"26","author":"Trew","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ejso.2021.02.012_bib10","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.neo.2020.09.006","article-title":"Injured tissues favor cancer cell implantation via fibrin deposits on scar zones","volume":"22","author":"Al Dybiat","year":"2020","journal-title":"Neoplasia"},{"key":"10.1016\/j.ejso.2021.02.012_bib11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4274\/balkanmedj.2015.1359","article-title":"Prevention of intraabdominal adhesions: an experimental study using mitomycin-C and 4% icodextrin","volume":"34","author":"Urkan","year":"2017","journal-title":"Balkan Med J"},{"key":"10.1016\/j.ejso.2021.02.012_bib12","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.ejso.2016.12.009","article-title":"Reduction of carcinomatosis risk using icodextrin as a carrier solution of intraperitoneal oxaliplatin chemotherapy","volume":"43","author":"Jouvin","year":"2017","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ejso.2021.02.012_bib13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1515\/pp-2016-0022","article-title":"Pharmacokinetic problems in peritoneal drug administration: an update after 20 years","volume":"1","author":"Flessner","year":"2016","journal-title":"Pleura Peritoneum"},{"key":"10.1016\/j.ejso.2021.02.012_bib14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000366553","article-title":"Imaging of the peritoneum evaluated by 99mTc-icodextrin scintigraphy in peritoneal dialysis patients: preliminary data","volume":"38","author":"Argentino","year":"2014","journal-title":"Blood Purif"},{"key":"10.1016\/j.ejso.2021.02.012_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12010034","article-title":"Overcoming drug resistance by taking advantage of physical principles: pressurized intraperitoneal aerosol chemotherapy (PIPAC)","volume":"12","author":"Nadiradze","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ejso.2021.02.012_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1515\/pp-2017-0015","article-title":"Experimental pharmacokinetics evaluation of chemotherapy delivery by PIPAC for colon cancer: first evidence for efficacy","volume":"2","author":"Eveno","year":"2017","journal-title":"Pleura Peritoneum"},{"key":"10.1016\/j.ejso.2021.02.012_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12957-017-1109-4","article-title":"Cytotoxic effect of different treatment parameters in pressurized intraperitoneal aerosol chemotherapy (PIPAC) on the in\u00a0vitro proliferation of human colonic cancer cells","volume":"15","author":"Khosrawipour","year":"2017","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.ejso.2021.02.012_bib18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1080\/02656736.2019.1704891","article-title":"PIPAC versus HIPEC: cisplatin spatial distribution and diffusion in a swine model","volume":"37","author":"Davigo","year":"2020","journal-title":"Int J Hyperther"},{"key":"10.1016\/j.ejso.2021.02.012_bib19","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1245\/s10434-019-07695-z","article-title":"Comparison of tissue and blood concentrations of oxaliplatin administrated by different modalities of intraperitoneal chemotherapy","volume":"26","author":"Giger-Pabst","year":"2019","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2021.02.012_bib20","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1245\/s10434-013-3213-1","article-title":"Intraperitoneal chemotherapy of peritoneal carcinomatosis using pressurized aerosol as an alternative to liquid solution: first evidence for efficacy","volume":"21","author":"Solass","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2021.02.012_bib21","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.ejso.2018.04.020","article-title":"Concentrations of cisplatin and doxorubicin in ascites and peritoneal tumor nodules before and after pressurized intraperitoneal aerosol chemotherapy (PIPAC) in patients with peritoneal metastasis","volume":"44","author":"Tempfer","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ejso.2021.02.012_bib22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11095-019-2646-z","article-title":"High pressure nebulization (PIPAC) versus injection for the intraperitoneal administration of mRNA complexes","volume":"36","author":"Shariati","year":"2019","journal-title":"Pharm Res"},{"key":"10.1016\/j.ejso.2021.02.012_bib23","doi-asserted-by":"crossref","first-page":"e368","DOI":"10.1016\/S1470-2045(19)30318-3","article-title":"Pressurised intraperitoneal aerosol chemotherapy: rationale, evidence, and potential indications","volume":"20","author":"Alyami","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ejso.2021.02.012_bib24","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.ejso.2018.02.014","article-title":"Multicenter comprehensive methodological and technical analysis of 832 pressurized intraperitoneal aerosol chemotherapy (PIPAC) interventions performed in 349 patients for peritoneal carcinomatosis treatment: an international survey study","volume":"44","author":"Nowacki","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ejso.2021.02.012_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1515\/pp-2017-0003","article-title":"Overview of the optimal perioperative intraperitoneal chemotherapy regimens used in current clinical practice","volume":"2","author":"Van der Speeten","year":"2017","journal-title":"Pleura Peritoneum"},{"key":"10.1016\/j.ejso.2021.02.012_bib26","first-page":"1785","article-title":"Establishment of peritoneal and hepatic metastasis mouse xenograft models using gastric cancer cell lines","volume":"33","author":"Miwa","year":"2019","journal-title":"In\u00a0Vivo"},{"key":"10.1016\/j.ejso.2021.02.012_bib27","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1007\/s00464-016-5174-5","article-title":"Technical description of the microinjection pump (MIP((R))) and granulometric characterization of the aerosol applied for pressurized intraperitoneal aerosol chemotherapy (PIPAC)","volume":"31","author":"Gohler","year":"2017","journal-title":"Surg Endosc"},{"key":"10.1016\/j.ejso.2021.02.012_bib28","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1177\/1553350615610653","article-title":"Adhesions and healing of intestinal anastomoses: the effect of anti-adhesion barriers","volume":"23","author":"Ntourakis","year":"2016","journal-title":"Surg Innovat"},{"key":"10.1016\/j.ejso.2021.02.012_bib29","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jss.2018.10.003","article-title":"Adhesion prevention to polypropylene meshes using combined icodextrin four percent and dimetindene maleate","volume":"234","author":"Bouliaris","year":"2019","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.ejso.2021.02.012_bib30","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1007\/s00464-016-5277-z","article-title":"Liquid antiadhesive agents for intraperitoneal hernia repair procedures: artiss((R)) compared to CoSeal((R)) and Adept((R)) in an IPOM rat model","volume":"31","author":"Gruber-Blum","year":"2017","journal-title":"Surg Endosc"},{"key":"10.1016\/j.ejso.2021.02.012_bib31","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s11605-011-1736-y","article-title":"P.O.P.A. study: prevention of postoperative abdominal adhesions by icodextrin 4% solution after laparotomy for adhesive small bowel obstruction. A prospective randomized controlled trial","volume":"16","author":"Catena","year":"2012","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.ejso.2021.02.012_bib32","first-page":"162","article-title":"New principles, better practices, and clearer perceptions in intraperitoneal chemotherapy: clinical experience using icodextrin 20 as a carrier solution","volume":"13","author":"Dobbie","year":"1997","journal-title":"Adv Perit Dial Conf"},{"key":"10.1016\/j.ejso.2021.02.012_bib33","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1053\/ejso.2002.1348","article-title":"A\u00a0pilot study of adjuvant intraperitoneal 5-fluorouracil using 4% icodextrin as a novel carrier solution","volume":"29","author":"Hosie","year":"2003","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ejso.2021.02.012_bib34","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1038\/bjc.1996.672","article-title":"Prolonged intraperitoneal infusion of 5-fluorouracil using a novel carrier solution","volume":"74","author":"Kerr","year":"1996","journal-title":"Br J Canc"},{"key":"10.1016\/j.ejso.2021.02.012_bib35","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ygyno.2006.06.005","article-title":"Icodextrin enhances survival in an intraperitoneal ovarian cancer murine model utilizing gene therapy","volume":"103","author":"Rocconi","year":"2006","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ejso.2021.02.012_bib36","doi-asserted-by":"crossref","first-page":"20190017","DOI":"10.1515\/pp-2019-0017","article-title":"A\u00a0real-time ex\u00a0vivo model (eIBUB) for optimizing intraperitoneal drug delivery as an alternative to living animal models","volume":"4","author":"Sautkin","year":"2019","journal-title":"Pleura Peritoneum"},{"key":"10.1016\/j.ejso.2021.02.012_bib37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1515\/pp-2017-0006","article-title":"A new ex vivo model for optimizing distribution of therapeutic aerosols: the (inverted) bovine urinary bladder","volume":"2","author":"Schnelle","year":"2017","journal-title":"Pleura Peritoneum"},{"key":"10.1016\/j.ejso.2021.02.012_bib38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1515\/pp-2017-0004","article-title":"Modelling drug transport during intraperitoneal chemotherapy","volume":"2","author":"Steuperaert","year":"2017","journal-title":"Pleura Peritoneum"},{"key":"10.1016\/j.ejso.2021.02.012_bib39","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317698381","article-title":"Laparoscopic subperitoneal injection of chemo-loaded particles lowers tumor growth on a rabbit model of peritoneal carcinomatosis","volume":"39","author":"Pascale","year":"2017","journal-title":"Tumour Biol"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798321001037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798321001037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:37:08Z","timestamp":1760060228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798321001037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S0748798321001037"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2021.02.012","relation":{},"ISSN":["0748-7983"],"issn-type":[{"type":"print","value":"0748-7983"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental evaluation of icodextrin delivery as pressurized aerosol (PIPAC): Antiadhesive and cytotoxic effects","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2021.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.","name":"copyright","label":"Copyright"}]}}