{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:43:13Z","timestamp":1792510993068,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.ejso.2021.03.248","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:01:34Z","timestamp":1616803294000},"page":"1900-1906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Trends and timing of risk-reducing mastectomy uptake in unaffected BRCA1 and BRCA2 carriers in Slovenia"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2893-5580","authenticated-orcid":false,"given":"Taja","family":"Lo\u017ear","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janez","family":"\u017dgajnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andra\u017e","family":"Perhavec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8657-9380","authenticated-orcid":false,"given":"Ana","family":"Blatnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdjan","family":"Novakovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0605-2592","authenticated-orcid":false,"given":"Mateja","family":"Krajc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejso.2021.03.248_bib1","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"JAMA, J Am Med Assoc"},{"key":"10.1016\/j.ejso.2021.03.248_bib2","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1093\/jnci\/djt095","article-title":"Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE","volume":"105","author":"Mavaddat","year":"2013","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.ejso.2021.03.248_bib3","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1086\/375033","article-title":"Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies","volume":"72","author":"Antoniou","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.ejso.2021.03.248_bib4","series-title":"Guidelines for diagnosis and treatment of breast cancer [Slovenian]","year":"2018"},{"key":"10.1016\/j.ejso.2021.03.248_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM199901143400201","article-title":"Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer","volume":"340","author":"Hartmann","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ejso.2021.03.248_bib6","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/jnci\/93.21.1633","article-title":"Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers","volume":"93","author":"Hartmann","year":"2001","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.ejso.2021.03.248_bib7","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1200\/JCO.2004.04.188","article-title":"Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE study group","volume":"22","author":"Rebbeck","year":"2004","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ejso.2021.03.248_bib8","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1001\/jama.2010.1237","article-title":"Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality","volume":"304","author":"Domchek","year":"2010","journal-title":"JAMA, J Am Med Assoc"},{"key":"10.1016\/j.ejso.2021.03.248_bib9","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1200\/JCO.2013.53.2820","article-title":"Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation","volume":"32","author":"Finch","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ejso.2021.03.248_bib10","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/S0140-6736(00)02347-3","article-title":"Presymptomatic DNA testing and prophylactic surgery in families with a BRCA1 or BRCA2 mutation","volume":"355","author":"Meijers-Heijboer","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.ejso.2021.03.248_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/GIM.0b013e318163487d","article-title":"Uptake and timing of bilateral prophylactic salpingo-oophorectomy among BRCA1 and BRCA2 mutation carriers","volume":"10","author":"Bradbury","year":"2008","journal-title":"Genet Med"},{"key":"10.1016\/j.ejso.2021.03.248_bib12","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1002\/ijc.23340","article-title":"International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers","volume":"122","author":"Metcalfe","year":"2008","journal-title":"Int J Canc"},{"key":"10.1016\/j.ejso.2021.03.248_bib13","doi-asserted-by":"crossref","DOI":"10.1089\/gte.2008.0067","article-title":"Uptake, time course, and predictors of risk-reducing surgeries in BRCA carriers","author":"Beattie","year":"2009","journal-title":"Genet Test"},{"key":"10.1016\/j.ejso.2021.03.248_bib14","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1158\/1055-9965.EPI-09-0171","article-title":"Uptake of risk-reducing surgery in unaffected women at high risk of breast and ovarian cancer is risk, age, and time dependent","volume":"18","author":"Evans","year":"2009","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"10.1016\/j.ejso.2021.03.248_bib15","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1399-0004.2009.01329.x","article-title":"Risk-reducing mastectomy and salpingo-oophorectomy in unaffected BRCA mutation carriers: uptake and timing","volume":"77","author":"Skytte","year":"2010","journal-title":"Clin Genet"},{"key":"10.1016\/j.ejso.2021.03.248_bib16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1471-0528.2011.03257.x","article-title":"Factors influencing uptake and timing of risk reducing salpingo- oophorectomy in women at risk of familial ovarian cancer: a competing risk time to event analysis","volume":"119","author":"Manchanda","year":"2012","journal-title":"BJOG An Int J Obstet Gynaecol"},{"key":"10.1016\/j.ejso.2021.03.248_bib17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s10689-012-9539-1","article-title":"Breast and ovarian cancer risk management in a French cohort of 158 women carrying a BRCA1 or BRCA2 germline mutation: patient choices and outcome","volume":"11","author":"This","year":"2012","journal-title":"Fam Cancer"},{"key":"10.1016\/j.ejso.2021.03.248_bib18","doi-asserted-by":"crossref","first-page":"680","DOI":"10.5694\/mja13.10848","article-title":"Preventing breast and ovarian cancers in high-risk BRCA1 and BRCA2 mutation carriers","volume":"199","author":"Collins","year":"2013","journal-title":"Med J Aust"},{"key":"10.1016\/j.ejso.2021.03.248_bib19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ajog.2013.01.026","article-title":"Impact of family history on choosing risk-reducing surgery among BRCA mutation carriers","volume":"208","author":"Singh","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ejso.2021.03.248_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41416-019-0446-1","article-title":"International trends in the uptake of cancer risk reduction strategies in women with a BRCA1 or BRCA2 mutation","volume":"121","author":"Metcalfe","year":"2019","journal-title":"Br J Canc"},{"key":"10.1016\/j.ejso.2021.03.248_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13058-015-0650-8","article-title":"Longer term effects of the Angelina Jolie effect: increased risk-reducing mastectomy rates in BRCA carriers and other high-risk women","volume":"17","author":"Evans","year":"2015","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.ejso.2021.03.248_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/s13058-014-0442-6","article-title":"The Angelina Jolie effect: how high celebrity profile can have a major impact on provision of cancer related services","volume":"16","author":"Evans","year":"2014","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.ejso.2021.03.248_bib23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4048\/jbc.2017.20.2.203","article-title":"Influence of the Angelina Jolie announcement and insurance reimbursement on practice patterns for hereditary breast cancer","volume":"20","author":"Lee","year":"2017","journal-title":"J\u00a0Breast Cancer"},{"key":"10.1016\/j.ejso.2021.03.248_bib24","series-title":"Guidelines for assessment of ovarian cancer patients [Slovenian]","year":"2016"},{"key":"10.1016\/j.ejso.2021.03.248_bib25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1080\/10810730.2015.1064498","article-title":"Celebrity influence and identification: a test of the Angelina effect","volume":"21","author":"Kosenko","year":"2016","journal-title":"J\u00a0Health Commun"},{"key":"10.1016\/j.ejso.2021.03.248_bib26","series-title":"My medical choice","first-page":"14","author":"Jolie","year":"2013"},{"key":"10.1016\/j.ejso.2021.03.248_bib27","doi-asserted-by":"crossref","first-page":"g5755","DOI":"10.1136\/bmj.g5755","article-title":"\u201cAngelina effect\u201d led to more appropriate breast cancer referrals, research shows","volume":"349","author":"Hawkes","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.ejso.2021.03.248_bib28","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10549-018-4824-9","article-title":"Risk-reducing mastectomy rates in the US: a closer examination of the Angelina Jolie effect","volume":"171","author":"Liede","year":"2018","journal-title":"Breast Canc Res Treat"},{"key":"10.1016\/j.ejso.2021.03.248_bib29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/PRS.0b013e3182729cde","article-title":"A\u00a0paradigm shift in U.S. Breast reconstruction: increasing implant rates","volume":"131","author":"Albornoz","year":"2013","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.ejso.2021.03.248_bib30","doi-asserted-by":"crossref","first-page":"404e","DOI":"10.1097\/PRS.0000000000005290","article-title":"Implant-based breast reconstruction: hot topics, controversies, and new directions","volume":"143","author":"Frey","year":"2019","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.ejso.2021.03.248_bib31","doi-asserted-by":"crossref","first-page":"S144","DOI":"10.1097\/SAP.0000000000001358","article-title":"Evaluation of contralateral and bilateral prophylactic mastectomy and reconstruction outcomes: comparing alloplastic and autologous reconstruction","volume":"80","author":"Bletsis","year":"2018","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.ejso.2021.03.248_bib32","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/01.PRS.0000041440.12442.05","article-title":"Recurrence following treatment of ductal carcinoma in situ with skin-sparing mastectomy and immediate breast reconstruction","volume":"111","author":"Spiegel","year":"2003","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.ejso.2021.03.248_bib33","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jamcollsurg.2007.01.063","article-title":"Local recurrence of ductal carcinoma in situ after skin-sparing mastectomy","volume":"204","author":"Carlson","year":"2007","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.ejso.2021.03.248_bib34","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s10434-999-0676-1","article-title":"Local and distant recurrence rates in skin-sparing mastectomies compared with non-skin-sparing mastectomies","volume":"6","author":"Simmons","year":"1999","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2021.03.248_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1245\/s10434-013-3230-0","article-title":"Total skin-sparing mastectomy in BRCA mutation carriers","volume":"21","author":"Peled","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2021.03.248_bib36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1001\/jamasurg.2017.3422","article-title":"Oncologic safety of prophylactic nipple-sparing mastectomy in a population with BRCA mutations: a multi-institutional study","volume":"153","author":"Jakub","year":"2018","journal-title":"JAMA Surg"},{"key":"10.1016\/j.ejso.2021.03.248_bib37","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1002\/bjs.9884","article-title":"Nipple-sparing mastectomy in patients with BRCA1\/2 mutations and variants of uncertain significance","volume":"102","author":"Manning","year":"2015","journal-title":"Br J Surg"},{"key":"10.1016\/j.ejso.2021.03.248_bib38","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1245\/s10434-014-3883-3","article-title":"Nipple-sparing mastectomy in BRCA1\/2 mutation carriers: an interim analysis and review of the literature","volume":"22","author":"Yao","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2021.03.248_bib39","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/bjs.11616","article-title":"Use of bilateral prophylactic nipple-sparing mastectomy in patients with high risk of breast cancer","volume":"107","author":"Valero","year":"2020","journal-title":"Br J Surg"},{"key":"10.1016\/j.ejso.2021.03.248_bib40","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1245\/s10434-011-1974-y","article-title":"Nipple-sparing mastectomy for breast cancer and risk-reducing surgery: the memorial sloan-kettering cancer center experience","volume":"108","author":"De Alcantara Filho","year":"2011","journal-title":"Ann Surg Oncol"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798321003930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798321003930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:39:16Z","timestamp":1760060356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798321003930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0748798321003930"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2021.03.248","relation":{},"ISSN":["0748-7983"],"issn-type":[{"value":"0748-7983","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trends and timing of risk-reducing mastectomy uptake in unaffected BRCA1 and BRCA2 carriers in Slovenia","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2021.03.248","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}