{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:12:24Z","timestamp":1760141544438,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.ejso.2022.08.018","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T22:47:40Z","timestamp":1661640460000},"page":"339-344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The oncological outcomes of isolated limb perfusion and neo-adjuvant radiotherapy in soft tissue sarcoma patients - A nationwide multicenter study"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1159-6711","authenticated-orcid":false,"given":"V.M.","family":"van Praag","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fiocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6701-6208","authenticated-orcid":false,"given":"R.F.","family":"Bleckman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2303-3468","authenticated-orcid":false,"given":"W.J.","family":"van Houdt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.L.M.","family":"Haas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Verhoef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8293-6002","authenticated-orcid":false,"given":"D.J.","family":"Grunhagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.J.","family":"van Ginkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"Bonenkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-7656","authenticated-orcid":false,"given":"M.A.J.","family":"van de Sande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejso.2022.08.018_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1200\/JCO.1998.16.1.197","article-title":"Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity","volume":"16","author":"Yang","year":"1998","journal-title":"J\u00a0Clin Oncol"},{"issue":"5","key":"10.1016\/j.ejso.2022.08.018_bib2","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1200\/JCO.1996.14.5.1679","article-title":"Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities","volume":"14","author":"Pisters","year":"1996","journal-title":"J\u00a0Clin Oncol : Off. J. Am. Soc. Clin. Oncol."},{"issue":"Supplement_4","key":"10.1016\/j.ejso.2022.08.018_bib3","doi-asserted-by":"crossref","first-page":"iv268","DOI":"10.1093\/annonc\/mdy321","article-title":"Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Casali","year":"2018","journal-title":"Ann Oncol : Off. J. Eur. Soc. Med. Oncol."},{"issue":"9325","key":"10.1016\/j.ejso.2022.08.018_bib4","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/S0140-6736(02)09292-9","article-title":"Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial","volume":"359","author":"O'Sullivan","year":"2002","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ejso.2022.08.018_bib5","article-title":"Time dependent dynamics of wound complications after preoperative radiotherapy in Extremity Soft Tissue Sarcomas","author":"Lansu","year":"2018","journal-title":"Eur J Surg Oncol : J. Eur. Soc. Surg. Oncol. Br. Assoc. Surg. Oncol."},{"issue":"22","key":"10.1016\/j.ejso.2022.08.018_bib6","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1200\/JCO.2002.03.084","article-title":"Function and health status outcomes in a randomized trial comparing preoperative and postoperative radiotherapy in extremity soft tissue sarcoma","volume":"20","author":"Davis","year":"2002","journal-title":"J\u00a0Clin Oncol : Off. J. Am. Soc. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.ejso.2022.08.018_bib7","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.radonc.2004.12.020","article-title":"Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma","volume":"75","author":"Davis","year":"2005","journal-title":"Radiother Oncol"},{"issue":"6","key":"10.1016\/j.ejso.2022.08.018_bib8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ctrv.2012.10.005","article-title":"Isolated limb perfusion of soft tissue sarcomas: a comprehensive review of literature","volume":"39","author":"Seinen","year":"2013","journal-title":"Cancer Treat Rev"},{"issue":"6","key":"10.1016\/j.ejso.2022.08.018_bib9","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/00000658-199612000-00011","article-title":"Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience","volume":"224","author":"Eggermont","year":"1996","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.ejso.2022.08.018_bib10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ejca.2014.11.020","article-title":"Treatment modifications in tumour necrosis factor-alpha (TNF)-based isolated limb perfusion in patients with advanced extremity soft tissue sarcomas","volume":"51","author":"Deroose","year":"2015","journal-title":"Eur. J. Cancer (Oxford, England : 1990)"},{"issue":"30","key":"10.1016\/j.ejso.2022.08.018_bib11","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1200\/JCO.2011.35.6618","article-title":"Long-term results of tumor necrosis factor alpha- and melphalanbased isolated limb perfusion in locally advanced extremity soft tissue sarcomas","volume":"29","author":"Deroose","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"issue":"2","key":"10.1016\/j.ejso.2022.08.018_bib12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1245\/s10434-010-1461-x","article-title":"ILP and RT: the study that will never be","volume":"18","author":"Bonvalot","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ejso.2022.08.018_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13569-018-0098-6","article-title":"Regional chemotherapy by isolated limb perfusion prior to surgery compared with surgery and post-operative radiotherapy for primary, locally advanced extremity sarcoma: a comparison of matched cohorts","volume":"8","author":"Jakob","year":"2018","journal-title":"Clin Sarcoma Res"},{"issue":"4","key":"10.1016\/j.ejso.2022.08.018_bib14","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1245\/s10434-006-9323-2","article-title":"Isolated limb perfusion with tumor necrosis factor alpha and melphalan for locally advanced soft tissue sarcoma: three time periods at risk for amputation","volume":"14","author":"van Ginkel","year":"2007","journal-title":"Ann Surg Oncol"},{"issue":"7","key":"10.1016\/j.ejso.2022.08.018_bib15","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/annonc\/mdi229","article-title":"Limb salvage with isolated perfusion for soft tissue sarcoma: could less TNF-\u03b1 be better?","volume":"16","author":"Bonvalot","year":"2005","journal-title":"Ann Oncol"},{"issue":"4","key":"10.1016\/j.ejso.2022.08.018_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0197-2456(96)00075-X","article-title":"A\u00a0note on quantifying follow-up in studies of failure time","volume":"17","author":"Schemper","year":"1996","journal-title":"Contr Clin Trials"},{"issue":"11","key":"10.1016\/j.ejso.2022.08.018_bib17","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1002\/sim.2712","article-title":"Tutorial in biostatistics: competing risks and multi-state models","volume":"26","author":"Putter","year":"2007","journal-title":"Stat Med"},{"issue":"7","key":"10.1016\/j.ejso.2022.08.018_bib18","article-title":"Mstate: an R package for the analysis of competing risks and multi-state models","volume":"38","author":"De Wreede","year":"2011","journal-title":"J\u00a0Stat Software"},{"journal-title":"R\u00a0Foundation Stat. Comput.","article-title":"A\u00a0language and environment for statistical computing","year":"2013","key":"10.1016\/j.ejso.2022.08.018_bib19"},{"issue":"30","key":"10.1016\/j.ejso.2022.08.018_bib20","first-page":"A6148","article-title":"Limb perfusion in soft tissue sarcomas: twenty years of experience","volume":"157","author":"Hoven-Gondrie","year":"2013","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"3","key":"10.1016\/j.ejso.2022.08.018_bib21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/jso.21081","article-title":"Isolated limb perfusion with tumor necrosis factor and melphalan for non-resectable soft tissue sarcomas: long-term results on efficacy and limb salvage in a selected group of patients","volume":"98","author":"Cherix","year":"2008","journal-title":"J\u00a0Surg Oncol"},{"issue":"2","key":"10.1016\/j.ejso.2022.08.018_bib22","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1245\/s10434-006-9251-1","article-title":"Advanced extremity soft tissue sarcoma: prognostic effect of isolated limb perfusion in a series of 88 patients treated at a single institution","volume":"14","author":"Pennacchioli","year":"2007","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"10.1016\/j.ejso.2022.08.018_bib23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1590\/1413-785220192704217574","article-title":"Long-term results of extremity soft tissue sarcomas limb-sparing surgery and radiotherapy","volume":"27","author":"Dogan \u00d6","year":"2019","journal-title":"Acta Ortop\u00e9dica Bras"},{"issue":"2","key":"10.1016\/j.ejso.2022.08.018_bib24","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ijrobp.2010.06.034","article-title":"Preoperative versus postoperative radiotherapy in soft-tissue sarcoma: multi-institutional analysis of 821 patients","volume":"81","author":"Sampath","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"20","key":"10.1016\/j.ejso.2022.08.018_bib25","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1200\/JCO.2008.16.6249","article-title":"Impact of intensity-modulated radiation therapy on local control in primary soft-tissue sarcoma of the extremity","volume":"26","author":"Alektiar","year":"2008","journal-title":"J\u00a0Clin Oncol : Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.ejso.2022.08.018_bib26","article-title":"Improvement in overall survival from extremity soft tissue sarcoma over twenty years","author":"Jacobs","year":"2015","journal-title":"Sarcoma 2015"},{"issue":"3","key":"10.1016\/j.ejso.2022.08.018_bib27","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1200\/JCO.1996.14.3.859","article-title":"Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma","volume":"14","author":"Pisters","year":"1996","journal-title":"J\u00a0Clin Oncol : Off. J. Am. Soc. Clin. Oncol."},{"issue":"10","key":"10.1016\/j.ejso.2022.08.018_bib28","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/1097-0142(20010515)91:10<1914::AID-CNCR1214>3.0.CO;2-3","article-title":"Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group","volume":"91","author":"Coindre","year":"2001","journal-title":"Cancer"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798322006242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798322006242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:46:07Z","timestamp":1760060767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798322006242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0748798322006242"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2022.08.018","relation":{},"ISSN":["0748-7983"],"issn-type":[{"type":"print","value":"0748-7983"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The oncological outcomes of isolated limb perfusion and neo-adjuvant radiotherapy in soft tissue sarcoma patients - A nationwide multicenter study","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2022.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}