{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:59:14Z","timestamp":1766087954735,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ejso.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Surgical Oncology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.ejso.2022.11.005","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T12:19:19Z","timestamp":1667909959000},"page":"771-779","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinically significant portal hypertension (CSPH) on early-stage HCC following hepatectomy: What's the impact?"],"prefix":"10.1016","volume":"49","author":[{"given":"Feng","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elijah","family":"Ndhlovu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bixiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ejso.2022.11.005_bib1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s12072-020-10085-3","article-title":"Effect of HBV-HDV co-infection on HBV-HCC co-recurrence in patients undergoing living donor liver transplantation","volume":"14","author":"Baskiran","year":"2020","journal-title":"Hepatol Int"},{"issue":"3","key":"10.1016\/j.ejso.2022.11.005_bib2","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1007\/s12029-020-00424-w","article-title":"Liver transplantation for hepatocellular carcinoma: malatya experience and proposals for expanded criteria","volume":"51","author":"Ince","year":"2020","journal-title":"J\u00a0Gastrointest Cancer"},{"issue":"9","key":"10.1016\/j.ejso.2022.11.005_bib3","first-page":"2993","article-title":"Recent progress in treatment of hepatocellular carcinoma","volume":"10","author":"Chen","year":"2020","journal-title":"Am J Cancer Res"},{"issue":"2","key":"10.1016\/j.ejso.2022.11.005_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12072-018-9919-1","article-title":"Goals and targets for personalized therapy for HCC","volume":"13","author":"Couri","year":"2019","journal-title":"Hepatol Int"},{"issue":"4","key":"10.1016\/j.ejso.2022.11.005_bib5","article-title":"New frontiers in liver resection for hepatocellular carcinoma","volume":"2","author":"Allaire","year":"2020","journal-title":"JHEP Rep : Innov Hepatol"},{"issue":"8","key":"10.1016\/j.ejso.2022.11.005_bib6","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/liv.14977","article-title":"Portal hypertension and hepatocellular carcinoma: des liaisons dangereuses","volume":"41","author":"Allaire","year":"2021","journal-title":"Liver Int : Off J Int Assoc Stud Liver"},{"issue":"2","key":"10.1016\/j.ejso.2022.11.005_bib7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/1535370219898141","article-title":"Mechanisms of liver fibrosis and its role in liver cancer","volume":"245","author":"Dhar","year":"2020","journal-title":"Exp Biol Med"},{"issue":"3","key":"10.1016\/j.ejso.2022.11.005_bib8","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jhep.2021.11.018","article-title":"BCLC strategy for prognosis prediction and treatment recommendation Barcelona Clinic Liver Cancer (BCLC) staging system. The 2022 update","volume":"76","author":"Reig","year":"2021","journal-title":"J\u00a0Hepatol"},{"issue":"9","key":"10.1016\/j.ejso.2022.11.005_bib9","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1245\/s10434-014-3704-8","article-title":"Comparison of survival of patients with BCLC stage A hepatocellular carcinoma after hepatic resection or transarterial chemoembolization: a propensity score-based analysis","volume":"21","author":"Guo","year":"2014","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"10.1016\/j.ejso.2022.11.005_bib10","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S1499-3872(16)60089-9","article-title":"Combined hepatectomy and radiofrequency ablation versus TACE in improving survival of patients with unresectable BCLC stage B HCC","volume":"15","author":"Hou","year":"2016","journal-title":"Hepatobiliary Pancreat Dis Int : HBPD INT."},{"issue":"3","key":"10.1016\/j.ejso.2022.11.005_bib11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s11605-013-2440-x","article-title":"Surgery versus transarterial chemoembolization for solitary large hepatocellular carcinoma of BCLC stage A","volume":"18","author":"Jin","year":"2014","journal-title":"J\u00a0Gastrointest Surg"},{"issue":"21","key":"10.1016\/j.ejso.2022.11.005_bib12","doi-asserted-by":"crossref","first-page":"18715","DOI":"10.18632\/oncotarget.4134","article-title":"Hepatic resection versus transarterial chemoembolization for the initial treatment of hepatocellular carcinoma: a systematic review and meta-analysis","volume":"6","author":"Qi","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejso.2022.11.005_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijsu.2018.04.048","article-title":"A\u00a0meta-analysis of long-term survival outcomes between surgical resection and radiofrequency ablation in patients with single hepatocellular carcinoma \u2264 2 cm (BCLC very early stage)","volume":"56","author":"Yin","year":"2018","journal-title":"Int J Surg"},{"issue":"4","key":"10.1016\/j.ejso.2022.11.005_bib14","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0016-5085(96)70070-7","article-title":"Surgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressure","volume":"111","author":"Bruix","year":"1996","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.ejso.2022.11.005_bib15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1478-3231.2010.02436.x","article-title":"Predictive factors for long-term survival in patients with clinically significant portal hypertension following resection of hepatocellular carcinoma","volume":"31","author":"Choi","year":"2011","journal-title":"Liver Int : Off J Int Assoc Stud Liver"},{"issue":"6","key":"10.1016\/j.ejso.2022.11.005_bib16","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/hep.510300629","article-title":"Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation","volume":"30","author":"Llovet","year":"1999","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.ejso.2022.11.005_bib17","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1007\/s00268-005-0524-9","article-title":"Portal hypertension: contraindication to liver surgery?","volume":"30","author":"Capussotti","year":"2006","journal-title":"World J Surg"},{"issue":"7","key":"10.1016\/j.ejso.2022.11.005_bib18","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1053\/j.gastro.2008.02.091","article-title":"Neither multiple tumors nor portal hypertension are surgical contraindications for hepatocellular carcinoma","volume":"134","author":"Ishizawa","year":"2008","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.ejso.2022.11.005_bib19","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1245\/s10434-008-9880-7","article-title":"Short- and long-term outcomes after hepatic resection for hepatocellular carcinoma with concomitant esophageal varices in patients with cirrhosis","volume":"15","author":"Kawano","year":"2008","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10.1016\/j.ejso.2022.11.005_bib20","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"Management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J\u00a0Hepatol"},{"issue":"5","key":"10.1016\/j.ejso.2022.11.005_bib21","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/annonc\/mdy510","article-title":"Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"30","author":"Vogel","year":"2019","journal-title":"Ann Oncol : Off J. Eur Soc Med Oncol"},{"issue":"2","key":"10.1016\/j.ejso.2022.11.005_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/136518202760378489","article-title":"The Brisbane 2000 terminology of liver anatomy and resections","volume":"4","author":"Pang","year":"2002","journal-title":"HPB : Off J Int Hepato Pancreato Biliary Assoc"},{"issue":"30","key":"10.1016\/j.ejso.2022.11.005_bib23","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.3748\/wjg.v26.i30.4564","article-title":"Comment on pediatric living donor liver transplantation decade progress in Shanghai: characteristics and risks factors of mortality","volume":"26","author":"Akbulut","year":"2020","journal-title":"World J Gastroenterol"},{"issue":"10127","key":"10.1016\/j.ejso.2022.11.005_bib24","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","volume":"391","author":"Forner","year":"2018","journal-title":"Lancet (London, England)"},{"issue":"2","key":"10.1016\/j.ejso.2022.11.005_bib25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.surg.2019.09.022","article-title":"Effect of surgical delay on survival outcomes in patients undergoing curative resection for primary hepatocellular carcinoma: inverse probability of treatment weighting using propensity scores and propensity score adjustment","volume":"167","author":"Kabir","year":"2020","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.ejso.2022.11.005_bib26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11605-021-05126-7","article-title":"Microscopic portal vein invasion in relation to tumor focality and dimension in patients with hepatocellular carcinoma","volume":"26","author":"Carr","year":"2022","journal-title":"J\u00a0Gastrointest Surg : Off J Soc Surg Aliment Tract"},{"issue":"1","key":"10.1016\/j.ejso.2022.11.005_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hpb.2018.07.005","article-title":"Impact of clinically significant portal hypertension on outcomes after partial hepatectomy for hepatocellular carcinoma: a systematic review and meta-analysis","volume":"21","author":"Liu","year":"2019","journal-title":"HPB : Off J Int Hepato Pancreato Biliary Assoc"},{"issue":"3","key":"10.1016\/j.ejso.2022.11.005_bib28","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00464-018-6347-1","article-title":"Safety of laparoscopic hepatectomy in patients with hepatocellular carcinoma and portal hypertension: interim analysis of an open prospective study","volume":"33","author":"Lim","year":"2019","journal-title":"Surg Endosc"},{"issue":"12","key":"10.1016\/j.ejso.2022.11.005_bib29","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1080\/00365521.2018.1538386","article-title":"Portal hypertension predicts short-term and long-term outcomes after hepatectomy in hepatocellular carcinoma patients","volume":"53","author":"Zheng","year":"2018","journal-title":"Scand J Gastroenterol"},{"issue":"6","key":"10.1016\/j.ejso.2022.11.005_bib30","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/hepr.13047","article-title":"Liver resection of hepatocellular carcinoma in patients with portal hypertension and multiple tumors","volume":"48","author":"Ohkubo","year":"2018","journal-title":"Hepatol Res : Off J Jpn Soc Hepatol"},{"issue":"6","key":"10.1016\/j.ejso.2022.11.005_bib31","doi-asserted-by":"crossref","first-page":"436","DOI":"10.5582\/bst.2020.03329","article-title":"Selection of patients with esophageal varices for liver resection of hepatocellular carcinoma","volume":"14","author":"Midorikawa","year":"2021","journal-title":"Biosci Trends"},{"issue":"1","key":"10.1016\/j.ejso.2022.11.005_bib32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1055\/s-0030-1247133","article-title":"Current strategy for staging and treatment: the BCLC update and future prospects","volume":"30","author":"Forner","year":"2010","journal-title":"Semin Liver Dis"},{"issue":"3","key":"10.1016\/j.ejso.2022.11.005_bib33","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-2007-1007122","article-title":"Prognosis of hepatocellular carcinoma: the BCLC staging classification","volume":"19","author":"Llovet","year":"1999","journal-title":"Semin Liver Dis"},{"issue":"4","key":"10.1016\/j.ejso.2022.11.005_bib34","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1055\/s-0034-1394143","article-title":"Systemic therapy for hepatocellular carcinoma: the issue of treatment stage migration and registration of progression using the BCLC-refined RECIST","volume":"34","author":"Reig","year":"2014","journal-title":"Semin Liver Dis"},{"issue":"6","key":"10.1016\/j.ejso.2022.11.005_bib35","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1002\/hep.31187","article-title":"Treatment of hepatocellular carcinoma in the precision medicine era: from treatment stage migration to therapeutic hierarchy","volume":"72","author":"Vitale","year":"2020","journal-title":"Hepatology"}],"container-title":["European Journal of Surgical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798322007338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0748798322007338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:45:57Z","timestamp":1760060757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0748798322007338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0748798322007338"],"URL":"https:\/\/doi.org\/10.1016\/j.ejso.2022.11.005","relation":{},"ISSN":["0748-7983"],"issn-type":[{"type":"print","value":"0748-7983"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinically significant portal hypertension (CSPH) on early-stage HCC following hepatectomy: What's the impact?","name":"articletitle","label":"Article Title"},{"value":"European Journal of Surgical Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejso.2022.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.","name":"copyright","label":"Copyright"}]}}